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Gene Expression Data
Assay Details
Assay
Reference: J:82457 Ligon KL, et al., Loss of Emx2 function leads to ectopic expression of Wnt1 in the developing telencephalon and cortical dysplasia. Development. 2003 May;130(10):2275-87
Assay type: RNA in situ
MGI Accession ID: MGI:2673718
Gene symbol: Wnt1
Gene name: wingless-type MMTV integration site family, member 1
Probe: Wnt1 probe
Assay notes: It is possible that probe (MGI:9304) was used in this assay.
Results
Specimen 2A: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: diencephalon roof plate Present Regionally restricted 2A Expression extended to the rostral diencephalon.
TS20: spinal cord roof plate Present 2A Expression was detected in the roofplate of the neural tube.
Specimen 2B: embryonic day 12.5; Emx2tm1Pgr/Emx2tm1Pgr (more )
Note: E12.5 was the peak age of ectopic expression.
Structure Level Pattern Image Note
TS20: diencephalon Strong 2B
TS20: spinal cord roof plate Present 2B Expression was normal in the mutant neural tube roofplate.
TS20: telencephalon Strong Regionally restricted 2B Expression was strong in the dorsomedial telencephalon.
TS20: cerebral cortex Strong Regionally restricted 2B Expression was strong in the cortical hem organizer region.
Specimen Not Shown: embryonic day 14.5; Emx2tm1Pgr/Emx2tm1Pgr (more )
Structure Level Pattern Image Note
TS22: diencephalon Weak Ectopic expression in the mutant diencephalon decreased at E14.5
TS22: telencephalon Weak Regionally restricted Ectopic expression in the mutant dorsomedial telencephalon decreased at E14.5
TS22: cerebral cortex Weak Regionally restricted Ectopic expression in the mutant cortical hem organizer region decreased at E14.5
Specimen Not Shown: embryonic day 18.5; Emx2tm1Pgr/Emx2tm1Pgr (more )
Structure Level Pattern Image Note
TS26: telencephalon Absent Ectopic expression in the mutant dorsomedial telencephalon was absent by E18.5.
TS26: diencephalon Absent Ectopic expression in the mutant diencephalon was absent by E18.5
TS26: cerebral cortex Absent Ectopic expression in the mutant cortical hem organizer region was absent by E18.5.
Specimen 2C: embryonic day 12.5; Emx2tm1Pgr/Emx2tm1Pgr (more )
Structure Level Pattern Image Note
TS20: telencephalon Present Regionally restricted 2C Ectopic expression was detected in the cortical hem ventricular zone and hippocampal primordium.
TS20: cerebral cortex ventricular layer Present 2C
Specimen 4F: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: telencephalon Absent 4F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory