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Gene Expression Data
Assay Details
Assay
Reference: J:130238 Tsutsumi T, et al., Disruption of the Fbxw8 gene results in pre- and postnatal growth retardation in mice. Mol Cell Biol. 2008 Jan;28(2):743-51
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3776753
Gene symbol: Fbxw8
Gene name: F-box and WD-40 domain protein 8
Reporter: lacZ
Direct Detection
Results
Specimen 3C: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS26: skeletal muscle Strong Non-Uniform 3C There is high expression in the skeletal muscle, with intense staining observed in the intercostals and abdominal walls. Muscles in the extremities are also stained.
TS26: diaphragm Very strong 3C
TS26: smooth muscle tissue Absent 3C There is slight, if any, expression in the smooth muscle.

Specimen 3E: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS26: skeleton Present Regionally restricted 3E Expression is present in bone, especially in the epiphysis of tubular bone corresponding to cartilage. It is not present in the diaphysis, where the formation of bone has occured.

Specimen 3F: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS26: skeleton Present Regionally restricted 3F Expression is present in bone, especially in the epiphysis of tubular bone corresponding to cartilage. It is not present in the diaphysis, where the formation of bone has occured.

Specimen 3G: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS26: bronchiole epithelium Strong 3G

Specimen 3H: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS28: placenta Present Regionally restricted 3H Expression is intense in the labyrinthine layer and moderate in the spongiotrophoblast layer.
TS28: decidua Absent 3H

Specimen 3I: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS28: placenta Present Regionally restricted 3I Expression is intense in the labyrinthine layer and moderate in the spongiotrophoblast layer.
TS28: decidua Absent 3I

Specimen Not shown: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS26: eye Weak
TS26: metanephros Weak
TS26: skin Weak
TS26: brain Absent There is little, if any, expression in the brain.

Specimen Not shown: embryonic day 18.5; Fbxw8Gt(RRT057)Byg/Fbxw8+ (more )
Structure Level Pattern Image Note
TS26: embryo Present Regionally restricted The expression patterns are similar to those seen in -/- animals, but the levels of expression are reduced.

Specimen Not shown: embryonic day 14.5; Fbxw8Gt(RRT057)Byg/Fbxw8Gt(RRT057)Byg (more )
Structure Level Pattern Image Note
TS22: embryo Present Regionally restricted The expression patterns are similar to those seen at E18.5.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory