Analysis Tools
immune system
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• there are higher numbers of CD45R(B220)+ putative B cells in the Peyer's Patches compared to controls, despite reduced total cellularity
(J:28868)
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to normal mice
(J:118712)
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• in mutants PPs have a dramatically reduced cell content compared to controls
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• there are small but highly active germinal centers
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• after immunization with antigens which elicit a restricted response in normal mice, there is an elevated antibody titer but mice display no titer increase after secondary challenge
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hematopoietic system
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• there are higher numbers of CD45R(B220)+ putative B cells in the Peyer's Patches compared to controls, despite reduced total cellularity
(J:28868)
• at stage when L chain rearrangement should have been completed, number of IgM+ B220+ cells (0.4 x 106) in bone marrow is reduced by >50% compared to normal mice
(J:118712)
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