Phenotypes associated with Cd244a<Chip>/Cd244a<Chip>

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Phenotypes associated with Cd244a^Chip/Cd244a^Chip

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd244a^Chip/Cd244a^Chip	C57BL/6J-Cd244a^Chip	MGI:5491506

Comparison Matrix Gene Expression + Phenotype

Allelic Composition	Cd244a^Chip/Cd244a^Chip
Genetic Background	C57BL/6J-Cd244a^Chip

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd244a^Chip mutation (0 available); any Cd244a mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK cell physiology ( J:196519 )

• reduced capacity to recognize and eliminate missing-self targets

• however, antigen-specific targeting and killing are normal

• mice exhibit increased clearance of B16 melanoma tumors

• towards missing-self targets

hematopoietic system

abnormal NK cell physiology ( J:196519 )

• reduced capacity to recognize and eliminate missing-self targets

• however, antigen-specific targeting and killing are normal

• mice exhibit increased clearance of B16 melanoma tumors

• towards missing-self targets

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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