Gene Expression Data
Assay Details
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Assay
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Reference:
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J:230757
Faden M, et al., Identification of a Recognizable Progressive Skeletal Dysplasia Caused by RSPRY1 Mutations. Am J Hum Genet. 2015 Oct 1;97(4):608-15
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Assay type:
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Immunohistochemistry
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MGI Accession ID:
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MGI:5779308
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Gene symbol:
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Rspry1
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Gene name:
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ring finger and SPRY domain containing 1
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Results
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Specimen
3A,B:
embryonic day 18.5
(more  )
Specimen
3A,B:
(close  )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: elbow |
Present |
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3A
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| TS26: forelimb muscle |
Strong |
Regionally restricted |
3A
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Strong expression surrounding the humerus and ulna.
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| TS26: perichondrium |
Strong |
Regionally restricted |
3A
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Strong expression surrounding the humerus and ulna.
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| TS26: periosteum |
Strong |
Regionally restricted |
3A
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Strong expression surrounding the humerus and ulna.
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| TS26: ulna |
Present |
Regionally restricted |
3A
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Expression was detected in presumptive osteoblasts and osteocytes. There was relative paucity of expression in the hyaline cartilage in the ulna.
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| TS26: humerus |
Present |
Regionally restricted |
3B
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3A
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Expression was detected in presumptive osteoblasts and osteocytes in developing cancellous bone in the humerus. There was minimal localization in chondrocytes.
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Specimen
3C:
embryonic day 18.5
(more )
Specimen
3C:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Embedding:
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Cryosection
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: humerus |
Present |
Regionally restricted |
3C
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Expression was detected in presumptive osteoblasts and osteocytes. There was minimal localization in chondrocytes.
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Specimen
3D:
embryonic day 18.5
(more )
Specimen
3D:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: perichondrium |
Present |
Regionally restricted |
3D
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Expression was detected in distal femur perichondrial tissue.
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| TS26: knee joint |
Present |
Regionally restricted |
3D
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Expression was detected in the fibromuscular connections to the fibula and tibia at the knee joint.
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| TS26: femur |
Present |
Regionally restricted |
3D
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Expression was detected in presumptive osteoblasts and osteocytes.
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Specimen
3E:
embryonic day 18.5
(more )
Specimen
3E:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: perichondrium |
Present |
Regionally restricted |
3E
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Expression was detected in perichondrial tissue in tarsals.
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| TS26: tarsal bone |
Present |
Regionally restricted |
3E
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Expression was detected in presumptive osteoblasts and osteocytes.
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Specimen
3F:
embryonic day 18.5
(more )
Specimen
3F:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: perichondrium |
Present |
Regionally restricted |
3F
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Expression was detected in perichondrial tissue in metatarsals.
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| TS26: metatarsal bone |
Present |
Regionally restricted |
3F
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Expression was detected in presumptive osteoblasts and osteocytes.
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Specimen
3G,H:
embryonic day 18.5
(more )
Specimen
3G,H:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: periosteum |
Present |
Regionally restricted |
3G
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Expression was detected in tibial and tarsal periosteum.
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| TS26: perichondrium |
Present |
Regionally restricted |
3H
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3G
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Expression was detected in tibial and tarsal perichondrium. The highest levels were in the innermost cellular layer.
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| TS26: tarsal bone |
Present |
Regionally restricted |
3G
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3H
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Expression was detected in presumptive osteoblasts and osteocytes.
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| TS26: tibia |
Present |
Regionally restricted |
3G
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3H
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Expression was detected in presumptive osteoblasts and osteocytes.
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Specimen
not shown:
embryonic day 18.5
(more )
Specimen
not shown:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: carpal bone |
Present |
Regionally restricted |
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Expression was detected in presumptive osteoblasts and osteocytes.
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| TS26: fibula |
Present |
Regionally restricted |
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Expression was detected in presumptive osteoblasts and osteocytes.
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| TS26: metacarpal bone |
Present |
Regionally restricted |
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Expression was detected in presumptive osteoblasts and osteocytes.
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| TS26: radius |
Present |
Regionally restricted |
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Expression was detected in presumptive osteoblasts and osteocytes.
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Specimen
not shown:
embryonic day 12.5
(more )
Specimen
not shown:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 12.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
S1c c1:
embryonic day 18.5
(more )
Specimen
S1c c1:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
S1c c2:
embryonic day 14.5
(more )
Specimen
S1c c2:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 14.5
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Sex:
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Not Specified
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Type:
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section
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Specimen
S2A 1-4:
embryonic day 18.5
(more )
Specimen
S2A 1-4:
(close )
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Genetic Background:
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Not Specified
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Age:
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embryonic day 18.5
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Sex:
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Not Specified
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Type:
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section
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| Structure |
Level |
Pattern |
Image |
Note |
| TS26: metacarpus |
Present |
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S2-3
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S2-2
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S2A
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| TS26: perichondrium |
Present |
Regionally restricted |
S2-1
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S2A
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Expression was detected in the phalangeal perichondrium.
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| TS26: hand muscle |
Present |
Regionally restricted |
S2-4
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S2A
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Expression was detected in phalangeal muscle.
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