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Gene Expression Data
Assay Details
Assay
Reference: J:56418 Lopes C, et al., Developmentally regulated expression of mtprd, the murine ortholog of tprd, a gene from the Down syndrome chromosomal region 1. Mech Dev. 1999 Jun;84(1-2):189-93
Assay type: RNA in situ
MGI Accession ID: MGI:5447487
Gene symbol: Ttc3
Gene name: tetratricopeptide repeat domain 3
Probe: mtprd cDNA
Probe preparation: Antisense labelled with S35 RNA
Results
Specimen 1A: embryonic day 8.5-9.0 (more )
Structure Level Pattern Image Note
TS14: embryo Present Uniform 1A
TS14: extraembryonic component Weak 1A
Specimen 1C: embryonic day 10.5-11.0 (more )
Structure Level Pattern Image Note
TS18: nervous system Strong Regionally restricted 1C
TS18: brain mantle layer Strong 1C
TS18: dorsal root ganglion Strong 1C
TS18: neural tube mantle layer Strong 1C
TS18: brain ventricular layer Present 1C
TS18: neural tube ventricular layer Present 1C
TS18: olfactory epithelium Present 1C
TS18: optic stalk Present 1C
TS18: branchial arch Present 1C
Specimen 1E: embryonic day 10.5-11.0 (more )
Structure Level Pattern Image Note
TS18: brain mantle layer Strong 1E
TS18: neural tube mantle layer Strong 1E
TS18: lung Present 1E
TS18: stomach Present 1E
TS18: vertebral cartilage condensation Present 1E
TS18: heart Weak 1E
Specimen 1F: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: neural tube mantle layer Strong 1F
TS19: neural tube ventricular layer Present 1F
TS19: spinal nerve Very strong Regionally restricted 1F Very strong expression in nerves such as the intercostal nerve.Very strong expression in nerves such as the intercostal nerve.
Specimen 1G: embryonic day 12.0-12.5 (more )
Structure Level Pattern Image Note
TS20: brain mantle layer Strong 1G
TS20: spinal cord mantle layer Strong 1G
TS20: metencephalon Present Regionally restricted 1G
TS20: midbrain Present Regionally restricted 1G
TS20: telencephalon Present Regionally restricted 1G
TS20: brain ventricular layer Present 1G
TS20: lung Present 1G
TS20: liver Weak 1G
TS20: axial skeleton Strong Regionally restricted 1G
Specimen 1H: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: nervous system Very strong 1H
TS21: axial skeleton Strong Regionally restricted 1H Pronounced expression in intervertebral disks.
TS21: rib cartilage condensation Strong 1H
TS21: diaphragm Present 1H
TS21: liver Weak 1H
Specimen 1I: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: dorsal root ganglion Very strong 1I
TS21: glossopharyngeal ganglion Very strong 1I
TS21: trigeminal ganglion Very strong 1I
TS21: brain mantle layer Very strong 1I
TS21: brain ventricular layer Present 1I
TS21: cochlea Present 1I
TS21: corpus striatum Present 1I
Specimen 1J: embryonic day 14.5-15.0 (more )
Structure Level Pattern Image Note
TS22: spinal cord Very strong 1J
TS22: diaphragm Strong 1J
TS22: intestine Present 1J
Specimen 1K: embryonic day 14.5-15.0 (more )
Structure Level Pattern Image Note
TS22: brain mantle layer Very strong 1K
TS22: trigeminal ganglion Very strong 1K
TS22: brain ventricular layer Present 1K
TS22: rib cartilage condensation Strong 1K
TS22: submandibular gland primordium Present 1K
Specimen 1L: embryonic day 14.5-15.0 (more )
Structure Level Pattern Image Note
TS22: skeletal muscle Strong 1L
TS22: intervertebral disc Strong 1L
TS22: dorsal root ganglion Very strong 1L
Specimen 1M: embryonic day 14.5-15.0 (more )
Structure Level Pattern Image Note
TS22: skeletal muscle Strong 1M
TS22: skeleton Strong Regionally restricted 1M Pronounced expression confined to the perichondrium in all bones.
Specimen 1N: embryonic day 14.5-15.0 (more )
Structure Level Pattern Image Note
TS22: brain Strong Regionally restricted 1N Strong expression in external layers of cortex.
TS22: neural retinal epithelium Strong 1N
Specimen not shown: embryonic day 14.5-15.0 (more )
Structure Level Pattern Image Note
TS22: tongue Strong
TS22: gland Present
TS22: lung Present
TS22: metanephros Present
TS22: heart Weak
TS22: liver Weak
Specimen 2A: postnatal adult (more )
Structure Level Pattern Image Note
TS28: caudate-putamen Present 2A
TS28: cerebellum Present 2A
TS28: cerebral cortex Present 2A
TS28: hippocampus Present 2A
TS28: dentate gyrus Strong 2A
TS28: hippocampus pyramidal cell layer Strong 2A
Specimen 2C: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cortical layer II Strong 2C
TS28: cortical layer III Strong 2C
TS28: cortical layer V Strong 2C
TS28: cortical layer VI Strong 2C
TS28: cortical layer I Trace 2C Only a few cells were labeled in layer I.
TS28: cortical layer IV Absent 2C
TS28: caudate-putamen Present 2C
Specimen 2D: postnatal adult (more )
Structure Level Pattern Image Note
TS28: dentate gyrus Present 2D
TS28: hippocampus pyramidal cell layer Present 2D
TS28: telencephalon Present Regionally restricted 2D Strongest expression restricted to specific cell types in the sub hippocampic region, where large neurons were clearly labeled.
Specimen 2E: postnatal adult (more )
Structure Level Pattern Image Note
TS28: main olfactory bulb Strong Regionally restricted 2E
TS28: main olfactory bulb glomerular layer Present 2E
TS28: main olfactory bulb granule cell layer Present 2E
TS28: main olfactory bulb mitral cell layer Present 2E
Specimen 2F: postnatal adult (more )
Structure Level Pattern Image Note
TS28: cerebellum granule cell layer Strong 2F
TS28: deep cerebellar nucleus Strong 2F
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/17/2024
MGI 6.24 		The Jackson Laboratory