GO_ancestor term aspect genes_annotated genes_experimental GO:0008247 2-acetyl-1-alkylglycerophosphocholine esterase complex C 2 0 GO:0005945 6-phosphofructokinase complex C 3 0 GO:0030686 90S preribosome C 1 1 GO:0031672 A band C 17 2 GO:0009317 acetyl-CoA carboxylase complex C 2 0 GO:0043159 acrosomal matrix C 3 1 GO:0002080 acrosomal membrane C 1 1 GO:0001669 acrosome C 24 20 GO:0030482 actin cable C 1 1 GO:0030478 actin cap C 1 1 GO:0015629 actin cytoskeleton C 192 80 GO:0005884 actin filament C 23 14 GO:0032432 actin filament bundle C 20 16 GO:0032444 activin responsive factor complex C 1 1 GO:0042641 actomyosin C 1 1 GO:0005912 adherens junction C 61 49 GO:0016235 aggresome C 1 0 GO:0005658 alpha DNA polymerase:primase complex C 4 2 GO:0042105 alpha-beta T cell receptor complex C 6 6 GO:0017177 alpha-glucosidase II complex C 2 2 GO:0045240 alpha-ketoglutarate dehydrogenase complex C 1 0 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex C 3 0 GO:0005680 anaphase-promoting complex C 7 0 GO:0031362 anchored to external side of plasma membrane C 2 2 GO:0031225 anchored to membrane C 10 9 GO:0046658 anchored to plasma membrane C 10 9 GO:0030934 anchoring collagen C 2 0 GO:0032311 angiogenin-PRI complex C 1 0 GO:0030121 AP-1 adaptor complex C 1 0 GO:0030122 AP-2 adaptor complex C 1 0 GO:0045179 apical cortex C 1 1 GO:0043296 apical junction complex C 89 43 GO:0045177 apical part of cell C 74 70 GO:0016324 apical plasma membrane C 49 45 GO:0016327 apicolateral plasma membrane C 91 45 GO:0043293 apoptosome C 1 1 GO:0030119 AP-type membrane coat adaptor complex C 24 0 GO:0005885 Arp2/3 protein complex C 7 0 GO:0005818 aster C 1 0 GO:0005776 autophagic vacuole C 8 6 GO:0030673 axolemma C 3 3 GO:0030424 axon C 60 57 GO:0043203 axon hillock C 1 1 GO:0033267 axon part C 9 9 GO:0005858 axonemal dynein complex C 12 2 GO:0005930 axoneme C 22 10 GO:0044447 axoneme part C 15 5 GO:0019815 B cell receptor complex C 6 6 GO:0001740 Barr body C 3 1 GO:0005932 basal body C 9 7 GO:0045180 basal cortex C 1 1 GO:0005605 basal lamina C 26 17 GO:0045178 basal part of cell C 9 7 GO:0009925 basal plasma membrane C 8 6 GO:0005604 basement membrane C 57 45 GO:0016323 basolateral plasma membrane C 70 59 GO:0009341 beta-galactosidase complex C 2 0 GO:0009343 biotin carboxylase complex C 2 0 GO:0002111 BRCA2-BRAF35 complex C 1 0 GO:0005903 brush border C 21 16 GO:0031526 brush border membrane C 4 4 GO:0015030 Cajal body C 7 3 GO:0005954 calcium- and calmodulin-dependent protein kinase complex C 6 1 GO:0005952 cAMP-dependent protein kinase complex C 9 0 GO:0016342 catenin complex C 1 0 GO:0005901 caveola C 9 6 GO:0002095 caveolar macromolecular signaling complex C 1 1 GO:0016599 caveolar membrane C 8 4 GO:0030014 CCR4-NOT complex C 1 1 GO:0005623 cell C 13431 3379 GO:0005938 cell cortex C 43 29 GO:0044448 cell cortex part C 28 18 GO:0032153 cell division site C 6 4 GO:0032155 cell division site part C 6 4 GO:0030313 cell envelope C 1 0 GO:0000267 cell fraction C 481 263 GO:0030054 cell junction C 380 116 GO:0044464 cell part C 13431 3379 GO:0042995 cell projection C 345 253 GO:0031253 cell projection membrane C 9 9 GO:0044463 cell projection part C 64 49 GO:0043025 cell soma C 55 53 GO:0009986 cell surface C 172 154 GO:0005913 cell-cell adherens junction C 26 20 GO:0030055 cell-matrix junction C 35 30 GO:0005924 cell-substrate adherens junction C 31 26 GO:0005575 cellular_component C 15314 3589 GO:0000801 central element C 4 4 GO:0005721 centric heterochromatin C 4 4 GO:0005814 centriole C 7 6 GO:0005813 centrosome C 42 29 GO:0005832 chaperonin-containing T-complex C 7 7 GO:0005712 chiasma C 1 1 GO:0009507 chloroplast C 1 0 GO:0000785 chromatin C 188 46 GO:0016585 chromatin remodeling complex C 19 6 GO:0005677 chromatin silencing complex C 8 1 GO:0033391 chromatoid body C 1 1 GO:0010369 chromocenter C 6 6 GO:0044427 chromosomal part C 295 95 GO:0005694 chromosome C 351 115 GO:0000775 chromosome, pericentric region C 61 24 GO:0000781 chromosome, telomeric region C 18 5 GO:0042627 chylomicron C 7 0 GO:0035253 ciliary rootlet C 9 9 GO:0005929 cilium C 64 37 GO:0035085 cilium axoneme C 4 1 GO:0044441 cilium part C 13 10 GO:0005801 cis-Golgi network C 7 3 GO:0009346 citrate lyase complex C 1 0 GO:0030131 clathrin adaptor complex C 24 0 GO:0030118 clathrin coat C 35 2 GO:0030132 clathrin coat of coated pit C 5 0 GO:0030128 clathrin coat of endocytic vesicle C 1 0 GO:0030130 clathrin coat of trans-Golgi network vesicle C 7 0 GO:0030665 clathrin coated vesicle membrane C 19 3 GO:0030125 clathrin vesicle coat C 17 2 GO:0045334 clathrin-coated endocytic vesicle C 1 0 GO:0030669 clathrin-coated endocytic vesicle membrane C 1 0 GO:0030136 clathrin-coated vesicle C 76 32 GO:0032154 cleavage furrow C 2 2 GO:0048475 coated membrane C 52 7 GO:0005905 coated pit C 31 5 GO:0030135 coated vesicle C 89 35 GO:0030662 coated vesicle membrane C 30 3 GO:0005581 collagen C 34 8 GO:0005587 collagen type IV C 6 6 GO:0005594 collagen type IX C 2 0 GO:0005588 collagen type V C 3 1 GO:0000793 condensed chromosome C 45 41 GO:0000777 condensed chromosome kinetochore C 5 4 GO:0000779 condensed chromosome, pericentric region C 7 6 GO:0000794 condensed nuclear chromosome C 28 25 GO:0000780 condensed nuclear chromosome, pericentric region C 2 2 GO:0005922 connexon complex C 18 0 GO:0043292 contractile fiber C 79 50 GO:0044449 contractile fiber part C 71 39 GO:0005826 contractile ring C 4 2 GO:0030663 COPI coated vesicle membrane C 9 0 GO:0030126 COPI vesicle coat C 9 0 GO:0030137 COPI-coated vesicle C 11 3 GO:0030127 COPII vesicle coat C 3 0 GO:0000439 core TFIIH complex C 1 0 GO:0001533 cornified envelope C 20 5 GO:0030864 cortical actin cytoskeleton C 11 9 GO:0030863 cortical cytoskeleton C 17 14 GO:0043034 costamere C 3 2 GO:0031461 cullin-RING ubiquitin ligase complex C 4 3 GO:0032437 cuticular plate C 1 1 GO:0016533 cyclin-dependent protein kinase 5 activator complex C 2 0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex C 7 6 GO:0005737 cytoplasm C 5219 1729 GO:0005868 cytoplasmic dynein complex C 10 1 GO:0016023 cytoplasmic membrane-bound vesicle C 191 114 GO:0005881 cytoplasmic microtubule C 6 6 GO:0044444 cytoplasmic part C 3008 1209 GO:0000153 cytoplasmic ubiquitin ligase complex C 2 1 GO:0031410 cytoplasmic vesicle C 290 128 GO:0030659 cytoplasmic vesicle membrane C 42 10 GO:0044433 cytoplasmic vesicle part C 53 19 GO:0044430 cytoskeletal part C 518 153 GO:0005856 cytoskeleton C 861 210 GO:0005829 cytosol C 332 141 GO:0005842 cytosolic large ribosomal subunit (sensu Eukaryota) C 9 3 GO:0044445 cytosolic part C 92 16 GO:0005830 cytosolic ribosome (sensu Eukaryota) C 48 3 GO:0005843 cytosolic small ribosomal subunit (sensu Eukaryota) C 14 0 GO:0030425 dendrite C 44 40 GO:0043198 dendritic shaft C 6 5 GO:0043197 dendritic spine C 7 5 GO:0031045 dense core granule C 1 0 GO:0032127 dense core granule membrane C 1 0 GO:0001651 dense fibrillar component C 1 0 GO:0030057 desmosome C 14 10 GO:0033202 DNA helicase complex C 1 0 GO:0005662 DNA replication factor A complex C 5 2 GO:0005663 DNA replication factor C complex C 4 0 GO:0005958 DNA-dependent protein kinase complex C 1 0 GO:0000428 DNA-directed RNA polymerase complex C 11 3 GO:0005736 DNA-directed RNA polymerase I complex C 3 3 GO:0005665 DNA-directed RNA polymerase II, core complex C 6 0 GO:0016591 DNA-directed RNA polymerase II, holoenzyme C 49 9 GO:0005666 DNA-directed RNA polymerase III complex C 2 0 GO:0005869 dynactin complex C 7 3 GO:0030286 dynein complex C 29 3 GO:0016014 dystrobrevin complex C 1 0 GO:0016011 dystroglycan complex C 7 4 GO:0016010 dystrophin-associated glycoprotein complex C 12 8 GO:0005769 early endosome C 23 17 GO:0045251 electron transfer flavoprotein complex C 3 0 GO:0030139 endocytic vesicle C 13 10 GO:0030666 endocytic vesicle membrane C 1 0 GO:0012505 endomembrane system C 293 116 GO:0005783 endoplasmic reticulum C 658 117 GO:0005788 endoplasmic reticulum lumen C 7 2 GO:0005789 endoplasmic reticulum membrane C 67 29 GO:0044432 endoplasmic reticulum part C 76 33 GO:0044440 endosomal part C 5 4 GO:0005768 endosome C 162 54 GO:0010008 endosome membrane C 5 4 GO:0031975 envelope C 380 227 GO:0030134 ER to Golgi transport vesicle C 3 0 GO:0012507 ER to Golgi transport vesicle membrane C 3 0 GO:0005793 ER-Golgi intermediate compartment C 4 4 GO:0035098 ESC/E(Z) complex C 3 0 GO:0000791 euchromatin C 1 1 GO:0005853 eukaryotic translation elongation factor 1 complex C 6 1 GO:0005850 eukaryotic translation initiation factor 2 complex C 1 0 GO:0005851 eukaryotic translation initiation factor 2B complex C 6 0 GO:0005852 eukaryotic translation initiation factor 3 complex C 2 0 GO:0016281 eukaryotic translation initiation factor 4F complex C 1 0 GO:0000145 exocyst C 5 0 GO:0000178 exosome (RNase complex) C 10 0 GO:0030312 external encapsulating structure C 1 0 GO:0044462 external encapsulating structure part C 1 0 GO:0032473 external side of mitochondrial outer membrane C 1 1 GO:0009897 external side of plasma membrane C 123 119 GO:0031012 extracellular matrix C 278 84 GO:0044420 extracellular matrix part C 89 47 GO:0005576 extracellular region C 2218 254 GO:0044421 extracellular region part C 2089 215 GO:0005615 extracellular space C 1973 138 GO:0031234 extrinsic to internal side of plasma membrane C 1 1 GO:0019898 extrinsic to membrane C 68 15 GO:0019897 extrinsic to plasma membrane C 50 13 GO:0005593 FACIT collagen C 2 0 GO:0008290 F-actin capping protein complex C 5 0 GO:0005916 fascia adherens C 5 5 GO:0032997 Fc receptor complex C 2 2 GO:0032998 Fc-epsilon receptor I complex C 2 2 GO:0001674 female germ cell nucleus C 4 4 GO:0001939 female pronucleus C 5 5 GO:0043205 fibril C 6 0 GO:0001650 fibrillar center C 1 1 GO:0005583 fibrillar collagen C 3 1 GO:0005577 fibrinogen complex C 2 0 GO:0031941 filamentous actin C 7 5 GO:0030175 filopodium C 13 12 GO:0031527 filopodium membrane C 1 1 GO:0032433 filopodium tip C 1 1 GO:0035086 flagellar axoneme C 1 1 GO:0009288 flagellin-based flagellum C 1 0 GO:0019861 flagellum C 39 22 GO:0044460 flagellum part C 2 2 GO:0016600 flotillin complex C 2 1 GO:0005925 focal adhesion C 27 23 GO:0005760 gamma DNA polymerase complex C 1 0 GO:0000930 gamma-tubulin complex C 1 0 GO:0005921 gap junction C 26 11 GO:0043073 germ cell nucleus C 9 7 GO:0042585 germinal vesicle C 1 1 GO:0017109 glutamate-cysteine ligase complex C 2 2 GO:0009331 glycerol-3-phosphate dehydrogenase complex C 3 0 GO:0005960 glycine cleavage complex C 2 0 GO:0005961 glycine dehydrogenase complex (decarboxylating) C 1 0 GO:0042587 glycogen granule C 2 2 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex C 1 0 GO:0005794 Golgi apparatus C 543 124 GO:0044431 Golgi apparatus part C 131 47 GO:0000137 Golgi cis cisterna C 2 2 GO:0031985 Golgi cisterna C 4 3 GO:0005796 Golgi lumen C 1 0 GO:0005797 Golgi medial cisterna C 1 1 GO:0000139 Golgi membrane C 68 19 GO:0005795 Golgi stack C 11 5 GO:0000138 Golgi trans cisterna C 1 0 GO:0005798 Golgi-associated vesicle C 28 8 GO:0030660 Golgi-associated vesicle membrane C 11 0 GO:0042765 GPI-anchor transamidase complex C 2 1 GO:0001652 granular component C 1 1 GO:0030426 growth cone C 14 12 GO:0008074 guanylate cyclase complex, soluble C 1 0 GO:0031673 H zone C 1 1 GO:0043189 H4/H2A histone acetyltransferase complex C 1 0 GO:0030056 hemidesmosome C 2 2 GO:0005833 hemoglobin complex C 3 1 GO:0000792 heterochromatin C 33 30 GO:0005834 heterotrimeric G-protein complex C 33 3 GO:0000123 histone acetyltransferase complex C 6 4 GO:0000118 histone deacetylase complex C 22 11 GO:0035097 histone methyltransferase complex C 8 0 GO:0005675 holo TFIIH complex C 1 0 GO:0031674 I band C 5 5 GO:0019814 immunoglobulin complex C 13 13 GO:0042571 immunoglobulin complex, circulating C 8 8 GO:0001772 immunological synapse C 20 18 GO:0016234 inclusion body C 4 3 GO:0000939 inner kinetochore of condensed chromosome C 2 2 GO:0005626 insoluble fraction C 10 9 GO:0016942 insulin-like growth factor binding protein complex C 1 0 GO:0030176 integral to endoplasmic reticulum membrane C 20 8 GO:0030173 integral to Golgi membrane C 25 0 GO:0016021 integral to membrane C 5593 130 GO:0000299 integral to membrane of membrane fraction C 12 8 GO:0005639 integral to nuclear inner membrane C 1 1 GO:0031301 integral to organelle membrane C 50 9 GO:0005779 integral to peroxisomal membrane C 4 0 GO:0005887 integral to plasma membrane C 809 84 GO:0030285 integral to synaptic vesicle membrane C 3 1 GO:0008305 integrin complex C 34 2 GO:0046581 intercellular canaliculus C 7 7 GO:0005911 intercellular junction C 151 83 GO:0045323 interleukin-1 receptor complex C 1 0 GO:0005895 interleukin-5 receptor complex C 1 1 GO:0005882 intermediate filament C 121 16 GO:0045111 intermediate filament cytoskeleton C 124 20 GO:0009898 internal side of plasma membrane C 6 5 GO:0005622 intracellular C 8498 2627 GO:0043231 intracellular membrane-bound organelle C 6017 1978 GO:0043232 intracellular non-membrane-bound organelle C 1466 397 GO:0043229 intracellular organelle C 6850 2180 GO:0044446 intracellular organelle part C 2277 835 GO:0044424 intracellular part C 8201 2604 GO:0031227 intrinsic to endoplasmic reticulum membrane C 23 8 GO:0031233 intrinsic to external side of plasma membrane C 2 2 GO:0031228 intrinsic to Golgi membrane C 25 0 GO:0031224 intrinsic to membrane C 5607 142 GO:0031304 intrinsic to mitochondrial inner membrane C 1 1 GO:0031229 intrinsic to nuclear inner membrane C 1 1 GO:0031300 intrinsic to organelle membrane C 55 11 GO:0031231 intrinsic to peroxisomal membrane C 5 1 GO:0031226 intrinsic to plasma membrane C 820 94 GO:0008328 ionotropic glutamate receptor complex C 7 2 GO:0030314 junctional membrane complex C 2 2 GO:0008352 katanin complex C 1 0 GO:0045095 keratin filament C 4 2 GO:0005871 kinesin complex C 39 5 GO:0016939 kinesin II complex C 1 1 GO:0000776 kinetochore C 18 14 GO:0060091 kinocilium C 1 1 GO:0042599 lamellar body C 1 0 GO:0030027 lamellipodium C 49 46 GO:0005638 lamin filament C 4 4 GO:0043256 laminin complex C 7 3 GO:0005606 laminin-1 complex C 5 0 GO:0043259 laminin-10 complex C 3 3 GO:0015934 large ribosomal subunit C 32 15 GO:0005770 late endosome C 27 21 GO:0000800 lateral element C 5 4 GO:0016328 lateral plasma membrane C 6 4 GO:0031252 leading edge C 75 65 GO:0031256 leading edge membrane C 3 3 GO:0005811 lipid particle C 10 5 GO:0045121 lipid raft C 33 27 GO:0005765 lysosomal membrane C 7 4 GO:0005764 lysosome C 169 53 GO:0000323 lytic vacuole C 169 53 GO:0031430 M line C 1 1 GO:0032991 macromolecular complex C 1949 370 GO:0001673 male germ cell nucleus C 5 3 GO:0001940 male pronucleus C 4 4 GO:0042629 mast cell granule C 1 1 GO:0000119 mediator complex C 21 8 GO:0042470 melanosome C 13 12 GO:0016020 membrane C 7242 1041 GO:0005579 membrane attack complex C 5 0 GO:0030117 membrane coat C 52 7 GO:0005624 membrane fraction C 433 228 GO:0044425 membrane part C 6082 564 GO:0043227 membrane-bound organelle C 6023 1985 GO:0031988 membrane-bound vesicle C 199 122 GO:0031974 membrane-enclosed lumen C 730 249 GO:0042612 MHC class I protein complex C 16 0 GO:0042613 MHC class II protein complex C 11 2 GO:0042611 MHC protein complex C 27 2 GO:0042579 microbody C 87 21 GO:0031903 microbody membrane C 17 9 GO:0044438 microbody part C 19 9 GO:0001527 microfibril C 5 0 GO:0005792 microsome C 147 47 GO:0005874 microtubule C 192 19 GO:0005875 microtubule associated complex C 101 16 GO:0015630 microtubule cytoskeleton C 288 97 GO:0005815 microtubule organizing center C 52 36 GO:0044450 microtubule organizing center part C 14 10 GO:0009434 microtubule-based flagellum C 23 20 GO:0044442 microtubule-based flagellum part C 2 2 GO:0005902 microvillus C 16 14 GO:0031528 microvillus membrane C 1 1 GO:0030496 midbody C 3 2 GO:0032300 mismatch repair complex C 4 4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex C 1 0 GO:0030061 mitochondrial crista C 1 0 GO:0017133 mitochondrial electron transfer flavoprotein complex C 3 0 GO:0005740 mitochondrial envelope C 272 187 GO:0005743 mitochondrial inner membrane C 234 172 GO:0042720 mitochondrial inner membrane peptidase complex C 1 1 GO:0005744 mitochondrial inner membrane presequence translocase complex C 7 0 GO:0005758 mitochondrial intermembrane space C 11 1 GO:0042719 mitochondrial intermembrane space protein transporter complex C 4 0 GO:0005762 mitochondrial large ribosomal subunit C 18 12 GO:0031980 mitochondrial lumen C 53 18 GO:0005759 mitochondrial matrix C 53 18 GO:0031966 mitochondrial membrane C 252 179 GO:0044455 mitochondrial membrane part C 44 4 GO:0005741 mitochondrial outer membrane C 19 5 GO:0005742 mitochondrial outer membrane translocase complex C 1 0 GO:0044429 mitochondrial part C 320 205 GO:0005753 mitochondrial proton-transporting ATP synthase complex C 4 0 GO:0005967 mitochondrial pyruvate dehydrogenase complex C 2 0 GO:0005746 mitochondrial respiratory chain C 28 1 GO:0005747 mitochondrial respiratory chain complex I C 7 1 GO:0005751 mitochondrial respiratory chain complex IV C 3 0 GO:0005761 mitochondrial ribosome C 40 14 GO:0005763 mitochondrial small ribosomal subunit C 8 0 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex C 1 0 GO:0005739 mitochondrion C 903 521 GO:0030870 Mre11 complex C 1 0 GO:0005845 mRNA cap complex C 1 0 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex C 1 0 GO:0005849 mRNA cleavage factor complex C 1 0 GO:0030681 multimeric ribonuclease P complex C 3 1 GO:0005771 multivesicular body C 9 7 GO:0005859 muscle myosin complex C 17 1 GO:0005927 muscle tendon junction C 2 2 GO:0005862 muscle thin filament tropomyosin C 4 0 GO:0032389 MutLalpha complex C 2 2 GO:0032301 MutSalpha complex C 2 2 GO:0032302 MutSbeta complex C 1 0 GO:0043209 myelin sheath C 3 3 GO:0030016 myofibril C 77 48 GO:0016459 myosin complex C 56 16 GO:0032982 myosin filament C 16 0 GO:0045160 myosin I complex C 1 1 GO:0016460 myosin II complex C 19 3 GO:0030964 NADH dehydrogenase complex (quinone) C 7 1 GO:0005883 neurofilament C 6 5 GO:0060053 neurofilament cytoskeleton C 9 8 GO:0031594 neuromuscular junction C 13 13 GO:0043005 neuron projection C 110 103 GO:0032589 neuron projection membrane C 3 3 GO:0005892 nicotinic acetylcholine-gated receptor-channel complex C 10 10 GO:0042564 NLS-dependent protein nuclear import complex C 1 1 GO:0017146 N-methyl-D-aspartate selective glutamate receptor complex C 2 2 GO:0030689 Noc complex C 1 1 GO:0030690 Noc1p-Noc2p complex C 1 1 GO:0043228 non-membrane-bound organelle C 1466 397 GO:0031513 nonmotile primary cilium C 16 15 GO:0016604 nuclear body C 38 25 GO:0000790 nuclear chromatin C 28 22 GO:0000228 nuclear chromosome C 76 56 GO:0044454 nuclear chromosome part C 64 46 GO:0000784 nuclear chromosome, telomeric region C 3 1 GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex C 1 0 GO:0055029 nuclear DNA-directed RNA polymerase complex C 11 3 GO:0005635 nuclear envelope C 109 41 GO:0005641 nuclear envelope lumen C 10 6 GO:0042175 nuclear envelope-endoplasmic reticulum network C 70 31 GO:0005719 nuclear euchromatin C 1 1 GO:0000176 nuclear exosome (RNase complex) C 1 0 GO:0005720 nuclear heterochromatin C 20 16 GO:0042405 nuclear inclusion body C 2 2 GO:0005637 nuclear inner membrane C 8 5 GO:0005652 nuclear lamina C 8 5 GO:0031981 nuclear lumen C 648 221 GO:0016363 nuclear matrix C 16 8 GO:0031965 nuclear membrane C 63 12 GO:0044453 nuclear membrane part C 61 12 GO:0005664 nuclear origin of replication recognition complex C 4 2 GO:0005640 nuclear outer membrane C 3 2 GO:0044428 nuclear part C 969 333 GO:0005643 nuclear pore C 51 5 GO:0043596 nuclear replication fork C 10 5 GO:0043601 nuclear replisome C 9 4 GO:0016607 nuclear speck C 10 6 GO:0000783 nuclear telomere cap complex C 1 0 GO:0000152 nuclear ubiquitin ligase complex C 7 0 GO:0031074 nucleocytoplasmic shuttling complex C 1 1 GO:0044452 nucleolar part C 37 9 GO:0030685 nucleolar preribosome C 3 1 GO:0030687 nucleolar preribosome, large subunit precursor C 1 1 GO:0030688 nucleolar preribosome, small subunit precursor C 1 0 GO:0005655 nucleolar ribonuclease P complex C 3 1 GO:0005730 nucleolus C 108 57 GO:0005654 nucleoplasm C 544 165 GO:0044451 nucleoplasm part C 519 150 GO:0000786 nucleosome C 98 0 GO:0000109 nucleotide-excision repair complex C 3 0 GO:0005634 nucleus C 3783 1053 GO:0016581 NuRD complex C 7 7 GO:0008250 oligosaccharyl transferase complex C 4 1 GO:0000315 organellar large ribosomal subunit C 18 12 GO:0000313 organellar ribosome C 40 14 GO:0000314 organellar small ribosomal subunit C 8 0 GO:0043226 organelle C 6854 2187 GO:0031967 organelle envelope C 380 227 GO:0031970 organelle envelope lumen C 21 7 GO:0019866 organelle inner membrane C 243 177 GO:0043233 organelle lumen C 730 249 GO:0031090 organelle membrane C 527 280 GO:0031968 organelle outer membrane C 22 7 GO:0044422 organelle part C 2286 845 GO:0031984 organelle subcompartment C 4 3 GO:0000808 origin recognition complex C 4 2 GO:0009348 ornithine carbamoyltransferase complex C 1 0 GO:0001520 outer dense fiber C 3 3 GO:0000940 outer kinetochore of condensed chromosome C 3 2 GO:0019867 outer membrane C 45 8 GO:0030288 outer membrane-bounded periplasmic space C 1 0 GO:0045252 oxoglutarate dehydrogenase complex C 1 0 GO:0031519 PcG protein complex C 11 8 GO:0043626 PCNA complex C 1 0 GO:0000242 pericentriolar material C 5 4 GO:0005726 perichromatin fibrils C 1 0 GO:0043204 perikaryon C 3 3 GO:0048471 perinuclear region of cytoplasm C 35 27 GO:0033011 perinuclear theca C 1 0 GO:0010370 perinucleolar chromocenter C 1 1 GO:0000300 peripheral to membrane of membrane fraction C 6 1 GO:0042597 periplasmic space C 1 0 GO:0005782 peroxisomal matrix C 3 0 GO:0005778 peroxisomal membrane C 17 9 GO:0044439 peroxisomal part C 19 9 GO:0005777 peroxisome C 87 21 GO:0001891 phagocytic cup C 2 2 GO:0045335 phagocytic vesicle C 1 0 GO:0005942 phosphoinositide 3-kinase complex C 11 2 GO:0000015 phosphopyruvate hydratase complex C 4 0 GO:0009320 phosphoribosylaminoimidazole carboxylase complex C 1 0 GO:0005964 phosphorylase kinase complex C 2 0 GO:0032391 photoreceptor connecting cilium C 1 1 GO:0001917 photoreceptor inner segment C 3 3 GO:0001750 photoreceptor outer segment C 14 13 GO:0048770 pigment granule C 13 12 GO:0005886 plasma membrane C 1882 665 GO:0044459 plasma membrane part C 1451 440 GO:0009536 plastid C 1 0 GO:0031091 platelet alpha granule C 1 0 GO:0031092 platelet alpha granule membrane C 1 0 GO:0042827 platelet dense granule C 2 0 GO:0031088 platelet dense granule membrane C 2 0 GO:0016605 PML body C 13 7 GO:0002102 podosome C 3 3 GO:0018994 polar granule C 2 2 GO:0045495 pole plasm C 2 2 GO:0042788 polysomal ribosome C 2 2 GO:0005844 polysome C 4 4 GO:0005700 polytene chromosome C 3 3 GO:0005701 polytene chromosome chromocenter C 3 3 GO:0046930 pore complex C 56 5 GO:0014069 postsynaptic density C 6 6 GO:0045211 postsynaptic membrane C 108 17 GO:0016272 prefoldin complex C 9 0 GO:0030684 preribosome C 3 1 GO:0048786 presynaptic active zone C 3 0 GO:0048787 presynaptic active zone membrane C 1 0 GO:0042734 presynaptic membrane C 12 8 GO:0045120 pronucleus C 14 14 GO:0008537 proteasome activator complex C 3 0 GO:0000502 proteasome complex (sensu Eukaryota) C 29 4 GO:0005839 proteasome core complex (sensu Eukaryota) C 19 2 GO:0005838 proteasome regulatory particle (sensu Eukaryota) C 2 1 GO:0043234 protein complex C 1552 333 GO:0005956 protein kinase CK2 complex C 3 0 GO:0000164 protein phosphatase type 1 complex C 1 1 GO:0000159 protein phosphatase type 2A complex C 7 0 GO:0008287 protein serine/threonine phosphatase complex C 21 1 GO:0005578 proteinaceous extracellular matrix C 275 81 GO:0045259 proton-transporting ATP synthase complex C 19 0 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) C 6 0 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) C 12 0 GO:0016469 proton-transporting two-sector ATPase complex C 41 3 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain C 7 0 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain C 12 0 GO:0033176 proton-transporting V-type ATPase complex C 6 3 GO:0033180 proton-transporting V-type ATPase, V1 domain C 1 0 GO:0031143 pseudopodium C 1 1 GO:0045254 pyruvate dehydrogenase complex C 2 0 GO:0005968 Rab-protein geranylgeranyltransferase complex C 2 0 GO:0043235 receptor complex C 69 28 GO:0005657 replication fork C 24 15 GO:0030894 replisome C 9 4 GO:0045271 respiratory chain complex I C 7 1 GO:0045275 respiratory chain complex III C 4 0 GO:0045277 respiratory chain complex IV C 3 0 GO:0030904 retromer complex C 3 0 GO:0000172 ribonuclease MRP complex C 1 0 GO:0030677 ribonuclease P complex C 4 1 GO:0030529 ribonucleoprotein complex C 435 38 GO:0005971 ribonucleoside-diphosphate reductase complex C 1 0 GO:0033279 ribosomal subunit C 62 15 GO:0005840 ribosome C 168 19 GO:0030880 RNA polymerase complex C 13 3 GO:0000120 RNA polymerase I transcription factor complex C 4 0 GO:0005791 rough endoplasmic reticulum C 4 2 GO:0030867 rough endoplasmic reticulum membrane C 4 2 GO:0001726 ruffle C 34 24 GO:0016012 sarcoglycan complex C 6 3 GO:0042383 sarcolemma C 22 21 GO:0030017 sarcomere C 68 36 GO:0016528 sarcoplasm C 27 15 GO:0016529 sarcoplasmic reticulum C 23 12 GO:0019005 SCF ubiquitin ligase complex C 4 3 GO:0030141 secretory granule C 38 25 GO:0030667 secretory granule membrane C 8 4 GO:0005969 serine-pyruvate aminotransferase, type 2B complex C 1 1 GO:0001739 sex chromatin C 9 7 GO:0000803 sex chromosome C 10 8 GO:0030935 sheet-forming collagen C 6 6 GO:0005787 signal peptidase complex C 2 0 GO:0048500 signal recognition particle C 19 0 GO:0005785 signal recognition particle receptor complex C 2 1 GO:0005786 signal recognition particle, endoplasmic reticulum targeting C 19 0 GO:0008180 signalosome C 9 7 GO:0016580 Sin3 complex C 2 1 GO:0017117 single-stranded DNA-dependent ATP-dependent DNA helicase complex C 1 0 GO:0030427 site of polarized growth C 14 12 GO:0030532 small nuclear ribonucleoprotein complex C 11 0 GO:0005732 small nucleolar ribonucleoprotein complex C 16 1 GO:0015935 small ribosomal subunit C 30 0 GO:0032040 small subunit processome C 5 0 GO:0005790 smooth endoplasmic reticulum C 4 2 GO:0030868 smooth endoplasmic reticulum membrane C 1 0 GO:0030485 smooth muscle contractile fiber C 1 1 GO:0031201 SNARE complex C 1 1 GO:0005686 snRNP U2 C 1 0 GO:0005682 snRNP U5 C 2 0 GO:0005683 snRNP U7 C 1 0 GO:0005890 sodium:potassium-exchanging ATPase complex C 1 0 GO:0005625 soluble fraction C 53 39 GO:0008091 spectrin C 2 0 GO:0005819 spindle C 39 29 GO:0005876 spindle microtubule C 9 5 GO:0051233 spindle midzone C 1 1 GO:0000922 spindle pole C 10 6 GO:0005816 spindle pole body C 1 1 GO:0031616 spindle pole centrosome C 1 1 GO:0005681 spliceosome C 140 7 GO:0005914 spot adherens junction C 2 0 GO:0000441 SSL2-core TFIIH complex C 1 0 GO:0032420 stereocilium C 8 8 GO:0032421 stereocilium bundle C 10 10 GO:0032426 stereocilium bundle tip C 1 1 GO:0005831 steroid hormone aporeceptor complex C 1 0 GO:0001725 stress fiber C 19 15 GO:0005863 striated muscle thick filament C 16 0 GO:0005865 striated muscle thin filament C 16 1 GO:0009336 sulfate adenylyltransferase complex (ATP) C 1 0 GO:0016514 SWI/SNF complex C 6 2 GO:0045202 synapse C 231 76 GO:0044456 synapse part C 118 26 GO:0008021 synaptic vesicle C 51 26 GO:0030672 synaptic vesicle membrane C 12 10 GO:0000795 synaptonemal complex C 18 15 GO:0019717 synaptosome C 50 24 GO:0042101 T cell receptor complex C 9 6 GO:0005697 telomerase holoenzyme complex C 1 1 GO:0000782 telomere cap complex C 1 0 GO:0043195 terminal button C 6 6 GO:0005923 tight junction C 70 27 GO:0031932 TORC 2 complex C 1 1 GO:0031254 trailing edge C 5 5 GO:0008023 transcription elongation factor complex C 4 0 GO:0005667 transcription factor complex C 416 108 GO:0005672 transcription factor TFIIA complex C 3 0 GO:0005669 transcription factor TFIID complex C 16 1 GO:0005673 transcription factor TFIIE complex C 2 0 GO:0005674 transcription factor TFIIF complex C 1 0 GO:0017053 transcriptional repressor complex C 10 5 GO:0005802 trans-Golgi network C 32 13 GO:0030140 trans-Golgi network transport vesicle C 12 3 GO:0012510 trans-Golgi network transport vesicle membrane C 8 0 GO:0005784 translocon complex C 2 1 GO:0030133 transport vesicle C 18 4 GO:0030658 transport vesicle membrane C 11 0 GO:0000802 transverse filament C 3 3 GO:0045239 tricarboxylic acid cycle enzyme complex C 2 0 GO:0000214 tRNA-intron endonuclease complex C 2 0 GO:0005861 troponin complex C 8 1 GO:0030315 T-tubule C 9 8 GO:0045298 tubulin complex C 2 0 GO:0045098 type III intermediate filament C 1 0 GO:0005689 U12-dependent spliceosome C 2 0 GO:0005684 U2-dependent spliceosome C 3 0 GO:0046540 U4/U6 x U5 tri-snRNP complex C 5 0 GO:0031371 ubiquitin conjugating enzyme complex C 1 0 GO:0000151 ubiquitin ligase complex C 40 15 GO:0016461 unconventional myosin complex C 3 3 GO:0005941 unlocalized protein complex C 7 0 GO:0001931 uropod C 5 5 GO:0005775 vacuolar lumen C 1 1 GO:0005774 vacuolar membrane C 16 8 GO:0044437 vacuolar part C 20 10 GO:0016471 vacuolar proton-transporting V-type ATPase complex C 6 3 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain C 1 0 GO:0005773 vacuole C 190 62 GO:0030891 VCB complex C 1 1 GO:0031982 vesicle C 295 135 GO:0030120 vesicle coat C 28 2 GO:0012506 vesicle membrane C 61 27 GO:0042598 vesicular fraction C 151 50 GO:0019028 viral capsid C 5 0 GO:0019031 viral envelope C 14 0 GO:0019012 virion C 19 0 GO:0044423 virion part C 19 0 GO:0005891 voltage-gated calcium channel complex C 16 7 GO:0008076 voltage-gated potassium channel complex C 52 4 GO:0001518 voltage-gated sodium channel complex C 8 0 GO:0000805 X chromosome C 4 2 GO:0000806 Y chromosome C 1 1 GO:0030018 Z disc C 29 24 GO:0005915 zonula adherens C 1 1 GO:0042588 zymogen granule C 5 5 GO:0042589 zymogen granule membrane C 4 4 GO:0047290 (alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3)-N-acetyl-galactosaminide 6-alpha-sialyltransferase activity F 1 0 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity F 1 0 GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity F 1 0 GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity F 1 0 GO:0003973 (S)-2-hydroxy-acid oxidase activity F 2 1 GO:0047298 (S)-3-amino-2-methylpropionate transaminase activity F 1 0 GO:0047323 [3-methyl-2-oxobutanoate dehydrogenase (lipoamide)] kinase activity F 1 0 GO:0004313 [acyl-carrier-protein] S-acetyltransferase activity F 1 0 GO:0004314 [acyl-carrier-protein] S-malonyltransferase activity F 2 0 GO:0016275 [cytochrome c]-arginine N-methyltransferase activity F 1 0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity F 4 0 GO:0030586 [methionine synthase] reductase activity F 1 0 GO:0004740 [pyruvate dehydrogenase (lipoamide)] kinase activity F 4 0 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity F 1 0 GO:0003844 1,4-alpha-glucan branching enzyme activity F 1 0 GO:0033237 11-beta-hydroxysteroid dehydrogenase (NADP+) activity F 1 0 GO:0003845 11-beta-hydroxysteroid dehydrogenase activity F 1 1 GO:0005502 11-cis retinal binding F 1 1 GO:0016404 15-hydroxyprostaglandin dehydrogenase (NAD+) activity F 1 0 GO:0047522 15-oxoprostaglandin 13-oxidase activity F 1 0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity F 9 2 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity F 1 1 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity F 3 0 GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity F 1 0 GO:0016847 1-aminocyclopropane-1-carboxylate synthase activity F 4 0 GO:0004430 1-phosphatidylinositol 4-kinase activity F 3 0 GO:0016303 1-phosphatidylinositol-3-kinase activity F 9 4 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity F 1 1 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity F 7 5 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity F 3 0 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity F 1 0 GO:0051537 2 iron, 2 sulfur cluster binding F 14 0 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity F 2 1 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity F 2 0 GO:0047006 20-alpha-hydroxysteroid dehydrogenase activity F 1 1 GO:0008403 25-hydroxycholecalciferol-24-hydroxylase activity F 1 1 GO:0001730 2'-5'-oligoadenylate synthetase activity F 3 3 GO:0003846 2-acylglycerol O-acyltransferase activity F 4 4 GO:0032440 2-alkenal reductase activity F 1 0 GO:0047536 2-aminoadipate transaminase activity F 1 0 GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity F 1 0 GO:0003851 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity F 1 0 GO:0047545 2-hydroxyglutarate dehydrogenase activity F 1 0 GO:0047547 2-methylcitrate dehydratase activity F 1 0 GO:0010302 2-oxoglutarate-dependent dioxygenase activity F 2 2 GO:0008665 2'-phosphotransferase activity F 1 1 GO:0008425 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity F 1 0 GO:0051538 3 iron, 4 sulfur cluster binding F 2 0 GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity F 1 1 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity F 5 2 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity F 6 1 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity F 23 4 GO:0043138 3'-5' DNA helicase activity F 1 1 GO:0008408 3'-5' exonuclease activity F 15 2 GO:0000175 3'-5'-exoribonuclease activity F 9 0 GO:0047042 3-alpha-hydroxysteroid dehydrogenase (B-specific) activity F 1 0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity F 8 0 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity F 7 4 GO:0003855 3-dehydroquinate dehydratase activity F 1 0 GO:0047560 3-dehydrosphinganine reductase activity F 1 0 GO:0019143 3-deoxy-manno-octulosonate-8-phosphatase activity F 1 0 GO:0047015 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity F 1 0 GO:0019171 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity F 1 0 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity F 4 0 GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity F 1 0 GO:0003858 3-hydroxybutyrate dehydrogenase activity F 2 0 GO:0008442 3-hydroxyisobutyrate dehydrogenase activity F 1 0 GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity F 1 0 GO:0004317 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity F 1 0 GO:0000253 3-keto sterol reductase activity F 1 1 GO:0050576 3-keto-steroid reductase activity F 1 0 GO:0016784 3-mercaptopyruvate sulfurtransferase activity F 1 0 GO:0003863 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity F 2 0 GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity F 2 2 GO:0047568 3-oxo-5-beta-steroid 4-dehydrogenase activity F 1 0 GO:0008260 3-oxoacid CoA-transferase activity F 2 2 GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase activity F 2 0 GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity F 2 0 GO:0004676 3-phosphoinositide-dependent protein kinase activity F 1 1 GO:0051539 4 iron, 4 sulfur cluster binding F 17 0 GO:0008124 4-alpha-hydroxytetrahydrobiopterin dehydratase activity F 2 0 GO:0003867 4-aminobutyrate transaminase activity F 1 0 GO:0003868 4-hydroxyphenylpyruvate dioxygenase activity F 2 0 GO:0003869 4-nitrophenylphosphatase activity F 1 1 GO:0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity F 1 0 GO:0008409 5'-3' exonuclease activity F 4 0 GO:0004534 5'-3' exoribonuclease activity F 2 0 GO:0003870 5-aminolevulinate synthase activity F 2 1 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity F 2 0 GO:0042084 5-methyltetrahydrofolate-dependent methyltransferase activity F 1 1 GO:0008253 5'-nucleotidase activity F 7 3 GO:0017168 5-oxoprolinase (ATP-hydrolyzing) activity F 1 0 GO:0008097 5S rRNA binding F 1 0 GO:0004155 6,7-dihydropteridine reductase activity F 1 0 GO:0003873 6-phosphofructo-2-kinase activity F 4 0 GO:0003872 6-phosphofructokinase activity F 4 1 GO:0017057 6-phosphogluconolactonase activity F 2 1 GO:0003874 6-pyruvoyltetrahydropterin synthase activity F 1 0 GO:0047598 7-dehydrocholesterol reductase activity F 1 1 GO:0008312 7S RNA binding F 4 0 GO:0008413 8-oxo-7,8-dihydroguanine triphosphatase activity F 2 2 GO:0001610 A1 adenosine receptor activity, G-protein coupled F 1 0 GO:0001611 A2A adenosine receptor activity, G-protein coupled F 1 1 GO:0001612 A2B adenosine receptor activity, G-protein coupled F 1 0 GO:0001613 A3 adenosine receptor activity, G-protein coupled F 1 1 GO:0043758 acetate-CoA ligase (ADP-forming) activity F 1 0 GO:0003987 acetate-CoA ligase activity F 2 2 GO:0030729 acetoacetate-CoA ligase activity F 1 0 GO:0042166 acetylcholine binding F 7 3 GO:0030549 acetylcholine receptor activator activity F 1 1 GO:0015464 acetylcholine receptor activity F 5 1 GO:0030550 acetylcholine receptor inhibitor activity F 1 1 GO:0030548 acetylcholine receptor regulator activity F 4 4 GO:0003990 acetylcholinesterase activity F 1 1 GO:0003985 acetyl-CoA C-acetyltransferase activity F 4 1 GO:0003988 acetyl-CoA C-acyltransferase activity F 3 0 GO:0003989 acetyl-CoA carboxylase activity F 3 1 GO:0003986 acetyl-CoA hydrolase activity F 2 2 GO:0008521 acetyl-CoA transporter activity F 1 0 GO:0008126 acetylesterase activity F 4 2 GO:0008376 acetylgalactosaminyltransferase activity F 18 7 GO:0008375 acetylglucosaminyltransferase activity F 29 5 GO:0003991 acetylglutamate kinase activity F 1 0 GO:0017096 acetylserotonin O-methyltransferase activity F 1 1 GO:0016407 acetyltransferase activity F 56 15 GO:0003993 acid phosphatase activity F 13 3 GO:0016881 acid-amino acid ligase activity F 130 28 GO:0016880 acid-ammonia (or amide) ligase activity F 4 0 GO:0015172 acidic amino acid transmembrane transporter activity F 6 5 GO:0016878 acid-thiol ligase activity F 13 2 GO:0043874 acireductone synthase activity F 1 0 GO:0003994 aconitate hydratase activity F 2 1 GO:0004284 acrosin activity F 1 1 GO:0003779 actin binding F 242 42 GO:0051015 actin filament binding F 24 15 GO:0003785 actin monomer binding F 2 1 GO:0030898 actin-dependent ATPase activity F 4 1 GO:0008129 actinidain activity F 1 0 GO:0042805 actinin binding F 2 1 GO:0022804 active transmembrane transporter activity F 321 43 GO:0048185 activin binding F 6 5 GO:0017106 activin inhibitor activity F 1 1 GO:0017002 activin receptor activity F 2 1 GO:0016361 activin receptor activity, type I F 2 1 GO:0015227 acyl carnitine transporter activity F 1 1 GO:0000036 acyl carrier activity F 1 0 GO:0016297 acyl-[acyl-carrier-protein] hydrolase activity F 2 0 GO:0008780 acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity F 1 0 GO:0010281 acyl-ACP thioesterase activity F 2 0 GO:0004254 acylaminoacyl-peptidase activity F 1 0 GO:0000062 acyl-CoA binding F 8 0 GO:0003995 acyl-CoA dehydrogenase activity F 17 0 GO:0003996 acyl-CoA ligase activity F 1 0 GO:0003997 acyl-CoA oxidase activity F 4 0 GO:0016291 acyl-CoA thioesterase activity F 13 7 GO:0016292 acyl-CoA thioesterase I activity F 1 1 GO:0008778 acyl-CoA thioesterase II activity F 1 0 GO:0047620 acylglycerol kinase activity F 1 0 GO:0047372 acylglycerol lipase activity F 1 0 GO:0016411 acylglycerol O-acyltransferase activity F 13 6 GO:0050528 acyloxyacyl hydrolase activity F 1 1 GO:0003998 acylphosphatase activity F 3 0 GO:0008415 acyltransferase activity F 164 41 GO:0002055 adenine binding F 1 1 GO:0003999 adenine phosphoribosyltransferase activity F 1 1 GO:0004000 adenosine deaminase activity F 7 1 GO:0004001 adenosine kinase activity F 1 1 GO:0001609 adenosine receptor activity, G-protein coupled F 6 3 GO:0004013 adenosylhomocysteinase activity F 3 1 GO:0004014 adenosylmethionine decarboxylase activity F 2 2 GO:0030554 adenyl nucleotide binding F 1314 33 GO:0032559 adenyl ribonucleotide binding F 1254 33 GO:0004016 adenylate cyclase activity F 11 1 GO:0008179 adenylate cyclase binding F 2 0 GO:0001640 adenylate cyclase inhibiting metabotropic glutamate receptor activity F 6 3 GO:0004017 adenylate kinase activity F 8 1 GO:0000774 adenyl-nucleotide exchange factor activity F 2 0 GO:0004018 adenylosuccinate lyase activity F 1 0 GO:0004019 adenylosuccinate synthase activity F 2 2 GO:0004020 adenylylsulfate kinase activity F 2 2 GO:0043531 ADP binding F 2 0 GO:0047631 ADP-ribose diphosphatase activity F 3 0 GO:0003875 ADP-ribosylarginine hydrolase activity F 2 0 GO:0030306 ADP-ribosylation factor binding F 2 0 GO:0043843 ADP-specific glucokinase activity F 1 0 GO:0031690 adrenergic receptor binding F 1 1 GO:0004935 adrenoceptor activity F 16 7 GO:0004978 adrenocorticotropin receptor activity F 1 0 GO:0017047 adrenocorticotropin-releasing hormone binding F 1 1 GO:0050682 AF-2 domain binding F 1 1 GO:0016284 alanine aminopeptidase activity F 11 0 GO:0004021 alanine transaminase activity F 2 0 GO:0022858 alanine transmembrane transporter activity F 2 2 GO:0008453 alanine-glyoxylate transaminase activity F 2 1 GO:0004813 alanine-tRNA ligase activity F 3 0 GO:0008106 alcohol dehydrogenase (NADP+) activity F 2 1 GO:0004022 alcohol dehydrogenase activity F 10 0 GO:0004024 alcohol dehydrogenase activity, zinc-dependent F 6 0 GO:0004027 alcohol sulfotransferase activity F 2 0 GO:0015665 alcohol transmembrane transporter activity F 1 0 GO:0004029 aldehyde dehydrogenase (NAD) activity F 7 0 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity F 5 0 GO:0004031 aldehyde oxidase activity F 3 2 GO:0004032 aldehyde reductase activity F 8 4 GO:0016832 aldehyde-lyase activity F 7 1 GO:0004033 aldo-keto reductase activity F 14 6 GO:0004034 aldose 1-epimerase activity F 1 0 GO:0031420 alkali metal ion binding F 172 0 GO:0004035 alkaline phosphatase activity F 6 1 GO:0018685 alkane 1-monooxygenase activity F 2 0 GO:0003905 alkylbase DNA N-glycosylase activity F 1 1 GO:0008609 alkylglycerone-phosphate synthase activity F 1 0 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity F 1 0 GO:0004037 allantoicase activity F 1 0 GO:0051786 all-trans-retinol 13,14-reductase activity F 1 1 GO:0031127 alpha(1,2)-fucosyltransferase activity F 3 1 GO:0046920 alpha(1,3)-fucosyltransferase activity F 1 1 GO:0046921 alpha(1,6)-fucosyltransferase activity F 1 1 GO:0004555 alpha,alpha-trehalase activity F 1 0 GO:0001962 alpha-1,3-galactosyltransferase activity F 1 0 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity F 2 0 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity F 3 0 GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity F 1 1 GO:0030144 alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity F 2 0 GO:0004937 alpha1-adrenergic receptor activity F 3 3 GO:0004938 alpha2-adrenergic receptor activity F 3 1 GO:0051393 alpha-actinin binding F 1 1 GO:0004936 alpha-adrenergic receptor activity F 6 4 GO:0004556 alpha-amylase activity F 5 0 GO:0045294 alpha-catenin binding F 1 1 GO:0004557 alpha-galactosidase activity F 1 1 GO:0004558 alpha-glucosidase activity F 4 4 GO:0003826 alpha-ketoacid dehydrogenase activity F 1 1 GO:0004560 alpha-L-fucosidase activity F 2 0 GO:0004559 alpha-mannosidase activity F 6 2 GO:0008111 alpha-methylacyl-CoA racemase activity F 1 0 GO:0008456 alpha-N-acetylgalactosaminidase activity F 1 0 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity F 2 2 GO:0004561 alpha-N-acetylglucosaminidase activity F 1 0 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity F 5 4 GO:0016997 alpha-sialidase activity F 3 2 GO:0003812 alternative-complement-pathway C3/C5 convertase activity F 1 0 GO:0004040 amidase activity F 1 0 GO:0042887 amide transporter activity F 2 2 GO:0016842 amidine-lyase activity F 3 0 GO:0015067 amidinotransferase activity F 1 0 GO:0015280 amiloride-sensitive sodium channel activity F 7 4 GO:0043176 amine binding F 15 5 GO:0030748 amine N-methyltransferase activity F 1 0 GO:0008131 amine oxidase activity F 5 0 GO:0008227 amine receptor activity F 51 17 GO:0047685 amine sulfotransferase activity F 1 0 GO:0005275 amine transmembrane transporter activity F 36 10 GO:0016843 amine-lyase activity F 1 0 GO:0016597 amino acid binding F 8 2 GO:0019202 amino acid kinase activity F 1 1 GO:0015171 amino acid transmembrane transporter activity F 36 25 GO:0004042 amino-acid N-acetyltransferase activity F 1 1 GO:0004046 aminoacylase activity F 3 1 GO:0004045 aminoacyl-tRNA hydrolase activity F 2 0 GO:0004812 aminoacyl-tRNA ligase activity F 55 0 GO:0019145 aminobutyraldehyde dehydrogenase activity F 1 0 GO:0001760 aminocarboxymuconate-semialdehyde decarboxylase activity F 1 0 GO:0004047 aminomethyltransferase activity F 4 0 GO:0004177 aminopeptidase activity F 41 6 GO:0030601 aminopeptidase B activity F 1 0 GO:0004250 aminopeptidase I activity F 1 0 GO:0015247 aminophospholipid transporter activity F 12 2 GO:0016211 ammonia ligase activity F 3 0 GO:0016841 ammonia-lyase activity F 3 1 GO:0008519 ammonium transmembrane transporter activity F 3 0 GO:0016208 AMP binding F 15 0 GO:0003876 AMP deaminase activity F 3 0 GO:0004679 AMP-activated protein kinase activity F 6 0 GO:0016160 amylase activity F 7 3 GO:0004942 anaphylatoxin receptor activity F 6 0 GO:0004882 androgen receptor activity F 1 1 GO:0050681 androgen receptor binding F 1 0 GO:0001595 angiotensin receptor activity F 8 3 GO:0031701 angiotensin receptor binding F 1 1 GO:0001596 angiotensin type I receptor activity F 2 1 GO:0004945 angiotensin type II receptor activity F 8 2 GO:0043168 anion binding F 51 0 GO:0005253 anion channel activity F 58 8 GO:0015380 anion exchanger activity F 10 3 GO:0008509 anion transmembrane transporter activity F 109 23 GO:0043225 anion transmembrane-transporting ATPase activity F 1 0 GO:0015301 anion:anion antiporter activity F 11 4 GO:0015296 anion:cation symporter activity F 18 3 GO:0030506 ankyrin binding F 2 0 GO:0042895 antibiotic transporter activity F 7 0 GO:0003823 antigen binding F 112 13 GO:0016209 antioxidant activity F 49 12 GO:0015297 antiporter activity F 38 9 GO:0030226 apolipoprotein receptor activity F 1 1 GO:0016505 apoptotic protease activator activity F 6 2 GO:0047138 aquacobalamin reductase activity F 1 0 GO:0004052 arachidonate 12-lipoxygenase activity F 3 0 GO:0050473 arachidonate 15-lipoxygenase activity F 1 0 GO:0004051 arachidonate 5-lipoxygenase activity F 1 0 GO:0047677 arachidonate 8-lipoxygenase activity F 1 0 GO:0004059 aralkylamine N-acetyltransferase activity F 1 0 GO:0008060 ARF GTPase activator activity F 3 1 GO:0005086 ARF guanyl-nucleotide exchange factor activity F 11 1 GO:0004053 arginase activity F 2 1 GO:0016273 arginine N-methyltransferase activity F 3 0 GO:0015181 arginine transmembrane transporter activity F 1 1 GO:0004814 arginine-tRNA ligase activity F 2 0 GO:0004056 argininosuccinate lyase activity F 1 0 GO:0004055 argininosuccinate synthase activity F 1 0 GO:0004057 arginyltransferase activity F 1 1 GO:0004058 aromatic-L-amino-acid decarboxylase activity F 1 0 GO:0008794 arsenate reductase (glutaredoxin) activity F 1 0 GO:0030612 arsenate reductase (thioredoxin) activity F 6 0 GO:0030611 arsenate reductase activity F 7 0 GO:0030791 arsenite methyltransferase activity F 1 0 GO:0008490 arsenite secondary active transmembrane transporter activity F 1 0 GO:0015105 arsenite transmembrane transporter activity F 2 0 GO:0015446 arsenite transmembrane-transporting ATPase activity F 1 0 GO:0017162 aryl hydrocarbon receptor binding F 1 1 GO:0004062 aryl sulfotransferase activity F 4 3 GO:0004060 arylamine N-acetyltransferase activity F 4 1 GO:0004063 aryldialkylphosphatase activity F 2 0 GO:0004064 arylesterase activity F 5 2 GO:0004061 arylformamidase activity F 5 2 GO:0004065 arylsulfatase activity F 3 1 GO:0004067 asparaginase activity F 5 1 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity F 2 0 GO:0004816 asparagine-tRNA ligase activity F 2 0 GO:0004070 aspartate carbamoyltransferase activity F 1 0 GO:0015922 aspartate oxidase activity F 1 0 GO:0004069 aspartate transaminase activity F 2 2 GO:0004815 aspartate-tRNA ligase activity F 5 0 GO:0004190 aspartic-type endopeptidase activity F 17 4 GO:0009049 aspartic-type signal peptidase activity F 1 0 GO:0019807 aspartoacylase activity F 2 0 GO:0042576 aspartyl aminopeptidase activity F 1 0 GO:0008533 astacin activity F 6 0 GO:0005524 ATP binding F 1239 33 GO:0003878 ATP citrate synthase activity F 1 0 GO:0005471 ATP:ADP antiporter activity F 1 0 GO:0015272 ATP-activated inward rectifier potassium channel activity F 2 0 GO:0001671 ATPase activator activity F 2 0 GO:0016887 ATPase activity F 273 30 GO:0042623 ATPase activity, coupled F 240 23 GO:0043492 ATPase activity, coupled to movement of substances F 123 15 GO:0042625 ATPase activity, coupled to transmembrane movement of ions F 85 13 GO:0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism F 61 13 GO:0042626 ATPase activity, coupled to transmembrane movement of substances F 123 15 GO:0042624 ATPase activity, uncoupled F 2 0 GO:0042030 ATPase inhibitor activity F 1 0 GO:0043140 ATP-dependent 3'-5' DNA helicase activity F 1 1 GO:0004003 ATP-dependent DNA helicase activity F 10 2 GO:0008026 ATP-dependent helicase activity F 88 3 GO:0004176 ATP-dependent peptidase activity F 4 0 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity F 2 0 GO:0051734 ATP-dependent polynucleotide kinase activity F 2 0 GO:0004004 ATP-dependent RNA helicase activity F 3 1 GO:0004931 ATP-gated cation channel activity F 6 3 GO:0004700 atypical protein kinase C activity F 2 0 GO:0017091 AU-rich element binding F 4 4 GO:0015457 auxiliary transport protein activity F 14 9 GO:0008046 axon guidance receptor activity F 5 5 GO:0008367 bacterial binding F 1 1 GO:0015174 basic amino acid transmembrane transporter activity F 4 3 GO:0003890 beta DNA polymerase activity F 2 0 GO:0047223 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase activity F 1 0 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity F 2 0 GO:0048531 beta-1,3-galactosyltransferase activity F 7 5 GO:0003830 beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity F 1 0 GO:0004940 beta1-adrenergic receptor activity F 1 1 GO:0004941 beta2-adrenergic receptor activity F 1 1 GO:0031699 beta-3 adrenergic receptor binding F 1 1 GO:0004939 beta-adrenergic receptor activity F 3 2 GO:0047696 beta-adrenergic receptor kinase activity F 2 0 GO:0001761 beta-alanine transmembrane transporter activity F 1 1 GO:0001540 beta-amyloid binding F 7 6 GO:0003834 beta-carotene 15,15'-monooxygenase activity F 1 0 GO:0008013 beta-catenin binding F 13 10 GO:0004565 beta-galactosidase activity F 4 1 GO:0003836 beta-galactoside alpha-2,3-sialyltransferase activity F 1 0 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity F 2 0 GO:0004566 beta-glucuronidase activity F 3 1 GO:0008800 beta-lactamase activity F 1 0 GO:0004567 beta-mannosidase activity F 1 1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity F 4 2 GO:0004563 beta-N-acetylhexosaminidase activity F 5 4 GO:0048487 beta-tubulin binding F 2 0 GO:0003837 beta-ureidopropionase activity F 2 1 GO:0051400 BH domain binding F 1 1 GO:0051434 BH3 domain binding F 1 1 GO:0015106 bicarbonate transmembrane transporter activity F 11 4 GO:0015125 bile acid transmembrane transporter activity F 7 0 GO:0008508 bile acid:sodium symporter activity F 6 0 GO:0047704 bile-salt sulfotransferase activity F 2 0 GO:0004074 biliverdin reductase activity F 2 0 GO:0005488 binding F 10076 2925 GO:0045125 bioactive lipid receptor activity F 12 3 GO:0009374 biotin binding F 4 0 GO:0004075 biotin carboxylase activity F 3 0 GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity F 1 0 GO:0004078 biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity F 1 0 GO:0004079 biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity F 1 0 GO:0004080 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity F 1 0 GO:0018271 biotin-protein ligase activity F 1 0 GO:0047710 bis(5'-adenosyl)-triphosphatase activity F 1 1 GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity F 1 0 GO:0008796 bis(5'-nucleosyl)-tetraphosphatase activity F 1 0 GO:0004082 bisphosphoglycerate mutase activity F 3 0 GO:0004083 bisphosphoglycerate phosphatase activity F 3 0 GO:0008423 bleomycin hydrolase activity F 1 1 GO:0004946 bombesin receptor activity F 3 0 GO:0031705 bombesin receptor binding F 1 1 GO:0004947 bradykinin receptor activity F 5 0 GO:0016527 brain-specific angiogenesis inhibitor activity F 3 1 GO:0004084 branched-chain-amino-acid transaminase activity F 2 2 GO:0047760 butyrate-CoA ligase activity F 5 0 GO:0004085 butyryl-CoA dehydrogenase activity F 1 0 GO:0004943 C3a anaphylatoxin receptor activity F 2 0 GO:0004944 C5a anaphylatoxin receptor activity F 3 0 GO:0000247 C-8 sterol isomerase activity F 2 1 GO:0004662 CAAX-protein geranylgeranyltransferase activity F 2 0 GO:0016453 C-acetyltransferase activity F 5 1 GO:0016408 C-acyltransferase activity F 11 2 GO:0045296 cadherin binding F 5 2 GO:0004498 calcidiol 1-monooxygenase activity F 1 0 GO:0001635 calcitonin gene-related polypeptide receptor activity F 2 2 GO:0004948 calcitonin receptor activity F 2 1 GO:0031716 calcitonin receptor binding F 1 1 GO:0005227 calcium activated cation channel activity F 14 7 GO:0005262 calcium channel activity F 64 29 GO:0019855 calcium channel inhibitor activity F 2 1 GO:0005246 calcium channel regulator activity F 10 8 GO:0005509 calcium ion binding F 797 19 GO:0015085 calcium ion transmembrane transporter activity F 8 1 GO:0008048 calcium sensitive guanylate cyclase activator activity F 2 2 GO:0008273 calcium, potassium:sodium antiporter activity F 3 1 GO:0015368 calcium:cation antiporter activity F 5 2 GO:0005432 calcium:sodium antiporter activity F 3 1 GO:0015269 calcium-activated potassium channel activity F 11 5 GO:0004198 calcium-dependent cysteine-type endopeptidase activity F 14 2 GO:0050429 calcium-dependent phospholipase C activity F 1 0 GO:0005544 calcium-dependent phospholipid binding F 19 3 GO:0048306 calcium-dependent protein binding F 3 3 GO:0004698 calcium-dependent protein kinase C activity F 1 1 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity F 1 0 GO:0047499 calcium-independent phospholipase A2 activity F 1 1 GO:0004699 calcium-independent protein kinase C activity F 1 1 GO:0015278 calcium-release channel activity F 4 2 GO:0005388 calcium-transporting ATPase activity F 8 1 GO:0005516 calmodulin binding F 104 5 GO:0004683 calmodulin-dependent protein kinase activity F 14 1 GO:0030161 calpain inhibitor activity F 1 0 GO:0030552 cAMP binding F 11 0 GO:0004691 cAMP-dependent protein kinase activity F 2 2 GO:0004862 cAMP-dependent protein kinase inhibitor activity F 3 0 GO:0008603 cAMP-dependent protein kinase regulator activity F 10 2 GO:0004949 cannabinoid receptor activity F 2 0 GO:0004087 carbamoyl-phosphate synthase (ammonia) activity F 1 0 GO:0004086 carbamoyl-phosphate synthase activity F 1 0 GO:0030246 carbohydrate binding F 267 36 GO:0019200 carbohydrate kinase activity F 29 7 GO:0019203 carbohydrate phosphatase activity F 9 2 GO:0015144 carbohydrate transmembrane transporter activity F 38 5 GO:0004089 carbonate dehydratase activity F 19 2 GO:0016830 carbon-carbon lyase activity F 39 8 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor F 8 0 GO:0016840 carbon-nitrogen lyase activity F 7 1 GO:0016835 carbon-oxygen lyase activity F 61 8 GO:0016838 carbon-oxygen lyase activity, acting on phosphates F 3 0 GO:0016846 carbon-sulfur lyase activity F 9 2 GO:0004090 carbonyl reductase (NADPH) activity F 4 0 GO:0016743 carboxyl- or carbamoyltransferase activity F 2 0 GO:0004091 carboxylesterase activity F 106 21 GO:0031406 carboxylic acid binding F 5 0 GO:0046943 carboxylic acid transmembrane transporter activity F 56 30 GO:0016831 carboxy-lyase activity F 27 7 GO:0004182 carboxypeptidase A activity F 27 1 GO:0004180 carboxypeptidase activity F 44 6 GO:0050425 carboxypeptidase B activity F 2 0 GO:0004186 carboxypeptidase C activity F 1 0 GO:0004187 carboxypeptidase D activity F 1 0 GO:0004183 carboxypeptidase E activity F 1 1 GO:0008808 cardiolipin synthase activity F 1 1 GO:0004092 carnitine O-acetyltransferase activity F 1 0 GO:0016406 carnitine O-acyltransferase activity F 6 1 GO:0008458 carnitine O-octanoyltransferase activity F 1 1 GO:0004095 carnitine O-palmitoyltransferase activity F 4 0 GO:0015226 carnitine transporter activity F 1 1 GO:0004680 casein kinase activity F 2 1 GO:0008656 caspase activator activity F 3 1 GO:0030693 caspase activity F 14 5 GO:0043028 caspase regulator activity F 3 1 GO:0004096 catalase activity F 1 1 GO:0003824 catalytic activity F 5001 908 GO:0016206 catechol O-methyltransferase activity F 1 0 GO:0004213 cathepsin B activity F 1 0 GO:0004192 cathepsin D activity F 1 1 GO:0004193 cathepsin E activity F 1 1 GO:0016946 cathepsin F activity F 1 0 GO:0004261 cathepsin G activity F 1 0 GO:0004215 cathepsin H activity F 1 0 GO:0004216 cathepsin K activity F 1 0 GO:0004217 cathepsin L activity F 4 0 GO:0004218 cathepsin S activity F 1 1 GO:0043169 cation binding F 3130 42 GO:0005261 cation channel activity F 242 75 GO:0008324 cation transmembrane transporter activity F 460 116 GO:0005416 cation:amino acid symporter activity F 10 5 GO:0015491 cation:cation antiporter activity F 12 5 GO:0015377 cation:chloride symporter activity F 7 1 GO:0005402 cation:sugar symporter activity F 1 0 GO:0015326 cationic amino acid transmembrane transporter activity F 1 1 GO:0019829 cation-transporting ATPase activity F 50 1 GO:0019957 C-C chemokine binding F 18 10 GO:0016493 C-C chemokine receptor activity F 18 10 GO:0048020 CCR chemokine receptor binding F 1 0 GO:0031727 CCR2 chemokine receptor binding F 1 0 GO:0005175 CD27 receptor binding F 1 1 GO:0017169 CDP-alcohol phosphatidyltransferase activity F 6 1 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity F 1 0 GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity F 1 1 GO:0050839 cell adhesion molecule binding F 5 2 GO:0019237 centromeric DNA binding F 3 3 GO:0017040 ceramidase activity F 6 4 GO:0047493 ceramide cholinephosphotransferase activity F 2 0 GO:0008120 ceramide glucosyltransferase activity F 2 0 GO:0001729 ceramide kinase activity F 2 1 GO:0004098 cerebroside-sulfatase activity F 1 0 GO:0030553 cGMP binding F 8 2 GO:0004692 cGMP-dependent protein kinase activity F 2 1 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity F 1 0 GO:0015267 channel activity F 369 92 GO:0016248 channel inhibitor activity F 5 2 GO:0016247 channel regulator activity F 14 9 GO:0051087 chaperone binding F 5 1 GO:0030190 chaperone inhibitor activity F 1 0 GO:0030188 chaperone regulator activity F 3 0 GO:0042056 chemoattractant activity F 2 2 GO:0008009 chemokine activity F 36 5 GO:0019956 chemokine binding F 25 12 GO:0004950 chemokine receptor activity F 25 12 GO:0042379 chemokine receptor binding F 37 5 GO:0045499 chemorepellent activity F 4 4 GO:0008061 chitin binding F 4 0 GO:0004568 chitinase activity F 7 0 GO:0004578 chitobiosyldiphosphodolichol beta-mannosyltransferase activity F 1 0 GO:0005254 chloride channel activity F 53 8 GO:0031404 chloride ion binding F 51 0 GO:0015108 chloride transmembrane transporter activity F 12 4 GO:0047747 cholate-CoA ligase activity F 1 0 GO:0004951 cholecystokinin receptor activity F 2 0 GO:0047749 cholestanetriol 26-monooxygenase activity F 1 0 GO:0047750 cholestenol delta-isomerase activity F 2 0 GO:0008123 cholesterol 7-alpha-monooxygenase activity F 1 1 GO:0015485 cholesterol binding F 7 0 GO:0008386 cholesterol monooxygenase (side-chain-cleaving) activity F 1 1 GO:0017127 cholesterol transporter activity F 7 2 GO:0008812 choline dehydrogenase activity F 1 0 GO:0004103 choline kinase activity F 2 2 GO:0004102 choline O-acetyltransferase activity F 1 1 GO:0015220 choline transmembrane transporter activity F 2 2 GO:0005307 choline:sodium symporter activity F 1 0 GO:0004105 choline-phosphate cytidylyltransferase activity F 2 0 GO:0004104 cholinesterase activity F 4 1 GO:0047756 chondroitin 4-sulfotransferase activity F 2 0 GO:0008459 chondroitin 6-sulfotransferase activity F 2 0 GO:0047757 chondroitin-glucuronate 5-epimerase activity F 1 0 GO:0003682 chromatin binding F 100 75 GO:0031490 chromatin DNA binding F 4 3 GO:0030271 chymase activity F 1 0 GO:0004263 chymotrypsin activity F 46 1 GO:0005127 ciliary neurotrophic factor receptor binding F 1 1 GO:0016859 cis-trans isomerase activity F 34 1 GO:0008815 citrate (pro-3S)-lyase activity F 1 0 GO:0004108 citrate (Si)-synthase activity F 2 0 GO:0015137 citrate transmembrane transporter activity F 2 1 GO:0003813 classical-complement-pathway C3/C5 convertase activity F 1 0 GO:0030276 clathrin binding F 6 0 GO:0008169 C-methyltransferase activity F 1 0 GO:0030338 CMP-N-acetylneuraminate monooxygenase activity F 1 1 GO:0016421 CoA carboxylase activity F 6 2 GO:0016289 CoA hydrolase activity F 16 9 GO:0003803 coagulation factor IXa activity F 1 0 GO:0003802 coagulation factor VIIa activity F 1 0 GO:0003804 coagulation factor Xa activity F 1 0 GO:0003805 coagulation factor XIa activity F 1 0 GO:0016405 CoA-ligase activity F 7 2 GO:0008410 CoA-transferase activity F 2 2 GO:0008817 cob(I)yrinic acid a,c-diamide adenosyltransferase activity F 1 0 GO:0031419 cobalamin binding F 5 0 GO:0050897 cobalt ion binding F 11 0 GO:0015087 cobalt ion transmembrane transporter activity F 3 1 GO:0050662 coenzyme binding F 114 0 GO:0051185 coenzyme transporter activity F 1 0 GO:0048037 cofactor binding F 165 1 GO:0051184 cofactor transporter activity F 8 2 GO:0005518 collagen binding F 7 3 GO:0008133 collagenase activity F 5 2 GO:0001848 complement binding F 1 1 GO:0003815 complement component C1r activity F 1 0 GO:0003816 complement component C1s activity F 2 0 GO:0003817 complement factor D activity F 1 0 GO:0003818 complement factor I activity F 1 0 GO:0004875 complement receptor activity F 1 1 GO:0016531 copper chaperone activity F 2 1 GO:0005507 copper ion binding F 62 6 GO:0005375 copper ion transmembrane transporter activity F 8 1 GO:0004785 copper, zinc superoxide dismutase activity F 6 2 GO:0004008 copper-exporting ATPase activity F 2 2 GO:0043682 copper-transporting ATPase activity F 2 2 GO:0004109 coproporphyrinogen oxidase activity F 2 0 GO:0015026 coreceptor activity F 7 3 GO:0015027 coreceptor, soluble ligand activity F 4 3 GO:0004110 corticosteroid side-chain-isomerase activity F 1 1 GO:0047783 corticosterone 18-monooxygenase activity F 2 1 GO:0001636 corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity F 3 2 GO:0015056 corticotrophin-releasing factor receptor activity F 2 2 GO:0051267 CP2 mannose-ethanolamine phosphotransferase activity F 1 0 GO:0016454 C-palmitoyltransferase activity F 3 0 GO:0016980 creatinase activity F 1 0 GO:0004111 creatine kinase activity F 4 1 GO:0005308 creatine transporter activity F 1 0 GO:0005309 creatine:sodium symporter activity F 1 0 GO:0008420 CTD phosphatase activity F 6 1 GO:0003880 C-terminal protein carboxyl methyltransferase activity F 3 1 GO:0003883 CTP synthase activity F 2 0 GO:0019958 C-X-C chemokine binding F 9 1 GO:0016494 C-X-C chemokine receptor activity F 9 1 GO:0009975 cyclase activity F 22 5 GO:0030551 cyclic nucleotide binding F 19 2 GO:0004690 cyclic nucleotide-dependent protein kinase activity F 4 3 GO:0043855 cyclic nucleotide-gated ion channel activity F 3 3 GO:0004112 cyclic-nucleotide phosphodiesterase activity F 25 6 GO:0030332 cyclin binding F 3 1 GO:0016534 cyclin-dependent protein kinase 5 activator activity F 2 0 GO:0016536 cyclin-dependent protein kinase 5 activator regulator activity F 1 1 GO:0004693 cyclin-dependent protein kinase activity F 30 3 GO:0004861 cyclin-dependent protein kinase inhibitor activity F 8 4 GO:0016538 cyclin-dependent protein kinase regulator activity F 21 3 GO:0019238 cyclohydrolase activity F 4 0 GO:0016882 cyclo-ligase activity F 3 0 GO:0004122 cystathionine beta-synthase activity F 1 0 GO:0004123 cystathionine gamma-lyase activity F 1 1 GO:0031071 cysteine desulfurase activity F 1 0 GO:0017172 cysteine dioxygenase activity F 1 0 GO:0004869 cysteine protease inhibitor activity F 30 2 GO:0047804 cysteine-S-conjugate beta-lyase activity F 2 0 GO:0004817 cysteine-tRNA ligase activity F 2 0 GO:0004197 cysteine-type endopeptidase activity F 94 10 GO:0008234 cysteine-type peptidase activity F 159 22 GO:0001631 cysteinyl leukotriene receptor activity F 1 1 GO:0004126 cytidine deaminase activity F 4 1 GO:0004127 cytidylate kinase activity F 1 0 GO:0004128 cytochrome-b5 reductase activity F 4 0 GO:0004129 cytochrome-c oxidase activity F 21 1 GO:0005125 cytokine activity F 214 55 GO:0019955 cytokine binding F 69 27 GO:0008093 cytoskeletal adaptor activity F 1 0 GO:0008092 cytoskeletal protein binding F 335 81 GO:0005519 cytoskeletal regulatory protein binding F 7 0 GO:0042315 cytosol nonspecific dipeptidase activity F 2 2 GO:0031750 D3 dopamine receptor binding F 1 1 GO:0008717 D-alanyl-D-alanine endopeptidase activity F 1 0 GO:0003684 damaged DNA binding F 21 7 GO:0003884 D-amino-acid oxidase activity F 2 0 GO:0003885 D-arabinono-1,4-lactone oxidase activity F 1 0 GO:0008445 D-aspartate oxidase activity F 1 0 GO:0004132 dCMP deaminase activity F 1 0 GO:0019213 deacetylase activity F 14 4 GO:0019239 deaminase activity F 20 2 GO:0005035 death receptor activity F 5 3 GO:0005123 death receptor binding F 3 1 GO:0005251 delayed rectifier potassium channel activity F 1 0 GO:0050613 delta14-sterol reductase activity F 1 0 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity F 1 0 GO:0004986 delta-opioid receptor activity F 1 1 GO:0032451 demethylase activity F 5 2 GO:0004137 deoxycytidine kinase activity F 1 0 GO:0017125 deoxycytidyl transferase activity F 2 1 GO:0004138 deoxyguanosine kinase activity F 1 1 GO:0019135 deoxyhypusine monooxygenase activity F 1 0 GO:0019136 deoxynucleoside kinase activity F 5 2 GO:0004536 deoxyribonuclease activity F 17 4 GO:0004530 deoxyribonuclease I activity F 2 0 GO:0004531 deoxyribonuclease II activity F 2 1 GO:0004139 deoxyribose-phosphate aldolase activity F 1 0 GO:0004140 dephospho-CoA kinase activity F 2 1 GO:0017050 D-erythro-sphingosine kinase activity F 1 1 GO:0015082 di-, tri-valent inorganic cation transmembrane transporter activity F 32 12 GO:0019992 diacylglycerol binding F 44 1 GO:0004142 diacylglycerol cholinephosphotransferase activity F 2 0 GO:0004143 diacylglycerol kinase activity F 12 2 GO:0004144 diacylglycerol O-acyltransferase activity F 2 2 GO:0004145 diamine N-acetyltransferase activity F 2 0 GO:0005310 dicarboxylic acid transmembrane transporter activity F 10 3 GO:0008839 dihydrodipicolinate reductase activity F 1 0 GO:0004146 dihydrofolate reductase activity F 1 1 GO:0030523 dihydrolipoamide S-acyltransferase activity F 1 0 GO:0004148 dihydrolipoyl dehydrogenase activity F 1 0 GO:0043754 dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity F 1 0 GO:0004742 dihydrolipoyllysine-residue acetyltransferase activity F 1 0 GO:0004149 dihydrolipoyllysine-residue succinyltransferase activity F 1 0 GO:0001512 dihydronicotinamide riboside quinone reductase activity F 1 0 GO:0004152 dihydroorotate dehydrogenase activity F 1 0 GO:0004158 dihydroorotate oxidase activity F 1 0 GO:0004156 dihydropteroate synthase activity F 1 0 GO:0015270 dihydropyridine-sensitive calcium channel activity F 2 1 GO:0004157 dihydropyrimidinase activity F 1 0 GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity F 1 1 GO:0004161 dimethylallyltranstransferase activity F 2 0 GO:0016403 dimethylargininase activity F 2 0 GO:0047865 dimethylglycine dehydrogenase activity F 1 0 GO:0051213 dioxygenase activity F 56 3 GO:0016805 dipeptidase activity F 14 7 GO:0017165 dipeptidase E activity F 1 1 GO:0008239 dipeptidyl-peptidase activity F 12 1 GO:0016806 dipeptidyl-peptidase and tripeptidyl-peptidase activity F 12 1 GO:0004214 dipeptidyl-peptidase I activity F 1 0 GO:0017039 dipeptidyl-peptidase III activity F 1 0 GO:0004274 dipeptidyl-peptidase IV activity F 7 1 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity F 2 2 GO:0004163 diphosphomevalonate decarboxylase activity F 1 0 GO:0016778 diphosphotransferase activity F 7 1 GO:0004164 diphthine synthase activity F 1 0 GO:0048030 disaccharide binding F 1 0 GO:0015036 disulfide oxidoreductase activity F 14 3 GO:0004458 D-lactate dehydrogenase (cytochrome) activity F 1 0 GO:0008720 D-lactate dehydrogenase activity F 1 0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity F 5 3 GO:0008301 DNA bending activity F 4 2 GO:0003677 DNA binding F 1871 423 GO:0003689 DNA clamp loader activity F 4 0 GO:0051747 DNA demethylase activity F 2 2 GO:0003678 DNA helicase activity F 20 6 GO:0003910 DNA ligase (ATP) activity F 4 0 GO:0003909 DNA ligase activity F 4 0 GO:0019104 DNA N-glycosylase activity F 9 5 GO:0003912 DNA nucleotidylexotransferase activity F 2 1 GO:0003913 DNA photolyase activity F 2 0 GO:0030337 DNA polymerase processivity factor activity F 1 0 GO:0003896 DNA primase activity F 3 0 GO:0003688 DNA replication origin binding F 2 2 GO:0000217 DNA secondary structure binding F 2 0 GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity F 6 1 GO:0003916 DNA topoisomerase activity F 9 2 GO:0003917 DNA topoisomerase type I activity F 4 1 GO:0015616 DNA translocase activity F 1 0 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity F 7 2 GO:0008094 DNA-dependent ATPase activity F 31 3 GO:0004677 DNA-dependent protein kinase activity F 1 0 GO:0003887 DNA-directed DNA polymerase activity F 28 5 GO:0003899 DNA-directed RNA polymerase activity F 34 1 GO:0009008 DNA-methyltransferase activity F 5 3 GO:0033170 DNA-protein loading ATPase activity F 4 0 GO:0004165 dodecenoyl-CoA delta-isomerase activity F 3 1 GO:0047874 dolichyldiphosphatase activity F 1 1 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity F 7 0 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity F 1 0 GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity F 1 0 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity F 2 0 GO:0004167 dopachrome isomerase activity F 1 1 GO:0004500 dopamine beta-monooxygenase activity F 4 0 GO:0035240 dopamine binding F 5 5 GO:0001590 dopamine D1 receptor activity F 1 1 GO:0001588 dopamine D1 receptor-like receptor activity F 2 2 GO:0001670 dopamine D2 receptor activity F 1 1 GO:0001591 dopamine D2 receptor-like receptor activity F 3 3 GO:0001592 dopamine D3 receptor activity F 1 1 GO:0001593 dopamine D4 receptor activity F 1 1 GO:0001589 dopamine D5 receptor activity F 1 1 GO:0004952 dopamine receptor activity F 5 5 GO:0050780 dopamine receptor binding F 4 1 GO:0005329 dopamine transmembrane transporter activity F 1 1 GO:0005330 dopamine:sodium symporter activity F 1 0 GO:0003690 double-stranded DNA binding F 20 12 GO:0003726 double-stranded RNA adenosine deaminase activity F 3 0 GO:0003725 double-stranded RNA binding F 24 6 GO:0008144 drug binding F 6 1 GO:0015238 drug transporter activity F 14 1 GO:0015307 drug:hydrogen antiporter activity F 7 0 GO:0008831 dTDP-4-dehydrorhamnose reductase activity F 1 0 GO:0008460 dTDP-glucose 4,6-dehydratase activity F 1 0 GO:0004170 dUTP diphosphatase activity F 1 0 GO:0047837 D-xylose 1-dehydrogenase (NADP+) activity F 1 1 GO:0045502 dynein binding F 4 3 GO:0004884 ecdysteroid hormone receptor activity F 1 0 GO:0042708 elastase activity F 3 0 GO:0009054 electron acceptor activity F 1 0 GO:0009055 electron carrier activity F 167 6 GO:0004174 electron-transferring-flavoprotein dehydrogenase activity F 2 0 GO:0004520 endodeoxyribonuclease activity F 10 4 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters F 2 1 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters F 2 0 GO:0030883 endogenous lipid antigen binding F 1 1 GO:0042606 endogenous peptide antigen binding F 1 0 GO:0004519 endonuclease activity F 93 9 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters F 19 1 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters F 22 3 GO:0004175 endopeptidase activity F 432 47 GO:0008462 endopeptidase Clp activity F 1 0 GO:0004866 endopeptidase inhibitor activity F 142 10 GO:0004521 endoribonuclease activity F 37 4 GO:0016892 endoribonuclease activity, producing 3'-phosphomonoesters F 17 0 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters F 20 3 GO:0031707 endothelin A receptor binding F 1 1 GO:0004962 endothelin receptor activity F 2 2 GO:0001600 endothelin-B receptor activity F 1 1 GO:0016512 endothelin-converting enzyme 1 activity F 1 0 GO:0016511 endothelin-converting enzyme activity F 2 0 GO:0004319 enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity F 1 0 GO:0016631 enoyl-[acyl-carrier-protein] reductase activity F 1 0 GO:0004300 enoyl-CoA hydratase activity F 4 1 GO:0004275 enteropeptidase activity F 1 0 GO:0008047 enzyme activator activity F 199 36 GO:0019899 enzyme binding F 133 58 GO:0004857 enzyme inhibitor activity F 205 32 GO:0030234 enzyme regulator activity F 602 108 GO:0005003 ephrin receptor activity F 14 2 GO:0046875 ephrin receptor binding F 3 2 GO:0005155 epidermal growth factor receptor activating ligand activity F 1 1 GO:0005006 epidermal growth factor receptor activity F 2 1 GO:0005154 epidermal growth factor receptor binding F 6 6 GO:0015058 epidermal growth factor-like module containing hormone receptor activity F 1 0 GO:0004301 epoxide hydrolase activity F 2 0 GO:0046923 ER retention sequence binding F 3 0 GO:0005176 ErbB-2 class receptor binding F 2 2 GO:0043125 ErbB-3 class receptor binding F 1 1 GO:0005128 erythropoietin receptor binding F 3 0 GO:0004303 estradiol 17-beta-dehydrogenase activity F 7 2 GO:0030331 estrogen receptor binding F 1 1 GO:0004304 estrone sulfotransferase activity F 1 0 GO:0004305 ethanolamine kinase activity F 3 0 GO:0004306 ethanolamine-phosphate cytidylyltransferase activity F 1 0 GO:0004307 ethanolaminephosphotransferase activity F 3 0 GO:0016803 ether hydrolase activity F 3 0 GO:0004686 eukaryotic elongation factor-2 kinase activity F 1 0 GO:0008190 eukaryotic initiation factor 4E binding F 4 1 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity F 1 1 GO:0005231 excitatory extracellular ligand-gated ion channel activity F 42 17 GO:0004308 exo-alpha-sialidase activity F 2 2 GO:0004529 exodeoxyribonuclease activity F 4 0 GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters F 4 0 GO:0008853 exodeoxyribonuclease III activity F 4 0 GO:0042607 exogenous peptide antigen binding F 8 0 GO:0004527 exonuclease activity F 44 4 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters F 17 0 GO:0008238 exopeptidase activity F 100 19 GO:0004532 exoribonuclease activity F 13 0 GO:0016896 exoribonuclease activity, producing 5'-phosphomonoesters F 13 0 GO:0008859 exoribonuclease II activity F 1 0 GO:0005230 extracellular ligand-gated ion channel activity F 65 17 GO:0050840 extracellular matrix binding F 6 5 GO:0030023 extracellular matrix constituent conferring elasticity F 2 1 GO:0005201 extracellular matrix structural constituent F 60 5 GO:0030021 extracellular matrix structural constituent conferring compression resistance F 2 0 GO:0030020 extracellular matrix structural constituent conferring tensile strength F 29 0 GO:0005234 extracellular-glutamate-gated ion channel activity F 17 1 GO:0016934 extracellular-glycine-gated chloride channel activity F 4 2 GO:0016933 extracellular-glycine-gated ion channel activity F 4 2 GO:0050660 FAD binding F 59 0 GO:0001918 farnesylated protein binding F 1 0 GO:0004310 farnesyl-diphosphate farnesyltransferase activity F 1 0 GO:0004311 farnesyltranstransferase activity F 4 1 GO:0005504 fatty acid binding F 12 2 GO:0015645 fatty-acid ligase activity F 13 3 GO:0004312 fatty-acid synthase activity F 5 0 GO:0004321 fatty-acyl-CoA synthase activity F 2 1 GO:0008937 ferredoxin reductase activity F 1 0 GO:0004324 ferredoxin-NADP+ reductase activity F 1 0 GO:0008199 ferric iron binding F 10 0 GO:0000293 ferric-chelate reductase activity F 3 3 GO:0004325 ferrochelatase activity F 1 1 GO:0015093 ferrous iron transmembrane transporter activity F 1 1 GO:0004322 ferroxidase activity F 3 1 GO:0017134 fibroblast growth factor binding F 3 0 GO:0005007 fibroblast growth factor receptor activity F 4 1 GO:0030353 fibroblast growth factor receptor antagonist activity F 4 0 GO:0005104 fibroblast growth factor receptor binding F 19 1 GO:0001968 fibronectin binding F 1 0 GO:0031005 filamin binding F 1 0 GO:0031008 filamin-C binding F 1 0 GO:0005528 FK506 binding F 5 1 GO:0048256 flap endonuclease activity F 1 1 GO:0042602 flavin reductase activity F 1 0 GO:0004499 flavin-containing monooxygenase activity F 5 0 GO:0016971 flavin-linked sulfhydryl oxidase activity F 1 0 GO:0003919 FMN adenylyltransferase activity F 1 0 GO:0010181 FMN binding F 10 0 GO:0005542 folic acid binding F 10 0 GO:0008517 folic acid transporter activity F 4 0 GO:0004963 follicle-stimulating hormone receptor activity F 2 0 GO:0048184 follistatin binding F 1 1 GO:0015499 formate transmembrane transporter activity F 1 1 GO:0004329 formate-tetrahydrofolate ligase activity F 2 0 GO:0030412 formimidoyltetrahydrofolate cyclodeaminase activity F 1 0 GO:0030407 formimidoyltransferase activity F 1 0 GO:0016155 formyltetrahydrofolate dehydrogenase activity F 2 1 GO:0000400 four-way junction DNA binding F 1 0 GO:0030387 fructosamine-3-kinase activity F 1 1 GO:0005353 fructose transmembrane transporter activity F 2 0 GO:0015284 fructose uniporter activity F 1 0 GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity F 4 0 GO:0042132 fructose-bisphosphatase activity F 3 0 GO:0004332 fructose-bisphosphate aldolase activity F 5 1 GO:0050201 fucokinase activity F 1 0 GO:0042806 fucose binding F 1 0 GO:0047341 fucose-1-phosphate guanylyltransferase activity F 1 0 GO:0015928 fucosidase activity F 2 0 GO:0004381 fucosylgalactoside 3-alpha-galactosyltransferase activity F 1 1 GO:0008417 fucosyltransferase activity F 11 4 GO:0004333 fumarate hydratase activity F 1 0 GO:0004334 fumarylacetoacetase activity F 1 1 GO:0004276 furin activity F 1 0 GO:0016917 GABA receptor activity F 29 2 GO:0050811 GABA receptor binding F 4 1 GO:0004890 GABA-A receptor activity F 26 2 GO:0004965 GABA-B receptor activity F 3 0 GO:0004335 galactokinase activity F 2 1 GO:0050694 galactose 3-O-sulfotransferase activity F 4 1 GO:0005534 galactose binding F 1 0 GO:0005354 galactose transmembrane transporter activity F 1 0 GO:0015925 galactosidase activity F 5 2 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity F 3 1 GO:0016936 galactoside binding F 1 0 GO:0004336 galactosylceramidase activity F 1 1 GO:0001733 galactosylceramide sulfotransferase activity F 3 1 GO:0047273 galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity F 1 0 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity F 3 0 GO:0008378 galactosyltransferase activity F 29 8 GO:0047220 galactosylxylosylprotein 3-beta-galactosyltransferase activity F 1 0 GO:0004966 galanin receptor activity F 3 0 GO:0003895 gamma DNA-directed DNA polymerase activity F 2 1 GO:0015495 gamma-aminobutyric acid:hydrogen symporter activity F 1 1 GO:0005332 gamma-aminobutyric acid:sodium symporter activity F 4 0 GO:0008336 gamma-butyrobetaine dioxygenase activity F 1 0 GO:0008488 gamma-glutamyl carboxylase activity F 1 0 GO:0008464 gamma-glutamyl hydrolase activity F 2 1 GO:0003839 gamma-glutamylcyclotransferase activity F 1 0 GO:0003840 gamma-glutamyltransferase activity F 3 1 GO:0004253 gamma-renin activity F 1 0 GO:0043015 gamma-tubulin binding F 4 3 GO:0047915 ganglioside galactosyltransferase activity F 1 0 GO:0005243 gap junction channel activity F 18 3 GO:0016519 gastric inhibitory peptide receptor activity F 1 0 GO:0015054 gastrin receptor activity F 1 0 GO:0022836 gated channel activity F 257 56 GO:0019003 GDP binding F 1 1 GO:0005092 GDP-dissociation inhibitor activity F 5 1 GO:0050577 GDP-L-fucose synthase activity F 1 0 GO:0008446 GDP-mannose 4,6-dehydratase activity F 1 0 GO:0004228 gelatinase A activity F 1 0 GO:0004229 gelatinase B activity F 1 0 GO:0016251 general RNA polymerase II transcription factor activity F 10 1 GO:0016565 general transcriptional repressor activity F 1 1 GO:0004337 geranyltranstransferase activity F 2 1 GO:0030160 GKAP/Homer scaffold activity F 1 1 GO:0030116 glial cell line-derived neurotrophic factor receptor binding F 1 0 GO:0047277 globoside alpha-N-acetylgalactosaminyltransferase activity F 1 1 GO:0004967 glucagon receptor activity F 3 0 GO:0004339 glucan 1,4-alpha-glucosidase activity F 1 0 GO:0004883 glucocorticoid receptor activity F 1 1 GO:0035259 glucocorticoid receptor binding F 1 1 GO:0004340 glucokinase activity F 1 1 GO:0004343 glucosamine 6-phosphate N-acetyltransferase activity F 1 1 GO:0004342 glucosamine-6-phosphate deaminase activity F 2 0 GO:0047936 glucose 1-dehydrogenase activity F 1 0 GO:0005536 glucose binding F 1 1 GO:0005355 glucose transmembrane transporter activity F 10 4 GO:0005412 glucose:sodium symporter activity F 1 0 GO:0004346 glucose-6-phosphatase activity F 2 2 GO:0004345 glucose-6-phosphate dehydrogenase activity F 3 2 GO:0004347 glucose-6-phosphate isomerase activity F 1 1 GO:0015926 glucosidase activity F 8 4 GO:0004348 glucosylceramidase activity F 2 0 GO:0046527 glucosyltransferase activity F 7 1 GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity F 2 0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity F 3 1 GO:0015020 glucuronosyltransferase activity F 19 2 GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity F 2 0 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity F 2 0 GO:0004349 glutamate 5-kinase activity F 1 1 GO:0016595 glutamate binding F 1 0 GO:0009980 glutamate carboxypeptidase activity F 1 1 GO:0043275 glutamate carboxypeptidase II activity F 3 0 GO:0004351 glutamate decarboxylase activity F 2 0 GO:0004353 glutamate dehydrogenase [NAD(P)+] activity F 2 1 GO:0030409 glutamate formimidoyltransferase activity F 1 0 GO:0008066 glutamate receptor activity F 44 12 GO:0035254 glutamate receptor binding F 3 2 GO:0015501 glutamate:sodium symporter activity F 2 2 GO:0004350 glutamate-5-semialdehyde dehydrogenase activity F 1 0 GO:0004356 glutamate-ammonia ligase activity F 2 0 GO:0004357 glutamate-cysteine ligase activity F 2 1 GO:0035226 glutamate-cysteine ligase catalytic subunit binding F 1 1 GO:0004818 glutamate-tRNA ligase activity F 2 0 GO:0004359 glutaminase activity F 2 0 GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity F 2 0 GO:0047316 glutamine-phenylpyruvate transaminase activity F 1 0 GO:0004819 glutamine-tRNA ligase activity F 1 0 GO:0016603 glutaminyl-peptide cyclotransferase activity F 1 0 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity F 1 0 GO:0004230 glutamyl aminopeptidase activity F 1 1 GO:0004361 glutaryl-CoA dehydrogenase activity F 1 0 GO:0015038 glutathione disulfide oxidoreductase activity F 1 1 GO:0004602 glutathione peroxidase activity F 9 4 GO:0004363 glutathione synthase activity F 1 0 GO:0004364 glutathione transferase activity F 23 7 GO:0004362 glutathione-disulfide reductase activity F 1 1 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity F 4 0 GO:0008943 glyceraldehyde-3-phosphate dehydrogenase activity F 4 1 GO:0008887 glycerate kinase activity F 1 0 GO:0004370 glycerol kinase activity F 2 1 GO:0015168 glycerol transmembrane transporter activity F 1 0 GO:0004367 glycerol-3-phosphate dehydrogenase (NAD+) activity F 3 1 GO:0004368 glycerol-3-phosphate dehydrogenase activity F 1 0 GO:0004366 glycerol-3-phosphate O-acyltransferase activity F 1 1 GO:0015169 glycerol-3-phosphate transmembrane transporter activity F 1 0 GO:0004371 glycerone kinase activity F 1 0 GO:0016287 glycerone-phosphate O-acyltransferase activity F 1 1 GO:0008889 glycerophosphodiester phosphodiesterase activity F 8 1 GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity F 1 0 GO:0015068 glycine amidinotransferase activity F 1 0 GO:0016594 glycine binding F 4 2 GO:0008890 glycine C-acetyltransferase activity F 1 0 GO:0004375 glycine dehydrogenase (decarboxylating) activity F 1 0 GO:0004372 glycine hydroxymethyltransferase activity F 7 0 GO:0047961 glycine N-acyltransferase activity F 3 0 GO:0047963 glycine N-choloyltransferase activity F 1 0 GO:0017174 glycine N-methyltransferase activity F 1 0 GO:0015187 glycine transmembrane transporter activity F 3 3 GO:0004891 glycine-inhibited chloride channel activity F 1 0 GO:0004820 glycine-tRNA ligase activity F 3 0 GO:0004373 glycogen (starch) synthase activity F 2 1 GO:0004133 glycogen debranching enzyme activity F 1 1 GO:0008184 glycogen phosphorylase activity F 2 1 GO:0004696 glycogen synthase kinase 3 activity F 1 0 GO:0051861 glycolipid binding F 2 0 GO:0017089 glycolipid transporter activity F 2 0 GO:0001948 glycoprotein binding F 3 3 GO:0004569 glycoprotein endo-alpha-1,2-mannosidase activity F 2 1 GO:0004380 glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity F 1 1 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity F 1 0 GO:0005539 glycosaminoglycan binding F 74 16 GO:0004621 glycosylphosphatidylinositol phospholipase D activity F 1 0 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity F 2 1 GO:0030267 glyoxylate reductase (NADP) activity F 1 0 GO:0019002 GMP binding F 8 2 GO:0003920 GMP reductase activity F 2 0 GO:0003922 GMP synthase (glutamine-hydrolyzing) activity F 1 0 GO:0003921 GMP synthase activity F 1 0 GO:0004968 gonadotropin-releasing hormone receptor activity F 1 0 GO:0048503 GPI anchor binding F 117 2 GO:0003923 GPI-anchor transamidase activity F 3 2 GO:0015467 G-protein activated inward rectifier potassium channel activity F 4 1 GO:0001965 G-protein alpha-subunit binding F 2 0 GO:0001637 G-protein chemoattractant receptor activity F 25 12 GO:0008020 G-protein coupled photoreceptor activity F 3 3 GO:0004930 G-protein coupled receptor activity F 1732 90 GO:0004703 G-protein coupled receptor kinase activity F 6 2 GO:0001664 G-protein-coupled receptor binding F 54 15 GO:0005129 granulocyte macrophage colony-stimulating factor receptor binding F 1 0 GO:0004277 granzyme A activity F 1 0 GO:0004278 granzyme B activity F 1 1 GO:0001641 group II metabotropic glutamate receptor activity F 2 2 GO:0001642 group III metabotropic glutamate receptor activity F 4 1 GO:0008083 growth factor activity F 149 15 GO:0019838 growth factor binding F 49 19 GO:0004903 growth hormone receptor activity F 1 1 GO:0005131 growth hormone receptor binding F 2 2 GO:0001616 growth hormone secretagogue receptor activity F 1 0 GO:0016608 growth hormone-releasing hormone activity F 1 0 GO:0016520 growth hormone-releasing hormone receptor activity F 2 1 GO:0031770 growth hormone-releasing hormone receptor binding F 1 1 GO:0005525 GTP binding F 311 9 GO:0003933 GTP cyclohydrolase activity F 1 0 GO:0003934 GTP cyclohydrolase I activity F 1 0 GO:0005096 GTPase activator activity F 148 14 GO:0003924 GTPase activity F 134 14 GO:0051020 GTPase binding F 55 17 GO:0005095 GTPase inhibitor activity F 3 1 GO:0030695 GTPase regulator activity F 290 40 GO:0030742 GTP-dependent protein binding F 2 2 GO:0017049 GTP-Rho binding F 1 1 GO:0030731 guanidinoacetate N-methyltransferase activity F 1 0 GO:0008892 guanine deaminase activity F 1 0 GO:0032137 guanine/thymine mispair binding F 3 3 GO:0004382 guanosine-diphosphatase activity F 1 0 GO:0019001 guanyl nucleotide binding F 319 13 GO:0032561 guanyl ribonucleotide binding F 319 11 GO:0030250 guanylate cyclase activator activity F 2 2 GO:0004383 guanylate cyclase activity F 11 4 GO:0030249 guanylate cyclase regulator activity F 2 2 GO:0004385 guanylate kinase activity F 4 0 GO:0005085 guanyl-nucleotide exchange factor activity F 119 22 GO:0004406 H3/H4 histone acetyltransferase activity F 3 3 GO:0031072 heat shock protein binding F 48 4 GO:0008158 hedgehog receptor activity F 5 0 GO:0004386 helicase activity F 128 7 GO:0004896 hematopoietin/interferon-class (D200-domain) cytokine receptor activity F 54 11 GO:0005126 hematopoietin/interferon-class (D200-domain) cytokine receptor binding F 39 7 GO:0020037 heme binding F 124 2 GO:0004392 heme oxygenase (decyclizing) activity F 2 0 GO:0015232 heme transporter activity F 1 1 GO:0015002 heme-copper terminal oxidase activity F 21 1 GO:0030492 hemoglobin binding F 2 0 GO:0004394 heparan sulfate 2-O-sulfotransferase activity F 1 1 GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity F 1 0 GO:0030305 heparanase activity F 1 0 GO:0008201 heparin binding F 59 14 GO:0008467 heparin-glucosamine 3-O-sulfotransferase activity F 5 2 GO:0005008 hepatocyte growth factor receptor activity F 1 1 GO:0005171 hepatocyte growth factor receptor binding F 1 0 GO:0004395 hexaprenyldihydroxybenzoate methyltransferase activity F 1 0 GO:0004396 hexokinase activity F 7 3 GO:0015929 hexosaminidase activity F 14 6 GO:0015149 hexose transmembrane transporter activity F 11 4 GO:0008516 hexose uniporter activity F 1 0 GO:0009679 hexose:hydrogen symporter activity F 1 0 GO:0015334 high affinity oligopeptide transporter activity F 1 1 GO:0015362 high affinity sodium:dicarboxylate symporter activity F 1 1 GO:0008331 high voltage-gated calcium channel activity F 6 3 GO:0008035 high-density lipoprotein binding F 3 2 GO:0004969 histamine receptor activity F 4 1 GO:0004397 histidine ammonia-lyase activity F 1 1 GO:0004398 histidine decarboxylase activity F 1 1 GO:0004821 histidine-tRNA ligase activity F 2 0 GO:0004402 histone acetyltransferase activity F 17 6 GO:0035035 histone acetyltransferase binding F 3 1 GO:0042393 histone binding F 8 5 GO:0004407 histone deacetylase activity F 12 4 GO:0042826 histone deacetylase binding F 4 3 GO:0032452 histone demethylase activity F 2 0 GO:0051864 histone demethylase activity (H3-K36 specific) F 2 0 GO:0046975 histone lysine N-methyltransferase activity (H3-K36 specific) F 1 1 GO:0042800 histone lysine N-methyltransferase activity (H3-K4 specific) F 1 1 GO:0042799 histone lysine N-methyltransferase activity (H4-K20 specific) F 3 3 GO:0042054 histone methyltransferase activity F 24 7 GO:0008469 histone-arginine N-methyltransferase activity F 3 0 GO:0018024 histone-lysine N-methyltransferase activity F 17 5 GO:0043398 HLH domain binding F 1 1 GO:0004408 holocytochrome-c synthase activity F 1 0 GO:0008898 homocysteine S-methyltransferase activity F 2 1 GO:0004411 homogentisate 1,2-dioxygenase activity F 1 0 GO:0005179 hormone activity F 121 8 GO:0042562 hormone binding F 7 3 GO:0051427 hormone receptor binding F 10 4 GO:0030544 Hsp70 protein binding F 2 1 GO:0030191 Hsp70/Hsc70 protein inhibitor activity F 1 0 GO:0030192 Hsp70/Hsc70 protein regulator activity F 1 0 GO:0051879 Hsp90 protein binding F 3 2 GO:0050501 hyaluronan synthase activity F 3 0 GO:0005540 hyaluronic acid binding F 16 3 GO:0004415 hyalurononglucosaminidase activity F 6 2 GO:0015078 hydrogen ion transmembrane transporter activity F 95 14 GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism F 39 0 GO:0046961 hydrogen ion transporting ATPase activity, rotational mechanism F 40 0 GO:0005280 hydrogen:amino acid symporter activity F 3 3 GO:0005356 hydrogen:glucose symporter activity F 1 0 GO:0008900 hydrogen:potassium-exchanging ATPase activity F 2 0 GO:0005403 hydrogen:sugar symporter activity F 1 0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism F 25 9 GO:0016787 hydrolase activity F 2047 321 GO:0016817 hydrolase activity, acting on acid anhydrides F 486 58 GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances F 125 15 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides F 484 58 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds F 2 1 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances F 2 1 GO:0016826 hydrolase activity, acting on acid sulfur-nitrogen bonds F 1 0 GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds F 89 16 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides F 4 0 GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines F 22 2 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides F 48 13 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines F 12 1 GO:0016788 hydrolase activity, acting on ester bonds F 596 118 GO:0016801 hydrolase activity, acting on ether bonds F 6 1 GO:0016798 hydrolase activity, acting on glycosyl bonds F 110 32 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds F 16 8 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds F 89 25 GO:0016836 hydro-lyase activity F 51 6 GO:0004416 hydroxyacylglutathione hydrolase activity F 1 1 GO:0016742 hydroxymethyl-, formyl- and related transferase activity F 5 0 GO:0004418 hydroxymethylbilane synthase activity F 1 0 GO:0004419 hydroxymethylglutaryl-CoA lyase activity F 1 0 GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity F 1 1 GO:0004421 hydroxymethylglutaryl-CoA synthase activity F 2 0 GO:0008903 hydroxypyruvate isomerase activity F 1 0 GO:0004422 hypoxanthine phosphoribosyltransferase activity F 2 2 GO:0004953 icosanoid receptor activity F 10 4 GO:0042802 identical protein binding F 169 133 GO:0004423 iduronate-2-sulfatase activity F 1 0 GO:0019863 IgE binding F 5 3 GO:0019767 IgE receptor activity F 2 2 GO:0019864 IgG binding F 5 4 GO:0019770 IgG receptor activity F 2 2 GO:0008384 IkappaB kinase activity F 3 1 GO:0050480 imidazolonepropionase activity F 1 0 GO:0019865 immunoglobulin binding F 9 6 GO:0019763 immunoglobulin receptor activity F 4 4 GO:0003937 IMP cyclohydrolase activity F 1 0 GO:0003938 IMP dehydrogenase activity F 2 2 GO:0008262 importin-alpha export receptor activity F 1 0 GO:0004425 indole-3-glycerol-phosphate synthase activity F 1 0 GO:0048186 inhibin beta-A binding F 1 1 GO:0005237 inhibitory extracellular ligand-gated ion channel activity F 1 0 GO:0005452 inorganic anion exchanger activity F 8 0 GO:0015103 inorganic anion transmembrane transporter activity F 28 8 GO:0022890 inorganic cation transmembrane transporter activity F 135 26 GO:0004427 inorganic diphosphatase activity F 3 0 GO:0030504 inorganic diphosphate transmembrane transporter activity F 1 1 GO:0005315 inorganic phosphate transmembrane transporter activity F 2 0 GO:0005220 inositol 1,4,5-triphosphate-sensitive calcium-release channel activity F 3 1 GO:0016312 inositol bisphosphate phosphatase activity F 1 0 GO:0050517 inositol hexakisphosphate kinase activity F 3 0 GO:0004428 inositol or phosphatidylinositol kinase activity F 29 12 GO:0004437 inositol or phosphatidylinositol phosphatase activity F 30 8 GO:0004434 inositol or phosphatidylinositol phosphodiesterase activity F 10 0 GO:0050113 inositol oxygenase activity F 1 0 GO:0050516 inositol polyphosphate multikinase activity F 1 1 GO:0047325 inositol tetrakisphosphate 1-kinase activity F 1 0 GO:0051765 inositol tetrakisphosphate kinase activity F 1 0 GO:0008440 inositol trisphosphate 3-kinase activity F 7 2 GO:0035300 inositol trisphosphate 5/6-kinase activity F 1 0 GO:0051766 inositol trisphosphate kinase activity F 8 2 GO:0046030 inositol trisphosphate phosphatase activity F 6 0 GO:0008934 inositol-1(or 4)-monophosphatase activity F 2 0 GO:0008095 inositol-1,4,5-triphosphate receptor activity F 2 1 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity F 1 0 GO:0004512 inositol-3-phosphate synthase activity F 1 0 GO:0004445 inositol-polyphosphate 5-phosphatase activity F 6 0 GO:0005158 insulin receptor binding F 13 1 GO:0043560 insulin receptor substrate binding F 3 3 GO:0005520 insulin-like growth factor binding F 21 7 GO:0005159 insulin-like growth factor receptor binding F 2 2 GO:0005360 insulin-responsive hydrogen:glucose symporter activity F 1 0 GO:0004231 insulysin activity F 1 0 GO:0008907 integrase activity F 5 0 GO:0005178 integrin binding F 20 13 GO:0019961 interferon binding F 2 2 GO:0004904 interferon receptor activity F 2 2 GO:0019962 interferon-alpha/beta binding F 1 1 GO:0004905 interferon-alpha/beta receptor activity F 1 1 GO:0005132 interferon-alpha/beta receptor binding F 1 1 GO:0005133 interferon-gamma receptor binding F 1 0 GO:0019965 interleukin binding F 38 10 GO:0004907 interleukin receptor activity F 35 6 GO:0019966 interleukin-1 binding F 7 2 GO:0004908 interleukin-1 receptor activity F 7 2 GO:0005152 interleukin-1 receptor antagonist activity F 4 0 GO:0005149 interleukin-1 receptor binding F 12 2 GO:0019967 interleukin-1, Type I, activating binding F 4 0 GO:0004909 interleukin-1, Type I, activating receptor activity F 4 0 GO:0019968 interleukin-1, Type II, blocking binding F 2 0 GO:0004910 interleukin-1, Type II, blocking receptor activity F 2 0 GO:0019969 interleukin-10 binding F 1 1 GO:0004920 interleukin-10 receptor activity F 1 1 GO:0019970 interleukin-11 binding F 2 0 GO:0004921 interleukin-11 receptor activity F 2 0 GO:0005142 interleukin-11 receptor binding F 1 0 GO:0042164 interleukin-12 alpha subunit binding F 1 1 GO:0042163 interleukin-12 beta subunit binding F 1 1 GO:0019972 interleukin-12 binding F 2 2 GO:0005143 interleukin-12 receptor binding F 1 0 GO:0005144 interleukin-13 receptor binding F 1 0 GO:0030380 interleukin-17E receptor binding F 1 0 GO:0019976 interleukin-2 binding F 3 3 GO:0004911 interleukin-2 receptor activity F 2 1 GO:0005134 interleukin-2 receptor binding F 2 1 GO:0045517 interleukin-20 receptor binding F 1 1 GO:0042019 interleukin-23 binding F 1 0 GO:0042020 interleukin-23 receptor activity F 1 0 GO:0045513 interleukin-27 binding F 1 1 GO:0045509 interleukin-27 receptor activity F 1 1 GO:0045523 interleukin-27 receptor binding F 2 2 GO:0005135 interleukin-3 receptor binding F 1 0 GO:0005136 interleukin-4 receptor binding F 1 0 GO:0005137 interleukin-5 receptor binding F 2 1 GO:0005138 interleukin-6 receptor binding F 3 0 GO:0005139 interleukin-7 receptor binding F 1 0 GO:0019959 interleukin-8 binding F 2 0 GO:0004918 interleukin-8 receptor activity F 2 0 GO:0005140 interleukin-9 receptor binding F 1 0 GO:0019215 intermediate filament binding F 2 0 GO:0004232 interstitial collagenase activity F 3 0 GO:0005229 intracellular calcium activated chloride channel activity F 2 1 GO:0005222 intracellular cAMP activated cation channel activity F 1 1 GO:0005223 intracellular cGMP activated cation channel activity F 1 1 GO:0005221 intracellular cyclic nucleotide activated cation channel activity F 3 3 GO:0005218 intracellular ligand-gated calcium channel activity F 1 1 GO:0005217 intracellular ligand-gated ion channel activity F 7 5 GO:0016872 intramolecular lyase activity F 1 0 GO:0016860 intramolecular oxidoreductase activity F 44 9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses F 10 4 GO:0016862 intramolecular oxidoreductase activity, interconverting keto- and enol-groups F 8 0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds F 18 3 GO:0016864 intramolecular oxidoreductase activity, transposing S-S bonds F 7 0 GO:0016866 intramolecular transferase activity F 29 6 GO:0016868 intramolecular transferase activity, phosphotransferases F 9 3 GO:0005242 inward rectifier potassium channel activity F 14 1 GO:0004447 iodide peroxidase activity F 2 1 GO:0015111 iodide transmembrane transporter activity F 1 0 GO:0043167 ion binding F 3455 55 GO:0005216 ion channel activity F 341 87 GO:0008200 ion channel inhibitor activity F 5 2 GO:0022839 ion gated channel activity F 13 6 GO:0015075 ion transmembrane transporter activity F 617 142 GO:0004970 ionotropic glutamate receptor activity F 18 9 GO:0005506 iron ion binding F 290 0 GO:0005381 iron ion transmembrane transporter activity F 4 3 GO:0030350 iron-responsive element binding F 2 2 GO:0051536 iron-sulfur cluster binding F 41 0 GO:0019782 ISG15 activating enzyme activity F 1 1 GO:0042296 ISG15 conjugating enzyme activity F 1 1 GO:0019785 ISG15-specific protease activity F 1 1 GO:0004449 isocitrate dehydrogenase (NAD+) activity F 4 0 GO:0004450 isocitrate dehydrogenase (NADP+) activity F 4 2 GO:0004448 isocitrate dehydrogenase activity F 7 2 GO:0004822 isoleucine-tRNA ligase activity F 2 0 GO:0016853 isomerase activity F 150 22 GO:0004452 isopentenyl-diphosphate delta-isomerase activity F 3 0 GO:0019840 isoprenoid binding F 13 3 GO:0008470 isovaleryl-CoA dehydrogenase activity F 1 0 GO:0004718 Janus kinase activity F 4 2 GO:0004705 JUN kinase activity F 3 2 GO:0008432 JUN kinase binding F 2 1 GO:0008545 JUN kinase kinase activity F 1 1 GO:0008579 JUN kinase phosphatase activity F 1 1 GO:0015277 kainate selective glutamate receptor activity F 2 2 GO:0016450 kappa DNA polymerase activity F 1 0 GO:0004987 kappa-opioid receptor activity F 1 0 GO:0005046 KDEL sequence binding F 2 0 GO:0045130 keratan sulfotransferase activity F 1 0 GO:0004454 ketohexokinase activity F 1 0 GO:0019209 kinase activator activity F 12 4 GO:0016301 kinase activity F 837 189 GO:0019900 kinase binding F 50 28 GO:0019210 kinase inhibitor activity F 22 7 GO:0019207 kinase regulator activity F 72 17 GO:0019894 kinesin binding F 8 6 GO:0043515 kinetochore binding F 1 1 GO:0030429 kynureninase activity F 1 0 GO:0004502 kynurenine 3-monooxygenase activity F 1 0 GO:0016212 kynurenine-oxoglutarate transaminase activity F 3 0 GO:0004457 lactate dehydrogenase activity F 5 2 GO:0030395 lactose binding F 1 0 GO:0004461 lactose synthase activity F 3 0 GO:0050512 lactosylceramide 4-alpha-galactosyltransferase activity F 1 0 GO:0004462 lactoylglutathione lyase activity F 1 1 GO:0015180 L-alanine transmembrane transporter activity F 2 2 GO:0005521 lamin binding F 1 0 GO:0043236 laminin binding F 3 2 GO:0005055 laminin receptor activity F 4 1 GO:0043237 laminin-1 binding F 1 1 GO:0015179 L-amino acid transmembrane transporter activity F 24 18 GO:0001716 L-amino-acid oxidase activity F 2 2 GO:0004043 L-aminoadipate-semialdehyde dehydrogenase activity F 2 0 GO:0000250 lanosterol synthase activity F 1 0 GO:0060072 large conductance calcium-activated potassium channel activity F 1 1 GO:0008520 L-ascorbate:sodium symporter activity F 1 1 GO:0031418 L-ascorbic acid binding F 18 0 GO:0016524 latrotoxin receptor activity F 6 0 GO:0015184 L-cystine transmembrane transporter activity F 1 1 GO:0003692 left-handed Z-DNA binding F 2 1 GO:0001509 legumain activity F 2 1 GO:0004823 leucine-tRNA ligase activity F 2 0 GO:0004178 leucyl aminopeptidase activity F 4 2 GO:0005146 leukemia inhibitory factor receptor binding F 2 1 GO:0001632 leukotriene B4 receptor activity F 2 2 GO:0004974 leukotriene receptor activity F 4 4 GO:0004463 leukotriene-A4 hydrolase activity F 3 0 GO:0050051 leukotriene-B4 20-monooxygenase activity F 3 0 GO:0004464 leukotriene-C4 synthase activity F 1 0 GO:0015185 L-gamma-aminobutyric acid transmembrane transporter activity F 5 1 GO:0047939 L-glucuronate reductase activity F 1 1 GO:0005313 L-glutamate transmembrane transporter activity F 6 5 GO:0015186 L-glutamine transmembrane transporter activity F 2 2 GO:0005290 L-histidine transmembrane transporter activity F 1 1 GO:0003939 L-iditol 2-dehydrogenase activity F 1 1 GO:0003940 L-iduronidase activity F 1 0 GO:0004879 ligand-dependent nuclear receptor activity F 48 11 GO:0016922 ligand-dependent nuclear receptor binding F 5 3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity F 5 5 GO:0022834 ligand-gated channel activity F 83 30 GO:0015276 ligand-gated ion channel activity F 83 30 GO:0016874 ligase activity F 327 37 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds F 55 0 GO:0016885 ligase activity, forming carbon-carbon bonds F 7 2 GO:0016879 ligase activity, forming carbon-nitrogen bonds F 161 30 GO:0016875 ligase activity, forming carbon-oxygen bonds F 55 0 GO:0016877 ligase activity, forming carbon-sulfur bonds F 23 5 GO:0016886 ligase activity, forming phosphoric ester bonds F 5 0 GO:0030274 LIM domain binding F 1 1 GO:0016213 linoleoyl-CoA desaturase activity F 1 0 GO:0016298 lipase activity F 65 13 GO:0030882 lipid antigen binding F 1 1 GO:0008289 lipid binding F 353 27 GO:0001727 lipid kinase activity F 21 10 GO:0042577 lipid phosphatase activity F 10 6 GO:0005319 lipid transporter activity F 45 5 GO:0016992 lipoate synthase activity F 1 0 GO:0016979 lipoate-protein ligase activity F 4 0 GO:0016978 lipoate-protein ligase B activity F 3 0 GO:0031405 lipoic acid binding F 5 0 GO:0017140 lipoic acid synthase activity F 1 1 GO:0001530 lipopolysaccharide binding F 2 2 GO:0008917 lipopolysaccharide N-acetylglucosaminyltransferase activity F 1 1 GO:0008034 lipoprotein binding F 13 8 GO:0004465 lipoprotein lipase activity F 2 1 GO:0030228 lipoprotein receptor activity F 8 5 GO:0016165 lipoxygenase activity F 7 0 GO:0031403 lithium ion binding F 5 0 GO:0004459 L-lactate dehydrogenase activity F 4 2 GO:0015189 L-lysine transmembrane transporter activity F 1 1 GO:0030060 L-malate dehydrogenase activity F 3 1 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity F 1 0 GO:0004466 long-chain-acyl-CoA dehydrogenase activity F 1 0 GO:0047196 long-chain-alcohol O-fatty-acyltransferase activity F 1 0 GO:0016508 long-chain-enoyl-CoA hydratase activity F 1 0 GO:0004467 long-chain-fatty-acid-CoA ligase activity F 11 1 GO:0050062 long-chain-fatty-acyl-CoA reductase activity F 2 2 GO:0008332 low voltage-gated calcium channel activity F 2 0 GO:0030169 low-density lipoprotein binding F 8 5 GO:0005041 low-density lipoprotein receptor activity F 7 5 GO:0050750 low-density lipoprotein receptor binding F 9 2 GO:0050031 L-pipecolate oxidase activity F 1 0 GO:0015193 L-proline transmembrane transporter activity F 3 2 GO:0003941 L-serine ammonia-lyase activity F 1 0 GO:0008743 L-threonine 3-dehydrogenase activity F 1 0 GO:0005183 luteinizing hormone-releasing factor activity F 1 0 GO:0004964 lutropin-choriogonadotropic hormone receptor activity F 1 0 GO:0050038 L-xylulose reductase activity F 1 0 GO:0016829 lyase activity F 154 28 GO:0004184 lysine carboxypeptidase activity F 1 0 GO:0004468 lysine N-acetyltransferase activity F 17 6 GO:0016278 lysine N-methyltransferase activity F 17 5 GO:0004824 lysine-tRNA ligase activity F 1 0 GO:0042171 lysophosphatidic acid acyltransferase activity F 1 1 GO:0004622 lysophospholipase activity F 5 0 GO:0001619 lysosphingolipid and lysophosphatidic acid receptor activity F 11 3 GO:0003796 lysozyme activity F 10 0 GO:0005527 macrolide binding F 5 1 GO:0022884 macromolecule transmembrane transporter activity F 13 0 GO:0004234 macrophage elastase activity F 1 0 GO:0000287 magnesium ion binding F 342 16 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity F 1 0 GO:0008924 malate dehydrogenase (acceptor) activity F 1 0 GO:0004471 malate dehydrogenase (decarboxylating) activity F 2 0 GO:0004473 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity F 3 1 GO:0016619 malate dehydrogenase (oxaloacetate-decarboxylating) activity F 1 0 GO:0016615 malate dehydrogenase activity F 8 2 GO:0016034 maleylacetoacetate isomerase activity F 1 0 GO:0004470 malic enzyme activity F 4 1 GO:0050080 malonyl-CoA decarboxylase activity F 1 0 GO:0016420 malonyltransferase activity F 2 0 GO:0030145 manganese ion binding F 128 5 GO:0008383 manganese superoxide dismutase activity F 1 1 GO:0005537 mannose binding F 12 8 GO:0015578 mannose transmembrane transporter activity F 1 0 GO:0004475 mannose-1-phosphate guanylyltransferase activity F 1 0 GO:0004476 mannose-6-phosphate isomerase activity F 2 1 GO:0051377 mannose-ethanolamine phosphotransferase activity F 1 0 GO:0008905 mannose-phosphate guanylyltransferase activity F 1 0 GO:0015923 mannosidase activity F 14 6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity F 6 1 GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity F 1 0 GO:0004573 mannosyl-oligosaccharide glucosidase activity F 1 0 GO:0015924 mannosyl-oligosaccharide mannosidase activity F 7 1 GO:0000030 mannosyltransferase activity F 7 1 GO:0004707 MAP kinase activity F 14 6 GO:0004708 MAP kinase kinase activity F 6 6 GO:0004709 MAP kinase kinase kinase activity F 16 1 GO:0033549 MAP kinase phosphatase activity F 9 1 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity F 9 1 GO:0005078 MAP-kinase scaffold activity F 3 2 GO:0004235 matrilysin activity F 1 0 GO:0030354 melanin-concentrating hormone activity F 1 0 GO:0030273 melanin-concentrating hormone receptor activity F 1 0 GO:0004977 melanocortin receptor activity F 6 0 GO:0004980 melanocyte stimulating hormone receptor activity F 1 0 GO:0008502 melatonin receptor activity F 3 0 GO:0004179 membrane alanyl aminopeptidase activity F 11 0 GO:0004237 membrane dipeptidase activity F 4 2 GO:0004238 meprin A activity F 2 0 GO:0015097 mercury ion transmembrane transporter activity F 1 0 GO:0008067 metabotropic glutamate, GABA-B-like receptor activity F 26 3 GO:0051540 metal cluster binding F 41 0 GO:0046872 metal ion binding F 3385 55 GO:0046873 metal ion transmembrane transporter activity F 282 87 GO:0004181 metallocarboxypeptidase activity F 31 2 GO:0008472 metallocarboxypeptidase D activity F 1 0 GO:0016530 metallochaperone activity F 2 1 GO:0004222 metalloendopeptidase activity F 105 13 GO:0008191 metalloendopeptidase inhibitor activity F 6 2 GO:0008235 metalloexopeptidase activity F 56 8 GO:0008237 metallopeptidase activity F 192 24 GO:0050093 methanol dehydrogenase activity F 1 0 GO:0004477 methenyltetrahydrofolate cyclohydrolase activity F 2 0 GO:0004478 methionine adenosyltransferase activity F 2 1 GO:0008705 methionine synthase activity F 1 1 GO:0004825 methionine-tRNA ligase activity F 2 0 GO:0004239 methionyl aminopeptidase activity F 5 1 GO:0004479 methionyl-tRNA formyltransferase activity F 1 0 GO:0003908 methylated-DNA-[protein]-cysteine S-methyltransferase activity F 2 0 GO:0008327 methyl-CpG binding F 2 2 GO:0004485 methylcrotonoyl-CoA carboxylase activity F 2 0 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity F 2 0 GO:0004486 methylenetetrahydrofolate dehydrogenase activity F 2 0 GO:0004489 methylenetetrahydrofolate reductase (NADPH) activity F 1 1 GO:0004490 methylglutaconyl-CoA hydratase activity F 1 0 GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity F 1 0 GO:0004492 methylmalonyl-CoA decarboxylase activity F 1 0 GO:0004493 methylmalonyl-CoA epimerase activity F 1 0 GO:0004494 methylmalonyl-CoA mutase activity F 1 1 GO:0008168 methyltransferase activity F 155 21 GO:0004496 mevalonate kinase activity F 1 1 GO:0032394 MHC class Ib receptor activity F 1 1 GO:0042289 MHC class II protein binding F 2 1 GO:0042287 MHC protein binding F 10 1 GO:0000146 microfilament motor activity F 5 3 GO:0008017 microtubule binding F 46 27 GO:0051011 microtubule minus-end binding F 1 0 GO:0003777 microtubule motor activity F 64 4 GO:0051010 microtubule plus-end binding F 4 4 GO:0008568 microtubule-severing ATPase activity F 2 0 GO:0008569 minus-end-directed microtubule motor activity F 1 0 GO:0032404 mismatch repair complex binding F 2 0 GO:0030983 mismatched DNA binding F 8 3 GO:0032134 mispaired DNA binding F 3 3 GO:0004244 mitochondrial inner membrane peptidase activity F 1 1 GO:0004243 mitochondrial intermediate peptidase activity F 1 0 GO:0004240 mitochondrial processing peptidase activity F 3 0 GO:0051019 mitogen-activated protein kinase binding F 2 2 GO:0060090 molecular adaptor activity F 44 9 GO:0060089 molecular transducer activity F 2978 253 GO:0003674 molecular_function F 15484 3886 GO:0030151 molybdenum ion binding F 8 1 GO:0008504 monoamine transmembrane transporter activity F 4 0 GO:0008028 monocarboxylic acid transmembrane transporter activity F 15 3 GO:0004497 monooxygenase activity F 122 22 GO:0004503 monophenol monooxygenase activity F 1 0 GO:0048029 monosaccharide binding F 19 12 GO:0015145 monosaccharide transmembrane transporter activity F 11 4 GO:0015373 monovalent anion:sodium symporter activity F 1 1 GO:0005451 monovalent cation:proton antiporter activity F 7 3 GO:0015077 monovalent inorganic cation transmembrane transporter activity F 100 14 GO:0003774 motor activity F 133 8 GO:0008339 MP kinase activity F 2 1 GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity F 1 0 GO:0004482 mRNA (guanine-N7-)-methyltransferase activity F 1 0 GO:0001734 mRNA (N6-adenosine)-methyltransferase activity F 1 0 GO:0003730 mRNA 3'-UTR binding F 2 1 GO:0003729 mRNA binding F 30 21 GO:0004484 mRNA guanylyltransferase activity F 1 0 GO:0008174 mRNA methyltransferase activity F 2 0 GO:0015559 multidrug efflux pump activity F 1 0 GO:0015239 multidrug transporter activity F 4 0 GO:0004446 multiple inositol-polyphosphate phosphatase activity F 1 0 GO:0004988 mu-opioid receptor activity F 1 1 GO:0004981 muscarinic acetylcholine receptor activity F 5 1 GO:0051371 muscle alpha-actinin binding F 1 1 GO:0032405 MutLalpha complex binding F 2 0 GO:0032407 MutSalpha complex binding F 2 0 GO:0017022 myosin binding F 8 6 GO:0032036 myosin heavy chain binding F 1 1 GO:0004687 myosin light chain kinase activity F 3 0 GO:0017018 myosin phosphatase activity F 5 0 GO:0031489 myosin V binding F 2 2 GO:0019107 myristoyltransferase activity F 2 1 GO:0003948 N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity F 1 0 GO:0001537 N-acetylgalactosamine 4-O-sulfotransferase activity F 3 2 GO:0003943 N-acetylgalactosamine-4-sulfatase activity F 2 0 GO:0043890 N-acetylgalactosamine-6-sulfatase activity F 1 0 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity F 2 0 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity F 1 1 GO:0045127 N-acetylglucosamine kinase activity F 1 1 GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity F 1 0 GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity F 1 0 GO:0008449 N-acetylglucosamine-6-sulfatase activity F 3 0 GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity F 1 0 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity F 2 1 GO:0003945 N-acetyllactosamine synthase activity F 4 0 GO:0047276 N-acetyllactosaminide 3-alpha-galactosyltransferase activity F 1 0 GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity F 1 0 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity F 1 0 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity F 2 0 GO:0008745 N-acetylmuramoyl-L-alanine amidase activity F 4 0 GO:0008747 N-acetylneuraminate lyase activity F 1 0 GO:0019007 N-acetylneuraminic acid phosphate synthase activity F 1 1 GO:0008080 N-acetyltransferase activity F 44 11 GO:0050121 N-acylglucosamine 2-epimerase activity F 1 1 GO:0009384 N-acylmannosamine kinase activity F 2 1 GO:0008781 N-acylneuraminate cytidylyltransferase activity F 1 0 GO:0050124 N-acylneuraminate-9-phosphatase activity F 1 0 GO:0016410 N-acyltransferase activity F 54 16 GO:0051287 NAD binding F 21 0 GO:0008746 NAD(P) transhydrogenase activity F 1 0 GO:0008750 NAD(P)+ transhydrogenase (AB-specific) activity F 1 0 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity F 7 2 GO:0003955 NAD(P)H dehydrogenase (quinone) activity F 1 1 GO:0003950 NAD+ ADP-ribosyltransferase activity F 12 2 GO:0000210 NAD+ diphosphatase activity F 1 0 GO:0003951 NAD+ kinase activity F 2 0 GO:0003953 NAD+ nucleosidase activity F 3 1 GO:0003952 NAD+ synthase (glutamine-hydrolyzing) activity F 1 0 GO:0008795 NAD+ synthase activity F 1 0 GO:0017136 NAD-dependent histone deacetylase activity F 1 1 GO:0050136 NADH dehydrogenase (quinone) activity F 45 1 GO:0008137 NADH dehydrogenase (ubiquinone) activity F 45 1 GO:0003954 NADH dehydrogenase activity F 45 1 GO:0050661 NADP binding F 11 0 GO:0003959 NADPH dehydrogenase activity F 1 0 GO:0003960 NADPH:quinone reductase activity F 2 0 GO:0003958 NADPH-hemoprotein reductase activity F 1 0 GO:0016919 nardilysin activity F 1 0 GO:0016941 natriuretic peptide receptor activity F 1 1 GO:0046703 natural killer cell lectin-like receptor binding F 9 9 GO:0019781 NEDD8 activating enzyme activity F 1 0 GO:0019784 NEDD8-specific protease activity F 1 0 GO:0004245 neprilysin activity F 6 1 GO:0048406 nerve growth factor binding F 1 1 GO:0005042 netrin receptor activity F 1 1 GO:0042043 neurexin binding F 7 5 GO:0005185 neurohypophyseal hormone activity F 2 0 GO:0042924 neuromedin U binding F 2 0 GO:0001607 neuromedin U receptor activity F 2 0 GO:0042922 neuromedin U receptor binding F 1 0 GO:0042923 neuropeptide binding F 52 11 GO:0005184 neuropeptide hormone activity F 19 4 GO:0008188 neuropeptide receptor activity F 52 11 GO:0004983 neuropeptide Y receptor activity F 40 5 GO:0016492 neurotensin receptor activity, G-protein coupled F 3 1 GO:0042165 neurotransmitter binding F 100 19 GO:0030594 neurotransmitter receptor activity F 100 17 GO:0005326 neurotransmitter transporter activity F 21 2 GO:0005328 neurotransmitter:sodium symporter activity F 19 0 GO:0043121 neurotrophin binding F 1 1 GO:0005166 neurotrophin p75 receptor binding F 2 0 GO:0005165 neurotrophin receptor binding F 2 0 GO:0015175 neutral amino acid transmembrane transporter activity F 9 8 GO:0008130 neutrophil collagenase activity F 2 0 GO:0004704 NF-kappaB-inducing kinase activity F 2 1 GO:0004982 N-formyl peptide receptor activity F 7 0 GO:0016151 nickel ion binding F 4 2 GO:0008112 nicotinamide N-methyltransferase activity F 1 0 GO:0047280 nicotinamide phosphoribosyltransferase activity F 1 1 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity F 3 0 GO:0004516 nicotinate phosphoribosyltransferase activity F 2 1 GO:0004515 nicotinate-nucleotide adenylyltransferase activity F 1 1 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity F 1 0 GO:0004889 nicotinic acetylcholine-activated cation-selective channel activity F 14 10 GO:0004517 nitric-oxide synthase activity F 3 1 GO:0050998 nitric-oxide synthase binding F 1 0 GO:0030235 nitric-oxide synthase regulator activity F 2 2 GO:0004972 N-methyl-D-aspartate selective glutamate receptor activity F 6 6 GO:0008170 N-methyltransferase activity F 40 7 GO:0004926 non-G-protein coupled 7TM receptor activity F 11 0 GO:0001566 non-kinase phorbol ester receptor activity F 2 0 GO:0004715 non-membrane spanning protein tyrosine kinase activity F 38 2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity F 5 2 GO:0001571 non-tyrosine kinase fibroblast growth factor receptor activity F 1 0 GO:0005112 Notch binding F 6 5 GO:0016749 N-succinyltransferase activity F 2 1 GO:0016250 N-sulfoglucosamine sulfohydrolase activity F 1 0 GO:0016451 nu DNA polymerase activity F 1 1 GO:0035257 nuclear hormone receptor binding F 10 4 GO:0008139 nuclear localization sequence binding F 3 1 GO:0004518 nuclease activity F 135 16 GO:0003676 nucleic acid binding F 2723 478 GO:0002054 nucleobase binding F 1 1 GO:0015205 nucleobase transmembrane transporter activity F 2 1 GO:0015932 nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity F 7 4 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity F 36 4 GO:0005487 nucleocytoplasmic transporter activity F 8 3 GO:0001882 nucleoside binding F 2 0 GO:0004550 nucleoside diphosphate kinase activity F 9 0 GO:0019206 nucleoside kinase activity F 11 3 GO:0005337 nucleoside transmembrane transporter activity F 6 4 GO:0046899 nucleoside triphosphate adenylate kinase activity F 1 0 GO:0005415 nucleoside:sodium symporter activity F 2 1 GO:0017110 nucleoside-diphosphatase activity F 10 6 GO:0017111 nucleoside-triphosphatase activity F 457 50 GO:0047429 nucleoside-triphosphate diphosphatase activity F 2 1 GO:0031493 nucleosomal histone binding F 1 0 GO:0031491 nucleosome binding F 1 0 GO:0008252 nucleotidase activity F 8 4 GO:0000166 nucleotide binding F 1804 48 GO:0004551 nucleotide diphosphatase activity F 7 1 GO:0019201 nucleotide kinase activity F 15 1 GO:0019204 nucleotide phosphatase activity F 2 0 GO:0016502 nucleotide receptor activity F 62 6 GO:0001608 nucleotide receptor activity, G-protein coupled F 62 5 GO:0005338 nucleotide-sugar transmembrane transporter activity F 3 1 GO:0016779 nucleotidyltransferase activity F 104 18 GO:0045735 nutrient reservoir activity F 2 0 GO:0016413 O-acetyltransferase activity F 4 2 GO:0008374 O-acyltransferase activity F 30 14 GO:0016415 octanoyltransferase activity F 1 1 GO:0005549 odorant binding F 100 5 GO:0004320 oleoyl-[acyl-carrier-protein] hydrolase activity F 2 0 GO:0004984 olfactory receptor activity F 1165 2 GO:0015198 oligopeptide transporter activity F 7 3 GO:0004576 oligosaccharyl transferase activity F 7 0 GO:0008242 omega peptidase activity F 4 1 GO:0008171 O-methyltransferase activity F 7 3 GO:0004924 oncostatin-M receptor activity F 1 1 GO:0005147 oncostatin-M receptor binding F 1 0 GO:0016414 O-octanoyltransferase activity F 1 1 GO:0016416 O-palmitoyltransferase activity F 4 0 GO:0001515 opioid peptide activity F 5 2 GO:0004985 opioid receptor activity F 4 2 GO:0002046 opsin binding F 2 2 GO:0001846 opsonin binding F 2 2 GO:0016499 orexin receptor activity F 2 1 GO:0005342 organic acid transmembrane transporter activity F 58 31 GO:0005343 organic acid:sodium symporter activity F 20 3 GO:0008514 organic anion transmembrane transporter activity F 7 4 GO:0015101 organic cation transmembrane transporter activity F 6 2 GO:0004585 ornithine carbamoyltransferase activity F 1 0 GO:0042978 ornithine decarboxylase activator activity F 2 2 GO:0004586 ornithine decarboxylase activity F 1 1 GO:0008073 ornithine decarboxylase inhibitor activity F 3 3 GO:0042979 ornithine decarboxylase regulator activity F 5 5 GO:0004587 ornithine-oxo-acid transaminase activity F 1 0 GO:0004588 orotate phosphoribosyltransferase activity F 1 0 GO:0004590 orotidine-5'-phosphate decarboxylase activity F 1 0 GO:0008450 O-sialoglycoprotein endopeptidase activity F 2 0 GO:0005034 osmosensor activity F 1 1 GO:0019531 oxalate transmembrane transporter activity F 1 1 GO:0017077 oxidative phosphorylation uncoupler activity F 2 2 GO:0000702 oxidized base lesion DNA N-glycosylase activity F 5 1 GO:0008534 oxidized purine base lesion DNA N-glycosylase activity F 4 1 GO:0016491 oxidoreductase activity F 794 134 GO:0016725 oxidoreductase activity, acting on CH2 groups F 4 2 GO:0016728 oxidoreductase activity, acting on CH2 groups, disulfide as acceptor F 3 1 GO:0016726 oxidoreductase activity, acting on CH2 groups, NAD or NADP as acceptor F 1 1 GO:0016727 oxidoreductase activity, acting on CH2 groups, oxygen as acceptor F 1 0 GO:0016614 oxidoreductase activity, acting on CH-OH group of donors F 117 31 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors F 11 0 GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor F 11 0 GO:0016675 oxidoreductase activity, acting on heme group of donors F 21 1 GO:0016676 oxidoreductase activity, acting on heme group of donors, oxygen as acceptor F 21 1 GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors F 1 0 GO:0016731 oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor F 1 0 GO:0016651 oxidoreductase activity, acting on NADH or NADPH F 65 6 GO:0016654 oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor F 3 0 GO:0016653 oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor F 5 0 GO:0016652 oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor F 1 0 GO:0016657 oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor F 2 0 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor F 48 2 GO:0050664 oxidoreductase activity, acting on NADH or NADPH, with oxygen as acceptor F 4 3 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors F 1 0 GO:0016663 oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor F 1 0 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen F 118 20 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors F 25 4 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen F 2 1 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen F 17 2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen F 5 0 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen F 38 0 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen F 5 3 GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen F 6 4 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water F 7 2 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor F 41 8 GO:0030613 oxidoreductase activity, acting on phosphorus or arsenic in donors F 1 0 GO:0030614 oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor F 1 0 GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen F 62 3 GO:0016703 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) F 5 0 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen F 56 3 GO:0016667 oxidoreductase activity, acting on sulfur group of donors F 20 8 GO:0016671 oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor F 8 3 GO:0016668 oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor F 6 4 GO:0016670 oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor F 5 1 GO:0016721 oxidoreductase activity, acting on superoxide radicals as acceptor F 8 3 GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors F 36 14 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor F 6 0 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor F 28 11 GO:0016623 oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor F 3 2 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors F 42 6 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor F 15 2 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor F 8 1 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor F 2 0 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors F 20 6 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor F 11 4 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor F 3 2 GO:0016649 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor F 2 0 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors F 22 6 GO:0016642 oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor F 1 0 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor F 2 1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor F 19 5 GO:0016898 oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor F 1 0 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor F 1 1 GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor F 108 28 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor F 3 1 GO:0016722 oxidoreductase activity, oxidizing metal ions F 7 4 GO:0016723 oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor F 4 3 GO:0016724 oxidoreductase activity, oxidizing metal ions, oxygen as acceptor F 3 1 GO:0031559 oxidosqualene cyclase activity F 1 0 GO:0016833 oxo-acid-lyase activity F 3 0 GO:0050164 oxoglutarate dehydrogenase (NADP+) activity F 1 1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity F 1 0 GO:0019825 oxygen binding F 5 0 GO:0005344 oxygen transporter activity F 12 2 GO:0008396 oxysterol 7-alpha-hydroxylase activity F 2 2 GO:0008142 oxysterol binding F 1 0 GO:0004990 oxytocin receptor activity F 1 0 GO:0002039 p53 binding F 4 2 GO:0008474 palmitoyl-(protein) hydrolase activity F 2 2 GO:0016290 palmitoyl-CoA hydrolase activity F 11 1 GO:0016409 palmitoyltransferase activity F 15 7 GO:0008132 pancreatic elastase activity F 2 0 GO:0008125 pancreatic elastase I activity F 1 0 GO:0004281 pancreatic elastase II activity F 1 0 GO:0001602 pancreatic polypeptide receptor activity F 3 3 GO:0004522 pancreatic ribonuclease activity F 15 0 GO:0004595 pantetheine-phosphate adenylyltransferase activity F 1 1 GO:0004594 pantothenate kinase activity F 4 2 GO:0004991 parathyroid hormone receptor activity F 1 1 GO:0022803 passive transmembrane transporter activity F 369 92 GO:0005113 patched binding F 2 2 GO:0001871 pattern binding F 85 21 GO:0008329 pattern recognition receptor activity F 3 1 GO:0030165 PDZ domain binding F 11 6 GO:0004194 pepsin A activity F 9 0 GO:0008233 peptidase activity F 682 95 GO:0004596 peptide alpha-N-acetyltransferase activity F 2 0 GO:0042605 peptide antigen binding F 11 3 GO:0042277 peptide binding F 141 40 GO:0015037 peptide disulfide oxidoreductase activity F 1 1 GO:0017046 peptide hormone binding F 2 2 GO:0001653 peptide receptor activity F 113 34 GO:0008528 peptide receptor activity, G-protein coupled F 113 33 GO:0015197 peptide transporter activity F 8 4 GO:0001601 peptide YY receptor activity F 5 5 GO:0004597 peptide-aspartate beta-dioxygenase activity F 3 0 GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity F 1 0 GO:0046922 peptide-O-fucosyltransferase activity F 2 0 GO:0042834 peptidoglycan binding F 2 0 GO:0016019 peptidoglycan receptor activity F 2 0 GO:0004598 peptidylamidoglycolate lyase activity F 1 0 GO:0004246 peptidyl-dipeptidase A activity F 3 0 GO:0008241 peptidyl-dipeptidase activity F 3 0 GO:0004504 peptidylglycine monooxygenase activity F 1 0 GO:0031544 peptidyl-proline 3-dioxygenase activity F 3 0 GO:0031545 peptidyl-proline 4-dioxygenase activity F 3 2 GO:0031543 peptidyl-proline dioxygenase activity F 6 2 GO:0003755 peptidyl-prolyl cis-trans isomerase activity F 33 1 GO:0004601 peroxidase activity F 41 8 GO:0051920 peroxiredoxin activity F 6 0 GO:0000268 peroxisome targeting sequence binding F 2 0 GO:0004505 phenylalanine 4-monooxygenase activity F 3 3 GO:0004826 phenylalanine-tRNA ligase activity F 3 0 GO:0004603 phenylethanolamine N-methyltransferase activity F 1 0 GO:0050178 phenylpyruvate tautomerase activity F 1 0 GO:0005550 pheromone binding F 95 1 GO:0016503 pheromone receptor activity F 111 0 GO:0001565 phorbol ester receptor activity F 17 4 GO:0019211 phosphatase activator activity F 1 0 GO:0019902 phosphatase binding F 7 3 GO:0019212 phosphatase inhibitor activity F 19 5 GO:0019208 phosphatase regulator activity F 35 11 GO:0015114 phosphate transmembrane transporter activity F 8 1 GO:0004605 phosphatidate cytidylyltransferase activity F 2 0 GO:0008195 phosphatidate phosphatase activity F 6 4 GO:0047173 phosphatidylcholine-retinol O-acyltransferase activity F 1 0 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity F 2 1 GO:0008429 phosphatidylethanolamine binding F 2 2 GO:0004608 phosphatidylethanolamine N-methyltransferase activity F 1 0 GO:0005545 phosphatidylinositol binding F 6 3 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity F 4 0 GO:0016307 phosphatidylinositol phosphate kinase activity F 10 5 GO:0008526 phosphatidylinositol transporter activity F 1 0 GO:0005547 phosphatidylinositol-3,4,5-triphosphate binding F 2 1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity F 1 1 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity F 2 0 GO:0004438 phosphatidylinositol-3-phosphatase activity F 1 1 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity F 4 0 GO:0001668 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity F 1 1 GO:0035005 phosphatidylinositol-4-phosphate 3-kinase activity F 2 0 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity F 1 1 GO:0001786 phosphatidylserine binding F 3 2 GO:0004609 phosphatidylserine decarboxylase activity F 3 0 GO:0030572 phosphatidyltransferase activity F 1 1 GO:0004610 phosphoacetylglucosamine mutase activity F 1 0 GO:0004528 phosphodiesterase I activity F 3 0 GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity F 2 0 GO:0004611 phosphoenolpyruvate carboxykinase activity F 2 1 GO:0008443 phosphofructokinase activity F 9 2 GO:0004614 phosphoglucomutase activity F 4 3 GO:0008114 phosphogluconate 2-dehydrogenase activity F 1 0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity F 2 1 GO:0004617 phosphoglycerate dehydrogenase activity F 1 0 GO:0004618 phosphoglycerate kinase activity F 2 1 GO:0004619 phosphoglycerate mutase activity F 3 0 GO:0008967 phosphoglycolate phosphatase activity F 3 0 GO:0035004 phosphoinositide 3-kinase activity F 9 4 GO:0035014 phosphoinositide 3-kinase regulator activity F 5 1 GO:0004439 phosphoinositide 5-phosphatase activity F 5 2 GO:0035091 phosphoinositide binding F 161 8 GO:0004435 phosphoinositide phospholipase C activity F 10 0 GO:0016005 phospholipase A2 activator activity F 1 1 GO:0004623 phospholipase A2 activity F 23 6 GO:0019834 phospholipase A2 inhibitor activity F 3 0 GO:0016004 phospholipase activator activity F 1 1 GO:0004620 phospholipase activity F 48 9 GO:0004629 phospholipase C activity F 16 2 GO:0004630 phospholipase D activity F 5 1 GO:0004859 phospholipase inhibitor activity F 4 0 GO:0005543 phospholipid binding F 197 20 GO:0005548 phospholipid transporter activity F 13 2 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity F 1 0 GO:0004012 phospholipid-translocating ATPase activity F 12 2 GO:0004615 phosphomannomutase activity F 2 0 GO:0004631 phosphomevalonate kinase activity F 1 1 GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity F 1 0 GO:0031177 phosphopantetheine binding F 2 0 GO:0008897 phosphopantetheinyltransferase activity F 1 0 GO:0004632 phosphopantothenate--cysteine ligase activity F 1 0 GO:0004633 phosphopantothenoylcysteine decarboxylase activity F 1 0 GO:0051219 phosphoprotein binding F 13 12 GO:0004721 phosphoprotein phosphatase activity F 143 27 GO:0004634 phosphopyruvate hydratase activity F 4 1 GO:0004637 phosphoribosylamine-glycine ligase activity F 2 0 GO:0004638 phosphoribosylaminoimidazole carboxylase activity F 1 0 GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity F 1 0 GO:0004639 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity F 1 0 GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity F 1 0 GO:0004642 phosphoribosylformylglycinamidine synthase activity F 1 0 GO:0004644 phosphoribosylglycinamide formyltransferase activity F 1 0 GO:0008081 phosphoric diester hydrolase activity F 65 12 GO:0042578 phosphoric ester hydrolase activity F 286 66 GO:0016791 phosphoric monoester hydrolase activity F 226 55 GO:0016849 phosphorus-oxygen lyase activity F 22 6 GO:0004645 phosphorylase activity F 4 1 GO:0004689 phosphorylase kinase activity F 2 0 GO:0004647 phosphoserine phosphatase activity F 1 0 GO:0004648 phosphoserine transaminase activity F 1 0 GO:0016773 phosphotransferase activity, alcohol group as acceptor F 659 168 GO:0016774 phosphotransferase activity, carboxyl group as acceptor F 4 2 GO:0016780 phosphotransferase activity, for other substituted phosphate groups F 16 4 GO:0016775 phosphotransferase activity, nitrogenous group as acceptor F 14 1 GO:0016781 phosphotransferase activity, paired acceptors F 2 0 GO:0016776 phosphotransferase activity, phosphate group as acceptor F 28 2 GO:0001784 phosphotyrosine binding F 6 5 GO:0009881 photoreceptor activity F 11 3 GO:0048244 phytanoyl-CoA dioxygenase activity F 1 0 GO:0003807 plasma kallikrein activity F 1 0 GO:0004283 plasmin activity F 1 0 GO:0008243 plasminogen activator activity F 4 0 GO:0004992 platelet activating factor receptor activity F 1 0 GO:0001621 platelet ADP receptor activity F 1 1 GO:0048407 platelet-derived growth factor binding F 2 1 GO:0005161 platelet-derived growth factor receptor binding F 2 1 GO:0001639 PLC activating metabotropic glutamate receptor activity F 2 0 GO:0008143 poly(A) binding F 6 2 GO:0004535 poly(A)-specific ribonuclease activity F 2 0 GO:0004649 poly(ADP-ribose) glycohydrolase activity F 2 1 GO:0008266 poly(U) binding F 4 3 GO:0046592 polyamine oxidase activity F 2 2 GO:0051733 polydeoxyribonucleotide kinase activity F 2 0 GO:0046403 polynucleotide 3'-phosphatase activity F 1 0 GO:0004651 polynucleotide 5'-phosphatase activity F 1 0 GO:0004652 polynucleotide adenylyltransferase activity F 4 0 GO:0051731 polynucleotide kinase activity F 2 0 GO:0015166 polyol transmembrane transporter activity F 1 0 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity F 6 5 GO:0017120 polyphosphoinositide phosphatase activity F 1 1 GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity F 1 0 GO:0008187 poly-pyrimidine tract binding F 1 1 GO:0004654 polyribonucleotide nucleotidyltransferase activity F 1 0 GO:0030247 polysaccharide binding F 81 19 GO:0001873 polysaccharide receptor activity F 1 1 GO:0004655 porphobilinogen synthase activity F 1 0 GO:0008159 positive transcription elongation factor activity F 3 0 GO:0005267 potassium channel activity F 124 11 GO:0019870 potassium channel inhibitor activity F 1 0 GO:0015459 potassium channel regulator activity F 1 0 GO:0030955 potassium ion binding F 108 0 GO:0015379 potassium:chloride symporter activity F 1 1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity F 13 0 GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity F 136 15 GO:0004727 prenylated protein tyrosine phosphatase activity F 8 0 GO:0001735 prenylcysteine oxidase activity F 1 1 GO:0004659 prenyltransferase activity F 23 3 GO:0015399 primary active transmembrane transporter activity F 136 15 GO:0016402 pristanoyl-CoA oxidase activity F 1 0 GO:0017026 procollagen C-endopeptidase activity F 1 0 GO:0017074 procollagen N-endopeptidase activity F 3 3 GO:0008475 procollagen-lysine 5-dioxygenase activity F 3 0 GO:0019797 procollagen-proline 3-dioxygenase activity F 3 0 GO:0004656 procollagen-proline 4-dioxygenase activity F 3 2 GO:0019798 procollagen-proline dioxygenase activity F 6 2 GO:0005522 profilin binding F 6 4 GO:0004925 prolactin receptor activity F 1 1 GO:0005148 prolactin receptor binding F 2 0 GO:0004657 proline dehydrogenase activity F 2 0 GO:0018112 proline racemase activity F 1 0 GO:0004827 proline-tRNA ligase activity F 2 0 GO:0016804 prolyl aminopeptidase activity F 1 0 GO:0004287 prolyl oligopeptidase activity F 4 0 GO:0004658 propionyl-CoA carboxylase activity F 2 1 GO:0004285 proprotein convertase 1 activity F 1 0 GO:0004286 proprotein convertase 2 activity F 1 0 GO:0016808 proprotein convertase activity F 2 0 GO:0016501 prostacyclin receptor activity F 2 0 GO:0004956 prostaglandin D receptor activity F 2 2 GO:0004957 prostaglandin E receptor activity F 4 1 GO:0004958 prostaglandin F receptor activity F 2 1 GO:0001785 prostaglandin J receptor activity F 2 2 GO:0004955 prostaglandin receptor activity F 9 3 GO:0015132 prostaglandin transmembrane transporter activity F 1 1 GO:0004667 prostaglandin-D synthase activity F 4 1 GO:0050220 prostaglandin-E synthase activity F 3 0 GO:0004666 prostaglandin-endoperoxide synthase activity F 2 0 GO:0008116 prostaglandin-I synthase activity F 1 0 GO:0004954 prostanoid receptor activity F 10 4 GO:0016504 protease activator activity F 12 5 GO:0002020 protease binding F 2 0 GO:0030414 protease inhibitor activity F 145 11 GO:0008538 proteasome activator activity F 3 2 GO:0043495 protein anchor F 1 1 GO:0005515 protein binding F 4684 2561 GO:0030674 protein binding, bridging F 25 8 GO:0003808 protein C (activated) activity F 1 0 GO:0032403 protein complex binding F 47 20 GO:0032947 protein complex scaffold F 6 3 GO:0008022 protein C-terminus binding F 10 5 GO:0033558 protein deacetylase activity F 12 4 GO:0046983 protein dimerization activity F 199 105 GO:0003756 protein disulfide isomerase activity F 7 0 GO:0015035 protein disulfide oxidoreductase activity F 7 0 GO:0019904 protein domain specific binding F 47 31 GO:0004660 protein farnesyltransferase activity F 2 0 GO:0004661 protein geranylgeranyltransferase activity F 6 1 GO:0046982 protein heterodimerization activity F 61 44 GO:0004673 protein histidine kinase activity F 10 0 GO:0042803 protein homodimerization activity F 102 76 GO:0051018 protein kinase A binding F 8 3 GO:0030295 protein kinase activator activity F 9 2 GO:0004672 protein kinase activity F 564 135 GO:0043422 protein kinase B binding F 1 1 GO:0019901 protein kinase binding F 48 28 GO:0004697 protein kinase C activity F 15 4 GO:0005080 protein kinase C binding F 7 3 GO:0004682 protein kinase CK2 activity F 2 1 GO:0008605 protein kinase CK2 regulator activity F 1 0 GO:0004860 protein kinase inhibitor activity F 20 6 GO:0019887 protein kinase regulator activity F 61 13 GO:0008276 protein methyltransferase activity F 33 12 GO:0016262 protein N-acetylglucosaminyltransferase activity F 1 0 GO:0008418 protein N-terminal asparagine amidohydrolase activity F 1 1 GO:0047485 protein N-terminus binding F 2 2 GO:0019903 protein phosphatase binding F 5 1 GO:0004864 protein phosphatase inhibitor activity F 16 3 GO:0019888 protein phosphatase regulator activity F 32 9 GO:0000163 protein phosphatase type 1 activity F 9 3 GO:0008599 protein phosphatase type 1 regulator activity F 5 2 GO:0000158 protein phosphatase type 2A activity F 6 0 GO:0008601 protein phosphatase type 2A regulator activity F 8 1 GO:0015071 protein phosphatase type 2C activity F 19 2 GO:0045309 protein phosphorylated amino acid binding F 8 7 GO:0008318 protein prenyltransferase activity F 17 1 GO:0043621 protein self-association F 6 6 GO:0004674 protein serine/threonine kinase activity F 410 68 GO:0004722 protein serine/threonine phosphatase activity F 31 8 GO:0004712 protein serine/threonine/tyrosine kinase activity F 8 7 GO:0031386 protein tag F 1 1 GO:0008320 protein transmembrane transporter activity F 20 0 GO:0008565 protein transporter activity F 146 12 GO:0030296 protein tyrosine kinase activator activity F 2 1 GO:0030292 protein tyrosine kinase inhibitor activity F 1 0 GO:0004725 protein tyrosine phosphatase activity F 88 7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity F 36 6 GO:0008330 protein tyrosine/threonine phosphatase activity F 1 1 GO:0030158 protein xylosyltransferase activity F 2 0 GO:0004668 protein-arginine deiminase activity F 5 0 GO:0016274 protein-arginine N-methyltransferase activity F 3 0 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity F 1 0 GO:0035241 protein-arginine omega-N monomethyltransferase activity F 1 0 GO:0019707 protein-cysteine S-acyltransferase activity F 1 0 GO:0019706 protein-cysteine S-palmitoleyltransferase activity F 1 0 GO:0019153 protein-disulfide reductase (glutathione) activity F 2 0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity F 6 2 GO:0016500 protein-hormone receptor activity F 10 2 GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity F 3 1 GO:0004720 protein-lysine 6-oxidase activity F 9 2 GO:0016279 protein-lysine N-methyltransferase activity F 17 5 GO:0000318 protein-methionine-R-oxide reductase activity F 3 2 GO:0008113 protein-methionine-S-oxide reductase activity F 2 1 GO:0004671 protein-S-isoprenylcysteine O-methyltransferase activity F 1 1 GO:0004713 protein-tyrosine kinase activity F 160 25 GO:0008476 protein-tyrosine sulfotransferase activity F 2 0 GO:0018445 prothoracicotrophic hormone activity F 2 0 GO:0030567 prothrombin activator activity F 1 0 GO:0008495 protoheme IX farnesyltransferase activity F 1 0 GO:0005427 proton-dependent oligopeptide secondary active transmembrane transporter activity F 2 2 GO:0004729 protoporphyrinogen oxidase activity F 1 1 GO:0008322 Pro-X carboxypeptidase activity F 1 0 GO:0001691 pseudophosphatase activity F 1 0 GO:0009982 pseudouridine synthase activity F 18 2 GO:0004730 pseudouridylate synthase activity F 9 0 GO:0051425 PTB domain binding F 1 1 GO:0002060 purine binding F 1 1 GO:0001883 purine nucleoside binding F 1 0 GO:0015211 purine nucleoside transmembrane transporter activity F 1 1 GO:0017076 purine nucleotide binding F 1612 45 GO:0032555 purine ribonucleotide binding F 1552 43 GO:0005345 purine transmembrane transporter activity F 1 1 GO:0004731 purine-nucleoside phosphorylase activity F 1 1 GO:0001614 purinergic nucleotide receptor activity F 62 6 GO:0045028 purinergic nucleotide receptor activity, G-protein coupled F 62 5 GO:0015390 purine-specific nucleoside:sodium symporter activity F 1 1 GO:0008478 pyridoxal kinase activity F 1 0 GO:0030170 pyridoxal phosphate binding F 45 1 GO:0004733 pyridoxamine-phosphate oxidase activity F 1 0 GO:0015389 pyrimidine- and adenine-specific:sodium symporter activity F 1 1 GO:0019103 pyrimidine nucleotide binding F 2 0 GO:0015165 pyrimidine nucleotide sugar transmembrane transporter activity F 1 1 GO:0005350 pyrimidine transmembrane transporter activity F 2 1 GO:0016920 pyroglutamyl-peptidase activity F 2 0 GO:0004219 pyroglutamyl-peptidase I activity F 1 0 GO:0016921 pyroglutamyl-peptidase II activity F 1 0 GO:0016462 pyrophosphatase activity F 480 58 GO:0004735 pyrroline-5-carboxylate reductase activity F 2 0 GO:0004736 pyruvate carboxylase activity F 1 0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity F 3 0 GO:0004738 pyruvate dehydrogenase activity F 3 1 GO:0004743 pyruvate kinase activity F 2 2 GO:0008127 quercetin 2,3-dioxygenase activity F 1 0 GO:0008479 queuine tRNA-ribosyltransferase activity F 1 0 GO:0048038 quinone binding F 3 0 GO:0030580 quinone cofactor methyltransferase activity F 1 0 GO:0005084 Rab escort protein activity F 2 0 GO:0005093 Rab GDP-dissociation inhibitor activity F 2 0 GO:0005097 Rab GTPase activator activity F 31 2 GO:0017137 Rab GTPase binding F 19 5 GO:0017112 Rab guanyl-nucleotide exchange factor activity F 2 1 GO:0004663 Rab-protein geranylgeranyltransferase activity F 4 1 GO:0030675 Rac GTPase activator activity F 7 4 GO:0048365 Rac GTPase binding F 1 0 GO:0030676 Rac guanyl-nucleotide exchange factor activity F 3 2 GO:0016854 racemase and epimerase activity F 12 4 GO:0016855 racemase and epimerase activity, acting on amino acids and derivatives F 3 1 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives F 7 3 GO:0017160 Ral GTPase binding F 3 2 GO:0008321 Ral guanyl-nucleotide exchange factor activity F 1 1 GO:0005098 Ran GTPase activator activity F 2 0 GO:0008536 Ran GTPase binding F 7 2 GO:0005087 Ran guanyl-nucleotide exchange factor activity F 2 0 GO:0005099 Ras GTPase activator activity F 47 10 GO:0017016 Ras GTPase binding F 49 17 GO:0005088 Ras guanyl-nucleotide exchange factor activity F 56 13 GO:0030546 receptor activator activity F 1 1 GO:0004872 receptor activity F 2769 205 GO:0048019 receptor antagonist activity F 4 0 GO:0005102 receptor binding F 580 160 GO:0030547 receptor inhibitor activity F 5 1 GO:0030545 receptor regulator activity F 8 4 GO:0030159 receptor signaling complex scaffold activity F 6 3 GO:0005057 receptor signaling protein activity F 86 33 GO:0004702 receptor signaling protein serine/threonine kinase activity F 46 11 GO:0004716 receptor signaling protein tyrosine kinase activity F 5 3 GO:0008518 reduced folate carrier activity F 3 0 GO:0016299 regulator of G-protein signaling activity F 2 2 GO:0004195 renin activity F 2 0 GO:0016918 retinal binding F 10 1 GO:0001758 retinal dehydrogenase activity F 4 3 GO:0001972 retinoic acid binding F 1 1 GO:0003708 retinoic acid receptor activity F 3 1 GO:0042974 retinoic acid receptor binding F 3 2 GO:0005501 retinoid binding F 13 3 GO:0046965 retinoid X receptor binding F 3 2 GO:0019841 retinol binding F 8 0 GO:0004745 retinol dehydrogenase activity F 7 2 GO:0005094 Rho GDP-dissociation inhibitor activity F 3 1 GO:0005100 Rho GTPase activator activity F 14 8 GO:0017048 Rho GTPase binding F 17 6 GO:0005089 Rho guanyl-nucleotide exchange factor activity F 50 8 GO:0050254 rhodopsin kinase activity F 1 0 GO:0001584 rhodopsin-like receptor activity F 1525 74 GO:0008531 riboflavin kinase activity F 1 0 GO:0004747 ribokinase activity F 1 0 GO:0004540 ribonuclease activity F 56 8 GO:0008995 ribonuclease E activity F 1 0 GO:0004523 ribonuclease H activity F 3 0 GO:0004525 ribonuclease III activity F 3 1 GO:0000171 ribonuclease MRP activity F 1 0 GO:0004526 ribonuclease P activity F 10 1 GO:0043021 ribonucleoprotein binding F 16 3 GO:0004748 ribonucleoside-diphosphate reductase activity F 3 1 GO:0032553 ribonucleotide binding F 1552 43 GO:0004749 ribose phosphate diphosphokinase activity F 6 0 GO:0004751 ribose-5-phosphate isomerase activity F 1 0 GO:0043023 ribosomal large subunit binding F 2 1 GO:0043024 ribosomal small subunit binding F 1 0 GO:0043022 ribosome binding F 4 1 GO:0008741 ribulokinase activity F 1 0 GO:0004750 ribulose-phosphate 3-epimerase activity F 1 0 GO:0030561 RNA 2'-O-ribose methylation guide activity F 1 0 GO:0003723 RNA binding F 520 60 GO:0003969 RNA editase activity F 5 1 GO:0008192 RNA guanylyltransferase activity F 1 0 GO:0003724 RNA helicase activity F 14 1 GO:0008419 RNA lariat debranching enzyme activity F 1 1 GO:0008173 RNA methyltransferase activity F 15 0 GO:0030555 RNA modification guide activity F 1 0 GO:0003716 RNA polymerase I transcription termination factor activity F 3 2 GO:0003702 RNA polymerase II transcription factor activity F 75 31 GO:0003705 RNA polymerase II transcription factor activity, enhancer binding F 19 15 GO:0016455 RNA polymerase II transcription mediator activity F 1 0 GO:0003709 RNA polymerase III transcription factor activity F 1 0 GO:0008353 RNA polymerase subunit kinase activity F 4 0 GO:0031202 RNA splicing factor activity, transesterification mechanism F 12 1 GO:0050265 RNA uridylyltransferase activity F 1 0 GO:0003963 RNA-3'-phosphate cyclase activity F 1 0 GO:0008186 RNA-dependent ATPase activity F 3 1 GO:0003964 RNA-directed DNA polymerase activity F 5 2 GO:0016433 rRNA (adenine) methyltransferase activity F 3 0 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity F 3 0 GO:0030562 rRNA 2'-O-ribose methylation guide activity F 1 0 GO:0019843 rRNA binding F 19 2 GO:0008649 rRNA methyltransferase activity F 3 0 GO:0030556 rRNA modification guide activity F 1 0 GO:0042134 rRNA primary transcript binding F 2 1 GO:0050733 RS domain binding F 1 0 GO:0005219 ryanodine-sensitive calcium-release channel activity F 1 1 GO:0051903 S-(hydroxymethyl)glutathione dehydrogenase activity F 1 0 GO:0047131 saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity F 1 1 GO:0004753 saccharopine dehydrogenase activity F 1 1 GO:0016418 S-acetyltransferase activity F 2 0 GO:0016417 S-acyltransferase activity F 5 0 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity F 72 13 GO:0016909 SAP kinase activity F 5 3 GO:0008480 sarcosine dehydrogenase activity F 1 0 GO:0008115 sarcosine oxidase activity F 1 0 GO:0005044 scavenger receptor activity F 26 2 GO:0015355 secondary active monocarboxylate transmembrane transporter activity F 4 0 GO:0015322 secondary active oligopeptide transmembrane transporter activity F 2 2 GO:0008271 secondary active sulfate transmembrane transporter activity F 8 1 GO:0015291 secondary active transmembrane transporter activity F 171 23 GO:0015055 secretin receptor activity F 1 0 GO:0001633 secretin-like receptor activity F 20 8 GO:0004756 selenide, water dikinase activity F 2 0 GO:0008430 selenium binding F 31 2 GO:0017154 semaphorin receptor activity F 5 5 GO:0030215 semaphorin receptor binding F 1 1 GO:0004757 sepiapterin reductase activity F 1 0 GO:0043565 sequence-specific DNA binding F 420 24 GO:0004185 serine carboxypeptidase activity F 4 0 GO:0004758 serine C-palmitoyltransferase activity F 3 0 GO:0017171 serine hydrolase activity F 204 17 GO:0030378 serine racemase activity F 1 1 GO:0004760 serine-pyruvate transaminase activity F 1 0 GO:0004828 serine-tRNA ligase activity F 2 0 GO:0004252 serine-type endopeptidase activity F 191 10 GO:0004867 serine-type endopeptidase inhibitor activity F 99 5 GO:0008236 serine-type peptidase activity F 204 17 GO:0004188 serine-type Pro-X carboxypeptidase activity F 1 0 GO:0004993 serotonin receptor activity F 15 2 GO:0005335 serotonin:sodium symporter activity F 1 0 GO:0005232 serotonin-activated cation-selective channel activity F 1 1 GO:0005118 sevenless binding F 2 0 GO:0018738 S-formylglutathione hydrolase activity F 1 0 GO:0042169 SH2 domain binding F 5 3 GO:0017124 SH3 domain binding F 10 9 GO:0005070 SH3/SH2 adaptor activity F 14 7 GO:0004765 shikimate kinase activity F 2 0 GO:0016937 short-branched-chain-acyl-CoA dehydrogenase activity F 1 0 GO:0001681 sialate O-acetylesterase activity F 1 0 GO:0015136 sialic acid transmembrane transporter activity F 1 0 GO:0008373 sialyltransferase activity F 20 9 GO:0016987 sigma factor activity F 1 0 GO:0009003 signal peptidase activity F 7 0 GO:0005047 signal recognition particle binding F 1 0 GO:0005048 signal sequence binding F 9 1 GO:0004871 signal transducer activity F 2978 253 GO:0017065 single-strand selective uracil DNA N-glycosylase activity F 1 0 GO:0003697 single-stranded DNA binding F 20 13 GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity F 1 0 GO:0043142 single-stranded DNA-dependent ATPase activity F 1 0 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity F 1 0 GO:0003727 single-stranded RNA binding F 12 8 GO:0035197 siRNA binding F 3 3 GO:0046332 SMAD binding F 7 6 GO:0016286 small conductance calcium-activated potassium channel activity F 3 0 GO:0032182 small conjugating protein binding F 3 3 GO:0019787 small conjugating protein ligase activity F 118 26 GO:0019783 small conjugating protein-specific protease activity F 62 12 GO:0031267 small GTPase binding F 51 17 GO:0005083 small GTPase regulator activity F 148 28 GO:0008641 small protein activating enzyme activity F 8 2 GO:0008639 small protein conjugating enzyme activity F 106 27 GO:0016419 S-malonyltransferase activity F 2 0 GO:0017061 S-methyl-5-thioadenosine phosphorylase activity F 1 0 GO:0008172 S-methyltransferase activity F 6 2 GO:0005484 SNAP receptor activity F 4 1 GO:0000149 SNARE binding F 16 10 GO:0030515 snoRNA binding F 2 0 GO:0030519 snoRNP binding F 4 0 GO:0017069 snRNA binding F 5 2 GO:0005272 sodium channel activity F 26 5 GO:0019871 sodium channel inhibitor activity F 1 0 GO:0017080 sodium channel regulator activity F 2 0 GO:0031402 sodium ion binding F 78 0 GO:0005283 sodium:amino acid symporter activity F 7 2 GO:0008510 sodium:bicarbonate symporter activity F 1 0 GO:0017153 sodium:dicarboxylate symporter activity F 8 1 GO:0015385 sodium:hydrogen antiporter activity F 7 3 GO:0015319 sodium:inorganic phosphate symporter activity F 1 0 GO:0008507 sodium:iodide symporter activity F 1 1 GO:0005436 sodium:phosphate symporter activity F 1 0 GO:0005391 sodium:potassium-exchanging ATPase activity F 10 1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity F 3 1 GO:0015298 solute:cation antiporter activity F 21 5 GO:0015294 solute:cation symporter activity F 52 10 GO:0015299 solute:hydrogen antiporter activity F 15 0 GO:0015295 solute:hydrogen symporter activity F 4 3 GO:0015370 solute:sodium symporter activity F 40 7 GO:0015300 solute:solute antiporter activity F 22 5 GO:0004994 somatostatin receptor activity F 5 2 GO:0003704 specific RNA polymerase II transcription factor activity F 6 5 GO:0016566 specific transcriptional repressor activity F 12 8 GO:0030507 spectrin binding F 2 0 GO:0004766 spermidine synthase activity F 1 0 GO:0016768 spermine synthase activity F 1 0 GO:0008481 sphinganine kinase activity F 2 0 GO:0008117 sphinganine-1-phosphate aldolase activity F 1 0 GO:0046625 sphingolipid binding F 1 0 GO:0004767 sphingomyelin phosphodiesterase activity F 5 2 GO:0050290 sphingomyelin phosphodiesterase D activity F 1 0 GO:0033188 sphingomyelin synthase activity F 2 1 GO:0000170 sphingosine hydroxylase activity F 1 1 GO:0050291 sphingosine N-acyltransferase activity F 2 2 GO:0042392 sphingosine-1-phosphate phosphatase activity F 1 1 GO:0004506 squalene monooxygenase activity F 1 0 GO:0016751 S-succinyltransferase activity F 1 0 GO:0004768 stearoyl-CoA 9-desaturase activity F 5 2 GO:0005020 stem cell factor receptor activity F 1 1 GO:0005173 stem cell factor receptor binding F 3 3 GO:0004507 steroid 11-beta-monooxygenase activity F 1 1 GO:0004508 steroid 17-alpha-monooxygenase activity F 1 1 GO:0004509 steroid 21-monooxygenase activity F 1 0 GO:0008387 steroid 7-alpha-hydroxylase activity F 1 1 GO:0005496 steroid binding F 47 1 GO:0016229 steroid dehydrogenase activity F 20 5 GO:0004769 steroid delta-isomerase activity F 8 0 GO:0003707 steroid hormone receptor activity F 47 3 GO:0035258 steroid hormone receptor binding F 3 2 GO:0008395 steroid hydroxylase activity F 10 9 GO:0008398 sterol 14-demethylase activity F 1 0 GO:0032934 sterol binding F 13 0 GO:0005498 sterol carrier activity F 5 0 GO:0004770 sterol carrier protein X-related thiolase activity F 1 0 GO:0004771 sterol esterase activity F 2 0 GO:0004772 sterol O-acyltransferase activity F 2 1 GO:0032810 sterol response element binding F 1 0 GO:0015248 sterol transporter activity F 7 2 GO:0047012 sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity F 1 0 GO:0004773 steryl-sulfatase activity F 1 0 GO:0015279 store-operated calcium channel activity F 2 2 GO:0016844 strictosidine synthase activity F 1 0 GO:0004248 stromelysin 1 activity F 1 0 GO:0030303 stromelysin 2 activity F 1 0 GO:0005199 structural constituent of cell wall F 1 0 GO:0005200 structural constituent of cytoskeleton F 90 6 GO:0030280 structural constituent of epidermis F 1 1 GO:0005212 structural constituent of eye lens F 25 4 GO:0008307 structural constituent of muscle F 9 2 GO:0019911 structural constituent of myelin sheath F 2 1 GO:0017056 structural constituent of nuclear pore F 2 0 GO:0003735 structural constituent of ribosome F 160 7 GO:0030345 structural constituent of tooth enamel F 2 0 GO:0008316 structural constituent of vitelline membrane F 1 0 GO:0005198 structural molecule activity F 520 35 GO:0043566 structure-specific DNA binding F 46 28 GO:0022838 substrate specific channel activity F 351 89 GO:0022891 substrate-specific transmembrane transporter activity F 712 175 GO:0022892 substrate-specific transporter activity F 906 200 GO:0004289 subtilase activity F 18 0 GO:0008177 succinate dehydrogenase (ubiquinone) activity F 2 0 GO:0000104 succinate dehydrogenase activity F 1 0 GO:0015141 succinate transmembrane transporter activity F 1 1 GO:0004776 succinate-CoA ligase (GDP-forming) activity F 2 0 GO:0004774 succinate-CoA ligase activity F 3 0 GO:0004777 succinate-semialdehyde dehydrogenase activity F 2 0 GO:0016748 succinyltransferase activity F 3 1 GO:0005529 sugar binding F 188 14 GO:0051119 sugar transmembrane transporter activity F 37 4 GO:0005351 sugar:hydrogen ion symporter activity F 36 0 GO:0004781 sulfate adenylyltransferase (ATP) activity F 2 2 GO:0004779 sulfate adenylyltransferase activity F 2 2 GO:0015116 sulfate transmembrane transporter activity F 8 2 GO:0004782 sulfinoalanine decarboxylase activity F 1 0 GO:0032542 sulfiredoxin activity F 1 0 GO:0008482 sulfite oxidase activity F 1 0 GO:0008281 sulfonylurea receptor activity F 1 0 GO:0008146 sulfotransferase activity F 44 16 GO:0000099 sulfur amino acid transmembrane transporter activity F 1 1 GO:0008484 sulfuric ester hydrolase activity F 11 1 GO:0016783 sulfurtransferase activity F 5 0 GO:0032183 SUMO binding F 1 1 GO:0019949 SUMO conjugating enzyme activity F 3 3 GO:0019789 SUMO ligase activity F 3 3 GO:0004784 superoxide dismutase activity F 8 3 GO:0016532 superoxide dismutase copper chaperone activity F 1 1 GO:0016176 superoxide-generating NADPH oxidase activator activity F 2 2 GO:0016175 superoxide-generating NADPH oxidase activity F 4 3 GO:0015293 symporter activity F 128 10 GO:0045545 syndecan binding F 1 1 GO:0019905 syntaxin binding F 12 5 GO:0017075 syntaxin-1 binding F 1 1 GO:0004995 tachykinin receptor activity F 3 0 GO:0008527 taste receptor activity F 12 0 GO:0017025 TATA-binding protein binding F 2 2 GO:0050321 tau-protein kinase activity F 2 1 GO:0005368 taurine transmembrane transporter activity F 1 1 GO:0005369 taurine:sodium symporter activity F 1 0 GO:0003720 telomerase activity F 2 2 GO:0042162 telomeric DNA binding F 3 0 GO:0003721 telomeric template RNA reverse transcriptase activity F 1 0 GO:0000332 template for synthesis of G-rich strand of telomere DNA activity F 1 1 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity F 1 0 GO:0050327 testosterone 17-beta-dehydrogenase activity F 3 1 GO:0008493 tetracycline transporter activity F 7 0 GO:0015520 tetracycline:hydrogen antiporter activity F 7 0 GO:0004326 tetrahydrofolylpolyglutamate synthase activity F 1 0 GO:0046906 tetrapyrrole binding F 124 2 GO:0004788 thiamin diphosphokinase activity F 1 1 GO:0030976 thiamin pyrophosphate binding F 2 0 GO:0015234 thiamin transmembrane transporter activity F 2 1 GO:0050333 thiamin-triphosphatase activity F 1 0 GO:0016596 thienylcyclohexylpiperidine binding F 1 0 GO:0016972 thiol oxidase activity F 3 0 GO:0030508 thiol-disulfide exchange intermediate activity F 1 1 GO:0016790 thiolester hydrolase activity F 79 16 GO:0008119 thiopurine S-methyltransferase activity F 1 0 GO:0008379 thioredoxin peroxidase activity F 1 0 GO:0004791 thioredoxin-disulfide reductase activity F 4 3 GO:0004792 thiosulfate sulfurtransferase activity F 4 0 GO:0004298 threonine endopeptidase activity F 20 0 GO:0018114 threonine racemase activity F 1 1 GO:0004795 threonine synthase activity F 2 0 GO:0004829 threonine-tRNA ligase activity F 3 0 GO:0003809 thrombin activity F 1 0 GO:0015057 thrombin receptor activity F 4 0 GO:0004960 thromboxane receptor activity F 5 1 GO:0004796 thromboxane-A synthase activity F 1 1 GO:0004797 thymidine kinase activity F 3 1 GO:0009032 thymidine phosphorylase activity F 1 0 GO:0004798 thymidylate kinase activity F 2 0 GO:0004799 thymidylate synthase activity F 1 0 GO:0004887 thyroid hormone receptor activity F 3 0 GO:0046966 thyroid hormone receptor binding F 1 1 GO:0030375 thyroid hormone receptor coactivator activity F 2 2 GO:0004996 thyroid-stimulating hormone receptor activity F 1 1 GO:0001615 thyrotropin releasing hormone and secretagogue-like receptors activity F 3 1 GO:0008437 thyrotropin-releasing hormone activity F 1 0 GO:0004997 thyrotropin-releasing hormone receptor activity F 2 0 GO:0004800 thyroxine 5'-deiodinase activity F 3 2 GO:0004293 tissue kallikrein activity F 13 2 GO:0050827 toxin receptor binding F 1 1 GO:0030911 TPR domain binding F 1 0 GO:0001594 trace-amine receptor activity F 2 1 GO:0045569 TRAIL binding F 2 1 GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity F 1 0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity F 2 0 GO:0004801 transaldolase activity F 1 0 GO:0008483 transaminase activity F 27 5 GO:0016563 transcription activator activity F 175 118 GO:0003713 transcription coactivator activity F 68 34 GO:0003712 transcription cofactor activity F 136 84 GO:0003714 transcription corepressor activity F 56 46 GO:0003711 transcription elongation regulator activity F 5 0 GO:0003700 transcription factor activity F 823 188 GO:0008134 transcription factor binding F 187 112 GO:0016986 transcription initiation factor activity F 6 0 GO:0030528 transcription regulator activity F 1137 412 GO:0016564 transcription repressor activity F 152 123 GO:0003715 transcription termination factor activity F 3 2 GO:0016740 transferase activity F 1709 362 GO:0016746 transferase activity, transferring acyl groups F 173 47 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer F 5 0 GO:0016744 transferase activity, transferring aldehyde or ketonic groups F 5 1 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups F 57 13 GO:0016755 transferase activity, transferring amino-acyl groups F 12 4 GO:0016757 transferase activity, transferring glycosyl groups F 224 47 GO:0016747 transferase activity, transferring groups other than amino-acyl groups F 166 43 GO:0016758 transferase activity, transferring hexosyl groups F 133 27 GO:0016769 transferase activity, transferring nitrogenous groups F 34 5 GO:0016741 transferase activity, transferring one-carbon groups F 158 21 GO:0016763 transferase activity, transferring pentosyl groups F 33 11 GO:0016772 transferase activity, transferring phosphorus-containing groups F 955 209 GO:0016782 transferase activity, transferring sulfur-containing groups F 51 18 GO:0004998 transferrin receptor activity F 2 0 GO:0050431 transforming growth factor beta binding F 1 1 GO:0005024 transforming growth factor beta receptor activity F 11 3 GO:0005025 transforming growth factor beta receptor activity, type I F 3 2 GO:0005026 transforming growth factor beta receptor activity, type II F 1 0 GO:0005160 transforming growth factor beta receptor binding F 7 0 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity F 1 0 GO:0000010 trans-hexaprenyltranstransferase activity F 2 2 GO:0046914 transition metal ion binding F 2241 25 GO:0046915 transition metal ion transmembrane transporter activity F 24 11 GO:0004802 transketolase activity F 4 1 GO:0008494 translation activator activity F 2 1 GO:0003746 translation elongation factor activity F 30 1 GO:0045183 translation factor activity, non-nucleic acid binding F 1 0 GO:0008135 translation factor activity, nucleic acid binding F 115 4 GO:0003743 translation initiation factor activity F 78 2 GO:0031369 translation initiation factor binding F 5 1 GO:0045182 translation regulator activity F 121 5 GO:0003747 translation release factor activity F 4 0 GO:0016149 translation release factor activity, codon specific F 2 0 GO:0030371 translation repressor activity F 5 0 GO:0000901 translation repressor activity, non-nucleic acid binding F 1 0 GO:0000900 translation repressor activity, nucleic acid binding F 1 0 GO:0008079 translation termination factor activity F 4 0 GO:0004888 transmembrane receptor activity F 2022 160 GO:0019199 transmembrane receptor protein kinase activity F 73 12 GO:0019198 transmembrane receptor protein phosphatase activity F 1 0 GO:0004675 transmembrane receptor protein serine/threonine kinase activity F 11 3 GO:0005071 transmembrane receptor protein serine/threonine kinase signaling protein activity F 1 0 GO:0004714 transmembrane receptor protein tyrosine kinase activity F 62 9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor protein activity F 2 1 GO:0005069 transmembrane receptor protein tyrosine kinase docking protein activity F 2 2 GO:0005066 transmembrane receptor protein tyrosine kinase signaling protein activity F 8 7 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity F 1 0 GO:0022857 transmembrane transporter activity F 825 190 GO:0005005 transmembrane-ephrin receptor activity F 3 0 GO:0050347 trans-octaprenyltranstransferase activity F 2 2 GO:0005215 transporter activity F 1196 218 GO:0015927 trehalase activity F 1 0 GO:0042497 triacylated lipoprotein binding F 1 0 GO:0004806 triacylglycerol lipase activity F 12 2 GO:0016802 trialkylsulfonium hydrolase activity F 3 1 GO:0015142 tricarboxylic acid transmembrane transporter activity F 2 1 GO:0017129 triglyceride binding F 1 1 GO:0050353 trimethyllysine dioxygenase activity F 1 0 GO:0004807 triose-phosphate isomerase activity F 1 1 GO:0045148 tripeptide aminopeptidase activity F 1 1 GO:0008240 tripeptidyl-peptidase activity F 2 0 GO:0019131 tripeptidyl-peptidase I activity F 1 0 GO:0004294 tripeptidyl-peptidase II activity F 1 0 GO:0030533 triplet codon-amino acid adaptor activity F 28 2 GO:0004808 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity F 1 0 GO:0016426 tRNA (adenine)-methyltransferase activity F 1 0 GO:0016429 tRNA (adenine-N1-)-methyltransferase activity F 1 0 GO:0016427 tRNA (cytosine)-methyltransferase activity F 2 0 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity F 2 0 GO:0016423 tRNA (guanine) methyltransferase activity F 4 0 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity F 1 0 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity F 2 0 GO:0008176 tRNA (guanine-N7-)-methyltransferase activity F 1 0 GO:0004810 tRNA adenylyltransferase activity F 1 0 GO:0000049 tRNA binding F 12 4 GO:0004811 tRNA isopentenyltransferase activity F 1 0 GO:0008175 tRNA methyltransferase activity F 8 0 GO:0009022 tRNA nucleotidyltransferase activity F 1 0 GO:0000213 tRNA-intron endonuclease activity F 2 0 GO:0016439 tRNA-pseudouridine synthase activity F 14 2 GO:0008251 tRNA-specific adenosine deaminase activity F 1 0 GO:0004549 tRNA-specific ribonuclease activity F 12 1 GO:0005523 tropomyosin binding F 6 0 GO:0004295 trypsin activity F 44 1 GO:0030304 trypsin inhibitor activity F 3 1 GO:0030019 tryptase activity F 2 1 GO:0004833 tryptophan 2,3-dioxygenase activity F 2 1 GO:0004510 tryptophan 5-monooxygenase activity F 2 1 GO:0004830 tryptophan-tRNA ligase activity F 2 0 GO:0015631 tubulin binding F 55 31 GO:0004835 tubulin-tyrosine ligase activity F 6 1 GO:0043120 tumor necrosis factor binding F 4 2 GO:0005031 tumor necrosis factor receptor activity F 4 2 GO:0005164 tumor necrosis factor receptor binding F 18 4 GO:0032813 tumor necrosis factor receptor superfamily binding F 18 4 GO:0000156 two-component response regulator activity F 1 0 GO:0000155 two-component sensor activity F 5 0 GO:0031702 type 1 angiotensin receptor binding F 1 1 GO:0004865 type 1 serine/threonine specific protein phosphatase inhibitor activity F 4 2 GO:0031703 type 2 angiotensin receptor binding F 1 1 GO:0004511 tyrosine 3-monooxygenase activity F 1 0 GO:0004838 tyrosine transaminase activity F 1 0 GO:0017067 tyrosine-ester sulfotransferase activity F 2 0 GO:0004831 tyrosine-tRNA ligase activity F 2 0 GO:0030629 U6 snRNA 3'-end binding F 1 0 GO:0017070 U6 snRNA binding F 2 0 GO:0008121 ubiquinol-cytochrome-c reductase activity F 11 0 GO:0004839 ubiquitin activating enzyme activity F 5 1 GO:0043130 ubiquitin binding F 2 2 GO:0031625 ubiquitin protein ligase binding F 1 1 GO:0004221 ubiquitin thiolesterase activity F 56 2 GO:0004842 ubiquitin-protein ligase activity F 103 23 GO:0004843 ubiquitin-specific protease activity F 61 11 GO:0045029 UDP-activated nucleotide receptor activity F 1 1 GO:0005459 UDP-galactose transmembrane transporter activity F 1 1 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity F 6 5 GO:0035250 UDP-galactosyltransferase activity F 18 8 GO:0003978 UDP-glucose 4-epimerase activity F 1 1 GO:0003979 UDP-glucose 6-dehydrogenase activity F 1 0 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity F 1 0 GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity F 1 1 GO:0035251 UDP-glucosyltransferase activity F 6 1 GO:0050379 UDP-glucuronate 5'-epimerase activity F 1 0 GO:0048040 UDP-glucuronate decarboxylase activity F 1 0 GO:0008194 UDP-glycosyltransferase activity F 85 21 GO:0008761 UDP-N-acetylglucosamine 2-epimerase activity F 1 0 GO:0003977 UDP-N-acetylglucosamine diphosphorylase activity F 1 0 GO:0003975 UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity F 1 1 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity F 1 0 GO:0008768 UDP-sugar diphosphatase activity F 1 0 GO:0051748 UDP-sugar pyrophosphorylase activity F 1 0 GO:0035252 UDP-xylosyltransferase activity F 2 0 GO:0051082 unfolded protein binding F 58 5 GO:0015292 uniporter activity F 1 0 GO:0050381 unspecific monooxygenase activity F 32 0 GO:0030377 U-plasminogen activator receptor activity F 1 0 GO:0004844 uracil DNA N-glycosylase activity F 2 1 GO:0004846 urate oxidase activity F 1 0 GO:0015143 urate transmembrane transporter activity F 1 1 GO:0015204 urea transmembrane transporter activity F 2 2 GO:0004849 uridine kinase activity F 5 0 GO:0045437 uridine nucleosidase activity F 1 0 GO:0015065 uridine nucleotide receptor activity F 2 2 GO:0004850 uridine phosphorylase activity F 2 1 GO:0045134 uridine-diphosphatase activity F 1 0 GO:0016153 urocanate hydratase activity F 1 0 GO:0004853 uroporphyrinogen decarboxylase activity F 1 1 GO:0004852 uroporphyrinogen-III synthase activity F 1 1 GO:0001604 urotensin II receptor activity F 1 0 GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity F 1 0 GO:0045030 UTP-activated nucleotide receptor activity F 1 1 GO:0004832 valine-tRNA ligase activity F 2 0 GO:0043185 vascular endothelial growth factor receptor 3 binding F 2 2 GO:0005021 vascular endothelial growth factor receptor activity F 10 3 GO:0005172 vascular endothelial growth factor receptor binding F 5 2 GO:0004999 vasoactive intestinal polypeptide receptor activity F 4 0 GO:0005000 vasopressin receptor activity F 5 0 GO:0001603 vasopressin-like receptor activity F 5 0 GO:0031957 very-long-chain-fatty-acid-CoA ligase activity F 1 0 GO:0030229 very-low-density lipoprotein receptor activity F 1 1 GO:0017166 vinculin binding F 1 1 GO:0001618 viral receptor activity F 1 1 GO:0019842 vitamin binding F 102 2 GO:0005499 vitamin D binding F 4 0 GO:0042809 vitamin D receptor binding F 1 0 GO:0030343 vitamin D3 25-hydroxylase activity F 1 1 GO:0008431 vitamin E binding F 1 0 GO:0051183 vitamin transporter activity F 7 2 GO:0047057 vitamin-K-epoxide reductase (warfarin-sensitive) activity F 1 1 GO:0022844 voltage-gated anion channel activity F 15 0 GO:0005245 voltage-gated calcium channel activity F 22 14 GO:0022843 voltage-gated cation channel activity F 116 21 GO:0022832 voltage-gated channel activity F 166 21 GO:0005247 voltage-gated chloride channel activity F 15 0 GO:0005244 voltage-gated ion channel activity F 166 21 GO:0008308 voltage-gated ion-selective channel activity F 5 0 GO:0005249 voltage-gated potassium channel activity F 82 5 GO:0030171 voltage-gated proton channel activity F 1 1 GO:0005248 voltage-gated sodium channel activity F 11 1 GO:0015250 water channel activity F 10 2 GO:0005372 water transporter activity F 11 3 GO:0022829 wide pore channel activity F 18 3 GO:0017114 wide-spectrum protease inhibitor activity F 5 0 GO:0042813 Wnt receptor activity F 4 2 GO:0017147 Wnt-protein binding F 4 3 GO:0050699 WW domain binding F 2 1 GO:0004854 xanthine dehydrogenase activity F 1 1 GO:0004855 xanthine oxidase activity F 1 0 GO:0042910 xenobiotic transporter activity F 3 0 GO:0008559 xenobiotic-transporting ATPase activity F 3 0 GO:0015051 X-opioid receptor activity F 1 0 GO:0008451 X-Pro aminopeptidase activity F 3 0 GO:0004251 X-Pro dipeptidase activity F 1 1 GO:0009045 xylose isomerase activity F 1 0 GO:0046525 xylosylprotein 4-beta-galactosyltransferase activity F 1 0 GO:0042285 xylosyltransferase activity F 2 0 GO:0004856 xylulokinase activity F 1 0 GO:0051370 ZASP binding F 1 1 GO:0008270 zinc ion binding F 1799 11 GO:0005385 zinc ion transmembrane transporter activity F 10 7 GO:0042156 zinc-mediated transcriptional activator activity F 1 1 GO:0001872 zymosan binding F 3 3 GO:0001874 zymosan receptor activity F 1 1 GO:0009257 10-formyltetrahydrofolate biosynthetic process P 1 0 GO:0009258 10-formyltetrahydrofolate catabolic process P 1 0 GO:0009256 10-formyltetrahydrofolate metabolic process P 2 0 GO:0050428 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process P 1 1 GO:0019471 4-hydroxyproline metabolic process P 3 2 GO:0046118 7-methylguanosine biosynthetic process P 1 0 GO:0008618 7-methylguanosine metabolic process P 1 0 GO:0006083 acetate metabolic process P 1 0 GO:0043438 acetoacetic acid metabolic process P 1 1 GO:0008292 acetylcholine biosynthetic process P 1 1 GO:0006581 acetylcholine catabolic process P 1 1 GO:0008291 acetylcholine metabolic process P 2 2 GO:0007213 acetylcholine receptor signaling, muscarinic pathway P 4 2 GO:0014055 acetylcholine secretion P 2 2 GO:0006085 acetyl-CoA biosynthetic process P 6 2 GO:0006086 acetyl-CoA biosynthetic process from pyruvate P 3 0 GO:0046356 acetyl-CoA catabolic process P 24 1 GO:0006084 acetyl-CoA metabolic process P 33 4 GO:0000705 achiasmate meiosis I P 1 1 GO:0046717 acid secretion P 2 2 GO:0015800 acidic amino acid transport P 5 5 GO:0001675 acrosome formation P 3 3 GO:0007340 acrosome reaction P 7 6 GO:0000147 actin cortical patch assembly P 1 0 GO:0030036 actin cytoskeleton organization and biogenesis P 154 79 GO:0031532 actin cytoskeleton reorganization P 3 3 GO:0051017 actin filament bundle formation P 13 12 GO:0051693 actin filament capping P 19 0 GO:0030042 actin filament depolymerization P 21 2 GO:0051639 actin filament network formation P 1 0 GO:0007015 actin filament organization P 40 30 GO:0030041 actin filament polymerization P 17 10 GO:0051014 actin filament severing P 2 0 GO:0030048 actin filament-based movement P 15 6 GO:0030029 actin filament-based process P 165 83 GO:0045010 actin nucleation P 3 1 GO:0008154 actin polymerization and/or depolymerization P 40 14 GO:0033275 actin-myosin filament sliding P 3 0 GO:0019227 action potential propagation P 3 3 GO:0006924 activated T cell apoptosis P 3 2 GO:0050798 activated T cell proliferation P 13 10 GO:0007228 activation of hh target transcription factor P 1 1 GO:0002253 activation of immune response P 77 42 GO:0002218 activation of innate immune response P 8 8 GO:0007257 activation of JNK activity P 10 7 GO:0007256 activation of JNKK activity P 3 3 GO:0000187 activation of MAPK activity P 36 31 GO:0000186 activation of MAPKK activity P 11 11 GO:0000185 activation of MAPKKK activity P 1 1 GO:0001905 activation of membrane attack complex P 1 1 GO:0051092 activation of NF-kappaB transcription factor P 14 8 GO:0007250 activation of NF-kappaB-inducing kinase P 5 1 GO:0002541 activation of plasma proteins during acute inflammatory response P 41 9 GO:0008633 activation of pro-apoptotic gene products P 1 1 GO:0032147 activation of protein kinase activity P 30 16 GO:0032148 activation of protein kinase B P 1 1 GO:0031032 actomyosin structure organization and biogenesis P 19 13 GO:0002526 acute inflammatory response P 77 21 GO:0002438 acute inflammatory response to antigenic stimulus P 12 12 GO:0006953 acute-phase response P 27 2 GO:0006844 acyl carnitine transport P 1 1 GO:0006637 acyl-CoA metabolic process P 13 4 GO:0046463 acylglycerol biosynthetic process P 7 5 GO:0046464 acylglycerol catabolic process P 2 2 GO:0006639 acylglycerol metabolic process P 22 17 GO:0022401 adaptation of signaling pathway P 2 2 GO:0002250 adaptive immune response P 86 59 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains P 86 59 GO:0046083 adenine metabolic process P 2 2 GO:0006168 adenine salvage P 2 2 GO:0021984 adenohypophysis development P 6 6 GO:0001973 adenosine receptor signaling pathway P 2 2 GO:0007190 adenylate cyclase activation P 12 3 GO:0046032 ADP catabolic process P 1 1 GO:0046031 ADP metabolic process P 1 1 GO:0030325 adrenal gland development P 9 9 GO:0030534 adult behavior P 59 59 GO:0008343 adult feeding behavior P 3 3 GO:0007512 adult heart development P 9 9 GO:0008344 adult locomotory behavior P 42 42 GO:0007527 adult somatic muscle development P 2 1 GO:0007628 adult walking behavior P 22 22 GO:0009060 aerobic respiration P 25 1 GO:0007571 age-dependent general metabolic decline P 1 1 GO:0001306 age-dependent response to oxidative stress P 1 1 GO:0007568 aging P 28 25 GO:0032328 alanine transport P 3 3 GO:0006419 alanyl-tRNA aminoacylation P 3 0 GO:0046165 alcohol biosynthetic process P 25 10 GO:0046164 alcohol catabolic process P 53 2 GO:0006066 alcohol metabolic process P 247 85 GO:0046185 aldehyde catabolic process P 1 1 GO:0006081 aldehyde metabolic process P 11 3 GO:0019400 alditol metabolic process P 1 1 GO:0032342 aldosterone biosynthetic process P 1 1 GO:0002017 aldosterone mediated regulation of body fluids P 1 1 GO:0032341 aldosterone metabolic process P 2 2 GO:0043450 alkene biosynthetic process P 16 4 GO:0043449 alkene metabolic process P 18 7 GO:0000255 allantoin metabolic process P 1 0 GO:0046631 alpha-beta T cell activation P 30 29 GO:0046632 alpha-beta T cell differentiation P 20 19 GO:0002293 alpha-beta T cell differentiation during immune response P 8 7 GO:0046633 alpha-beta T cell proliferation P 12 12 GO:0007024 alpha-tubulin folding P 1 0 GO:0048286 alveolus development P 11 11 GO:0001667 ameboidal cell migration P 4 4 GO:0043603 amide metabolic process P 7 0 GO:0042886 amide transport P 2 1 GO:0015898 amiloride transport P 1 0 GO:0009309 amine biosynthetic process P 59 15 GO:0009310 amine catabolic process P 55 19 GO:0009308 amine metabolic process P 328 126 GO:0015837 amine transport P 52 29 GO:0043038 amino acid activation P 52 0 GO:0006519 amino acid and derivative metabolic process P 283 110 GO:0008652 amino acid biosynthetic process P 35 4 GO:0009063 amino acid catabolic process P 45 10 GO:0042398 amino acid derivative biosynthetic process P 28 13 GO:0042219 amino acid derivative catabolic process P 16 13 GO:0006575 amino acid derivative metabolic process P 85 47 GO:0043090 amino acid import P 1 1 GO:0006520 amino acid metabolic process P 217 70 GO:0006865 amino acid transport P 44 24 GO:0051933 amino acid uptake during transmission of nerve impulse P 1 1 GO:0046349 amino sugar biosynthetic process P 2 0 GO:0046348 amino sugar catabolic process P 8 0 GO:0006040 amino sugar metabolic process P 23 7 GO:0006023 aminoglycan biosynthetic process P 7 4 GO:0006026 aminoglycan catabolic process P 1 1 GO:0006022 aminoglycan metabolic process P 19 10 GO:0015696 ammonium transport P 2 0 GO:0042983 amyloid precursor protein biosynthetic process P 2 2 GO:0042987 amyloid precursor protein catabolic process P 2 2 GO:0042982 amyloid precursor protein metabolic process P 4 4 GO:0019642 anaerobic glycolysis P 3 0 GO:0042640 anagen P 10 10 GO:0048856 anatomical structure development P 1852 1467 GO:0048646 anatomical structure formation P 181 136 GO:0009653 anatomical structure morphogenesis P 1072 810 GO:0060033 anatomical structure regression P 3 3 GO:0006702 androgen biosynthetic process P 2 2 GO:0008209 androgen metabolic process P 4 4 GO:0030521 androgen receptor signaling pathway P 2 2 GO:0001525 angiogenesis P 134 89 GO:0060055 angiogenesis involved in wound healing P 1 1 GO:0002003 angiotensin maturation P 1 1 GO:0002019 angiotensin mediated regulation of renal output P 2 2 GO:0001998 angiotensin mediated vasoconstriction during regulation of blood pressure P 2 2 GO:0002033 angiotensin mediated vasodilation during regulation of blood pressure P 2 2 GO:0055081 anion homeostasis P 7 3 GO:0006820 anion transport P 165 19 GO:0021960 anterior commissure morphogenesis P 1 1 GO:0007387 anterior compartment specification P 1 0 GO:0021506 anterior neuropore closure P 1 1 GO:0009948 anterior/posterior axis specification P 11 11 GO:0009952 anterior/posterior pattern formation P 93 92 GO:0008089 anterograde axon cargo transport P 2 2 GO:0006916 anti-apoptosis P 78 58 GO:0019731 antibacterial humoral response P 3 3 GO:0017000 antibiotic biosynthetic process P 3 0 GO:0017001 antibiotic catabolic process P 1 0 GO:0016999 antibiotic metabolic process P 4 0 GO:0042891 antibiotic transport P 1 1 GO:0001788 antibody-dependent cellular cytotoxicity P 4 4 GO:0019882 antigen processing and presentation P 57 29 GO:0019883 antigen processing and presentation of endogenous antigen P 4 0 GO:0002483 antigen processing and presentation of endogenous peptide antigen P 4 0 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I P 4 0 GO:0019884 antigen processing and presentation of exogenous antigen P 23 22 GO:0002478 antigen processing and presentation of exogenous peptide antigen P 18 17 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I P 3 3 GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II P 16 15 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib P 3 3 GO:0048002 antigen processing and presentation of peptide antigen P 34 18 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I P 19 3 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II P 16 15 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II P 19 15 GO:0002475 antigen processing and presentation via MHC class Ib P 3 3 GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib P 3 3 GO:0050851 antigen receptor-mediated signaling pathway P 27 24 GO:0019730 antimicrobial humoral response P 4 4 GO:0001547 antral ovarian follicle growth P 2 2 GO:0043297 apical junction assembly P 3 3 GO:0045176 apical protein localization P 7 6 GO:0043288 apocarotenoid metabolic process P 5 4 GO:0006915 apoptosis P 582 309 GO:0060057 apoptosis involved in mammary gland involution P 1 1 GO:0008637 apoptotic mitochondrial changes P 18 15 GO:0030262 apoptotic nuclear changes P 8 6 GO:0008632 apoptotic program P 44 30 GO:0048736 appendage development P 75 74 GO:0035107 appendage morphogenesis P 74 73 GO:0050482 arachidonic acid secretion P 1 1 GO:0032011 ARF protein signal transduction P 11 0 GO:0006526 arginine biosynthetic process P 5 0 GO:0042450 arginine biosynthetic process via ornithine P 1 0 GO:0006527 arginine catabolic process P 5 1 GO:0006525 arginine metabolic process P 9 1 GO:0015809 arginine transport P 1 1 GO:0006420 arginyl-tRNA aminoacylation P 2 0 GO:0035140 arm morphogenesis P 2 2 GO:0009073 aromatic amino acid family biosynthetic process P 1 0 GO:0009074 aromatic amino acid family catabolic process P 10 2 GO:0009072 aromatic amino acid family metabolic process P 26 6 GO:0019438 aromatic compound biosynthetic process P 12 0 GO:0019439 aromatic compound catabolic process P 13 3 GO:0006725 aromatic compound metabolic process P 112 34 GO:0048844 artery morphogenesis P 5 5 GO:0006529 asparagine biosynthetic process P 2 0 GO:0006528 asparagine metabolic process P 2 0 GO:0006421 asparaginyl-tRNA aminoacylation P 2 0 GO:0006533 aspartate catabolic process P 1 0 GO:0009067 aspartate family amino acid biosynthetic process P 11 3 GO:0009068 aspartate family amino acid catabolic process P 1 0 GO:0009066 aspartate family amino acid metabolic process P 13 4 GO:0006531 aspartate metabolic process P 2 1 GO:0015810 aspartate transport P 1 1 GO:0006422 aspartyl-tRNA aminoacylation P 5 0 GO:0000244 assembly of spliceosomal tri-snRNP P 3 0 GO:0000351 assembly of spliceosomal tri-snRNP U4/U6.U5 P 2 0 GO:0008306 associative learning P 14 14 GO:0030954 astral microtubule nucleation P 1 0 GO:0030953 astral microtubule organization and biogenesis P 1 0 GO:0048143 astrocyte activation P 1 1 GO:0014002 astrocyte development P 3 3 GO:0048708 astrocyte differentiation P 7 7 GO:0060018 astrocyte fate commitment P 1 1 GO:0008356 asymmetric cell division P 2 2 GO:0008105 asymmetric protein localization P 9 8 GO:0006754 ATP biosynthetic process P 39 0 GO:0006200 ATP catabolic process P 2 2 GO:0015991 ATP hydrolysis coupled proton transport P 7 3 GO:0046034 ATP metabolic process P 43 2 GO:0042773 ATP synthesis coupled electron transport P 17 0 GO:0015986 ATP synthesis coupled proton transport P 34 0 GO:0043044 ATP-dependent chromatin remodeling P 1 1 GO:0006510 ATP-dependent proteolysis P 4 0 GO:0055009 atrial cardiac muscle morphogenesis P 1 1 GO:0016255 attachment of GPI anchor to protein P 1 0 GO:0008608 attachment of spindle microtubules to kinetochore P 2 0 GO:0031223 auditory behavior P 1 1 GO:0060117 auditory receptor cell development P 8 8 GO:0042491 auditory receptor cell differentiation P 23 23 GO:0009912 auditory receptor cell fate commitment P 5 4 GO:0042668 auditory receptor cell fate determination P 3 3 GO:0042667 auditory receptor cell fate specification P 1 1 GO:0002093 auditory receptor cell morphogenesis P 7 7 GO:0060088 auditory receptor cell stereocilium organization and biogenesis P 7 7 GO:0048483 autonomic nervous system development P 7 7 GO:0000045 autophagic vacuole formation P 9 1 GO:0000046 autophagic vacuole fusion P 1 1 GO:0006914 autophagy P 22 5 GO:0048318 axial mesoderm development P 4 4 GO:0048319 axial mesoderm morphogenesis P 1 1 GO:0009798 axis specification P 16 16 GO:0008088 axon cargo transport P 10 10 GO:0016198 axon choice point recognition P 4 4 GO:0008366 axon ensheathment P 27 24 GO:0048675 axon extension P 21 19 GO:0048846 axon extension involved in axon guidance P 3 3 GO:0048676 axon extension involved in development P 3 3 GO:0048677 axon extension involved in regeneration P 2 2 GO:0007411 axon guidance P 79 74 GO:0016199 axon midline choice point recognition P 2 2 GO:0031103 axon regeneration P 5 3 GO:0014012 axon regeneration in the peripheral nervous system P 1 1 GO:0007412 axon target recognition P 3 3 GO:0019896 axon transport of mitochondrion P 1 1 GO:0007413 axonal fasciculation P 7 6 GO:0035082 axoneme biogenesis P 5 5 GO:0007409 axonogenesis P 150 138 GO:0042113 B cell activation P 83 68 GO:0002312 B cell activation during immune response P 1 1 GO:0001783 B cell apoptosis P 1 1 GO:0031296 B cell costimulation P 2 2 GO:0030183 B cell differentiation P 34 31 GO:0001782 B cell homeostasis P 10 10 GO:0002358 B cell homeostatic proliferation P 1 1 GO:0019724 B cell mediated immunity P 69 45 GO:0042100 B cell proliferation P 26 24 GO:0050853 B cell receptor signaling pathway P 7 6 GO:0002514 B cell tolerance induction P 1 1 GO:0001923 B-1 B cell differentiation P 1 1 GO:0001922 B-1 B cell homeostasis P 1 1 GO:0051016 barbed-end actin filament capping P 18 0 GO:0001978 baroreceptor feedback regulation of blood pressure P 5 5 GO:0001983 baroreceptor response to increased blood pressure P 3 3 GO:0001982 baroreceptor response to lowering of blood pressure P 2 2 GO:0000917 barrier septum formation P 1 0 GO:0045175 basal protein localization P 1 1 GO:0016553 base conversion or substitution editing P 3 1 GO:0006284 base-excision repair P 17 7 GO:0006287 base-excision repair, gap-filling P 4 3 GO:0015802 basic amino acid transport P 3 3 GO:0007610 behavior P 305 238 GO:0002209 behavioral defense response P 9 8 GO:0001662 behavioral fear response P 9 8 GO:0051705 behavioral interaction between organisms P 22 22 GO:0048148 behavioral response to cocaine P 6 6 GO:0048149 behavioral response to ethanol P 3 3 GO:0035095 behavioral response to nicotine P 5 5 GO:0048266 behavioral response to pain P 3 3 GO:0042537 benzene and derivative metabolic process P 1 1 GO:0060020 Bergmann glial cell differentiation P 1 1 GO:0043366 beta selection P 2 2 GO:0001762 beta-alanine transport P 1 1 GO:0050435 beta-amyloid metabolic process P 5 5 GO:0015759 beta-glucoside transport P 1 0 GO:0006578 betaine biosynthetic process P 1 0 GO:0006577 betaine metabolic process P 1 0 GO:0030655 beta-lactam antibiotic catabolic process P 1 0 GO:0030653 beta-lactam antibiotic metabolic process P 1 0 GO:0015701 bicarbonate transport P 4 3 GO:0015721 bile acid and bile salt transport P 2 1 GO:0006699 bile acid biosynthetic process P 4 3 GO:0030573 bile acid catabolic process P 2 0 GO:0008206 bile acid metabolic process P 11 9 GO:0007339 binding of sperm to zona pellucida P 17 12 GO:0042401 biogenic amine biosynthetic process P 24 11 GO:0042402 biogenic amine catabolic process P 14 11 GO:0006576 biogenic amine metabolic process P 70 39 GO:0022610 biological adhesion P 583 174 GO:0065007 biological regulation P 3767 1730 GO:0008150 biological_process P 14348 3982 GO:0031214 biomineral formation P 92 64 GO:0043284 biopolymer biosynthetic process P 66 12 GO:0043285 biopolymer catabolic process P 230 71 GO:0043413 biopolymer glycosylation P 79 16 GO:0043283 biopolymer metabolic process P 4002 962 GO:0043414 biopolymer methylation P 46 24 GO:0043412 biopolymer modification P 1441 318 GO:0009058 biosynthetic process P 1141 286 GO:0006768 biotin metabolic process P 1 0 GO:0001824 blastocyst development P 30 28 GO:0001825 blastocyst formation P 5 5 GO:0001832 blastocyst growth P 13 11 GO:0001835 blastocyst hatching P 4 4 GO:0007350 blastoderm segmentation P 6 6 GO:0007596 blood coagulation P 52 14 GO:0008217 blood pressure regulation P 39 39 GO:0001568 blood vessel development P 201 161 GO:0043534 blood vessel endothelial cell migration P 3 3 GO:0001955 blood vessel maturation P 3 3 GO:0048514 blood vessel morphogenesis P 172 131 GO:0001974 blood vessel remodeling P 15 15 GO:0030509 BMP signaling pathway P 27 26 GO:0010171 body morphogenesis P 3 3 GO:0030282 bone mineralization P 23 16 GO:0046849 bone remodeling P 101 71 GO:0045453 bone resorption P 15 14 GO:0007420 brain development P 177 173 GO:0048854 brain morphogenesis P 4 4 GO:0002035 brain renin-angiotensin system P 3 3 GO:0009082 branched chain family amino acid biosynthetic process P 2 0 GO:0009083 branched chain family amino acid catabolic process P 5 2 GO:0009081 branched chain family amino acid metabolic process P 6 2 GO:0048755 branching morphogenesis of a nerve P 2 2 GO:0048754 branching morphogenesis of a tube P 58 58 GO:0050873 brown fat cell differentiation P 5 5 GO:0043437 butanoic acid metabolic process P 1 1 GO:0046359 butyrate catabolic process P 1 1 GO:0019605 butyrate metabolic process P 2 1 GO:0006700 C21-steroid hormone biosynthetic process P 14 1 GO:0008208 C21-steroid hormone catabolic process P 1 1 GO:0008207 C21-steroid hormone metabolic process P 17 4 GO:0055074 calcium ion homeostasis P 60 45 GO:0006816 calcium ion transport P 103 42 GO:0017156 calcium ion-dependent exocytosis P 17 14 GO:0048791 calcium ion-dependent exocytosis of neurotransmitter P 1 1 GO:0016339 calcium-dependent cell-cell adhesion P 10 4 GO:0016340 calcium-dependent cell-matrix adhesion P 1 1 GO:0016338 calcium-independent cell-cell adhesion P 6 4 GO:0019722 calcium-mediated signaling P 18 14 GO:0043010 camera-type eye development P 73 72 GO:0048593 camera-type eye morphogenesis P 18 17 GO:0006171 cAMP biosynthetic process P 17 4 GO:0006198 cAMP catabolic process P 1 1 GO:0046058 cAMP metabolic process P 20 7 GO:0019933 cAMP-mediated signaling P 60 42 GO:0015722 canalicular bile acid transport P 1 0 GO:0016051 carbohydrate biosynthetic process P 73 33 GO:0016052 carbohydrate catabolic process P 70 7 GO:0033500 carbohydrate homeostasis P 26 24 GO:0005975 carbohydrate metabolic process P 340 80 GO:0046835 carbohydrate phosphorylation P 6 4 GO:0008643 carbohydrate transport P 61 23 GO:0015670 carbon dioxide transport P 1 1 GO:0015976 carbon utilization P 1 0 GO:0046394 carboxylic acid biosynthetic process P 70 19 GO:0046395 carboxylic acid catabolic process P 6 3 GO:0019752 carboxylic acid metabolic process P 445 149 GO:0046942 carboxylic acid transport P 59 30 GO:0035051 cardiac cell differentiation P 14 13 GO:0002027 cardiac chronotropy P 6 6 GO:0002026 cardiac inotropy P 10 10 GO:0055013 cardiac muscle cell development P 6 6 GO:0055007 cardiac muscle cell differentiation P 9 9 GO:0060038 cardiac muscle cell proliferation P 7 7 GO:0060048 cardiac muscle contraction P 5 5 GO:0048738 cardiac muscle development P 8 8 GO:0048739 cardiac muscle fiber development P 2 2 GO:0055008 cardiac muscle morphogensis P 6 6 GO:0055003 cardiac myofibril assembly P 4 4 GO:0042684 cardioblast cell fate commitment P 1 1 GO:0042685 cardioblast cell fate specification P 1 1 GO:0010002 cardioblast differentiation P 3 3 GO:0045329 carnitine biosynthetic process P 2 1 GO:0009437 carnitine metabolic process P 3 2 GO:0016119 carotene metabolic process P 1 1 GO:0016117 carotenoid biosynthetic process P 3 0 GO:0016116 carotenoid metabolic process P 4 1 GO:0001502 cartilage condensation P 10 10 GO:0051216 cartilage development P 43 30 GO:0006919 caspase activation P 20 12 GO:0008635 caspase activation via cytochrome c P 3 3 GO:0009056 catabolic process P 523 130 GO:0042637 catagen P 2 2 GO:0042423 catecholamine biosynthetic process P 10 7 GO:0042424 catecholamine catabolic process P 4 4 GO:0006584 catecholamine metabolic process P 28 19 GO:0050432 catecholamine secretion P 7 7 GO:0051937 catecholamine transport P 3 3 GO:0051934 catecholamine uptake during transmission of nerve impulse P 3 3 GO:0055080 cation homeostasis P 105 64 GO:0006812 cation transport P 460 95 GO:0043367 CD4-positive, alpha beta T cell differentiation P 11 10 GO:0002294 CD4-positive, alpha-beta T cell differentiation during immune response P 8 7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation P 2 2 GO:0043374 CD8-positive, alpha-beta T cell differentiation P 1 1 GO:0032488 Cdc42 protein signal transduction P 1 1 GO:0016024 CDP-diacylglycerol biosynthetic process P 1 0 GO:0046341 CDP-diacylglycerol metabolic process P 1 0 GO:0001775 cell activation P 218 186 GO:0002263 cell activation during immune response P 9 8 GO:0007155 cell adhesion P 583 174 GO:0033627 cell adhesion mediated by integrin P 1 1 GO:0007569 cell aging P 13 11 GO:0007154 cell communication P 3720 844 GO:0007049 cell cycle P 687 185 GO:0007050 cell cycle arrest P 41 20 GO:0000075 cell cycle checkpoint P 26 20 GO:0022403 cell cycle phase P 269 92 GO:0022402 cell cycle process P 546 172 GO:0008219 cell death P 615 325 GO:0048468 cell development P 1079 766 GO:0030154 cell differentiation P 1636 1057 GO:0021533 cell differentiation in hindbrain P 7 7 GO:0021515 cell differentiation in spinal cord P 7 7 GO:0051301 cell division P 231 24 GO:0045165 cell fate commitment P 100 96 GO:0001709 cell fate determination P 24 21 GO:0001708 cell fate specification P 23 22 GO:0001678 cell glucose homeostasis P 4 3 GO:0016049 cell growth P 95 14 GO:0001906 cell killing P 22 22 GO:0048469 cell maturation P 73 62 GO:0016477 cell migration P 271 246 GO:0021535 cell migration in hindbrain P 2 2 GO:0042074 cell migration involved in gastrulation P 8 8 GO:0000902 cell morphogenesis P 452 296 GO:0006928 cell motility P 322 283 GO:0032990 cell part morphogenesis P 257 222 GO:0030031 cell projection biogenesis P 47 41 GO:0048858 cell projection morphogenesis P 257 222 GO:0030030 cell projection organization and biogenesis P 257 222 GO:0008283 cell proliferation P 451 378 GO:0021534 cell proliferation in hindbrain P 8 8 GO:0021924 cell proliferation in the external granule layer P 8 8 GO:0021846 cell proliferation in the forebrain P 1 1 GO:0008037 cell recognition P 43 37 GO:0045454 cell redox homeostasis P 42 1 GO:0006921 cell structure disassembly during apoptosis P 8 6 GO:0002752 cell surface pattern recognition receptor signaling pathway P 2 2 GO:0007166 cell surface receptor linked signal transduction P 2456 428 GO:0016998 cell wall catabolic process P 15 0 GO:0010382 cell wall metabolic process P 15 0 GO:0007047 cell wall organization and biogenesis P 15 0 GO:0016337 cell-cell adhesion P 204 103 GO:0021813 cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration P 1 1 GO:0033631 cell-cell adhesion mediated by integrin P 1 1 GO:0009988 cell-cell recognition P 19 14 GO:0007267 cell-cell signaling P 316 217 GO:0045168 cell-cell signaling during cell fate commitment P 14 14 GO:0007160 cell-matrix adhesion P 62 34 GO:0031589 cell-substrate adhesion P 66 38 GO:0007044 cell-substrate junction assembly P 5 5 GO:0030002 cellular anion homeostasis P 7 3 GO:0044249 cellular biosynthetic process P 846 208 GO:0006874 cellular calcium ion homeostasis P 59 44 GO:0044275 cellular carbohydrate catabolic process P 64 7 GO:0044262 cellular carbohydrate metabolic process P 237 73 GO:0044248 cellular catabolic process P 403 109 GO:0030003 cellular cation homeostasis P 103 63 GO:0055082 cellular chemical homeostasis P 106 65 GO:0030644 cellular chloride ion homeostasis P 3 1 GO:0022607 cellular component assembly P 371 111 GO:0022411 cellular component disassembly P 22 7 GO:0016043 cellular component organization and biogenesis P 2307 927 GO:0006878 cellular copper ion homeostasis P 8 6 GO:0006968 cellular defense response P 176 6 GO:0048869 cellular developmental process P 1636 1057 GO:0030319 cellular di-, tri-valent inorganic anion homeostasis P 3 2 GO:0030005 cellular di-, tri-valent inorganic cation homeostasis P 94 60 GO:0045123 cellular extravasation P 6 6 GO:0019725 cellular homeostasis P 204 116 GO:0030641 cellular hydrogen ion homeostasis P 3 0 GO:0006873 cellular ion homeostasis P 106 65 GO:0006879 cellular iron ion homeostasis P 23 7 GO:0044242 cellular lipid catabolic process P 27 15 GO:0044255 cellular lipid metabolic process P 495 178 GO:0051641 cellular localization P 737 241 GO:0044265 cellular macromolecule catabolic process P 223 48 GO:0044260 cellular macromolecule metabolic process P 2623 554 GO:0044237 cellular metabolic process P 6097 1567 GO:0006875 cellular metal ion homeostasis P 66 48 GO:0030320 cellular monovalent inorganic anion homeostasis P 4 1 GO:0030004 cellular monovalent inorganic cation homeostasis P 7 1 GO:0000904 cellular morphogenesis during differentiation P 181 167 GO:0051452 cellular pH reduction P 2 0 GO:0030643 cellular phosphate ion homeostasis P 3 2 GO:0043482 cellular pigment accumulation P 1 0 GO:0033059 cellular pigmentation P 8 8 GO:0044247 cellular polysaccharide catabolic process P 12 4 GO:0044264 cellular polysaccharide metabolic process P 45 15 GO:0030007 cellular potassium ion homeostasis P 1 0 GO:0009987 cellular process P 10967 3191 GO:0044257 cellular protein catabolic process P 127 33 GO:0043623 cellular protein complex assembly P 40 19 GO:0043624 cellular protein complex disassembly P 12 0 GO:0044267 cellular protein metabolic process P 2586 540 GO:0045333 cellular respiration P 29 4 GO:0031668 cellular response to extracellular stimulus P 9 6 GO:0042149 cellular response to glucose starvation P 1 0 GO:0032870 cellular response to hormone stimulus P 2 2 GO:0032869 cellular response to insulin stimulus P 2 2 GO:0031669 cellular response to nutrient levels P 7 5 GO:0009267 cellular response to starvation P 7 5 GO:0051716 cellular response to stimulus P 20 16 GO:0033554 cellular response to stress P 17 14 GO:0006883 cellular sodium ion homeostasis P 3 1 GO:0032989 cellular structure morphogenesis P 452 296 GO:0006882 cellular zinc ion homeostasis P 6 5 GO:0007417 central nervous system development P 219 212 GO:0021956 central nervous system interneuron axonogenesis P 1 1 GO:0021626 central nervous system maturation P 1 1 GO:0021955 central nervous system neuron axonogenesis P 7 7 GO:0021954 central nervous system neuron development P 16 16 GO:0021953 central nervous system neuron differentiation P 19 19 GO:0021952 central nervous system projection neuron axonogenesis P 5 5 GO:0031508 centric heterochromatin formation P 1 1 GO:0007098 centrosome cycle P 7 6 GO:0051298 centrosome duplication P 3 2 GO:0051642 centrosome localization P 1 1 GO:0051297 centrosome organization and biogenesis P 8 6 GO:0051299 centrosome separation P 2 2 GO:0046513 ceramide biosynthetic process P 5 4 GO:0046514 ceramide catabolic process P 4 3 GO:0006672 ceramide metabolic process P 23 15 GO:0021695 cerebellar cortex development P 14 14 GO:0021697 cerebellar cortex formation P 7 7 GO:0021696 cerebellar cortex morphogenesis P 10 10 GO:0021681 cerebellar granular layer development P 3 3 GO:0021684 cerebellar granular layer formation P 3 3 GO:0021683 cerebellar granular layer morphogenesis P 3 3 GO:0021707 cerebellar granule cell differentiation P 3 3 GO:0021679 cerebellar molecular layer development P 1 1 GO:0021702 cerebellar Purkinje cell differentiation P 6 6 GO:0021680 cerebellar Purkinje cell layer development P 10 10 GO:0021694 cerebellar Purkinje cell layer formation P 6 6 GO:0021692 cerebellar Purkinje cell layer morphogenesis P 6 6 GO:0021549 cerebellum development P 19 19 GO:0021590 cerebellum maturation P 1 1 GO:0021587 cerebellum morphogenesis P 11 11 GO:0021589 cerebellum structural organization P 1 1 GO:0021795 cerebral cortex cell migration P 4 4 GO:0021987 cerebral cortex development P 8 8 GO:0021894 cerebral cortex GABAergic interneuron development P 3 3 GO:0021892 cerebral cortex GABAergic interneuron differentiation P 3 3 GO:0021853 cerebral cortex GABAergic interneuron migration P 3 3 GO:0021895 cerebral cortex neuron differentiation P 9 9 GO:0021801 cerebral cortex radial glia guided migration P 1 1 GO:0021799 cerebral cortex radially oriented cell migration P 1 1 GO:0021800 cerebral cortex tangential migration P 1 1 GO:0033326 cerebrospinal fluid secretion P 1 1 GO:0006182 cGMP biosynthetic process P 11 7 GO:0046069 cGMP catabolic process P 1 1 GO:0046068 cGMP metabolic process P 15 11 GO:0019934 cGMP-mediated signaling P 3 0 GO:0051085 chaperone cofactor-dependent protein folding P 12 7 GO:0007022 chaperonin-mediated tubulin folding P 1 0 GO:0048878 chemical homeostasis P 163 110 GO:0048875 chemical homeostasis within a tissue P 4 4 GO:0042033 chemokine biosynthetic process P 7 7 GO:0050755 chemokine metabolic process P 7 7 GO:0032602 chemokine production P 8 8 GO:0007635 chemosensory behavior P 3 2 GO:0006935 chemotaxis P 101 40 GO:0051026 chiasma formation P 1 1 GO:0006032 chitin catabolic process P 8 0 GO:0006030 chitin metabolic process P 8 0 GO:0042892 chloramphenicol transport P 1 1 GO:0055064 chloride ion homeostasis P 3 1 GO:0006821 chloride transport P 58 12 GO:0030299 cholesterol absorption P 5 5 GO:0006695 cholesterol biosynthetic process P 22 4 GO:0006707 cholesterol catabolic process P 4 4 GO:0033344 cholesterol efflux P 4 4 GO:0042632 cholesterol homeostasis P 14 13 GO:0008203 cholesterol metabolic process P 64 26 GO:0030301 cholesterol transport P 13 11 GO:0019695 choline metabolic process P 2 1 GO:0015871 choline transport P 2 2 GO:0002063 chondrocyte development P 3 3 GO:0002062 chondrocyte differentiation P 12 12 GO:0030206 chondroitin sulfate biosynthetic process P 3 1 GO:0030204 chondroitin sulfate metabolic process P 3 1 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process P 3 1 GO:0050654 chondroitin sulfate proteoglycan metabolic process P 3 1 GO:0043009 chordate embryonic development P 209 207 GO:0046417 chorismate metabolic process P 1 0 GO:0031497 chromatin assembly P 104 9 GO:0006333 chromatin assembly or disassembly P 130 12 GO:0031498 chromatin disassembly P 1 0 GO:0016568 chromatin modification P 164 42 GO:0006338 chromatin remodeling P 37 16 GO:0031055 chromatin remodeling at centromere P 1 1 GO:0006342 chromatin silencing P 13 4 GO:0048096 chromatin-mediated maintenance of transcription P 1 1 GO:0030261 chromosome condensation P 15 3 GO:0050000 chromosome localization P 2 1 GO:0051276 chromosome organization and biogenesis P 374 85 GO:0007001 chromosome organization and biogenesis (sensu Eukaryota) P 369 84 GO:0007059 chromosome segregation P 46 14 GO:0051304 chromosome separation P 2 1 GO:0002544 chronic inflammatory response P 2 2 GO:0001539 ciliary or flagellar motility P 8 7 GO:0035083 cilium axoneme biogenesis P 1 1 GO:0042384 cilium biogenesis P 13 11 GO:0048512 circadian behavior P 5 4 GO:0032922 circadian regulation of gene expression P 2 2 GO:0007623 circadian rhythm P 29 20 GO:0042745 circadian sleep/wake cycle P 3 3 GO:0022410 circadian sleep/wake cycle process P 2 2 GO:0042748 circadian sleep/wake cycle, non-REM sleep P 1 1 GO:0042747 circadian sleep/wake cycle, REM sleep P 1 1 GO:0050802 circadian sleep/wake cycle, sleep P 2 2 GO:0008015 circulation P 91 78 GO:0006101 citrate metabolic process P 2 0 GO:0015746 citrate transport P 2 1 GO:0048268 clathrin cage assembly P 3 0 GO:0006055 CMP-N-acetylneuraminate biosynthetic process P 1 0 GO:0046381 CMP-N-acetylneuraminate metabolic process P 2 1 GO:0050817 coagulation P 53 15 GO:0009236 cobalamin biosynthetic process P 1 0 GO:0009235 cobalamin metabolic process P 1 0 GO:0015889 cobalamin transport P 2 0 GO:0006824 cobalt ion transport P 4 1 GO:0015937 coenzyme A biosynthetic process P 5 1 GO:0015938 coenzyme A catabolic process P 1 1 GO:0015936 coenzyme A metabolic process P 7 2 GO:0009108 coenzyme biosynthetic process P 85 9 GO:0009109 coenzyme catabolic process P 28 1 GO:0006732 coenzyme metabolic process P 159 31 GO:0051188 cofactor biosynthetic process P 98 14 GO:0051187 cofactor catabolic process P 31 1 GO:0051186 cofactor metabolic process P 185 40 GO:0051181 cofactor transport P 3 2 GO:0030574 collagen catabolic process P 16 2 GO:0030199 collagen fibril organization P 15 15 GO:0032963 collagen metabolic process P 17 3 GO:0048668 collateral sprouting P 1 1 GO:0048669 collateral sprouting in the absence of injury P 1 1 GO:0002066 columnar/cuboidal epithelial cell development P 2 2 GO:0002065 columnar/cuboidal epithelial cell differentiation P 2 2 GO:0002069 columnar/cuboidal epithelial cell maturation P 1 1 GO:0021902 commitment of a neuronal cell to a specific type of neuron in the forebrain P 1 1 GO:0007182 common-partner SMAD protein phosphorylation P 9 2 GO:0007386 compartment specification P 5 4 GO:0006956 complement activation P 41 9 GO:0006957 complement activation, alternative pathway P 10 1 GO:0006958 complement activation, classical pathway P 28 5 GO:0001661 conditioned taste aversion P 2 2 GO:0060003 copper ion export P 1 1 GO:0055070 copper ion homeostasis P 9 6 GO:0015677 copper ion import P 1 1 GO:0006825 copper ion transport P 9 3 GO:0007620 copulation P 4 3 GO:0022038 corpus callosum development P 1 1 GO:0030866 cortical actin cytoskeleton organization and biogenesis P 8 3 GO:0030865 cortical cytoskeleton organization and biogenesis P 10 3 GO:0031958 corticosteroid receptor signaling pathway P 1 1 GO:0006613 cotranslational protein targeting to membrane P 19 1 GO:0007619 courtship behavior P 1 1 GO:0016569 covalent chromatin modification P 37 30 GO:0021545 cranial nerve development P 3 3 GO:0021602 cranial nerve morphogenesis P 2 2 GO:0006601 creatine biosynthetic process P 2 1 GO:0006600 creatine metabolic process P 3 1 GO:0015881 creatine transport P 1 0 GO:0006481 C-terminal protein amino acid methylation P 3 0 GO:0006241 CTP biosynthetic process P 9 0 GO:0046036 CTP metabolic process P 9 0 GO:0009190 cyclic nucleotide biosynthetic process P 28 11 GO:0009214 cyclic nucleotide catabolic process P 3 2 GO:0009187 cyclic nucleotide metabolic process P 37 18 GO:0019935 cyclic-nucleotide-mediated signaling P 63 42 GO:0008054 cyclin catabolic process P 1 0 GO:0019344 cysteine biosynthetic process P 2 0 GO:0006535 cysteine biosynthetic process from serine P 1 0 GO:0019343 cysteine biosynthetic process via cystathionine P 1 0 GO:0009093 cysteine catabolic process P 2 0 GO:0006534 cysteine metabolic process P 5 1 GO:0006423 cysteinyl-tRNA aminoacylation P 2 0 GO:0006216 cytidine catabolic process P 1 0 GO:0009972 cytidine deamination P 1 0 GO:0046087 cytidine metabolic process P 2 0 GO:0016554 cytidine to uridine editing P 2 1 GO:0017004 cytochrome complex assembly P 1 1 GO:0019221 cytokine and chemokine mediated signaling pathway P 43 27 GO:0042089 cytokine biosynthetic process P 60 54 GO:0042107 cytokine metabolic process P 61 54 GO:0001816 cytokine production P 98 90 GO:0002367 cytokine production during immune response P 2 2 GO:0050663 cytokine secretion P 6 5 GO:0000910 cytokinesis P 25 6 GO:0000281 cytokinesis after mitosis P 3 2 GO:0033205 cytokinesis during cell cycle P 4 3 GO:0032506 cytokinetic process P 1 0 GO:0009691 cytokinin biosynthetic process P 1 0 GO:0009690 cytokinin metabolic process P 1 0 GO:0019835 cytolysis P 23 5 GO:0007028 cytoplasm organization and biogenesis P 17 15 GO:0031122 cytoplasmic microtubule organization and biogenesis P 3 2 GO:0051220 cytoplasmic sequestering of protein P 2 2 GO:0042994 cytoplasmic sequestering of transcription factor P 2 2 GO:0016482 cytoplasmic transport P 1 1 GO:0019858 cytosine metabolic process P 1 1 GO:0007016 cytoskeletal anchoring P 4 1 GO:0007010 cytoskeleton organization and biogenesis P 450 177 GO:0030705 cytoskeleton-dependent intracellular transport P 101 23 GO:0051480 cytosolic calcium ion homeostasis P 19 16 GO:0043316 cytotoxic T cell degranulation P 1 1 GO:0045065 cytotoxic T cell differentiation P 2 1 GO:0042941 D-alanine transport P 1 1 GO:0019478 D-amino acid catabolic process P 2 0 GO:0046416 D-amino acid metabolic process P 2 0 GO:0042940 D-amino acid transport P 1 1 GO:0006189 'de novo' IMP biosynthetic process P 2 0 GO:0051084 'de novo' posttranslational protein folding P 14 8 GO:0006458 'de novo' protein folding P 14 8 GO:0006207 'de novo' pyrimidine base biosynthetic process P 3 0 GO:0000290 deadenylation-dependent decapping P 1 0 GO:0016265 death P 617 327 GO:0001986 decreased strength of heart contraction during baroreceptor response to increased blood pressure P 1 1 GO:0006952 defense response P 656 141 GO:0042742 defense response to bacterium P 83 27 GO:0050832 defense response to fungus P 3 2 GO:0050829 defense response to Gram-negative bacterium P 3 3 GO:0050830 defense response to Gram-positive bacterium P 3 3 GO:0042832 defense response to protozoan P 2 2 GO:0051607 defense response to virus P 6 6 GO:0016358 dendrite development P 39 39 GO:0048813 dendrite morphogenesis P 13 13 GO:0021542 dentate gyrus development P 1 1 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process P 2 0 GO:0009186 deoxyribonucleoside diphosphate metabolic process P 4 0 GO:0009120 deoxyribonucleoside metabolic process P 4 1 GO:0009157 deoxyribonucleoside monophosphate biosynthetic process P 1 0 GO:0009162 deoxyribonucleoside monophosphate metabolic process P 1 0 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process P 3 1 GO:0009204 deoxyribonucleoside triphosphate catabolic process P 2 2 GO:0009200 deoxyribonucleoside triphosphate metabolic process P 5 3 GO:0009263 deoxyribonucleotide biosynthetic process P 5 2 GO:0009264 deoxyribonucleotide catabolic process P 4 3 GO:0009262 deoxyribonucleotide metabolic process P 10 6 GO:0016311 dephosphorylation P 117 24 GO:0030208 dermatan sulfate biosynthetic process P 1 0 GO:0030205 dermatan sulfate metabolic process P 1 0 GO:0050651 dermatan sulfate proteoglycan biosynthetic process P 1 0 GO:0050655 dermatan sulfate proteoglycan metabolic process P 1 0 GO:0002029 desensitization of G-protein coupled receptor protein signaling pathway P 2 2 GO:0009582 detection of abiotic stimulus P 43 32 GO:0042494 detection of bacterial lipoprotein P 1 0 GO:0016045 detection of bacterium P 3 2 GO:0009595 detection of biotic stimulus P 5 4 GO:0009593 detection of chemical stimulus P 20 2 GO:0050907 detection of chemical stimulus during sensory perception P 18 1 GO:0001580 detection of chemical stimulus during sensory perception of bitter taste P 17 0 GO:0050968 detection of chemical stimulus during sensory perception of pain P 1 1 GO:0050912 detection of chemical stimulus during sensory perception of taste P 17 0 GO:0009581 detection of external stimulus P 47 35 GO:0016046 detection of fungus P 2 2 GO:0009590 detection of gravity P 1 1 GO:0009583 detection of light stimulus P 26 15 GO:0050962 detection of light stimulus during sensory perception P 24 12 GO:0050908 detection of light stimulus during visual perception P 24 12 GO:0050982 detection of mechanical stimulus P 12 12 GO:0050973 detection of mechanical stimulus during equilibrioception P 2 2 GO:0050974 detection of mechanical stimulus during sensory perception P 10 10 GO:0050966 detection of mechanical stimulus during sensory perception of pain P 3 3 GO:0050910 detection of mechanical stimulus during sensory perception of sound P 6 6 GO:0032490 detection of molecule of bacterial origin P 1 0 GO:0051606 detection of stimulus P 67 37 GO:0050906 detection of stimulus during sensory perception P 54 24 GO:0016048 detection of temperature stimulus P 6 6 GO:0050961 detection of temperature stimulus during sensory perception P 4 4 GO:0050965 detection of temperature stimulus during sensory perception of pain P 4 4 GO:0042495 detection of triacylated bacterial lipoprotein P 1 0 GO:0002355 detection of tumor cell P 1 1 GO:0009589 detection of UV P 1 1 GO:0009584 detection of visible light P 24 12 GO:0001879 detection of yeast P 2 2 GO:0008340 determination of adult life span P 7 7 GO:0008595 determination of anterior/posterior axis, embryo P 5 5 GO:0009855 determination of bilateral symmetry P 35 35 GO:0007368 determination of left/right symmetry P 34 34 GO:0009799 determination of symmetry P 35 35 GO:0010273 detoxification of copper ion P 3 3 GO:0050787 detoxification of mercury ion P 1 0 GO:0046545 development of primary female sexual characteristics P 36 36 GO:0046546 development of primary male sexual characteristics P 23 23 GO:0045137 development of primary sexual characteristics P 58 57 GO:0046543 development of secondary female sexual characteristics P 2 2 GO:0046544 development of secondary male sexual characteristics P 2 2 GO:0045136 development of secondary sexual characteristics P 3 3 GO:0048589 developmental growth P 46 40 GO:0021700 developmental maturation P 91 80 GO:0032502 developmental process P 2739 1821 GO:0042840 D-glucuronate catabolic process P 1 1 GO:0042839 D-glucuronate metabolic process P 1 1 GO:0006203 dGTP catabolic process P 1 1 GO:0046070 dGTP metabolic process P 1 1 GO:0055061 di-, tri-valent inorganic anion homeostasis P 3 2 GO:0055066 di-, tri-valent inorganic cation homeostasis P 96 61 GO:0015674 di-, tri-valent inorganic cation transport P 134 49 GO:0006651 diacylglycerol biosynthetic process P 4 2 GO:0046340 diacylglycerol catabolic process P 1 1 GO:0046339 diacylglycerol metabolic process P 8 4 GO:0046451 diaminopimelate metabolic process P 1 0 GO:0002086 diaphragm contraction P 1 1 GO:0043648 dicarboxylic acid metabolic process P 10 1 GO:0006835 dicarboxylic acid transport P 10 3 GO:0021536 diencephalon development P 20 20 GO:0048852 diencephalon morphogenesis P 1 1 GO:0002024 diet induced thermogenesis P 3 3 GO:0007586 digestion P 40 16 GO:0022600 digestive process P 13 12 GO:0048546 digestive tract morphogenesis P 13 13 GO:0033058 directional locomotion P 2 2 GO:0046351 disaccharide biosynthetic process P 2 1 GO:0005984 disaccharide metabolic process P 3 1 GO:0016101 diterpenoid metabolic process P 12 10 GO:0030146 diuresis P 4 4 GO:0006305 DNA alkylation P 21 7 GO:0006308 DNA catabolic process P 13 8 GO:0000737 DNA catabolic process, endonucleolytic P 2 2 GO:0000077 DNA damage checkpoint P 17 14 GO:0042770 DNA damage response, signal transduction P 35 28 GO:0030330 DNA damage response, signal transduction by p53 class mediator P 13 10 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest P 2 2 GO:0042771 DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis P 9 6 GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator P 1 1 GO:0008630 DNA damage response, signal transduction resulting in induction of apoptosis P 17 13 GO:0042772 DNA damage response, signal transduction resulting in transcription P 1 1 GO:0006307 DNA dealkylation P 1 1 GO:0032508 DNA duplex unwinding P 9 5 GO:0006309 DNA fragmentation during apoptosis P 7 5 GO:0032392 DNA geometric change P 9 5 GO:0015074 DNA integration P 5 1 GO:0031570 DNA integrity checkpoint P 20 16 GO:0006266 DNA ligation P 2 2 GO:0051102 DNA ligation during DNA recombination P 1 1 GO:0051103 DNA ligation during DNA repair P 1 1 GO:0006259 DNA metabolic process P 607 172 GO:0006306 DNA methylation P 21 7 GO:0006304 DNA modification P 24 7 GO:0006323 DNA packaging P 272 53 GO:0006310 DNA recombination P 71 39 GO:0006281 DNA repair P 184 56 GO:0006260 DNA replication P 132 41 GO:0000076 DNA replication checkpoint P 3 2 GO:0006270 DNA replication initiation P 13 4 GO:0045004 DNA replication proofreading P 1 1 GO:0006269 DNA replication, synthesis of RNA primer P 4 0 GO:0006265 DNA topological change P 10 2 GO:0006268 DNA unwinding during replication P 9 5 GO:0006261 DNA-dependent DNA replication P 44 25 GO:0006488 dolichol-linked oligosaccharide biosynthetic process P 2 0 GO:0042416 dopamine biosynthetic process P 4 4 GO:0006585 dopamine biosynthetic process from tyrosine P 1 1 GO:0042420 dopamine catabolic process P 4 4 GO:0042417 dopamine metabolic process P 19 17 GO:0007212 dopamine receptor signaling pathway P 18 14 GO:0007191 dopamine receptor, adenylate cyclase activating pathway P 7 6 GO:0007195 dopamine receptor, adenylate cyclase inhibiting pathway P 3 3 GO:0060158 dopamine receptor, phospholipase C activating pathway P 4 4 GO:0014046 dopamine secretion P 5 5 GO:0015872 dopamine transport P 5 5 GO:0051583 dopamine uptake P 3 3 GO:0009950 dorsal/ventral axis specification P 4 4 GO:0009953 dorsal/ventral pattern formation P 42 42 GO:0021904 dorsoventral neural tube patterning P 3 3 GO:0007549 dosage compensation P 9 6 GO:0009048 dosage compensation, by inactivation of X chromosome P 7 6 GO:0006302 double-strand break repair P 19 17 GO:0000724 double-strand break repair via homologous recombination P 8 8 GO:0006303 double-strand break repair via nonhomologous end joining P 6 3 GO:0006014 D-ribose metabolic process P 1 0 GO:0042756 drinking behavior P 5 5 GO:0042737 drug catabolic process P 1 1 GO:0017144 drug metabolic process P 5 1 GO:0015893 drug transport P 13 2 GO:0042942 D-serine transport P 1 1 GO:0031050 dsRNA fragmentation P 3 2 GO:0006233 dTDP biosynthetic process P 2 0 GO:0046072 dTDP metabolic process P 2 0 GO:0006231 dTMP biosynthetic process P 1 0 GO:0046073 dTMP metabolic process P 1 0 GO:0006235 dTTP biosynthetic process P 3 1 GO:0046075 dTTP metabolic process P 3 1 GO:0042843 D-xylose catabolic process P 1 1 GO:0042732 D-xylose metabolic process P 3 1 GO:0043583 ear development P 74 73 GO:0042471 ear morphogenesis P 58 57 GO:0045022 early endosome to late endosome transport P 4 3 GO:0042755 eating behavior P 8 8 GO:0007499 ectoderm and mesoderm interaction P 1 1 GO:0007398 ectoderm development P 99 70 GO:0007439 ectodermal gut development P 10 10 GO:0048567 ectodermal gut morphogenesis P 10 10 GO:0007343 egg activation P 2 1 GO:0048251 elastic fiber assembly P 2 2 GO:0051542 elastin biosynthetic process P 1 1 GO:0051541 elastin metabolic process P 1 1 GO:0006118 electron transport P 349 7 GO:0007204 elevation of cytosolic calcium ion concentration P 17 14 GO:0051482 elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) P 2 2 GO:0007566 embryo implantation P 21 9 GO:0035113 embryonic appendage morphogenesis P 61 59 GO:0035117 embryonic arm morphogenesis P 2 2 GO:0000578 embryonic axis specification P 5 5 GO:0010172 embryonic body morphogenesis P 3 3 GO:0040016 embryonic cleavage P 6 6 GO:0048701 embryonic cranial skeleton morphogenesis P 5 5 GO:0009790 embryonic development P 434 415 GO:0009792 embryonic development ending in birth or egg hatching P 212 210 GO:0001700 embryonic development via the syncytial blastoderm P 1 1 GO:0048557 embryonic digestive tract morphogenesis P 9 9 GO:0042733 embryonic digit morphogenesis P 13 13 GO:0048611 embryonic ectodermal gut development P 6 6 GO:0048613 embryonic ectodermal gut morphogenesis P 6 6 GO:0001838 embryonic epithelial tube formation P 56 56 GO:0048048 embryonic eye morphogenesis P 6 6 GO:0048617 embryonic foregut morphogenesis P 4 4 GO:0035115 embryonic forelimb morphogenesis P 11 10 GO:0030538 embryonic genitalia morphogenesis P 3 3 GO:0048566 embryonic gut development P 13 13 GO:0048558 embryonic gut morphogenesis P 8 8 GO:0035054 embryonic heart tube anterior/posterior pattern formation P 2 2 GO:0035050 embryonic heart tube development P 13 13 GO:0035162 embryonic hemopoiesis P 5 5 GO:0048619 embryonic hindgut morphogenesis P 2 2 GO:0035116 embryonic hindlimb morphogenesis P 12 11 GO:0030326 embryonic limb morphogenesis P 61 59 GO:0048598 embryonic morphogenesis P 195 193 GO:0048702 embryonic neurocranium morphogenesis P 1 1 GO:0048568 embryonic organ development P 35 35 GO:0048562 embryonic organ morphogenesis P 21 21 GO:0009880 embryonic pattern specification P 40 40 GO:0001892 embryonic placenta development P 11 11 GO:0048706 embryonic skeletal development P 14 14 GO:0048704 embryonic skeletal morphogenesis P 10 10 GO:0048703 embryonic viscerocranium morphogenesis P 4 3 GO:0001958 endochondral ossification P 7 7 GO:0031018 endocrine pancreas development P 7 7 GO:0050886 endocrine process P 17 17 GO:0035270 endocrine system development P 48 47 GO:0006897 endocytosis P 158 68 GO:0007492 endoderm development P 17 13 GO:0001706 endoderm formation P 2 2 GO:0001711 endodermal cell fate commitment P 2 1 GO:0001714 endodermal cell fate specification P 1 0 GO:0007113 endomitotic cell cycle P 1 1 GO:0032469 endoplasmic reticulum calcium ion homeostasis P 2 2 GO:0007029 endoplasmic reticulum organization and biogenesis P 4 4 GO:0007032 endosome organization and biogenesis P 6 4 GO:0008333 endosome to lysosome transport P 3 2 GO:0016197 endosome transport P 19 10 GO:0001885 endothelial cell development P 3 3 GO:0045446 endothelial cell differentiation P 10 7 GO:0043542 endothelial cell migration P 7 7 GO:0001886 endothelial cell morphogenesis P 1 1 GO:0001935 endothelial cell proliferation P 8 8 GO:0015988 energy coupled proton transport, against electrochemical gradient P 8 3 GO:0015985 energy coupled proton transport, down electrochemical gradient P 34 0 GO:0015980 energy derivation by oxidation of organic compounds P 65 19 GO:0006112 energy reserve metabolic process P 35 14 GO:0032291 ensheathment of axons in the central nervous system P 1 1 GO:0032292 ensheathment of axons in the peripheral nervous system P 2 2 GO:0007272 ensheathment of neurons P 27 24 GO:0048484 enteric nervous system development P 3 3 GO:0009649 entrainment of circadian clock P 2 2 GO:0043153 entrainment of circadian clock by photoperiod P 1 1 GO:0043353 enucleate erythrocyte differentiation P 4 4 GO:0007167 enzyme linked receptor protein signaling pathway P 263 161 GO:0030222 eosinophil differentiation P 1 1 GO:0048013 ephrin receptor signaling pathway P 4 3 GO:0009913 epidermal cell differentiation P 34 10 GO:0007173 epidermal growth factor receptor signaling pathway P 12 10 GO:0008544 epidermis development P 94 65 GO:0048730 epidermis morphogenesis P 48 24 GO:0042414 epinephrine metabolic process P 1 1 GO:0002064 epithelial cell development P 7 7 GO:0030855 epithelial cell differentiation P 36 35 GO:0002070 epithelial cell maturation P 5 5 GO:0050673 epithelial cell proliferation P 30 30 GO:0001837 epithelial to mesenchymal transition P 8 7 GO:0050957 equilibrioception P 3 3 GO:0051643 ER localization P 2 2 GO:0006983 ER overload response P 6 5 GO:0006888 ER to Golgi vesicle-mediated transport P 16 1 GO:0030433 ER-associated protein catabolic process P 5 5 GO:0006696 ergosterol biosynthetic process P 1 0 GO:0008204 ergosterol metabolic process P 1 0 GO:0006984 ER-nuclear signaling pathway P 18 16 GO:0045020 error-prone DNA repair P 1 1 GO:0042276 error-prone postreplication DNA repair P 1 1 GO:0048821 erythrocyte development P 7 3 GO:0030218 erythrocyte differentiation P 35 31 GO:0043249 erythrocyte maturation P 5 1 GO:0030950 establishment and/or maintenance of actin cytoskeleton polarity P 1 1 GO:0035088 establishment and/or maintenance of apical/basal cell polarity P 11 10 GO:0007163 establishment and/or maintenance of cell polarity P 24 19 GO:0006325 establishment and/or maintenance of chromatin architecture P 264 53 GO:0030952 establishment and/or maintenance of cytoskeleton polarity P 1 1 GO:0045197 establishment and/or maintenance of epithelial cell polarity P 7 6 GO:0035089 establishment of apical/basal cell polarity P 6 5 GO:0008065 establishment of blood-nerve barrier P 1 1 GO:0030010 establishment of cell polarity P 13 10 GO:0051649 establishment of cellular localization P 725 233 GO:0051303 establishment of chromosome localization P 2 1 GO:0045198 establishment of epithelial cell polarity P 4 3 GO:0051234 establishment of localization P 2332 530 GO:0001767 establishment of lymphocyte polarity P 2 2 GO:0051295 establishment of meiotic spindle localization P 1 1 GO:0032401 establishment of melanosome localization P 4 3 GO:0040001 establishment of mitotic spindle localization P 1 0 GO:0040023 establishment of nucleus localization P 6 6 GO:0051656 establishment of organelle localization P 21 15 GO:0051905 establishment of pigment granule localization P 5 4 GO:0001736 establishment of planar polarity P 6 6 GO:0042249 establishment of polarity of embryonic epithelium P 2 2 GO:0045184 establishment of protein localization P 678 107 GO:0051236 establishment of RNA localization P 50 9 GO:0051293 establishment of spindle localization P 2 1 GO:0007529 establishment of synaptic specificity at neuromuscular junction P 2 2 GO:0001768 establishment of T cell polarity P 2 2 GO:0007164 establishment of tissue polarity P 6 6 GO:0051650 establishment of vesicle localization P 11 7 GO:0006703 estrogen biosynthetic process P 2 0 GO:0008210 estrogen metabolic process P 4 2 GO:0030520 estrogen receptor signaling pathway P 2 2 GO:0042439 ethanolamine and derivative metabolic process P 4 3 GO:0008611 ether lipid biosynthetic process P 1 1 GO:0046485 ether lipid metabolic process P 1 1 GO:0007588 excretion P 19 16 GO:0031017 exocrine pancreas development P 1 1 GO:0035272 exocrine system development P 14 14 GO:0006887 exocytosis P 82 38 GO:0042738 exogenous drug catabolic process P 1 1 GO:0045229 external encapsulating structure organization and biogenesis P 15 0 GO:0030198 extracellular matrix organization and biogenesis P 57 48 GO:0045226 extracellular polysaccharide biosynthetic process P 1 0 GO:0046379 extracellular polysaccharide metabolic process P 1 0 GO:0043062 extracellular structure organization and biogenesis P 99 87 GO:0002074 extraocular skeletal muscle development P 2 2 GO:0033078 extrathymic T cell differentiation P 1 1 GO:0045062 extrathymic T cell selection P 1 1 GO:0060082 eye blink reflex P 1 1 GO:0001654 eye development P 102 100 GO:0048592 eye morphogenesis P 43 42 GO:0042462 eye photoreceptor cell development P 14 14 GO:0001754 eye photoreceptor cell differentiation P 16 16 GO:0042706 eye photoreceptor cell fate commitment P 1 1 GO:0008057 eye pigment granule organization and biogenesis P 1 0 GO:0045210 FasL biosynthetic process P 1 1 GO:0001976 fast regulation of arterial pressure P 20 20 GO:0045444 fat cell differentiation P 23 22 GO:0042362 fat-soluble vitamin biosynthetic process P 1 0 GO:0006775 fat-soluble vitamin metabolic process P 22 18 GO:0001561 fatty acid alpha-oxidation P 2 2 GO:0006635 fatty acid beta-oxidation P 13 8 GO:0006633 fatty acid biosynthetic process P 66 16 GO:0009062 fatty acid catabolic process P 2 2 GO:0030497 fatty acid elongation P 2 1 GO:0006631 fatty acid metabolic process P 156 53 GO:0019395 fatty acid oxidation P 20 13 GO:0015908 fatty acid transport P 5 4 GO:0002431 Fc receptor mediated stimulatory signaling pathway P 1 1 GO:0042596 fear response P 13 12 GO:0007631 feeding behavior P 34 33 GO:0007292 female gamete generation P 35 27 GO:0030540 female genitalia development P 1 1 GO:0008585 female gonad development P 35 35 GO:0007143 female meiosis P 8 5 GO:0016321 female meiosis chromosome segregation P 1 0 GO:0051309 female meiosis chromosome separation P 1 0 GO:0007144 female meiosis I P 3 3 GO:0007066 female meiosis sister chromatid cohesion P 3 2 GO:0007565 female pregnancy P 41 13 GO:0035038 female pronucleus formation P 1 0 GO:0030237 female sex determination P 1 1 GO:0046660 female sex differentiation P 36 36 GO:0019101 female somatic sex determination P 1 1 GO:0006113 fermentation P 1 1 GO:0009566 fertilization P 46 33 GO:0001660 fever P 3 1 GO:0043206 fibril organization and biogenesis P 2 1 GO:0042730 fibrinolysis P 3 1 GO:0008543 fibroblast growth factor receptor signaling pathway P 14 12 GO:0048144 fibroblast proliferation P 8 7 GO:0046847 filopodium formation P 9 5 GO:0035084 flagellum axoneme biogenesis P 4 4 GO:0009296 flagellum biogenesis P 6 6 GO:0043064 flagellum organization and biogenesis P 7 6 GO:0021508 floor plate formation P 1 1 GO:0007589 fluid secretion P 8 6 GO:0042044 fluid transport P 11 2 GO:0048041 focal adhesion formation P 5 5 GO:0009396 folic acid and derivative biosynthetic process P 7 0 GO:0009397 folic acid and derivative catabolic process P 1 0 GO:0006760 folic acid and derivative metabolic process P 11 2 GO:0046655 folic acid metabolic process P 1 1 GO:0002266 follicular dendritic cell activation P 2 2 GO:0002268 follicular dendritic cell differentiation P 2 2 GO:0021897 forebrain astrocyte development P 1 1 GO:0021896 forebrain astrocyte differentiation P 1 1 GO:0021885 forebrain cell migration P 6 6 GO:0030900 forebrain development P 98 98 GO:0021798 forebrain dorsal/ventral pattern formation P 4 4 GO:0048853 forebrain morphogenesis P 3 3 GO:0021873 forebrain neuroblast division P 1 1 GO:0021884 forebrain neuron development P 3 3 GO:0021879 forebrain neuron differentiation P 5 5 GO:0021877 forebrain neuron fate commitment P 1 1 GO:0021871 forebrain regionalization P 6 6 GO:0007440 foregut morphogenesis P 5 5 GO:0035136 forelimb morphogenesis P 14 12 GO:0015724 formate transport P 1 1 GO:0048859 formation of anatomical boundary P 1 1 GO:0001771 formation of immunological synapse P 1 1 GO:0010160 formation of organ boundary P 1 1 GO:0001704 formation of primary germ layer P 27 27 GO:0043056 forward locomotion P 1 1 GO:0021592 fourth ventricle development P 1 1 GO:0030389 fructosamine metabolic process P 1 1 GO:0006003 fructose 2,6-bisphosphate metabolic process P 4 0 GO:0006002 fructose 6-phosphate metabolic process P 1 0 GO:0046370 fructose biosynthetic process P 1 0 GO:0006000 fructose metabolic process P 5 0 GO:0015755 fructose transport P 1 0 GO:0042353 fucose biosynthetic process P 1 0 GO:0006004 fucose metabolic process P 4 0 GO:0006106 fumarate metabolic process P 1 0 GO:0048165 fused antrum stage, oogenesis P 1 1 GO:0007342 fusion of sperm to egg plasma membrane P 6 3 GO:0031571 G1 DNA damage checkpoint P 3 3 GO:0051318 G1 phase P 6 3 GO:0000080 G1 phase of mitotic cell cycle P 6 3 GO:0031575 G1/S transition checkpoint P 5 4 GO:0000082 G1/S transition of mitotic cell cycle P 24 19 GO:0000083 G1/S-specific transcription in mitotic cell cycle P 2 2 GO:0051319 G2 phase P 3 2 GO:0000085 G2 phase of mitotic cell cycle P 3 2 GO:0031576 G2/M transition checkpoint P 3 2 GO:0031572 G2/M transition DNA damage checkpoint P 3 2 GO:0000086 G2/M transition of mitotic cell cycle P 3 2 GO:0019402 galactitol metabolic process P 1 1 GO:0019375 galactolipid biosynthetic process P 1 1 GO:0019376 galactolipid catabolic process P 1 0 GO:0019374 galactolipid metabolic process P 3 2 GO:0006012 galactose metabolic process P 5 3 GO:0015757 galactose transport P 1 0 GO:0006682 galactosylceramide biosynthetic process P 1 1 GO:0006683 galactosylceramide catabolic process P 1 0 GO:0006681 galactosylceramide metabolic process P 3 2 GO:0007276 gamete generation P 244 148 GO:0009450 gamma-aminobutyric acid catabolic process P 1 1 GO:0009448 gamma-aminobutyric acid metabolic process P 2 1 GO:0014051 gamma-aminobutyric acid secretion P 2 2 GO:0007214 gamma-aminobutyric acid signaling pathway P 19 4 GO:0046629 gamma-delta T cell activation P 2 2 GO:0042492 gamma-delta T cell differentiation P 2 2 GO:0007402 ganglion mother cell fate determination P 1 1 GO:0001574 ganglioside biosynthetic process P 3 2 GO:0006689 ganglioside catabolic process P 3 3 GO:0001573 ganglioside metabolic process P 8 6 GO:0033483 gas homeostasis P 1 1 GO:0015669 gas transport P 14 3 GO:0007369 gastrulation P 62 56 GO:0010003 gastrulation (sensu Mammalia) P 24 23 GO:0048276 gastrulation (sensu Vertebrata) P 31 26 GO:0001702 gastrulation with mouth forming second P 31 26 GO:0042350 GDP-L-fucose biosynthetic process P 1 0 GO:0046368 GDP-L-fucose metabolic process P 1 0 GO:0019673 GDP-mannose metabolic process P 1 0 GO:0016458 gene silencing P 27 9 GO:0003001 generation of a signal involved in cell-cell signaling P 86 71 GO:0019228 generation of action potential P 1 1 GO:0060112 generation of menstrual cycle rhythm P 1 1 GO:0048699 generation of neurons P 308 286 GO:0021872 generation of neurons in the forebrain P 6 6 GO:0006091 generation of precursor metabolites and energy P 446 29 GO:0006349 genetic imprinting P 7 7 GO:0048806 genitalia development P 11 11 GO:0035112 genitalia morphogenesis P 3 3 GO:0007281 germ cell development P 27 23 GO:0008354 germ cell migration P 6 6 GO:0035234 germ cell programmed cell death P 1 1 GO:0002467 germinal center formation P 7 7 GO:0048134 germ-line cyst formation P 1 1 GO:0018992 germ-line sex determination P 2 2 GO:0042078 germ-line stem cell division P 1 1 GO:0030718 germ-line stem cell maintenance P 1 1 GO:0048732 gland development P 72 71 GO:0022612 gland morphogenesis P 6 6 GO:0002068 glandular epithelial cell development P 1 1 GO:0002067 glandular epithelial cell differentiation P 1 1 GO:0002071 glandular epithelial cell maturation P 1 1 GO:0021782 glial cell development P 10 10 GO:0010001 glial cell differentiation P 37 37 GO:0021781 glial cell fate commitment P 2 2 GO:0007403 glial cell fate determination P 2 2 GO:0008347 glial cell migration P 3 3 GO:0042063 gliogenesis P 40 40 GO:0021759 globus pallidus development P 1 1 GO:0032836 glomerular basement membrane development P 1 1 GO:0032835 glomerulus development P 1 1 GO:0009250 glucan biosynthetic process P 11 4 GO:0009251 glucan catabolic process P 4 4 GO:0006073 glucan metabolic process P 31 12 GO:0006704 glucocorticoid biosynthetic process P 5 5 GO:0008211 glucocorticoid metabolic process P 9 8 GO:0042921 glucocorticoid receptor signaling pathway P 1 1 GO:0006094 gluconeogenesis P 17 7 GO:0006042 glucosamine biosynthetic process P 1 0 GO:0006043 glucosamine catabolic process P 8 0 GO:0006041 glucosamine metabolic process P 17 4 GO:0019255 glucose 1-phosphate metabolic process P 1 1 GO:0051156 glucose 6-phosphate metabolic process P 1 1 GO:0006007 glucose catabolic process P 51 2 GO:0042593 glucose homeostasis P 26 24 GO:0046323 glucose import P 6 5 GO:0006006 glucose metabolic process P 93 24 GO:0015758 glucose transport P 27 22 GO:0015760 glucose-6-phosphate transport P 3 3 GO:0042946 glucoside transport P 1 0 GO:0006679 glucosylceramide biosynthetic process P 1 0 GO:0006678 glucosylceramide metabolic process P 2 1 GO:0006064 glucuronate catabolic process P 1 1 GO:0019585 glucuronate metabolic process P 2 2 GO:0006537 glutamate biosynthetic process P 2 0 GO:0006536 glutamate metabolic process P 4 1 GO:0014047 glutamate secretion P 4 4 GO:0007215 glutamate signaling pathway P 8 4 GO:0015813 glutamate transport P 4 4 GO:0051935 glutamate uptake during transmission of nerve impulse P 1 1 GO:0006542 glutamine biosynthetic process P 2 0 GO:0009084 glutamine family amino acid biosynthetic process P 13 0 GO:0009065 glutamine family amino acid catabolic process P 8 1 GO:0009064 glutamine family amino acid metabolic process P 29 2 GO:0006541 glutamine metabolic process P 14 0 GO:0006868 glutamine transport P 2 2 GO:0006424 glutamyl-tRNA aminoacylation P 2 0 GO:0006750 glutathione biosynthetic process P 6 2 GO:0006749 glutathione metabolic process P 19 12 GO:0019682 glyceraldehyde-3-phosphate metabolic process P 1 1 GO:0006114 glycerol biosynthetic process P 1 1 GO:0046327 glycerol biosynthetic process from pyruvate P 1 1 GO:0019563 glycerol catabolic process P 2 0 GO:0046504 glycerol ether biosynthetic process P 8 6 GO:0044269 glycerol ether catabolic process P 2 2 GO:0006662 glycerol ether metabolic process P 24 18 GO:0006071 glycerol metabolic process P 19 5 GO:0015793 glycerol transport P 1 0 GO:0046168 glycerol-3-phosphate catabolic process P 2 0 GO:0006072 glycerol-3-phosphate metabolic process P 6 3 GO:0015794 glycerol-3-phosphate transport P 1 0 GO:0045017 glycerolipid biosynthetic process P 8 6 GO:0046503 glycerolipid catabolic process P 2 2 GO:0046486 glycerolipid metabolic process P 23 18 GO:0006127 glycerophosphate shuttle P 1 0 GO:0046474 glycerophospholipid biosynthetic process P 30 9 GO:0006650 glycerophospholipid metabolic process P 56 17 GO:0031456 glycine betaine biosynthetic process P 1 0 GO:0019285 glycine betaine biosynthetic process from choline P 1 0 GO:0031455 glycine betaine metabolic process P 1 0 GO:0006545 glycine biosynthetic process P 1 0 GO:0006546 glycine catabolic process P 6 0 GO:0019464 glycine decarboxylation via glycine cleavage system P 1 0 GO:0006544 glycine metabolic process P 8 0 GO:0015816 glycine transport P 3 3 GO:0005978 glycogen biosynthetic process P 11 4 GO:0005980 glycogen catabolic process P 4 4 GO:0005977 glycogen metabolic process P 31 12 GO:0009247 glycolipid biosynthetic process P 8 4 GO:0019377 glycolipid catabolic process P 5 4 GO:0006664 glycolipid metabolic process P 16 10 GO:0046836 glycolipid transport P 2 0 GO:0006096 glycolysis P 44 0 GO:0009101 glycoprotein biosynthetic process P 84 21 GO:0006516 glycoprotein catabolic process P 10 7 GO:0009100 glycoprotein metabolic process P 97 31 GO:0006024 glycosaminoglycan biosynthetic process P 7 4 GO:0006027 glycosaminoglycan catabolic process P 1 1 GO:0030203 glycosaminoglycan metabolic process P 19 10 GO:0006688 glycosphingolipid biosynthetic process P 5 2 GO:0046479 glycosphingolipid catabolic process P 3 3 GO:0006687 glycosphingolipid metabolic process P 10 6 GO:0046476 glycosylceramide biosynthetic process P 2 1 GO:0046477 glycosylceramide catabolic process P 2 1 GO:0006677 glycosylceramide metabolic process P 5 3 GO:0006426 glycyl-tRNA aminoacylation P 3 0 GO:0006097 glyoxylate cycle P 3 0 GO:0046487 glyoxylate metabolic process P 4 1 GO:0006177 GMP biosynthetic process P 3 0 GO:0046038 GMP catabolic process P 1 0 GO:0046037 GMP metabolic process P 4 0 GO:0007030 Golgi organization and biogenesis P 5 3 GO:0006895 Golgi to endosome transport P 1 1 GO:0043001 Golgi to plasma membrane protein transport P 2 0 GO:0006893 Golgi to plasma membrane transport P 5 0 GO:0006896 Golgi to vacuole transport P 1 0 GO:0048193 Golgi vesicle transport P 38 6 GO:0008406 gonad development P 51 50 GO:0007506 gonadal mesoderm development P 1 0 GO:0006506 GPI anchor biosynthetic process P 21 2 GO:0006505 GPI anchor metabolic process P 22 3 GO:0006507 GPI anchor release P 1 1 GO:0002031 G-protein coupled receptor internalization P 1 1 GO:0007186 G-protein coupled receptor protein signaling pathway P 1823 108 GO:0007189 G-protein signaling, adenylate cyclase activating pathway P 35 22 GO:0007193 G-protein signaling, adenylate cyclase inhibiting pathway P 12 11 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger P 55 38 GO:0007199 G-protein signaling, coupled to cGMP nucleotide second messenger P 3 0 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger P 58 38 GO:0007200 G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) P 30 17 GO:0031583 G-protein signaling, phospholipase D activating pathway P 1 1 GO:0021930 granule cell precursor proliferation P 8 8 GO:0030851 granulocyte differentiation P 7 5 GO:0042253 granulocyte macrophage colony-stimulating factor biosynthetic process P 3 3 GO:0032604 granulocyte macrophage colony-stimulating factor production P 3 3 GO:0002432 granuloma formation P 1 1 GO:0060014 granulosa cell differentiation P 1 1 GO:0033380 granzyme B localization in T cell secretory granule P 1 1 GO:0007625 grooming behavior P 6 6 GO:0006752 group transfer coenzyme metabolic process P 57 4 GO:0040007 growth P 231 126 GO:0030252 growth hormone secretion P 5 5 GO:0006183 GTP biosynthetic process P 9 0 GO:0046039 GTP metabolic process P 9 0 GO:0046098 guanine metabolic process P 1 1 GO:0006178 guanine salvage P 1 1 GO:0046114 guanosine biosynthetic process P 1 0 GO:0008617 guanosine metabolic process P 1 0 GO:0048565 gut development P 18 18 GO:0048547 gut morphogenesis P 11 11 GO:0035315 hair cell differentiation P 1 0 GO:0042633 hair cycle P 40 38 GO:0022405 hair cycle process P 37 36 GO:0001942 hair follicle development P 37 36 GO:0048820 hair follicle maturation P 13 13 GO:0031069 hair follicle morphogenesis P 14 14 GO:0035188 hatching P 4 4 GO:0008258 head involution P 1 1 GO:0035287 head segmentation P 1 1 GO:0002246 healing during inflammatory response P 1 1 GO:0060047 heart contraction P 42 39 GO:0007507 heart development P 164 160 GO:0001947 heart looping P 14 14 GO:0003007 heart morphogenesis P 32 31 GO:0031649 heat generation P 6 4 GO:0006784 heme a biosynthetic process P 1 1 GO:0046160 heme a metabolic process P 1 1 GO:0006783 heme biosynthetic process P 11 3 GO:0042167 heme catabolic process P 1 0 GO:0042168 heme metabolic process P 16 4 GO:0006788 heme oxidation P 2 0 GO:0015886 heme transport P 1 1 GO:0042386 hemocyte differentiation P 1 1 GO:0042541 hemoglobin biosynthetic process P 4 3 GO:0020027 hemoglobin metabolic process P 5 3 GO:0030097 hemopoiesis P 201 176 GO:0048534 hemopoietic or lymphoid organ development P 226 197 GO:0002244 hemopoietic progenitor cell differentiation P 5 5 GO:0007599 hemostasis P 53 15 GO:0015012 heparan sulfate proteoglycan biosynthetic process P 6 6 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process P 1 1 GO:0030201 heparan sulfate proteoglycan metabolic process P 7 6 GO:0030210 heparin biosynthetic process P 1 1 GO:0030202 heparin metabolic process P 2 2 GO:0048012 hepatocyte growth factor receptor signaling pathway P 3 3 GO:0031507 heterochromatin formation P 13 4 GO:0046483 heterocycle metabolic process P 65 23 GO:0007157 heterophilic cell adhesion P 16 4 GO:0006059 hexitol metabolic process P 1 1 GO:0019319 hexose biosynthetic process P 23 8 GO:0019320 hexose catabolic process P 51 2 GO:0019318 hexose metabolic process P 126 31 GO:0008645 hexose transport P 28 22 GO:0030902 hindbrain development P 38 38 GO:0021578 hindbrain maturation P 1 1 GO:0021575 hindbrain morphogenesis P 12 12 GO:0021932 hindbrain radial glia guided cell migration P 1 1 GO:0021577 hindbrain structural organization P 1 1 GO:0007442 hindgut morphogenesis P 5 5 GO:0035137 hindlimb morphogenesis P 21 20 GO:0021766 hippocampus development P 5 5 GO:0000105 histidine biosynthetic process P 1 0 GO:0006548 histidine catabolic process P 9 3 GO:0019556 histidine catabolic process to glutamate and formamide P 1 0 GO:0009076 histidine family amino acid biosynthetic process P 1 0 GO:0009077 histidine family amino acid catabolic process P 9 3 GO:0009075 histidine family amino acid metabolic process P 9 3 GO:0006547 histidine metabolic process P 9 3 GO:0015817 histidine transport P 1 1 GO:0006427 histidyl-tRNA aminoacylation P 2 0 GO:0016573 histone acetylation P 9 7 GO:0016575 histone deacetylation P 6 1 GO:0043486 histone exchange P 1 1 GO:0051568 histone H3-K4 methylation P 1 1 GO:0051567 histone H3-K9 methylation P 4 4 GO:0016571 histone methylation P 15 15 GO:0016570 histone modification P 34 27 GO:0006398 histone mRNA 3'-end processing P 2 1 GO:0008334 histone mRNA metabolic process P 2 1 GO:0016572 histone phosphorylation P 1 1 GO:0016574 histone ubiquitination P 5 5 GO:0048872 homeostasis of number of cells P 26 25 GO:0048873 homeostasis of number of cells within a tissue P 1 1 GO:0042592 homeostatic process P 312 206 GO:0042309 homoiothermy P 1 1 GO:0045143 homologous chromosome segregation P 3 3 GO:0007156 homophilic cell adhesion P 84 12 GO:0042446 hormone biosynthetic process P 36 15 GO:0042447 hormone catabolic process P 3 3 GO:0042445 hormone metabolic process P 80 53 GO:0046879 hormone secretion P 41 34 GO:0009755 hormone-mediated signaling P 7 2 GO:0006959 humoral immune response P 135 22 GO:0002455 humoral immune response mediated by circulating immunoglobulin P 33 10 GO:0030212 hyaluronan metabolic process P 4 0 GO:0050665 hydrogen peroxide biosynthetic process P 1 1 GO:0042744 hydrogen peroxide catabolic process P 6 3 GO:0042743 hydrogen peroxide metabolic process P 7 4 GO:0006818 hydrogen transport P 65 6 GO:0006972 hyperosmotic response P 4 4 GO:0042538 hyperosmotic salinity response P 1 1 GO:0002524 hypersensitivity P 12 12 GO:0048850 hypophysis morphogenesis P 1 1 GO:0021979 hypothalamus cell differentiation P 3 3 GO:0021854 hypothalamus development P 3 3 GO:0046100 hypoxanthine metabolic process P 1 1 GO:0046515 hypusine biosynthetic process P 1 0 GO:0008612 hypusine biosynthetic process from peptidyl-lysine P 1 0 GO:0046516 hypusine metabolic process P 1 0 GO:0046456 icosanoid biosynthetic process P 24 5 GO:0006690 icosanoid metabolic process P 30 10 GO:0046709 IDP catabolic process P 1 1 GO:0046707 IDP metabolic process P 1 1 GO:0007249 I-kappaB kinase/NF-kappaB cascade P 35 21 GO:0007252 I-kappaB phosphorylation P 3 1 GO:0002327 immature B cell differentiation P 1 1 GO:0033079 immature T cell proliferation P 4 4 GO:0033080 immature T cell proliferation in the thymus P 4 4 GO:0002252 immune effector process P 129 91 GO:0006955 immune response P 485 144 GO:0002418 immune response to tumor cell P 4 4 GO:0002429 immune response-activating cell surface receptor signaling pathway P 32 29 GO:0002757 immune response-activating signal transduction P 36 33 GO:0002768 immune response-regulating cell surface receptor signaling pathway P 34 31 GO:0002764 immune response-regulating signal transduction P 38 35 GO:0002520 immune system development P 243 213 GO:0002376 immune system process P 721 375 GO:0016064 immunoglobulin mediated immune response P 68 44 GO:0002377 immunoglobulin production P 37 34 GO:0002381 immunoglobulin production during immune response P 20 18 GO:0002426 immunoglobulin production in mucosal tissue P 1 1 GO:0048305 immunoglobulin secretion P 11 10 GO:0033152 immunoglobulin V(D)J recombination P 4 4 GO:0006188 IMP biosynthetic process P 2 0 GO:0046040 IMP metabolic process P 2 0 GO:0001701 in utero embryonic development P 109 105 GO:0000188 inactivation of MAPK activity P 9 8 GO:0001997 increased strength of heart contraction by epinephrine-norepinephrine P 3 3 GO:0046219 indolalkylamine biosynthetic process P 3 1 GO:0046218 indolalkylamine catabolic process P 3 2 GO:0006586 indolalkylamine metabolic process P 10 5 GO:0042430 indole and derivative metabolic process P 10 5 GO:0042435 indole derivative biosynthetic process P 3 1 GO:0042436 indole derivative catabolic process P 3 2 GO:0042434 indole derivative metabolic process P 10 5 GO:0031128 induction P 14 14 GO:0001759 induction of an organ P 13 13 GO:0006917 induction of apoptosis P 126 97 GO:0008624 induction of apoptosis by extracellular signals P 17 14 GO:0008626 induction of apoptosis by granzyme P 1 1 GO:0008629 induction of apoptosis by intracellular signals P 29 22 GO:0008631 induction of apoptosis by oxidative stress P 5 5 GO:0008625 induction of apoptosis via death domain receptors P 6 5 GO:0050930 induction of positive chemotaxis P 7 6 GO:0012502 induction of programmed cell death P 126 97 GO:0031129 inductive cell-cell signaling P 1 1 GO:0006925 inflammatory cell apoptosis P 2 2 GO:0006954 inflammatory response P 202 68 GO:0002437 inflammatory response to antigenic stimulus P 12 12 GO:0001544 initiation of primordial ovarian follicle growth P 1 1 GO:0045087 innate immune response P 88 27 GO:0002220 innate immune response activating cell surface receptor signaling pathway P 4 4 GO:0002758 innate immune response-activating signal transduction P 8 8 GO:0001826 inner cell mass cell differentiation P 2 2 GO:0001833 inner cell mass cell proliferation P 8 8 GO:0048839 inner ear development P 69 69 GO:0042472 inner ear morphogenesis P 53 52 GO:0060119 inner ear receptor cell development P 8 8 GO:0060113 inner ear receptor cell differentiation P 27 27 GO:0060120 inner ear receptor cell fate commitment P 5 4 GO:0060122 inner ear receptor stereocilium organization and biogenesis P 7 7 GO:0007007 inner mitochondrial membrane organization and biogenesis P 4 0 GO:0015698 inorganic anion transport P 139 16 GO:0046853 inositol and derivative phosphorylation P 1 1 GO:0006021 inositol biosynthetic process P 2 1 GO:0048017 inositol lipid-mediated signaling P 1 0 GO:0006020 inositol metabolic process P 9 3 GO:0032958 inositol phosphate biosynthetic process P 1 1 GO:0046855 inositol phosphate dephosphorylation P 1 0 GO:0043647 inositol phosphate metabolic process P 2 1 GO:0048016 inositol phosphate-mediated signaling P 2 0 GO:0032959 inositol trisphosphate biosynthetic process P 1 1 GO:0032957 inositol trisphosphate metabolic process P 2 1 GO:0007320 insemination P 4 3 GO:0030070 insulin processing P 1 1 GO:0008286 insulin receptor signaling pathway P 25 23 GO:0030073 insulin secretion P 22 18 GO:0048009 insulin-like growth factor receptor signaling pathway P 9 8 GO:0033622 integrin activation P 1 1 GO:0045112 integrin biosynthetic process P 1 1 GO:0007229 integrin-mediated signaling pathway P 88 8 GO:0016539 intein-mediated protein splicing P 3 0 GO:0007043 intercellular junction assembly P 4 4 GO:0045216 intercellular junction assembly and maintenance P 8 7 GO:0045217 intercellular junction maintenance P 2 2 GO:0045351 interferon type I biosynthetic process P 7 6 GO:0032606 interferon type I production P 7 6 GO:0045350 interferon-beta biosynthetic process P 2 1 GO:0032608 interferon-beta production P 2 1 GO:0042095 interferon-gamma biosynthetic process P 8 6 GO:0032609 interferon-gamma production P 15 13 GO:0048219 inter-Golgi cisterna vesicle-mediated transport P 1 0 GO:0032611 interleukin-1 beta production P 1 1 GO:0050702 interleukin-1 beta secretion P 1 1 GO:0042222 interleukin-1 biosynthetic process P 1 0 GO:0032612 interleukin-1 production P 2 1 GO:0050701 interleukin-1 secretion P 1 1 GO:0042091 interleukin-10 biosynthetic process P 1 1 GO:0032613 interleukin-10 production P 5 5 GO:0042090 interleukin-12 biosynthetic process P 7 7 GO:0032615 interleukin-12 production P 11 11 GO:0042231 interleukin-13 biosynthetic process P 2 0 GO:0032616 interleukin-13 production P 2 0 GO:0042094 interleukin-2 biosynthetic process P 15 14 GO:0032623 interleukin-2 production P 16 15 GO:0042223 interleukin-3 biosynthetic process P 3 3 GO:0032632 interleukin-3 production P 3 3 GO:0042097 interleukin-4 biosynthetic process P 3 3 GO:0032633 interleukin-4 production P 4 4 GO:0042225 interleukin-5 biosynthetic process P 1 1 GO:0032634 interleukin-5 production P 2 2 GO:0042226 interleukin-6 biosynthetic process P 10 9 GO:0032635 interleukin-6 production P 15 14 GO:0045110 intermediate filament bundle assembly P 3 3 GO:0045104 intermediate filament cytoskeleton organization and biogenesis P 17 17 GO:0045109 intermediate filament organization P 9 9 GO:0045103 intermediate filament-based process P 20 20 GO:0048389 intermediate mesoderm development P 1 1 GO:0006475 internal protein amino acid acetylation P 2 0 GO:0021830 interneuron migration from the subpallium to the cortex P 3 3 GO:0051325 interphase P 42 30 GO:0051329 interphase of mitotic cell cycle P 42 30 GO:0044419 interspecies interaction between organisms P 4 1 GO:0050892 intestinal absorption P 9 9 GO:0015680 intracellular copper ion transport P 1 1 GO:0048312 intracellular distribution of mitochondria P 1 1 GO:0008298 intracellular mRNA localization P 2 2 GO:0006886 intracellular protein transport P 405 75 GO:0065002 intracellular protein transport across a membrane P 66 12 GO:0030522 intracellular receptor-mediated signaling pathway P 18 16 GO:0007242 intracellular signaling cascade P 976 351 GO:0046907 intracellular transport P 585 131 GO:0042073 intraflagellar transport P 1 0 GO:0006891 intra-Golgi vesicle-mediated transport P 5 1 GO:0001957 intramembranous ossification P 3 3 GO:0031573 intra-S DNA damage checkpoint P 3 3 GO:0050801 ion homeostasis P 124 74 GO:0006811 ion transport P 682 118 GO:0035235 ionotropic glutamate receptor signaling pathway P 2 2 GO:0055072 iron ion homeostasis P 23 7 GO:0006826 iron ion transport P 27 7 GO:0016226 iron-sulfur cluster assembly P 2 0 GO:0001980 ischemic regulation of blood pressure P 1 1 GO:0032020 ISG15-protein conjugation P 4 4 GO:0006428 isoleucyl-tRNA aminoacylation P 2 0 GO:0008299 isoprenoid biosynthetic process P 18 2 GO:0008300 isoprenoid catabolic process P 1 0 GO:0006720 isoprenoid metabolic process P 30 13 GO:0045190 isotype switching P 20 18 GO:0048290 isotype switching to IgA isotypes P 2 1 GO:0048289 isotype switching to IgE isotypes P 4 4 GO:0048291 isotype switching to IgG isotypes P 8 8 GO:0007259 JAK-STAT cascade P 27 19 GO:0007254 JNK cascade P 43 35 GO:0007258 JUN phosphorylation P 2 2 GO:0018146 keratan sulfate biosynthetic process P 1 1 GO:0042339 keratan sulfate metabolic process P 1 1 GO:0031424 keratinization P 27 3 GO:0030216 keratinocyte differentiation P 23 9 GO:0051546 keratinocyte migration P 2 2 GO:0043616 keratinocyte proliferation P 1 1 GO:0046950 ketone body metabolic process P 2 2 GO:0001822 kidney development P 69 68 GO:0051383 kinetochore organization and biogenesis P 1 0 GO:0032808 lacrimal gland development P 1 1 GO:0006089 lactate metabolic process P 1 1 GO:0007595 lactation P 15 13 GO:0005989 lactose biosynthetic process P 2 1 GO:0005988 lactose metabolic process P 2 1 GO:0015808 L-alanine transport P 2 2 GO:0030032 lamellipodium biogenesis P 15 15 GO:0043092 L-amino acid import P 1 1 GO:0015807 L-amino acid transport P 10 10 GO:0019853 L-ascorbic acid biosynthetic process P 2 2 GO:0019852 L-ascorbic acid metabolic process P 3 3 GO:0019042 latent virus infection P 1 1 GO:0021771 lateral geniculate nucleus development P 1 1 GO:0048368 lateral mesoderm development P 1 1 GO:0021670 lateral ventricle development P 2 2 GO:0019448 L-cysteine catabolic process P 2 0 GO:0019452 L-cysteine catabolic process to taurine P 2 0 GO:0046439 L-cysteine metabolic process P 2 0 GO:0015811 L-cystine transport P 1 1 GO:0035026 leading edge cell differentiation P 1 1 GO:0007612 learning P 46 45 GO:0007611 learning and/or memory P 66 64 GO:0006653 lecithin metabolic process P 1 0 GO:0035110 leg morphogenesis P 3 2 GO:0002088 lens development in camera-type eye P 10 9 GO:0002089 lens morphogenesis in camera-type eye P 1 0 GO:0006429 leucyl-tRNA aminoacylation P 2 0 GO:0045321 leukocyte activation P 203 176 GO:0002366 leukocyte activation during immune response P 9 8 GO:0007159 leukocyte adhesion P 5 5 GO:0030595 leukocyte chemotaxis P 19 15 GO:0043299 leukocyte degranulation P 10 7 GO:0002521 leukocyte differentiation P 123 108 GO:0001776 leukocyte homeostasis P 24 23 GO:0001909 leukocyte mediated cytotoxicity P 22 22 GO:0002443 leukocyte mediated immunity P 96 68 GO:0050900 leukocyte migration P 29 25 GO:0050901 leukocyte tethering or rolling P 2 2 GO:0019370 leukotriene biosynthetic process P 16 4 GO:0006691 leukotriene metabolic process P 17 6 GO:0033327 Leydig cell differentiation P 2 2 GO:0006005 L-fucose biosynthetic process P 1 0 GO:0042354 L-fucose metabolic process P 1 0 GO:0051938 L-glutamate import P 1 1 GO:0060173 limb development P 75 74 GO:0035108 limb morphogenesis P 74 73 GO:0021761 limbic system development P 10 10 GO:0008610 lipid biosynthetic process P 230 61 GO:0016042 lipid catabolic process P 95 17 GO:0044241 lipid digestion P 5 5 GO:0030259 lipid glycosylation P 4 0 GO:0006629 lipid metabolic process P 580 193 GO:0030258 lipid modification P 23 1 GO:0046834 lipid phosphorylation P 10 1 GO:0031580 lipid raft distribution P 1 1 GO:0051665 lipid raft localization P 1 1 GO:0031579 lipid raft organization and biogenesis P 2 2 GO:0001766 lipid raft polarization P 1 1 GO:0006869 lipid transport P 69 17 GO:0009107 lipoate biosynthetic process P 2 0 GO:0009106 lipoate metabolic process P 2 0 GO:0009105 lipoic acid biosynthetic process P 2 1 GO:0000273 lipoic acid metabolic process P 2 1 GO:0009103 lipopolysaccharide biosynthetic process P 2 0 GO:0008653 lipopolysaccharide metabolic process P 3 1 GO:0031663 lipopolysaccharide-mediated signaling pathway P 11 11 GO:0042158 lipoprotein biosynthetic process P 52 18 GO:0042159 lipoprotein catabolic process P 3 3 GO:0042157 lipoprotein metabolic process P 62 24 GO:0042953 lipoprotein transport P 3 2 GO:0001889 liver development P 19 19 GO:0051179 localization P 2631 811 GO:0051674 localization of cell P 322 283 GO:0051668 localization within membrane P 7 5 GO:0040011 locomotion P 72 61 GO:0031987 locomotion during locomotory behavior P 2 2 GO:0045475 locomotor rhythm P 3 2 GO:0007626 locomotory behavior P 200 135 GO:0042759 long-chain fatty acid biosynthetic process P 4 3 GO:0001676 long-chain fatty acid metabolic process P 14 6 GO:0015909 long-chain fatty acid transport P 2 1 GO:0007616 long-term memory P 3 3 GO:0045192 low-density lipoprotein catabolic process P 1 1 GO:0032802 low-density lipoprotein receptor catabolic process P 1 1 GO:0032799 low-density lipoprotein receptor metabolic process P 1 1 GO:0006559 L-phenylalanine catabolic process P 7 0 GO:0006558 L-phenylalanine metabolic process P 8 0 GO:0006564 L-serine biosynthetic process P 3 0 GO:0006563 L-serine metabolic process P 5 0 GO:0035148 lumen formation P 1 1 GO:0030324 lung development P 60 59 GO:0001553 luteinization P 3 3 GO:0048535 lymph node development P 17 10 GO:0001945 lymph vessel development P 5 5 GO:0001946 lymphangiogenesis P 2 1 GO:0046649 lymphocyte activation P 186 163 GO:0002285 lymphocyte activation during immune response P 8 7 GO:0002249 lymphocyte anergy P 1 1 GO:0031294 lymphocyte costimulation P 8 8 GO:0030098 lymphocyte differentiation P 89 78 GO:0002260 lymphocyte homeostasis P 18 17 GO:0002449 lymphocyte mediated immunity P 89 65 GO:0046651 lymphocyte proliferation P 74 69 GO:0002320 lymphoid progenitor cell differentiation P 3 3 GO:0009085 lysine biosynthetic process P 1 0 GO:0009089 lysine biosynthetic process via diaminopimelate P 1 0 GO:0006553 lysine metabolic process P 1 0 GO:0015819 lysine transport P 1 1 GO:0030069 lysogeny P 1 0 GO:0007042 lysosomal lumen acidification P 2 0 GO:0007041 lysosomal transport P 8 5 GO:0007040 lysosome organization and biogenesis P 14 11 GO:0006430 lysyl-tRNA aminoacylation P 1 0 GO:0000279 M phase P 230 62 GO:0051327 M phase of meiotic cell cycle P 73 39 GO:0000087 M phase of mitotic cell cycle P 168 24 GO:0000072 M phase specific microtubule process P 1 1 GO:0016236 macroautophagy P 11 3 GO:0065003 macromolecular complex assembly P 316 70 GO:0032984 macromolecular complex disassembly P 14 1 GO:0009059 macromolecule biosynthetic process P 648 166 GO:0009057 macromolecule catabolic process P 289 75 GO:0033036 macromolecule localization P 751 161 GO:0043170 macromolecule metabolic process P 5285 1212 GO:0042116 macrophage activation P 7 5 GO:0002281 macrophage activation during immune response P 1 1 GO:0048246 macrophage chemotaxis P 1 1 GO:0030225 macrophage differentiation P 9 9 GO:0035090 maintenance of apical/basal cell polarity P 1 1 GO:0030011 maintenance of cell polarity P 1 1 GO:0051651 maintenance of cellular localization P 8 5 GO:0032507 maintenance of cellular protein localization P 6 3 GO:0051661 maintenance of centrosome localization P 1 1 GO:0010216 maintenance of DNA methylation P 3 3 GO:0051685 maintenance of ER localization P 1 1 GO:0045005 maintenance of fidelity during DNA-dependent DNA replication P 11 8 GO:0033382 maintenance of granzyme B localization in T cell secretory granule P 1 1 GO:0051235 maintenance of localization P 15 10 GO:0051657 maintenance of organelle localization P 2 2 GO:0033373 maintenance of protease localization in mast cell secretory granule P 1 1 GO:0033379 maintenance of protease localization in T cell secretory granule P 1 1 GO:0045185 maintenance of protein localization P 9 5 GO:0033370 maintenance of protein localization in mast cell secretory granule P 1 1 GO:0051457 maintenance of protein localization in nucleus P 1 1 GO:0033377 maintenance of protein localization in T cell secretory granule P 1 1 GO:0006108 malate metabolic process P 5 0 GO:0043490 malate-aspartate shuttle P 2 2 GO:0008049 male courtship behavior P 1 1 GO:0048232 male gamete generation P 189 104 GO:0030539 male genitalia development P 6 6 GO:0048136 male germ-line cyst formation P 1 1 GO:0019100 male germ-line sex determination P 2 2 GO:0048133 male germ-line stem cell division P 1 1 GO:0008584 male gonad development P 17 17 GO:0007140 male meiosis P 9 8 GO:0007060 male meiosis chromosome segregation P 1 1 GO:0007141 male meiosis I P 3 3 GO:0007065 male meiosis sister chromatid cohesion P 1 0 GO:0035039 male pronucleus formation P 1 0 GO:0030238 male sex determination P 10 10 GO:0046661 male sex differentiation P 27 27 GO:0019102 male somatic sex determination P 1 1 GO:0030879 mammary gland development P 20 20 GO:0060056 mammary gland involution P 3 3 GO:0019307 mannose biosynthetic process P 2 0 GO:0006013 mannose metabolic process P 10 1 GO:0015761 mannose transport P 1 0 GO:0000165 MAPKKK cascade P 119 101 GO:0002315 marginal zone B cell differentiation P 1 1 GO:0045576 mast cell activation P 12 7 GO:0033024 mast cell apoptosis P 1 1 GO:0032762 mast cell cytokine production P 2 2 GO:0043303 mast cell degranulation P 7 4 GO:0033023 mast cell homeostasis P 1 1 GO:0002448 mast cell mediated immunity P 7 4 GO:0033364 mast cell secretory granule organization and biogenesis P 1 1 GO:0042711 maternal behavior P 4 4 GO:0001893 maternal placenta development P 1 1 GO:0007618 mating P 12 11 GO:0007617 mating behavior P 9 9 GO:0042628 mating plug formation P 1 1 GO:0030490 maturation of SSU-rRNA P 1 0 GO:0002335 mature B cell differentiation P 2 2 GO:0002313 mature B cell differentiation during immune response P 1 1 GO:0042256 mature ribosome assembly P 1 0 GO:0042490 mechanoreceptor differentiation P 33 33 GO:0007638 mechanosensory behavior P 4 4 GO:0021526 medial motor column neuron differentiation P 2 2 GO:0030219 megakaryocyte differentiation P 1 0 GO:0007126 meiosis P 73 39 GO:0007127 meiosis I P 28 20 GO:0051321 meiotic cell cycle P 74 40 GO:0033313 meiotic cell cycle checkpoint P 1 1 GO:0033315 meiotic cell cycle DNA replication checkpoint P 1 1 GO:0010032 meiotic chromosome condensation P 1 1 GO:0045132 meiotic chromosome segregation P 7 5 GO:0051307 meiotic chromosome separation P 2 1 GO:0042138 meiotic DNA double-strand break formation P 1 1 GO:0006311 meiotic gene conversion P 1 1 GO:0007132 meiotic metaphase I P 2 2 GO:0043060 meiotic metaphase I plate congression P 1 1 GO:0051311 meiotic metaphase plate congression P 1 1 GO:0007128 meiotic prophase I P 9 5 GO:0007131 meiotic recombination P 7 3 GO:0051177 meiotic sister chromatid cohesion P 3 2 GO:0000212 meiotic spindle organization and biogenesis P 3 3 GO:0042438 melanin biosynthetic process P 10 7 GO:0006583 melanin biosynthetic process from tyrosine P 6 1 GO:0006582 melanin metabolic process P 10 8 GO:0030318 melanocyte differentiation P 17 17 GO:0032400 melanosome localization P 5 4 GO:0032438 melanosome organization and biogenesis P 4 4 GO:0032402 melanosome transport P 3 3 GO:0030187 melatonin biosynthetic process P 1 1 GO:0030186 melatonin metabolic process P 1 1 GO:0006900 membrane budding P 3 0 GO:0051899 membrane depolarization P 14 13 GO:0022406 membrane docking P 16 0 GO:0006944 membrane fusion P 14 7 GO:0060081 membrane hyperpolarization P 3 3 GO:0010324 membrane invagination P 158 68 GO:0046467 membrane lipid biosynthetic process P 72 18 GO:0046466 membrane lipid catabolic process P 16 6 GO:0006643 membrane lipid metabolic process P 149 45 GO:0016044 membrane organization and biogenesis P 215 99 GO:0006509 membrane protein ectodomain proteolysis P 1 1 GO:0033619 membrane protein proteolysis P 1 1 GO:0007613 memory P 16 16 GO:0043379 memory T cell differentiation P 1 1 GO:0042698 menstrual cycle P 40 31 GO:0022601 menstrual cycle phase P 29 29 GO:0022602 menstrual cycle process P 30 30 GO:0015694 mercury ion transport P 1 0 GO:0014031 mesenchymal cell development P 39 36 GO:0048762 mesenchymal cell differentiation P 39 36 GO:0048382 mesendoderm development P 1 1 GO:0007498 mesoderm development P 49 44 GO:0001707 mesoderm formation P 25 25 GO:0007509 mesoderm migration P 2 2 GO:0048332 mesoderm morphogenesis P 26 26 GO:0048333 mesodermal cell differentiation P 3 3 GO:0001710 mesodermal cell fate commitment P 3 3 GO:0007500 mesodermal cell fate determination P 1 1 GO:0008078 mesodermal cell migration P 2 2 GO:0001823 mesonephros development P 2 2 GO:0043094 metabolic compound salvage P 4 3 GO:0008152 metabolic process P 6778 1630 GO:0007216 metabotropic glutamate receptor signaling pathway P 4 0 GO:0055065 metal ion homeostasis P 67 49 GO:0030001 metal ion transport P 386 81 GO:0031163 metallo-sulfur cluster assembly P 2 0 GO:0001656 metanephros development P 45 45 GO:0051323 metaphase P 6 5 GO:0051310 metaphase plate congression P 2 1 GO:0022037 metencephalon development P 19 19 GO:0009086 methionine biosynthetic process P 7 3 GO:0006555 methionine metabolic process P 7 3 GO:0006431 methionyl-tRNA aminoacylation P 2 0 GO:0032259 methylation P 48 24 GO:0006346 methylation-dependent chromatin silencing P 4 4 GO:0045341 MHC class I biosynthetic process P 2 1 GO:0045342 MHC class II biosynthetic process P 4 4 GO:0030035 microspike biogenesis P 10 6 GO:0001578 microtubule bundle formation P 9 8 GO:0000226 microtubule cytoskeleton organization and biogenesis P 63 45 GO:0007019 microtubule depolymerization P 11 7 GO:0007020 microtubule nucleation P 3 1 GO:0031023 microtubule organizing center organization and biogenesis P 9 6 GO:0046785 microtubule polymerization P 3 3 GO:0031109 microtubule polymerization or depolymerization P 14 11 GO:0007018 microtubule-based movement P 86 17 GO:0060152 microtubule-based peroxisome localization P 2 1 GO:0007017 microtubule-based process P 178 67 GO:0030033 microvillus biogenesis P 3 3 GO:0032528 microvillus organization and biogenesis P 3 3 GO:0060073 micturition P 5 5 GO:0030901 midbrain development P 11 11 GO:0030917 midbrain-hindbrain boundary development P 3 3 GO:0021732 midbrain-hindbrain boundary maturation P 1 1 GO:0022004 midbrain-hindbrain boundary maturation during brain development P 1 1 GO:0021555 midbrain-hindbrain boundary morphogenesis P 1 1 GO:0042474 middle ear morphogenesis P 5 5 GO:0007494 midgut development P 2 2 GO:0006705 mineralocorticoid biosynthetic process P 1 1 GO:0008212 mineralocorticoid metabolic process P 2 2 GO:0035195 miRNA-mediated gene silencing P 3 2 GO:0035196 miRNA-mediated gene silencing, production of miRNAs P 3 2 GO:0006515 misfolded or incompletely synthesized protein catabolic process P 6 5 GO:0006298 mismatch repair P 10 7 GO:0006851 mitochondrial calcium ion transport P 1 1 GO:0051882 mitochondrial depolarization P 2 2 GO:0032042 mitochondrial DNA metabolic process P 1 1 GO:0006264 mitochondrial DNA replication P 1 1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone P 11 0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c P 4 0 GO:0000266 mitochondrial fission P 1 1 GO:0008053 mitochondrial fusion P 4 4 GO:0000002 mitochondrial genome maintenance P 4 1 GO:0048250 mitochondrial iron ion transport P 1 1 GO:0007006 mitochondrial membrane organization and biogenesis P 13 7 GO:0006627 mitochondrial protein processing P 1 1 GO:0006839 mitochondrial transport P 22 4 GO:0048311 mitochondrion distribution P 1 1 GO:0051646 mitochondrion localization P 1 1 GO:0007005 mitochondrion organization and biogenesis P 65 38 GO:0047497 mitochondrion transport along microtubule P 1 1 GO:0007067 mitosis P 166 24 GO:0000278 mitotic cell cycle P 223 69 GO:0007093 mitotic cell cycle checkpoint P 13 9 GO:0007095 mitotic cell cycle G2/M transition DNA damage checkpoint P 3 2 GO:0007094 mitotic cell cycle spindle assembly checkpoint P 4 2 GO:0045448 mitotic cell cycle, embryonic P 1 1 GO:0007100 mitotic centrosome separation P 2 2 GO:0007076 mitotic chromosome condensation P 13 1 GO:0000089 mitotic metaphase P 4 3 GO:0007091 mitotic metaphase/anaphase transition P 8 1 GO:0006312 mitotic recombination P 2 2 GO:0000070 mitotic sister chromatid segregation P 17 5 GO:0007052 mitotic spindle organization and biogenesis P 3 0 GO:0043632 modification-dependent macromolecule catabolic process P 122 29 GO:0019941 modification-dependent protein catabolic process P 122 29 GO:0042303 molting cycle P 40 38 GO:0022404 molting cycle process P 37 36 GO:0032324 molybdopterin cofactor biosynthetic process P 5 0 GO:0043545 molybdopterin cofactor metabolic process P 5 0 GO:0006777 Mo-molybdopterin cofactor biosynthetic process P 5 0 GO:0019720 Mo-molybdopterin cofactor metabolic process P 5 0 GO:0046462 monoacylglycerol metabolic process P 1 0 GO:0015844 monoamine transport P 3 0 GO:0032787 monocarboxylic acid metabolic process P 208 75 GO:0015718 monocarboxylic acid transport P 6 4 GO:0030224 monocyte differentiation P 3 2 GO:0032943 mononuclear cell proliferation P 74 69 GO:0046364 monosaccharide biosynthetic process P 25 10 GO:0046365 monosaccharide catabolic process P 51 2 GO:0005996 monosaccharide metabolic process P 129 35 GO:0015749 monosaccharide transport P 28 22 GO:0055083 monovalent inorganic anion homeostasis P 4 1 GO:0055067 monovalent inorganic cation homeostasis P 7 1 GO:0015672 monovalent inorganic cation transport P 291 32 GO:0001763 morphogenesis of a branching structure P 63 63 GO:0001738 morphogenesis of a polarized epithelium P 11 10 GO:0002011 morphogenesis of an epithelial sheet P 5 5 GO:0002009 morphogenesis of an epithelium P 121 120 GO:0016331 morphogenesis of embryonic epithelium P 71 71 GO:0008045 motor axon guidance P 9 9 GO:0031124 mRNA 3'-end processing P 14 6 GO:0006370 mRNA capping P 2 0 GO:0006402 mRNA catabolic process P 28 6 GO:0000288 mRNA catabolic process, deadenylation-dependent decay P 8 5 GO:0000294 mRNA catabolic process, endonucleolytic cleavage-dependent decay P 1 0 GO:0000291 mRNA catabolic process, exonucleolytic P 1 0 GO:0000184 mRNA catabolic process, nonsense-mediated decay P 16 0 GO:0006379 mRNA cleavage P 3 0 GO:0006406 mRNA export from nucleus P 11 6 GO:0016071 mRNA metabolic process P 248 27 GO:0016556 mRNA modification P 4 3 GO:0006378 mRNA polyadenylation P 8 2 GO:0006397 mRNA processing P 221 16 GO:0006376 mRNA splice site selection P 13 5 GO:0048255 mRNA stabilization P 2 2 GO:0009299 mRNA transcription P 1 0 GO:0042789 mRNA transcription from RNA polymerase II promoter P 1 0 GO:0051028 mRNA transport P 47 6 GO:0002385 mucosal immune response P 2 2 GO:0048537 mucosal-associated lymphoid tissue development P 1 1 GO:0001880 Mullerian duct regression P 1 1 GO:0035264 multicellular organism growth P 56 54 GO:0032504 multicellular organism reproduction P 67 55 GO:0010259 multicellular organismal aging P 9 9 GO:0044243 multicellular organismal catabolic process P 16 2 GO:0007275 multicellular organismal development P 2070 1485 GO:0048871 multicellular organismal homeostasis P 25 24 GO:0044266 multicellular organismal macromolecule catabolic process P 16 2 GO:0044259 multicellular organismal macromolecule metabolic process P 16 2 GO:0044236 multicellular organismal metabolic process P 19 5 GO:0050879 multicellular organismal movement P 50 50 GO:0032501 multicellular organismal process P 3914 1874 GO:0044254 multicellular organismal protein catabolic process P 16 2 GO:0044268 multicellular organismal protein metabolic process P 16 2 GO:0033555 multicellular organismal response to stress P 22 21 GO:0006855 multidrug transport P 2 0 GO:0051704 multi-organism process P 225 110 GO:0007207 muscarinic acetylcholine receptor, phospholipase C activating pathway P 1 0 GO:0055001 muscle cell development P 15 13 GO:0042692 muscle cell differentiation P 62 56 GO:0042693 muscle cell fate commitment P 2 2 GO:0007521 muscle cell fate determination P 1 1 GO:0042694 muscle cell fate specification P 1 1 GO:0033002 muscle cell proliferation P 11 10 GO:0006936 muscle contraction P 82 42 GO:0007517 muscle development P 163 131 GO:0048747 muscle fiber development P 63 56 GO:0030049 muscle filament sliding P 2 0 GO:0046716 muscle maintenance P 8 8 GO:0048644 muscle morphogenesis P 8 8 GO:0043500 muscle plasticity P 1 1 GO:0030240 muscle thin filament assembly P 1 1 GO:0050881 musculoskeletal movement P 8 8 GO:0050883 musculoskeletal movement, spinal reflex action P 2 2 GO:0002755 MyD88-dependent toll-like receptor signaling pathway P 2 2 GO:0002756 MyD88-independent toll-like receptor signaling pathway P 1 1 GO:0032288 myelin formation P 1 1 GO:0043217 myelin maintenance P 1 1 GO:0032287 myelin maintenance in the peripheral nervous system P 1 1 GO:0042552 myelination P 25 22 GO:0022010 myelination in the central nervous system P 1 1 GO:0022011 myelination in the peripheral nervous system P 2 2 GO:0002275 myeloid cell activation during immune response P 1 1 GO:0033028 myeloid cell apoptosis P 1 1 GO:0030099 myeloid cell differentiation P 89 77 GO:0002262 myeloid cell homeostasis P 7 7 GO:0001773 myeloid dendritic cell activation P 6 6 GO:0043011 myeloid dendritic cell differentiation P 5 5 GO:0002274 myeloid leukocyte activation P 25 19 GO:0002573 myeloid leukocyte differentiation P 39 35 GO:0002444 myeloid leukocyte mediated immunity P 15 12 GO:0002318 myeloid progenitor cell differentiation P 2 2 GO:0048625 myoblast cell fate commitment P 1 1 GO:0007518 myoblast cell fate determination P 1 1 GO:0048627 myoblast development P 22 19 GO:0045445 myoblast differentiation P 35 29 GO:0007520 myoblast fusion P 7 6 GO:0048628 myoblast maturation P 21 18 GO:0051451 myoblast migration P 2 2 GO:0051450 myoblast proliferation P 2 2 GO:0030239 myofibril assembly P 14 12 GO:0015798 myo-inositol transport P 1 1 GO:0031034 myosin filament assembly P 1 1 GO:0031033 myosin filament assembly or disassembly P 1 1 GO:0006045 N-acetylglucosamine biosynthetic process P 1 0 GO:0006046 N-acetylglucosamine catabolic process P 8 0 GO:0006044 N-acetylglucosamine metabolic process P 17 4 GO:0046380 N-acetylneuraminate biosynthetic process P 1 0 GO:0006054 N-acetylneuraminate metabolic process P 5 2 GO:0009435 NAD biosynthetic process P 7 2 GO:0019674 NAD metabolic process P 8 2 GO:0006734 NADH metabolic process P 1 0 GO:0006116 NADH oxidation P 1 0 GO:0006741 NADP biosynthetic process P 1 1 GO:0006742 NADP catabolic process P 3 0 GO:0006739 NADP metabolic process P 13 4 GO:0006740 NADPH regeneration P 7 1 GO:0030147 natriuresis P 2 2 GO:0030101 natural killer cell activation P 12 12 GO:0043320 natural killer cell degranulation P 2 2 GO:0001779 natural killer cell differentiation P 4 4 GO:0042267 natural killer cell mediated cytotoxicity P 15 15 GO:0002420 natural killer cell mediated cytotoxicity directed against tumor cell target P 1 1 GO:0002423 natural killer cell mediated immune response to tumor cell P 1 1 GO:0002228 natural killer cell mediated immunity P 15 15 GO:0001787 natural killer cell proliferation P 1 1 GO:0050919 negative chemotaxis P 4 4 GO:0030835 negative regulation of actin filament depolymerization P 19 0 GO:0030837 negative regulation of actin filament polymerization P 1 0 GO:0045759 negative regulation of action potential P 1 1 GO:0046007 negative regulation of activated T cell proliferation P 1 1 GO:0001971 negative regulation of activation of membrane attack complex P 1 1 GO:0002674 negative regulation of acute inflammatory response P 2 2 GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus P 2 2 GO:0002820 negative regulation of adaptive immune response P 5 5 GO:0002823 negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains P 5 5 GO:0007194 negative regulation of adenylate cyclase activity P 1 1 GO:0046636 negative regulation of alpha-beta T cell activation P 3 3 GO:0046639 negative regulation of alpha-beta T cell differentiation P 1 1 GO:0046642 negative regulation of alpha-beta T cell proliferation P 2 2 GO:0033239 negative regulation of amine metabolic process P 7 4 GO:0045763 negative regulation of amino acid metabolic process P 7 4 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process P 1 1 GO:0016525 negative regulation of angiogenesis P 16 9 GO:0019987 negative regulation of anti-apoptosis P 2 1 GO:0050858 negative regulation of antigen receptor-mediated signaling pathway P 5 5 GO:0043066 negative regulation of apoptosis P 147 119 GO:0032099 negative regulation of appetite P 2 2 GO:0048712 negative regulation of astrocyte differentiation P 2 2 GO:0045769 negative regulation of asymmetric cell division P 1 1 GO:0045608 negative regulation of auditory receptor cell differentiation P 2 2 GO:0030517 negative regulation of axon extension P 8 6 GO:0048843 negative regulation of axon extension involved in axon guidance P 3 3 GO:0050771 negative regulation of axonogenesis P 9 7 GO:0050869 negative regulation of B cell activation P 10 10 GO:0045578 negative regulation of B cell differentiation P 1 1 GO:0002713 negative regulation of B cell mediated immunity P 1 1 GO:0030889 negative regulation of B cell proliferation P 7 7 GO:0048521 negative regulation of behavior P 1 1 GO:0051100 negative regulation of binding P 2 2 GO:0048519 negative regulation of biological process P 863 603 GO:0009890 negative regulation of biosynthetic process P 32 22 GO:0030195 negative regulation of blood coagulation P 3 1 GO:0045776 negative regulation of blood pressure P 5 5 GO:0030514 negative regulation of BMP signaling pathway P 13 12 GO:0040015 negative regulation of body size P 9 9 GO:0030502 negative regulation of bone mineralization P 3 2 GO:0046851 negative regulation of bone remodeling P 13 12 GO:0045779 negative regulation of bone resorption P 4 4 GO:0051926 negative regulation of calcium ion transport P 2 2 GO:0030818 negative regulation of cAMP biosynthetic process P 3 3 GO:0030815 negative regulation of cAMP metabolic process P 3 3 GO:0045912 negative regulation of carbohydrate metabolic process P 2 2 GO:0043154 negative regulation of caspase activity P 4 4 GO:0009895 negative regulation of catabolic process P 4 4 GO:0007162 negative regulation of cell adhesion P 13 7 GO:0045596 negative regulation of cell differentiation P 79 72 GO:0051782 negative regulation of cell division P 1 1 GO:0009996 negative regulation of cell fate specification P 2 1 GO:0030308 negative regulation of cell growth P 13 4 GO:0030336 negative regulation of cell migration P 14 14 GO:0051271 negative regulation of cell motility P 18 17 GO:0051129 negative regulation of cell organization and biogenesis P 34 11 GO:0008285 negative regulation of cell proliferation P 113 104 GO:0045792 negative regulation of cell size P 19 7 GO:0045794 negative regulation of cell volume P 1 1 GO:0022408 negative regulation of cell-cell adhesion P 4 3 GO:0001953 negative regulation of cell-matrix adhesion P 3 3 GO:0031327 negative regulation of cellular biosynthetic process P 26 18 GO:0031330 negative regulation of cellular catabolic process P 1 1 GO:0031324 negative regulation of cellular metabolic process P 292 228 GO:0048523 negative regulation of cellular process P 803 550 GO:0045079 negative regulation of chemokine biosynthetic process P 2 2 GO:0032682 negative regulation of chemokine production P 1 1 GO:0032331 negative regulation of chondrocyte differentiation P 3 3 GO:0002677 negative regulation of chronic inflammatory response P 1 1 GO:0050819 negative regulation of coagulation P 6 1 GO:0045916 negative regulation of complement activation P 2 2 GO:0031280 negative regulation of cyclase activity P 1 1 GO:0030803 negative regulation of cyclic nucleotide biosynthetic process P 3 3 GO:0030800 negative regulation of cyclic nucleotide metabolic process P 3 3 GO:0045736 negative regulation of cyclin-dependent protein kinase activity P 4 4 GO:0001960 negative regulation of cytokine and chemokine mediated signaling pathway P 2 2 GO:0042036 negative regulation of cytokine biosynthetic process P 10 10 GO:0001818 negative regulation of cytokine production P 7 6 GO:0002719 negative regulation of cytokine production during immune response P 1 1 GO:0050710 negative regulation of cytokine secretion P 3 3 GO:0045918 negative regulation of cytolysis P 1 1 GO:0051494 negative regulation of cytoskeleton organization and biogenesis P 1 1 GO:0031348 negative regulation of defense response P 11 11 GO:0050774 negative regulation of dendrite morphogenesis P 3 3 GO:0051093 negative regulation of developmental process P 97 87 GO:0043392 negative regulation of DNA binding P 2 2 GO:0051053 negative regulation of DNA metabolic process P 14 11 GO:0045910 negative regulation of DNA recombination P 4 4 GO:0008156 negative regulation of DNA replication P 8 6 GO:0032297 negative regulation of DNA replication initiation P 3 2 GO:0060160 negative regulation of dopamine receptor signaling pathway P 3 3 GO:0045806 negative regulation of endocytosis P 4 3 GO:0042664 negative regulation of endodermal cell fate specification P 1 0 GO:0045602 negative regulation of endothelial cell differentiation P 1 1 GO:0001937 negative regulation of endothelial cell proliferation P 3 3 GO:0043086 negative regulation of enzyme activity P 47 40 GO:0045605 negative regulation of epidermal cell differentiation P 2 2 GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway P 1 1 GO:0045683 negative regulation of epidermis development P 2 2 GO:0030857 negative regulation of epithelial cell differentiation P 1 1 GO:0050680 negative regulation of epithelial cell proliferation P 6 6 GO:0045647 negative regulation of erythrocyte differentiation P 4 4 GO:0045599 negative regulation of fat cell differentiation P 2 2 GO:0007621 negative regulation of female receptivity P 1 1 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway P 1 1 GO:0048147 negative regulation of fibroblast proliferation P 3 3 GO:0045810 negative regulation of frizzled signaling pathway P 1 1 GO:0045814 negative regulation of gene expression, epigenetic P 15 4 GO:0045686 negative regulation of glial cell differentiation P 5 5 GO:0014014 negative regulation of gliogenesis P 5 5 GO:0031947 negative regulation of glucocorticoid biosynthetic process P 1 1 GO:0031944 negative regulation of glucocorticoid metabolic process P 1 1 GO:0045721 negative regulation of gluconeogenesis P 1 1 GO:0046325 negative regulation of glucose import P 3 2 GO:0045818 negative regulation of glycogen catabolic process P 1 1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway P 7 7 GO:0030853 negative regulation of granulocyte differentiation P 1 1 GO:0045926 negative regulation of growth P 25 16 GO:0051799 negative regulation of hair follicle development P 1 0 GO:0045822 negative regulation of heart contraction P 6 6 GO:0001985 negative regulation of heart contraction rate in baroreceptor response to increased blood pressure P 1 1 GO:0046986 negative regulation of hemoglobin biosynthetic process P 1 1 GO:0035067 negative regulation of histone acetylation P 2 1 GO:0051573 negative regulation of histone H3-K9 methylation P 1 1 GO:0031061 negative regulation of histone methylation P 1 1 GO:0031057 negative regulation of histone modification P 3 2 GO:0032353 negative regulation of hormone biosynthetic process P 1 1 GO:0032351 negative regulation of hormone metabolic process P 1 1 GO:0046888 negative regulation of hormone secretion P 8 2 GO:0051346 negative regulation of hydrolase activity P 5 5 GO:0002884 negative regulation of hypersensitivity P 2 2 GO:0033087 negative regulation of immature T cell proliferation P 2 2 GO:0033088 negative regulation of immature T cell proliferation in the thymus P 2 2 GO:0002698 negative regulation of immune effector process P 3 3 GO:0050777 negative regulation of immune response P 6 6 GO:0002683 negative regulation of immune system process P 6 6 GO:0002890 negative regulation of immunoglobulin mediated immune response P 1 1 GO:0050728 negative regulation of inflammatory response P 11 11 GO:0002862 negative regulation of inflammatory response to antigenic stimulus P 2 2 GO:0046627 negative regulation of insulin receptor signaling pathway P 3 3 GO:0046676 negative regulation of insulin secretion P 3 1 GO:0045077 negative regulation of interferon-gamma biosynthetic process P 2 2 GO:0032689 negative regulation of interferon-gamma production P 1 1 GO:0032691 negative regulation of interleukin-1 beta production P 1 1 GO:0032692 negative regulation of interleukin-1 production P 1 1 GO:0032693 negative regulation of interleukin-10 production P 1 1 GO:0045083 negative regulation of interleukin-12 biosynthetic process P 1 1 GO:0032695 negative regulation of interleukin-12 production P 1 1 GO:0045085 negative regulation of interleukin-2 biosynthetic process P 3 3 GO:0032703 negative regulation of interleukin-2 production P 2 2 GO:0032713 negative regulation of interleukin-4 production P 1 1 GO:0032714 negative regulation of interleukin-5 production P 1 1 GO:0045409 negative regulation of interleukin-6 biosynthetic process P 1 1 GO:0032715 negative regulation of interleukin-6 production P 2 2 GO:0043271 negative regulation of ion transport P 3 3 GO:0045829 negative regulation of isotype switching P 2 2 GO:0048294 negative regulation of isotype switching to IgE isotypes P 2 2 GO:0046426 negative regulation of JAK-STAT cascade P 3 2 GO:0043508 negative regulation of JNK activity P 2 2 GO:0046329 negative regulation of JNK cascade P 1 0 GO:0045617 negative regulation of keratinocyte differentiation P 1 0 GO:0033673 negative regulation of kinase activity P 36 31 GO:0001911 negative regulation of leukocyte mediated cytotoxicity P 4 4 GO:0002704 negative regulation of leukocyte mediated immunity P 2 2 GO:0051352 negative regulation of ligase activity P 1 0 GO:0051005 negative regulation of lipoprotein lipase activity P 1 1 GO:0040013 negative regulation of locomotion P 19 18 GO:0051350 negative regulation of lyase activity P 1 1 GO:0051250 negative regulation of lymphocyte activation P 24 24 GO:0045620 negative regulation of lymphocyte differentiation P 3 3 GO:0002707 negative regulation of lymphocyte mediated immunity P 2 2 GO:0050672 negative regulation of lymphocyte proliferation P 18 18 GO:0016242 negative regulation of macroautophagy P 2 2 GO:0045650 negative regulation of macrophage differentiation P 1 1 GO:0043407 negative regulation of MAP kinase activity P 17 16 GO:0043409 negative regulation of MAPKKK cascade P 5 5 GO:0033026 negative regulation of mast cell apoptosis P 1 1 GO:0032764 negative regulation of mast cell cytokine production P 1 1 GO:0045632 negative regulation of mechanoreceptor differentiation P 2 2 GO:0045653 negative regulation of megakaryocyte differentiation P 1 0 GO:0009892 negative regulation of metabolic process P 329 239 GO:0048553 negative regulation of metalloenzyme activity P 1 1 GO:0045347 negative regulation of MHC class II biosynthetic process P 1 1 GO:0007026 negative regulation of microtubule depolymerization P 10 7 GO:0031115 negative regulation of microtubule polymerization P 1 1 GO:0031111 negative regulation of microtubule polymerization or depolymerization P 11 8 GO:0045839 negative regulation of mitosis P 2 0 GO:0045841 negative regulation of mitotic metaphase/anaphase transition P 1 0 GO:0045950 negative regulation of mitotic recombination P 2 2 GO:0045656 negative regulation of monocyte differentiation P 1 1 GO:0032945 negative regulation of mononuclear cell proliferation P 18 18 GO:0050686 negative regulation of mRNA processing P 1 1 GO:0040033 negative regulation of mRNA translation, snRNA-mediated P 1 0 GO:0051241 negative regulation of multicellular organismal process P 29 28 GO:0051148 negative regulation of muscle cell differentiation P 2 2 GO:0045932 negative regulation of muscle contraction P 6 6 GO:0031642 negative regulation of myelination P 2 2 GO:0033033 negative regulation of myeloid cell apoptosis P 1 1 GO:0045638 negative regulation of myeloid cell differentiation P 19 16 GO:0030886 negative regulation of myeloid dendritic cell activation P 1 1 GO:0002762 negative regulation of myeloid leukocyte differentiation P 9 8 GO:0045662 negative regulation of myoblast differentiation P 3 2 GO:0045953 negative regulation of natural killer cell mediated cytotoxicity P 3 3 GO:0007406 negative regulation of neuroblast proliferation P 5 5 GO:0050768 negative regulation of neurogenesis P 18 16 GO:0031645 negative regulation of neurological process P 5 4 GO:0043524 negative regulation of neuron apoptosis P 23 23 GO:0045665 negative regulation of neuron differentiation P 15 14 GO:0046929 negative regulation of neurotransmitter secretion P 1 1 GO:0045659 negative regulation of neutrophil differentiation P 1 1 GO:0042347 negative regulation of NF-kappaB import into nucleus P 1 1 GO:0045019 negative regulation of nitric oxide biosynthetic process P 2 1 GO:0051001 negative regulation of nitric-oxide synthase activity P 1 1 GO:0045746 negative regulation of Notch signaling pathway P 2 2 GO:0048025 negative regulation of nuclear mRNA splicing, via spliceosome P 1 1 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process P 255 202 GO:0046823 negative regulation of nucleocytoplasmic transport P 4 4 GO:0030809 negative regulation of nucleotide biosynthetic process P 3 3 GO:0045980 negative regulation of nucleotide metabolic process P 4 3 GO:0042483 negative regulation of odontogenesis P 1 1 GO:0042489 negative regulation of odontogenesis of dentine-containing teeth P 1 1 GO:0048715 negative regulation of oligodendrocyte differentiation P 2 2 GO:0046621 negative regulation of organ growth P 1 1 GO:0030279 negative regulation of ossification P 9 8 GO:0045668 negative regulation of osteoblast differentiation P 5 5 GO:0045671 negative regulation of osteoclast differentiation P 8 7 GO:0051354 negative regulation of oxidoreductase activity P 1 1 GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation P 2 1 GO:0045936 negative regulation of phosphate metabolic process P 3 2 GO:0014067 negative regulation of phosphoinositide 3-kinase cascade P 1 1 GO:0042326 negative regulation of phosphorylation P 3 2 GO:0046533 negative regulation of photoreceptor cell differentiation P 2 2 GO:0043267 negative regulation of potassium ion transport P 2 2 GO:0002701 negative regulation of production of molecular mediator of immune response P 1 1 GO:0043069 negative regulation of programmed cell death P 149 120 GO:0045786 negative regulation of progression through cell cycle P 110 27 GO:0045930 negative regulation of progression through mitotic cell cycle P 5 3 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process P 1 1 GO:0031953 negative regulation of protein amino acid autophosphorylation P 1 1 GO:0001933 negative regulation of protein amino acid phosphorylation P 7 4 GO:0017148 negative regulation of protein biosynthetic process P 25 17 GO:0042177 negative regulation of protein catabolic process P 3 3 GO:0042308 negative regulation of protein import into nucleus P 4 4 GO:0006469 negative regulation of protein kinase activity P 36 31 GO:0051898 negative regulation of protein kinase B signaling cascade P 4 4 GO:0051248 negative regulation of protein metabolic process P 67 33 GO:0031400 negative regulation of protein modification process P 2 2 GO:0050709 negative regulation of protein secretion P 3 3 GO:0051224 negative regulation of protein transport P 4 4 GO:0031397 negative regulation of protein ubiquitination P 2 2 GO:0045861 negative regulation of proteolysis P 5 4 GO:0035021 negative regulation of Rac protein signal transduction P 2 2 GO:0046580 negative regulation of Ras protein signal transduction P 3 3 GO:0001920 negative regulation of receptor recycling P 1 0 GO:0032102 negative regulation of response to external stimulus P 7 7 GO:0032105 negative regulation of response to extracellular stimulus P 2 2 GO:0032096 negative regulation of response to food P 2 2 GO:0032108 negative regulation of response to nutrient levels P 2 2 GO:0048585 negative regulation of response to stimulus P 7 7 GO:0046671 negative regulation of retinal cell programmed cell death P 1 1 GO:0035024 negative regulation of Rho protein signal transduction P 2 2 GO:0051253 negative regulation of RNA metabolic process P 1 1 GO:0045749 negative regulation of S phase of mitotic cell cycle P 3 2 GO:0051048 negative regulation of secretion P 12 6 GO:0051283 negative regulation of sequestering of calcium ion P 3 2 GO:0009968 negative regulation of signal transduction P 91 56 GO:0045875 negative regulation of sister chromatid cohesion P 1 1 GO:0051058 negative regulation of small GTPase mediated signal transduction P 5 5 GO:0051151 negative regulation of smooth muscle cell differentiation P 1 1 GO:0045986 negative regulation of smooth muscle contraction P 5 5 GO:0045879 negative regulation of smoothened signaling pathway P 4 4 GO:0051154 negative regulation of striated muscle cell differentiation P 1 1 GO:0045988 negative regulation of striated muscle contraction P 1 1 GO:0045843 negative regulation of striated muscle development P 7 4 GO:0008634 negative regulation of survival gene product activity P 2 2 GO:0050805 negative regulation of synaptic transmission P 2 1 GO:0051967 negative regulation of synaptic transmission, glutamatergic P 2 1 GO:0050868 negative regulation of T cell activation P 17 17 GO:0045581 negative regulation of T cell differentiation P 2 2 GO:0001915 negative regulation of T cell mediated cytotoxicity P 1 1 GO:0002710 negative regulation of T cell mediated immunity P 1 1 GO:0042130 negative regulation of T cell proliferation P 13 13 GO:0050860 negative regulation of T cell receptor signaling pathway P 5 5 GO:0045629 negative regulation of T-helper 2 cell differentiation P 2 2 GO:0002829 negative regulation of T-helper 2 type immune response P 3 3 GO:0045623 negative regulation of T-helper cell differentiation P 3 3 GO:0050760 negative regulation of thymidylate synthase biosynthetic process P 1 1 GO:0016481 negative regulation of transcription P 238 188 GO:0043433 negative regulation of transcription factor activity P 2 2 GO:0042992 negative regulation of transcription factor import into nucleus P 4 4 GO:0000122 negative regulation of transcription from RNA polymerase II promoter P 139 115 GO:0045892 negative regulation of transcription, DNA-dependent P 186 150 GO:0051348 negative regulation of transferase activity P 38 33 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway P 3 3 GO:0032913 negative regulation of transforming growth factor-beta3 production P 1 0 GO:0045900 negative regulation of translational elongation P 2 0 GO:0045947 negative regulation of translational initiation P 5 1 GO:0051970 negative regulation of transmission of nerve impulse P 2 1 GO:0051051 negative regulation of transport P 17 12 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process P 1 1 GO:0032720 negative regulation of tumor necrosis factor production P 2 2 GO:0001811 negative regulation of type I hypersensitivity P 1 1 GO:0001808 negative regulation of type IV hypersensitivity P 1 1 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein P 2 1 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein P 1 1 GO:0042527 negative regulation of tyrosine phosphorylation of Stat6 protein P 1 0 GO:0051444 negative regulation of ubiquitin-protein ligase activity P 1 0 GO:0051442 negative regulation of ubiquitin-protein ligase activity during meiotic cell cycle P 1 0 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway P 1 1 GO:0045908 negative regulation of vasodilation P 1 1 GO:0048525 negative regulation of viral reproduction P 1 1 GO:0030178 negative regulation of Wnt receptor signaling pathway P 17 13 GO:0043383 negative T cell selection P 8 8 GO:0045060 negative thymic T cell selection P 8 8 GO:0021675 nerve development P 9 9 GO:0048011 nerve growth factor receptor signaling pathway P 5 3 GO:0007270 nerve-nerve synaptic transmission P 24 22 GO:0007399 nervous system development P 601 509 GO:0014032 neural crest cell development P 32 30 GO:0014033 neural crest cell differentiation P 32 30 GO:0001755 neural crest cell migration P 23 21 GO:0001842 neural fold formation P 2 2 GO:0048857 neural nucleus development P 3 3 GO:0001840 neural plate development P 55 55 GO:0021990 neural plate formation P 1 1 GO:0001839 neural plate morphogenesis P 54 54 GO:0001843 neural tube closure P 42 42 GO:0021915 neural tube development P 63 63 GO:0001841 neural tube formation P 53 53 GO:0021532 neural tube patterning P 7 7 GO:0031175 neurite development P 186 171 GO:0048812 neurite morphogenesis P 159 146 GO:0031102 neurite regeneration P 5 3 GO:0014016 neuroblast differentiation P 1 1 GO:0055057 neuroblast division P 1 1 GO:0014017 neuroblast fate commitment P 1 1 GO:0007400 neuroblast fate determination P 1 1 GO:0007405 neuroblast proliferation P 25 23 GO:0060052 neurofilament cytoskeleton organization and biogenesis P 9 9 GO:0022008 neurogenesis P 330 308 GO:0021985 neurohypophysis development P 2 2 GO:0002087 neurological control of breathing P 2 2 GO:0050877 neurological process P 1680 319 GO:0007528 neuromuscular junction development P 20 19 GO:0050905 neuromuscular process P 46 46 GO:0050885 neuromuscular process controlling balance P 32 32 GO:0007274 neuromuscular synaptic transmission P 12 11 GO:0007158 neuron adhesion P 1 1 GO:0051402 neuron apoptosis P 38 35 GO:0048666 neuron development P 209 192 GO:0030182 neuron differentiation P 268 247 GO:0048663 neuron fate commitment P 21 21 GO:0048664 neuron fate determination P 3 3 GO:0048665 neuron fate specification P 5 5 GO:0042551 neuron maturation P 9 7 GO:0001764 neuron migration P 55 55 GO:0048667 neuron morphogenesis during differentiation P 159 146 GO:0008038 neuron recognition P 12 11 GO:0016322 neuron remodeling P 4 3 GO:0045161 neuronal ion channel clustering P 1 0 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration P 1 1 GO:0007218 neuropeptide signaling pathway P 89 10 GO:0021995 neuropore closure P 1 1 GO:0043526 neuroprotection P 4 3 GO:0042136 neurotransmitter biosynthetic process P 13 8 GO:0042135 neurotransmitter catabolic process P 10 7 GO:0042133 neurotransmitter metabolic process P 36 26 GO:0045212 neurotransmitter receptor biosynthetic process P 2 1 GO:0045213 neurotransmitter receptor metabolic process P 6 5 GO:0007269 neurotransmitter secretion P 50 41 GO:0006836 neurotransmitter transport P 48 10 GO:0001504 neurotransmitter uptake P 7 6 GO:0015804 neutral amino acid transport P 6 6 GO:0046460 neutral lipid biosynthetic process P 7 5 GO:0046461 neutral lipid catabolic process P 2 2 GO:0006638 neutral lipid metabolic process P 23 18 GO:0042119 neutrophil activation P 1 1 GO:0001781 neutrophil apoptosis P 2 2 GO:0030593 neutrophil chemotaxis P 12 11 GO:0043312 neutrophil degranulation P 1 1 GO:0030223 neutrophil differentiation P 2 2 GO:0001780 neutrophil homeostasis P 3 3 GO:0002446 neutrophil mediated immunity P 1 1 GO:0042348 NF-kappaB import into nucleus P 4 4 GO:0006491 N-glycan processing P 3 1 GO:0006769 nicotinamide metabolic process P 21 6 GO:0006809 nitric oxide biosynthetic process P 16 12 GO:0033484 nitric oxide homeostasis P 1 1 GO:0007263 nitric oxide mediated signal transduction P 4 2 GO:0046209 nitric oxide metabolic process P 16 12 GO:0018916 nitrobenzene metabolic process P 1 1 GO:0044271 nitrogen compound biosynthetic process P 75 27 GO:0044270 nitrogen compound catabolic process P 55 19 GO:0006807 nitrogen compound metabolic process P 352 139 GO:0019740 nitrogen utilization P 1 0 GO:0051132 NK T cell activation P 2 2 GO:0001865 NK T cell differentiation P 4 4 GO:0001866 NK T cell proliferation P 2 2 GO:0006607 NLS-bearing substrate import into nucleus P 1 0 GO:0016244 non-apoptotic programmed cell death P 1 1 GO:0019794 nonprotein amino acid metabolic process P 2 1 GO:0000726 non-recombinational repair P 6 3 GO:0042421 norepinephrine biosynthetic process P 3 3 GO:0042415 norepinephrine metabolic process P 5 5 GO:0048243 norepinephrine secretion P 1 1 GO:0001993 norepinephrine-epinephrine regulation of blood pressure P 7 7 GO:0001994 norepinephrine-epinephrine vasoconstriction during regulation of blood pressure P 3 3 GO:0002025 norepinephrine-epinephrine vasodilation during regulation of blood pressure P 3 3 GO:0043584 nose development P 4 4 GO:0007220 Notch receptor processing P 3 2 GO:0007219 Notch signaling pathway P 50 22 GO:0030903 notochord development P 7 7 GO:0048570 notochord morphogenesis P 4 4 GO:0060032 notochord regression P 2 2 GO:0018008 N-terminal peptidyl-glycine N-myristoylation P 2 0 GO:0018009 N-terminal peptidyl-L-cysteine N-palmitoylation P 1 1 GO:0006474 N-terminal protein amino acid acetylation P 1 0 GO:0031365 N-terminal protein amino acid modification P 4 2 GO:0006498 N-terminal protein lipidation P 3 2 GO:0006499 N-terminal protein myristoylation P 2 1 GO:0006500 N-terminal protein palmitoylation P 1 1 GO:0030575 nuclear body organization and biogenesis P 1 1 GO:0051168 nuclear export P 23 15 GO:0030264 nuclear fragmentation during apoptosis P 1 1 GO:0051170 nuclear import P 58 35 GO:0006998 nuclear membrane organization and biogenesis P 5 2 GO:0007097 nuclear migration P 3 3 GO:0000395 nuclear mRNA 5'-splice site recognition P 1 0 GO:0006374 nuclear mRNA splicing via U2-type spliceosome P 3 0 GO:0000398 nuclear mRNA splicing, via spliceosome P 41 9 GO:0006997 nuclear organization and biogenesis P 25 19 GO:0051169 nuclear transport P 92 55 GO:0050657 nucleic acid transport P 50 9 GO:0018143 nucleic acid-protein covalent cross-linking P 1 0 GO:0046112 nucleobase biosynthetic process P 5 0 GO:0046113 nucleobase catabolic process P 1 1 GO:0009112 nucleobase metabolic process P 15 5 GO:0015851 nucleobase transport P 1 0 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process P 2921 795 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport P 55 12 GO:0006913 nucleocytoplasmic transport P 92 55 GO:0007000 nucleolus organization and biogenesis P 3 3 GO:0009163 nucleoside biosynthetic process P 1 0 GO:0009164 nucleoside catabolic process P 1 0 GO:0009133 nucleoside diphosphate biosynthetic process P 4 2 GO:0009134 nucleoside diphosphate catabolic process P 6 4 GO:0009132 nucleoside diphosphate metabolic process P 13 6 GO:0009116 nucleoside metabolic process P 20 6 GO:0009124 nucleoside monophosphate biosynthetic process P 16 1 GO:0009125 nucleoside monophosphate catabolic process P 1 0 GO:0009123 nucleoside monophosphate metabolic process P 17 1 GO:0006753 nucleoside phosphate metabolic process P 39 0 GO:0043174 nucleoside salvage P 3 3 GO:0015858 nucleoside transport P 4 3 GO:0009142 nucleoside triphosphate biosynthetic process P 51 1 GO:0009143 nucleoside triphosphate catabolic process P 6 5 GO:0009141 nucleoside triphosphate metabolic process P 59 6 GO:0006334 nucleosome assembly P 92 2 GO:0006337 nucleosome disassembly P 1 0 GO:0016584 nucleosome positioning P 3 3 GO:0009165 nucleotide biosynthetic process P 124 24 GO:0009166 nucleotide catabolic process P 22 10 GO:0009117 nucleotide metabolic process P 180 45 GO:0006289 nucleotide-excision repair P 21 9 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion P 1 1 GO:0009226 nucleotide-sugar biosynthetic process P 1 0 GO:0009225 nucleotide-sugar metabolic process P 9 2 GO:0015780 nucleotide-sugar transport P 3 0 GO:0021768 nucleus accumbens development P 1 1 GO:0051647 nucleus localization P 6 6 GO:0009935 nutrient import P 1 1 GO:0042476 odontogenesis P 38 35 GO:0042475 odontogenesis of dentine-containing teeth P 36 34 GO:0016266 O-glycan processing P 1 0 GO:0016267 O-glycan processing, core 1 P 1 0 GO:0042048 olfactory behavior P 1 1 GO:0021772 olfactory bulb development P 3 3 GO:0021889 olfactory bulb interneuron differentiation P 1 1 GO:0021988 olfactory lobe development P 3 3 GO:0060166 olfactory pit development P 1 1 GO:0030910 olfactory placode formation P 1 1 GO:0014003 oligodendrocyte development P 5 5 GO:0048709 oligodendrocyte differentiation P 9 9 GO:0006857 oligopeptide transport P 8 3 GO:0009312 oligosaccharide biosynthetic process P 6 5 GO:0009313 oligosaccharide catabolic process P 2 2 GO:0009311 oligosaccharide metabolic process P 9 7 GO:0006730 one-carbon compound metabolic process P 79 25 GO:0048599 oocyte development P 8 8 GO:0009994 oocyte differentiation P 8 8 GO:0001556 oocyte maturation P 5 5 GO:0048477 oogenesis P 20 14 GO:0022605 oogenesis stage P 1 1 GO:0008228 opsonization P 2 2 GO:0002072 optic cup morphogenesis involved in camera-type eye development P 2 2 GO:0021554 optic nerve development P 2 2 GO:0021631 optic nerve morphogenesis P 2 2 GO:0001743 optic placode formation P 1 1 GO:0046619 optic placode formation involved in camera-type eye P 1 1 GO:0010199 organ boundary specification between lateral organs and the meristem P 1 1 GO:0048513 organ development P 1298 1085 GO:0048645 organ formation P 3 3 GO:0035265 organ growth P 11 11 GO:0009887 organ morphogenesis P 491 387 GO:0002251 organ or tissue specific immune response P 2 2 GO:0042775 organelle ATP synthesis coupled electron transport P 15 0 GO:0048285 organelle fission P 4 1 GO:0048284 organelle fusion P 6 6 GO:0051640 organelle localization P 27 20 GO:0006996 organelle organization and biogenesis P 1090 355 GO:0016053 organic acid biosynthetic process P 70 19 GO:0016054 organic acid catabolic process P 6 3 GO:0006082 organic acid metabolic process P 446 150 GO:0015849 organic acid transport P 60 31 GO:0015711 organic anion transport P 11 1 GO:0015695 organic cation transport P 4 0 GO:0048532 organization of an anatomical structure P 1 1 GO:0006591 ornithine metabolic process P 2 1 GO:0018987 osmoregulation P 3 2 GO:0007231 osmosensory signaling pathway P 1 1 GO:0001503 ossification P 91 63 GO:0002076 osteoblast development P 4 4 GO:0001649 osteoblast differentiation P 26 26 GO:0030316 osteoclast differentiation P 19 18 GO:0030916 otic vesicle formation P 1 1 GO:0048840 otolith development P 1 1 GO:0045299 otolith mineralization P 1 1 GO:0042473 outer ear morphogenesis P 3 3 GO:0001550 ovarian cumulus expansion P 1 1 GO:0001541 ovarian follicle development P 18 18 GO:0001543 ovarian follicle rupture P 2 2 GO:0030728 ovulation P 10 10 GO:0001542 ovulation from ovarian follicle P 10 10 GO:0019532 oxalate transport P 1 1 GO:0046724 oxalic acid secretion P 1 1 GO:0006119 oxidative phosphorylation P 54 2 GO:0009854 oxidative photosynthetic carbon pathway P 1 0 GO:0006733 oxidoreduction coenzyme metabolic process P 31 8 GO:0006800 oxygen and reactive oxygen species metabolic process P 28 16 GO:0015671 oxygen transport P 13 2 GO:0000239 pachytene P 4 3 GO:0060021 palate development P 4 3 GO:0021543 pallium development P 14 14 GO:0031016 pancreas development P 13 13 GO:0030157 pancreatic juice secretion P 1 0 GO:0030046 parallel actin filament bundle formation P 2 2 GO:0030913 paranodal junction assembly P 1 1 GO:0060017 parathyroid gland development P 6 4 GO:0048339 paraxial mesoderm development P 13 13 GO:0048341 paraxial mesoderm formation P 6 6 GO:0048340 paraxial mesoderm morphogenesis P 9 9 GO:0048342 paraxial mesodermal cell differentiation P 2 2 GO:0048343 paraxial mesodermal cell fate commitment P 2 2 GO:0007567 parturition P 2 2 GO:0007225 patched ligand processing P 1 1 GO:0009405 pathogenesis P 3 0 GO:0002221 pattern recognition receptor signaling pathway P 6 6 GO:0007389 pattern specification process P 232 197 GO:0001569 patterning of blood vessels P 22 22 GO:0007341 penetration of zona pellucida P 6 6 GO:0043084 penile erection P 1 1 GO:0019322 pentose biosynthetic process P 2 2 GO:0019321 pentose metabolic process P 7 4 GO:0006098 pentose-phosphate shunt P 7 1 GO:0009052 pentose-phosphate shunt, non-oxidative branch P 1 0 GO:0050823 peptide antigen stabilization P 1 1 GO:0043171 peptide catabolic process P 1 0 GO:0018149 peptide cross-linking P 6 1 GO:0016486 peptide hormone processing P 7 4 GO:0030072 peptide hormone secretion P 27 24 GO:0006518 peptide metabolic process P 8 2 GO:0018409 peptide or protein amino-terminal blocking P 4 2 GO:0018410 peptide or protein carboxyl-terminal blocking P 3 0 GO:0002790 peptide secretion P 28 25 GO:0050822 peptide stabilization P 1 1 GO:0015833 peptide transport P 37 29 GO:0009253 peptidoglycan catabolic process P 6 0 GO:0000270 peptidoglycan metabolic process P 6 0 GO:0018193 peptidyl-amino acid modification P 91 61 GO:0018120 peptidyl-arginine ADP-ribosylation P 1 1 GO:0018216 peptidyl-arginine methylation P 2 0 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine P 1 0 GO:0018195 peptidyl-arginine modification P 3 1 GO:0035246 peptidyl-arginine N-methylation P 2 0 GO:0035247 peptidyl-arginine omega-N-methylation P 1 0 GO:0018196 peptidyl-asparagine modification P 5 1 GO:0018198 peptidyl-cysteine modification P 1 1 GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine P 1 0 GO:0017182 peptidyl-diphthamide metabolic process P 1 0 GO:0017187 peptidyl-glutamic acid carboxylation P 1 0 GO:0018200 peptidyl-glutamic acid modification P 1 0 GO:0018201 peptidyl-glycine modification P 2 0 GO:0018202 peptidyl-histidine modification P 6 0 GO:0018106 peptidyl-histidine phosphorylation P 5 0 GO:0018205 peptidyl-lysine modification P 2 1 GO:0019511 peptidyl-proline hydroxylation P 3 2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline P 3 2 GO:0018208 peptidyl-proline modification P 4 3 GO:0018209 peptidyl-serine modification P 9 4 GO:0018105 peptidyl-serine phosphorylation P 9 4 GO:0018210 peptidyl-threonine modification P 7 5 GO:0018107 peptidyl-threonine phosphorylation P 7 5 GO:0018212 peptidyl-tyrosine modification P 54 48 GO:0018108 peptidyl-tyrosine phosphorylation P 54 48 GO:0060039 pericardium development P 1 1 GO:0007422 peripheral nervous system development P 23 23 GO:0048934 peripheral nervous system neuron differentiation P 1 1 GO:0002458 peripheral T cell tolerance induction P 1 1 GO:0002465 peripheral tolerance induction P 1 1 GO:0030432 peristalsis P 4 4 GO:0043574 peroxisomal transport P 5 2 GO:0016559 peroxisome fission P 3 0 GO:0060151 peroxisome localization P 2 1 GO:0007031 peroxisome organization and biogenesis P 22 4 GO:0048541 Peyer's patch development P 1 1 GO:0045851 pH reduction P 2 0 GO:0006909 phagocytosis P 33 23 GO:0006911 phagocytosis, engulfment P 14 12 GO:0006910 phagocytosis, recognition P 10 10 GO:0001845 phagolysosome formation P 1 1 GO:0060037 pharyngeal system development P 3 2 GO:0018958 phenol metabolic process P 28 19 GO:0006432 phenylalanyl-tRNA aminoacylation P 3 0 GO:0042396 phosphagen biosynthetic process P 3 2 GO:0006599 phosphagen metabolic process P 5 2 GO:0055062 phosphate ion homeostasis P 3 2 GO:0006796 phosphate metabolic process P 785 194 GO:0006817 phosphate transport P 67 1 GO:0006654 phosphatidic acid biosynthetic process P 1 1 GO:0046473 phosphatidic acid metabolic process P 1 1 GO:0006656 phosphatidylcholine biosynthetic process P 6 5 GO:0046470 phosphatidylcholine metabolic process P 7 5 GO:0046471 phosphatidylglycerol metabolic process P 1 0 GO:0046488 phosphatidylinositol metabolic process P 10 4 GO:0006659 phosphatidylserine biosynthetic process P 2 1 GO:0006658 phosphatidylserine metabolic process P 2 1 GO:0046314 phosphocreatine biosynthetic process P 1 1 GO:0006603 phosphocreatine metabolic process P 2 1 GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system P 8 0 GO:0014065 phosphoinositide 3-kinase cascade P 3 3 GO:0046489 phosphoinositide biosynthetic process P 21 2 GO:0030384 phosphoinositide metabolic process P 44 9 GO:0046854 phosphoinositide phosphorylation P 9 0 GO:0048015 phosphoinositide-mediated signaling P 44 18 GO:0008654 phospholipid biosynthetic process P 58 11 GO:0009395 phospholipid catabolic process P 9 0 GO:0046839 phospholipid dephosphorylation P 9 0 GO:0006644 phospholipid metabolic process P 114 29 GO:0006649 phospholipid transfer to membrane P 1 1 GO:0045332 phospholipid translocation P 2 2 GO:0015914 phospholipid transport P 11 2 GO:0006793 phosphorus metabolic process P 785 194 GO:0046838 phosphorylated carbohydrate dephosphorylation P 1 0 GO:0016310 phosphorylation P 665 170 GO:0009648 photoperiodism P 1 1 GO:0042461 photoreceptor cell development P 17 17 GO:0046530 photoreceptor cell differentiation P 21 21 GO:0046552 photoreceptor cell fate commitment P 1 1 GO:0045494 photoreceptor cell maintenance P 8 8 GO:0009853 photorespiration P 1 0 GO:0007602 phototransduction P 22 10 GO:0007603 phototransduction, visible light P 2 1 GO:0043476 pigment accumulation P 2 1 GO:0043480 pigment accumulation in tissues P 1 1 GO:0046148 pigment biosynthetic process P 26 11 GO:0046149 pigment catabolic process P 1 0 GO:0050931 pigment cell differentiation P 17 17 GO:0051875 pigment granule localization P 6 5 GO:0048753 pigment granule organization and biogenesis P 4 4 GO:0051904 pigment granule transport P 4 4 GO:0042440 pigment metabolic process P 31 13 GO:0043473 pigmentation P 50 50 GO:0048066 pigmentation during development P 29 29 GO:0006907 pinocytosis P 3 2 GO:0021983 pituitary gland development P 18 18 GO:0001890 placenta development P 27 27 GO:0045026 plasma membrane fusion P 7 4 GO:0007009 plasma membrane organization and biogenesis P 10 9 GO:0001778 plasma membrane repair P 4 4 GO:0048227 plasma membrane to endosome transport P 1 0 GO:0031639 plasminogen activation P 1 1 GO:0030168 platelet activation P 11 7 GO:0030220 platelet formation P 1 1 GO:0048008 platelet-derived growth factor receptor signaling pathway P 5 4 GO:0030578 PML body organization and biogenesis P 1 1 GO:0051694 pointed-end actin filament capping P 1 0 GO:0030859 polarized epithelial cell differentiation P 5 4 GO:0000289 poly(A) tail shortening P 4 3 GO:0016973 poly(A)+ mRNA export from nucleus P 4 3 GO:0006596 polyamine biosynthetic process P 7 1 GO:0006598 polyamine catabolic process P 4 2 GO:0006595 polyamine metabolic process P 16 4 GO:0046173 polyol biosynthetic process P 1 1 GO:0046174 polyol catabolic process P 2 0 GO:0019751 polyol metabolic process P 20 6 GO:0015791 polyol transport P 2 1 GO:0006798 polyphosphate catabolic process P 1 0 GO:0006797 polyphosphate metabolic process P 1 0 GO:0000271 polysaccharide biosynthetic process P 16 6 GO:0000272 polysaccharide catabolic process P 12 4 GO:0005976 polysaccharide metabolic process P 45 15 GO:0021548 pons development P 1 1 GO:0006779 porphyrin biosynthetic process P 13 5 GO:0006787 porphyrin catabolic process P 3 0 GO:0006778 porphyrin metabolic process P 18 6 GO:0050918 positive chemotaxis P 8 7 GO:0030836 positive regulation of actin filament depolymerization P 2 2 GO:0030838 positive regulation of actin filament polymerization P 3 3 GO:0051127 positive regulation of actin nucleation P 1 1 GO:0042104 positive regulation of activated T cell proliferation P 8 5 GO:0002675 positive regulation of acute inflammatory response P 10 10 GO:0002866 positive regulation of acute inflammatory response to antigenic stimulus P 10 10 GO:0002821 positive regulation of adaptive immune response P 15 15 GO:0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains P 15 15 GO:0045762 positive regulation of adenylate cyclase activity P 13 4 GO:0046635 positive regulation of alpha-beta T cell activation P 8 8 GO:0046638 positive regulation of alpha-beta T cell differentiation P 3 3 GO:0046641 positive regulation of alpha-beta T cell proliferation P 7 7 GO:0033240 positive regulation of amine metabolic process P 25 23 GO:0045764 positive regulation of amino acid metabolic process P 25 23 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process P 1 1 GO:0045766 positive regulation of angiogenesis P 7 4 GO:0045768 positive regulation of anti-apoptosis P 1 1 GO:0050857 positive regulation of antigen receptor-mediated signaling pathway P 3 2 GO:0043065 positive regulation of apoptosis P 160 122 GO:0060058 positive regulation of apoptosis involved in mammary gland involution P 1 1 GO:0032100 positive regulation of appetite P 2 2 GO:0048711 positive regulation of astrocyte differentiation P 2 2 GO:0045609 positive regulation of auditory receptor cell differentiation P 1 1 GO:0045773 positive regulation of axon extension P 5 5 GO:0048691 positive regulation of axon extension involved in regeneration P 1 1 GO:0050772 positive regulation of axonogenesis P 12 11 GO:0050871 positive regulation of B cell activation P 26 24 GO:0045579 positive regulation of B cell differentiation P 5 5 GO:0002714 positive regulation of B cell mediated immunity P 10 10 GO:0030890 positive regulation of B cell proliferation P 13 12 GO:0050861 positive regulation of B cell receptor signaling pathway P 1 1 GO:0002663 positive regulation of B cell tolerance induction P 1 1 GO:0051099 positive regulation of binding P 7 4 GO:0048518 positive regulation of biological process P 816 676 GO:0009891 positive regulation of biosynthetic process P 52 46 GO:0045777 positive regulation of blood pressure P 2 2 GO:0030513 positive regulation of BMP signaling pathway P 3 3 GO:0040018 positive regulation of body size P 22 21 GO:0030501 positive regulation of bone mineralization P 4 3 GO:0046852 positive regulation of bone remodeling P 7 6 GO:0045780 positive regulation of bone resorption P 1 1 GO:0046587 positive regulation of calcium-dependent cell-cell adhesion P 1 1 GO:0050850 positive regulation of calcium-mediated signaling P 11 10 GO:0030819 positive regulation of cAMP biosynthetic process P 2 1 GO:0030816 positive regulation of cAMP metabolic process P 2 1 GO:0045913 positive regulation of carbohydrate metabolic process P 4 3 GO:0060045 positive regulation of cardiac muscle cell proliferation P 3 3 GO:0043280 positive regulation of caspase activity P 21 13 GO:0009896 positive regulation of catabolic process P 4 3 GO:0045915 positive regulation of catecholamine metabolic process P 1 1 GO:0033605 positive regulation of catecholamine secretion P 1 1 GO:0051944 positive regulation of catecholamine uptake during transmission of nerve impulse P 1 1 GO:0032831 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation P 2 2 GO:0043089 positive regulation of Cdc42 GTPase activity P 1 1 GO:0045785 positive regulation of cell adhesion P 12 12 GO:0045597 positive regulation of cell differentiation P 45 40 GO:0042660 positive regulation of cell fate specification P 1 1 GO:0030307 positive regulation of cell growth P 1 0 GO:0030335 positive regulation of cell migration P 13 10 GO:0051272 positive regulation of cell motility P 16 14 GO:0051130 positive regulation of cell organization and biogenesis P 6 6 GO:0008284 positive regulation of cell proliferation P 173 154 GO:0045793 positive regulation of cell size P 3 2 GO:0022409 positive regulation of cell-cell adhesion P 4 4 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin P 1 1 GO:0001954 positive regulation of cell-matrix adhesion P 2 2 GO:0031328 positive regulation of cellular biosynthetic process P 42 37 GO:0031331 positive regulation of cellular catabolic process P 1 1 GO:0031325 positive regulation of cellular metabolic process P 343 296 GO:0048522 positive regulation of cellular process P 706 601 GO:0032270 positive regulation of cellular protein metabolic process P 1 1 GO:0046607 positive regulation of centrosome cycle P 1 1 GO:0030828 positive regulation of cGMP biosynthetic process P 2 2 GO:0030825 positive regulation of cGMP metabolic process P 2 2 GO:0045080 positive regulation of chemokine biosynthetic process P 5 5 GO:0050921 positive regulation of chemotaxis P 7 6 GO:0050820 positive regulation of coagulation P 1 1 GO:0031281 positive regulation of cyclase activity P 13 4 GO:0030804 positive regulation of cyclic nucleotide biosynthetic process P 4 3 GO:0030801 positive regulation of cyclic nucleotide metabolic process P 4 3 GO:0045737 positive regulation of cyclin-dependent protein kinase activity P 2 2 GO:0042108 positive regulation of cytokine biosynthetic process P 32 29 GO:0001819 positive regulation of cytokine production P 19 18 GO:0002720 positive regulation of cytokine production during immune response P 1 1 GO:0050715 positive regulation of cytokine secretion P 2 1 GO:0045585 positive regulation of cytotoxic T cell differentiation P 1 0 GO:0031349 positive regulation of defense response P 15 15 GO:0048639 positive regulation of developmental growth P 1 0 GO:0051094 positive regulation of developmental process P 65 57 GO:0043388 positive regulation of DNA binding P 5 3 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator P 1 1 GO:0051054 positive regulation of DNA metabolic process P 3 2 GO:0045739 positive regulation of DNA repair P 1 0 GO:0045740 positive regulation of DNA replication P 1 1 GO:0045964 positive regulation of dopamine metabolic process P 1 1 GO:0060161 positive regulation of dopamine receptor signaling pathway P 1 1 GO:0033603 positive regulation of dopamine secretion P 1 1 GO:0051586 positive regulation of dopamine uptake P 1 1 GO:0040019 positive regulation of embryonic development P 1 1 GO:0045807 positive regulation of endocytosis P 21 20 GO:0045603 positive regulation of endothelial cell differentiation P 2 0 GO:0001938 positive regulation of endothelial cell proliferation P 4 4 GO:0043085 positive regulation of enzyme activity P 134 89 GO:0045606 positive regulation of epidermal cell differentiation P 1 1 GO:0045741 positive regulation of epidermal growth factor receptor activity P 2 1 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway P 4 3 GO:0045684 positive regulation of epidermis development P 1 1 GO:0030858 positive regulation of epithelial cell differentiation P 2 2 GO:0050679 positive regulation of epithelial cell proliferation P 15 15 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing P 1 1 GO:0045648 positive regulation of erythrocyte differentiation P 5 4 GO:0031536 positive regulation of exit from mitosis P 1 1 GO:0045921 positive regulation of exocytosis P 6 5 GO:0045600 positive regulation of fat cell differentiation P 3 3 GO:0045723 positive regulation of fatty acid biosynthetic process P 1 1 GO:0045923 positive regulation of fatty acid metabolic process P 3 3 GO:0046321 positive regulation of fatty acid oxidation P 1 1 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway P 1 1 GO:0048146 positive regulation of fibroblast proliferation P 5 4 GO:0045724 positive regulation of flagellum biogenesis P 1 1 GO:0046645 positive regulation of gamma-delta T cell activation P 1 1 GO:0045588 positive regulation of gamma-delta T cell differentiation P 1 1 GO:0045815 positive regulation of gene expression, epigenetic P 2 2 GO:0043193 positive regulation of gene-specific transcription P 4 3 GO:0002636 positive regulation of germinal center formation P 3 3 GO:0045687 positive regulation of glial cell differentiation P 5 5 GO:0014015 positive regulation of gliogenesis P 5 5 GO:0046326 positive regulation of glucose import P 2 2 GO:0035229 positive regulation of glutamate-cysteine ligase activity P 1 1 GO:0045725 positive regulation of glycogen biosynthetic process P 1 1 GO:0045819 positive regulation of glycogen catabolic process P 1 1 GO:0045821 positive regulation of glycolysis P 1 0 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway P 5 5 GO:0021940 positive regulation of granule cell precursor proliferation P 7 7 GO:0045425 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process P 3 3 GO:0045927 positive regulation of growth P 24 22 GO:0060124 positive regulation of growth hormone secretion P 3 2 GO:0043547 positive regulation of GTPase activity P 2 1 GO:0051798 positive regulation of hair follicle development P 1 0 GO:0045823 positive regulation of heart contraction P 5 5 GO:0001996 positive regulation of heart contraction rate by epinephrine-norepinephrine P 3 3 GO:0001988 positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure P 1 1 GO:0035066 positive regulation of histone acetylation P 1 1 GO:0031058 positive regulation of histone modification P 1 1 GO:0046886 positive regulation of hormone biosynthetic process P 1 1 GO:0032352 positive regulation of hormone metabolic process P 1 1 GO:0046887 positive regulation of hormone secretion P 4 4 GO:0051345 positive regulation of hydrolase activity P 24 15 GO:0002885 positive regulation of hypersensitivity P 10 10 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB cascade P 11 9 GO:0033091 positive regulation of immature T cell proliferation P 2 2 GO:0033092 positive regulation of immature T cell proliferation in the thymus P 2 2 GO:0002699 positive regulation of immune effector process P 13 13 GO:0050778 positive regulation of immune response P 94 60 GO:0002839 positive regulation of immune response to tumor cell P 4 4 GO:0002684 positive regulation of immune system process P 96 62 GO:0002891 positive regulation of immunoglobulin mediated immune response P 10 10 GO:0002639 positive regulation of immunoglobulin production P 1 1 GO:0051024 positive regulation of immunoglobulin secretion P 1 1 GO:0050729 positive regulation of inflammatory response P 15 15 GO:0002863 positive regulation of inflammatory response to antigenic stimulus P 10 10 GO:0045089 positive regulation of innate immune response P 10 10 GO:0032962 positive regulation of inositol trisphosphate biosynthetic process P 1 1 GO:0032024 positive regulation of insulin secretion P 1 1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway P 1 1 GO:0033625 positive regulation of integrin activation P 1 1 GO:0032481 positive regulation of interferon type I production P 1 1 GO:0045359 positive regulation of interferon-beta biosynthetic process P 2 1 GO:0045078 positive regulation of interferon-gamma biosynthetic process P 4 3 GO:0032729 positive regulation of interferon-gamma production P 7 7 GO:0050718 positive regulation of interleukin-1 beta secretion P 1 1 GO:0045362 positive regulation of interleukin-1 biosynthetic process P 1 0 GO:0050716 positive regulation of interleukin-1 secretion P 1 1 GO:0045082 positive regulation of interleukin-10 biosynthetic process P 1 1 GO:0032733 positive regulation of interleukin-10 production P 1 1 GO:0045084 positive regulation of interleukin-12 biosynthetic process P 5 5 GO:0032735 positive regulation of interleukin-12 production P 1 1 GO:0045368 positive regulation of interleukin-13 biosynthetic process P 1 0 GO:0045086 positive regulation of interleukin-2 biosynthetic process P 8 7 GO:0045401 positive regulation of interleukin-3 biosynthetic process P 3 3 GO:0045404 positive regulation of interleukin-4 biosynthetic process P 3 3 GO:0045407 positive regulation of interleukin-5 biosynthetic process P 1 1 GO:0045410 positive regulation of interleukin-6 biosynthetic process P 6 5 GO:0032755 positive regulation of interleukin-6 production P 5 5 GO:0045830 positive regulation of isotype switching P 9 8 GO:0048298 positive regulation of isotype switching to IgA isotypes P 2 1 GO:0048295 positive regulation of isotype switching to IgE isotypes P 2 2 GO:0048304 positive regulation of isotype switching to IgG isotypes P 6 6 GO:0046427 positive regulation of JAK-STAT cascade P 7 6 GO:0043507 positive regulation of JNK activity P 11 7 GO:0046330 positive regulation of JNK cascade P 11 10 GO:0051549 positive regulation of keratinocyte migration P 1 1 GO:0033674 positive regulation of kinase activity P 88 65 GO:0043302 positive regulation of leukocyte degranulation P 4 4 GO:0001912 positive regulation of leukocyte mediated cytotoxicity P 11 11 GO:0002705 positive regulation of leukocyte mediated immunity P 12 12 GO:0051351 positive regulation of ligase activity P 1 1 GO:0046889 positive regulation of lipid biosynthetic process P 1 1 GO:0045834 positive regulation of lipid metabolic process P 5 3 GO:0051006 positive regulation of lipoprotein lipase activity P 1 1 GO:0040017 positive regulation of locomotion P 16 14 GO:0048170 positive regulation of long-term neuronal synaptic plasticity P 1 1 GO:0051349 positive regulation of lyase activity P 13 4 GO:0051251 positive regulation of lymphocyte activation P 61 54 GO:0002913 positive regulation of lymphocyte anergy P 1 1 GO:0045621 positive regulation of lymphocyte differentiation P 15 13 GO:0002708 positive regulation of lymphocyte mediated immunity P 12 12 GO:0050671 positive regulation of lymphocyte proliferation P 36 32 GO:0043032 positive regulation of macrophage activation P 3 3 GO:0045651 positive regulation of macrophage differentiation P 2 2 GO:0043406 positive regulation of MAP kinase activity P 41 33 GO:0043410 positive regulation of MAPKKK cascade P 9 5 GO:0032765 positive regulation of mast cell cytokine production P 1 1 GO:0043306 positive regulation of mast cell degranulation P 4 4 GO:0045633 positive regulation of mechanoreceptor differentiation P 1 1 GO:0045836 positive regulation of meiosis P 1 1 GO:0002053 positive regulation of mesenchymal cell proliferation P 9 9 GO:0009893 positive regulation of metabolic process P 363 313 GO:0048554 positive regulation of metalloenzyme activity P 2 2 GO:0045345 positive regulation of MHC class I biosynthetic process P 1 0 GO:0045348 positive regulation of MHC class II biosynthetic process P 3 3 GO:0031116 positive regulation of microtubule polymerization P 1 1 GO:0031112 positive regulation of microtubule polymerization or depolymerization P 1 1 GO:0045840 positive regulation of mitosis P 3 2 GO:0046604 positive regulation of mitotic centrosome separation P 1 1 GO:0032946 positive regulation of mononuclear cell proliferation P 36 32 GO:0044253 positive regulation of multicellular organismal metabolic process P 3 3 GO:0051240 positive regulation of multicellular organismal process P 115 80 GO:0051149 positive regulation of muscle cell differentiation P 2 1 GO:0045933 positive regulation of muscle contraction P 5 5 GO:0045639 positive regulation of myeloid cell differentiation P 12 11 GO:0002763 positive regulation of myeloid leukocyte differentiation P 5 5 GO:0002888 positive regulation of myeloid leukocyte mediated immunity P 8 8 GO:0045663 positive regulation of myoblast differentiation P 4 1 GO:0032816 positive regulation of natural killer cell activation P 3 3 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity P 9 9 GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target P 1 1 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell P 1 1 GO:0002717 positive regulation of natural killer cell mediated immunity P 1 1 GO:0051962 positive regulation of nervous system development P 2 2 GO:0002052 positive regulation of neuroblast proliferation P 7 5 GO:0050769 positive regulation of neurogenesis P 15 14 GO:0031646 positive regulation of neurological process P 4 3 GO:0043525 positive regulation of neuron apoptosis P 4 3 GO:0045666 positive regulation of neuron differentiation P 5 4 GO:0001956 positive regulation of neurotransmitter secretion P 2 2 GO:0051590 positive regulation of neurotransmitter transport P 1 1 GO:0051582 positive regulation of neurotransmitter uptake P 1 1 GO:0042346 positive regulation of NF-kappaB import into nucleus P 2 2 GO:0045429 positive regulation of nitric oxide biosynthetic process P 7 7 GO:0051135 positive regulation of NK T cell activation P 2 2 GO:0051138 positive regulation of NK T cell differentiation P 4 4 GO:0043071 positive regulation of non-apoptotic programmed cell death P 1 1 GO:0045747 positive regulation of Notch signaling pathway P 1 1 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process P 284 247 GO:0046824 positive regulation of nucleocytoplasmic transport P 4 3 GO:0030810 positive regulation of nucleotide biosynthetic process P 4 3 GO:0045981 positive regulation of nucleotide metabolic process P 4 3 GO:0042482 positive regulation of odontogenesis P 2 2 GO:0042488 positive regulation of odontogenesis of dentine-containing teeth P 2 2 GO:0048714 positive regulation of oligodendrocyte differentiation P 1 1 GO:0046622 positive regulation of organ growth P 1 1 GO:0045778 positive regulation of ossification P 6 5 GO:0045669 positive regulation of osteoblast differentiation P 6 5 GO:0045672 positive regulation of osteoclast differentiation P 3 3 GO:0051353 positive regulation of oxidoreductase activity P 1 1 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation P 19 19 GO:0002851 positive regulation of peripheral T cell tolerance induction P 1 1 GO:0002660 positive regulation of peripheral tolerance induction P 1 1 GO:0050766 positive regulation of phagocytosis P 16 16 GO:0045937 positive regulation of phosphate metabolic process P 20 19 GO:0043552 positive regulation of phosphoinositide 3-kinase activity P 5 5 GO:0014068 positive regulation of phosphoinositide 3-kinase cascade P 1 1 GO:0042327 positive regulation of phosphorylation P 20 19 GO:0048549 positive regulation of pinocytosis P 1 1 GO:0050927 positive regulation of positive chemotaxis P 7 6 GO:0002702 positive regulation of production of molecular mediator of immune response P 2 2 GO:0043068 positive regulation of programmed cell death P 162 123 GO:0045787 positive regulation of progression through cell cycle P 12 11 GO:0045931 positive regulation of progression through mitotic cell cycle P 4 4 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process P 2 1 GO:0001934 positive regulation of protein amino acid phosphorylation P 25 23 GO:0032092 positive regulation of protein binding P 2 1 GO:0045727 positive regulation of protein biosynthetic process P 39 34 GO:0045732 positive regulation of protein catabolic process P 3 2 GO:0046827 positive regulation of protein export from nucleus P 1 0 GO:0042307 positive regulation of protein import into nucleus P 3 3 GO:0045860 positive regulation of protein kinase activity P 83 60 GO:0051247 positive regulation of protein metabolic process P 69 60 GO:0031401 positive regulation of protein modification process P 4 3 GO:0050714 positive regulation of protein secretion P 4 3 GO:0051222 positive regulation of protein transport P 4 3 GO:0031398 positive regulation of protein ubiquitination P 2 1 GO:0045862 positive regulation of proteolysis P 5 2 GO:0035022 positive regulation of Rac protein signal transduction P 2 1 GO:0032320 positive regulation of Ras GTPase activity P 2 2 GO:0046579 positive regulation of Ras protein signal transduction P 4 4 GO:0048260 positive regulation of receptor-mediated endocytosis P 1 0 GO:0045591 positive regulation of regulatory T cell differentiation P 2 2 GO:0002833 positive regulation of response to biotic stimulus P 4 4 GO:0032103 positive regulation of response to external stimulus P 2 2 GO:0032106 positive regulation of response to extracellular stimulus P 2 2 GO:0032097 positive regulation of response to food P 2 2 GO:0032109 positive regulation of response to nutrient levels P 2 2 GO:0048584 positive regulation of response to stimulus P 7 7 GO:0002836 positive regulation of response to tumor cell P 4 4 GO:0032321 positive regulation of Rho GTPase activity P 1 1 GO:0035025 positive regulation of Rho protein signal transduction P 1 1 GO:0045872 positive regulation of rhodopsin gene activity P 2 2 GO:0046878 positive regulation of saliva secretion P 1 1 GO:0051047 positive regulation of secretion P 9 8 GO:0009967 positive regulation of signal transduction P 62 54 GO:0043415 positive regulation of skeletal muscle regeneration P 1 1 GO:0051057 positive regulation of small GTPase mediated signal transduction P 8 7 GO:0048661 positive regulation of smooth muscle cell proliferation P 3 2 GO:0045987 positive regulation of smooth muscle contraction P 4 4 GO:0045880 positive regulation of smoothened signaling pathway P 4 4 GO:0032874 positive regulation of stress-activated MAPK cascade P 2 1 GO:0051155 positive regulation of striated muscle cell differentiation P 2 1 GO:0045989 positive regulation of striated muscle contraction P 1 1 GO:0045844 positive regulation of striated muscle development P 1 1 GO:0045885 positive regulation of survival gene product activity P 6 5 GO:0050806 positive regulation of synaptic transmission P 4 3 GO:0032224 positive regulation of synaptic transmission, cholinergic P 1 1 GO:0032226 positive regulation of synaptic transmission, dopaminergic P 1 1 GO:0032230 positive regulation of synaptic transmission, GABAergic P 1 1 GO:0051965 positive regulation of synaptogenesis P 2 2 GO:0050870 positive regulation of T cell activation P 43 38 GO:0002669 positive regulation of T cell anergy P 1 1 GO:0045582 positive regulation of T cell differentiation P 12 10 GO:0001916 positive regulation of T cell mediated cytotoxicity P 2 2 GO:0002711 positive regulation of T cell mediated immunity P 1 1 GO:0042102 positive regulation of T cell proliferation P 27 24 GO:0050862 positive regulation of T cell receptor signaling pathway P 1 0 GO:0002666 positive regulation of T cell tolerance induction P 2 2 GO:0045627 positive regulation of T-helper 1 cell differentiation P 1 1 GO:0002827 positive regulation of T-helper 1 type immune response P 1 1 GO:0045630 positive regulation of T-helper 2 cell differentiation P 1 1 GO:0045624 positive regulation of T-helper cell differentiation P 2 2 GO:0002645 positive regulation of tolerance induction P 2 2 GO:0002654 positive regulation of tolerance induction dependent upon immune response P 1 1 GO:0002651 positive regulation of tolerance induction to self antigen P 1 1 GO:0045941 positive regulation of transcription P 278 243 GO:0051091 positive regulation of transcription factor activity P 19 11 GO:0042993 positive regulation of transcription factor import into nucleus P 2 2 GO:0045944 positive regulation of transcription from RNA polymerase II promoter P 194 171 GO:0046022 positive regulation of transcription from RNA polymerase II promoter, mitotic P 2 1 GO:0006990 positive regulation of transcription of target genes involved in unfolded protein response P 1 0 GO:0045893 positive regulation of transcription, DNA-dependent P 233 209 GO:0045897 positive regulation of transcription, mitotic P 2 1 GO:0051347 positive regulation of transferase activity P 89 66 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway P 3 3 GO:0032914 positive regulation of transforming growth factor-beta1 production P 1 1 GO:0045948 positive regulation of translational initiation P 2 2 GO:0045994 positive regulation of translational initiation by iron P 1 1 GO:0051971 positive regulation of transmission of nerve impulse P 4 3 GO:0051050 positive regulation of transport P 33 30 GO:0042535 positive regulation of tumor necrosis factor biosynthetic process P 4 4 GO:0032760 positive regulation of tumor necrosis factor production P 8 7 GO:0001812 positive regulation of type I hypersensitivity P 7 7 GO:0002894 positive regulation of type II hypersensitivity P 8 8 GO:0001798 positive regulation of type IIa hypersensitivity P 8 8 GO:0001805 positive regulation of type III hypersensitivity P 3 3 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein P 5 5 GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein P 1 1 GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein P 2 2 GO:0050677 positive regulation of urothelial cell proliferation P 1 1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway P 4 4 GO:0045907 positive regulation of vasoconstriction P 2 2 GO:0030177 positive regulation of Wnt receptor signaling pathway P 1 1 GO:0043368 positive T cell selection P 7 7 GO:0045059 positive thymic T cell selection P 7 7 GO:0035120 post-embryonic appendage morphogenesis P 2 2 GO:0031077 post-embryonic camera-type eye development P 1 1 GO:0009791 post-embryonic development P 16 16 GO:0048050 post-embryonic eye morphogenesis P 1 1 GO:0035166 post-embryonic hemopoiesis P 1 1 GO:0035129 post-embryonic hindlimb morphogenesis P 2 2 GO:0035127 post-embryonic limb morphogenesis P 2 2 GO:0009886 post-embryonic morphogenesis P 7 7 GO:0048569 post-embryonic organ development P 6 6 GO:0048563 post-embryonic organ morphogenesis P 5 5 GO:0007388 posterior compartment specification P 1 0 GO:0035289 posterior head segmentation P 1 1 GO:0007497 posterior midgut development P 1 1 GO:0006892 post-Golgi vesicle-mediated transport P 10 1 GO:0045297 post-mating behavior P 1 1 GO:0006301 postreplication repair P 4 3 GO:0001941 postsynaptic membrane organization P 1 1 GO:0016441 posttranscriptional gene silencing P 3 2 GO:0043687 post-translational protein modification P 1192 270 GO:0006620 posttranslational protein targeting to membrane P 3 1 GO:0055075 potassium ion homeostasis P 1 0 GO:0006813 potassium ion transport P 155 12 GO:0002329 pre-B cell differentiation P 1 1 GO:0030327 prenylated protein catabolic process P 2 2 GO:0030328 prenylcysteine catabolic process P 1 1 GO:0030329 prenylcysteine metabolic process P 1 1 GO:0060134 prepulse inhibition P 5 5 GO:0044238 primary metabolic process P 6092 1530 GO:0031053 primary microRNA processing P 1 0 GO:0014020 primary neural tube formation P 44 44 GO:0007538 primary sex determination P 2 2 GO:0007542 primary sex determination, germ-line P 2 2 GO:0002328 pro-B cell differentiation P 3 3 GO:0002440 production of molecular mediator of immune response P 38 35 GO:0006709 progesterone catabolic process P 1 1 GO:0042448 progesterone metabolic process P 3 3 GO:0050847 progesterone receptor signaling pathway P 2 2 GO:0012501 programmed cell death P 591 315 GO:0006561 proline biosynthetic process P 4 0 GO:0006562 proline catabolic process P 3 0 GO:0006560 proline metabolic process P 6 0 GO:0015824 proline transport P 2 2 GO:0006433 prolyl-tRNA aminoacylation P 2 0 GO:0051324 prophase P 9 5 GO:0019543 propionate catabolic process P 1 0 GO:0019541 propionate metabolic process P 1 0 GO:0019230 proprioception P 1 1 GO:0051355 proprioception during equilibrioception P 1 1 GO:0001516 prostaglandin biosynthetic process P 8 1 GO:0006693 prostaglandin metabolic process P 13 4 GO:0015732 prostaglandin transport P 1 1 GO:0046457 prostanoid biosynthetic process P 8 1 GO:0006692 prostanoid metabolic process P 13 4 GO:0030850 prostate gland development P 2 2 GO:0033368 protease localization in mast cell secretory granule P 1 1 GO:0033375 protease localization in T cell secretory granule P 1 1 GO:0043161 proteasomal ubiquitin-dependent protein catabolic process P 13 11 GO:0042270 protection from natural killer cell mediated cytotoxicity P 2 2 GO:0006473 protein amino acid acetylation P 12 7 GO:0043543 protein amino acid acylation P 22 16 GO:0006471 protein amino acid ADP-ribosylation P 16 3 GO:0008213 protein amino acid alkylation P 27 18 GO:0046777 protein amino acid autophosphorylation P 32 26 GO:0018214 protein amino acid carboxylation P 1 0 GO:0006476 protein amino acid deacetylation P 8 2 GO:0006470 protein amino acid dephosphorylation P 106 22 GO:0018347 protein amino acid farnesylation P 1 0 GO:0006486 protein amino acid glycosylation P 76 16 GO:0006497 protein amino acid lipidation P 49 15 GO:0006479 protein amino acid methylation P 27 18 GO:0018319 protein amino acid myristoylation P 2 1 GO:0017014 protein amino acid nitrosylation P 1 0 GO:0006487 protein amino acid N-linked glycosylation P 18 5 GO:0018279 protein amino acid N-linked glycosylation via asparagine P 5 1 GO:0006493 protein amino acid O-linked glycosylation P 14 6 GO:0018318 protein amino acid palmitoylation P 1 1 GO:0006468 protein amino acid phosphorylation P 592 161 GO:0018346 protein amino acid prenylation P 10 0 GO:0006477 protein amino acid sulfation P 2 2 GO:0006494 protein amino acid terminal glycosylation P 1 1 GO:0006496 protein amino acid terminal N-glycosylation P 1 1 GO:0016598 protein arginylation P 1 1 GO:0016540 protein autoprocessing P 34 27 GO:0051865 protein autoubiquitination P 1 0 GO:0030163 protein catabolic process P 174 52 GO:0006461 protein complex assembly P 125 50 GO:0043241 protein complex disassembly P 13 1 GO:0031503 protein complex localization P 2 2 GO:0002084 protein depalmitoylation P 1 1 GO:0051261 protein depolymerization P 32 9 GO:0031648 protein destabilization P 1 1 GO:0016926 protein desumoylation P 2 2 GO:0016579 protein deubiquitination P 9 6 GO:0044256 protein digestion P 16 2 GO:0006611 protein export from nucleus P 11 7 GO:0018343 protein farnesylation P 2 0 GO:0006457 protein folding P 132 16 GO:0018344 protein geranylgeranylation P 1 1 GO:0051291 protein heterooligomerization P 4 4 GO:0051290 protein heterotetramerization P 2 2 GO:0051260 protein homooligomerization P 21 16 GO:0051289 protein homotetramerization P 2 2 GO:0017038 protein import P 65 37 GO:0045039 protein import into mitochondrial inner membrane P 4 0 GO:0043681 protein import into mitochondrion P 4 0 GO:0006606 protein import into nucleus P 57 35 GO:0000059 protein import into nucleus, docking P 15 0 GO:0000060 protein import into nucleus, translocation P 15 12 GO:0016558 protein import into peroxisome matrix P 3 2 GO:0016560 protein import into peroxisome matrix, docking P 1 1 GO:0045046 protein import into peroxisome membrane P 1 0 GO:0051205 protein insertion into membrane P 6 4 GO:0051204 protein insertion into mitochondrial membrane P 3 3 GO:0001844 protein insertion into mitochondrial membrane during induction of apoptosis P 3 3 GO:0043491 protein kinase B signaling cascade P 10 10 GO:0007205 protein kinase C activation P 12 2 GO:0007243 protein kinase cascade P 218 170 GO:0008104 protein localization P 729 152 GO:0033367 protein localization in mast cell secretory granule P 1 1 GO:0033365 protein localization in organelle P 1 1 GO:0033366 protein localization in secretory granule P 1 1 GO:0033374 protein localization in T cell secretory granule P 1 1 GO:0051604 protein maturation P 10 8 GO:0051605 protein maturation via proteolysis P 9 8 GO:0019538 protein metabolic process P 2696 586 GO:0032446 protein modification by small protein conjugation P 45 24 GO:0006464 protein modification process P 1383 306 GO:0018377 protein myristoylation P 2 1 GO:0045116 protein neddylation P 1 0 GO:0051259 protein oligomerization P 30 24 GO:0018345 protein palmitoylation P 8 8 GO:0051258 protein polymerization P 39 13 GO:0000209 protein polyubiquitination P 3 3 GO:0018342 protein prenylation P 14 1 GO:0016485 protein processing P 64 42 GO:0042026 protein refolding P 1 0 GO:0030091 protein repair P 3 2 GO:0006621 protein retention in ER P 3 0 GO:0009306 protein secretion P 30 21 GO:0030908 protein splicing P 3 0 GO:0050821 protein stabilization P 7 2 GO:0016925 protein sumoylation P 6 6 GO:0006605 protein targeting P 195 64 GO:0045047 protein targeting to ER P 19 1 GO:0000042 protein targeting to Golgi P 1 1 GO:0006622 protein targeting to lysosome P 2 1 GO:0006612 protein targeting to membrane P 27 3 GO:0006626 protein targeting to mitochondrion P 7 1 GO:0006625 protein targeting to peroxisome P 5 2 GO:0006623 protein targeting to vacuole P 4 0 GO:0051262 protein tetramerization P 8 8 GO:0006467 protein thiol-disulfide exchange P 3 1 GO:0015031 protein transport P 646 82 GO:0016567 protein ubiquitination P 38 18 GO:0042787 protein ubiquitination during ubiquitin-dependent protein catabolic process P 3 1 GO:0018298 protein-chromophore linkage P 11 0 GO:0065004 protein-DNA complex assembly P 120 7 GO:0022618 protein-RNA complex assembly P 71 13 GO:0032988 protein-RNA complex disassembly P 1 0 GO:0030166 proteoglycan biosynthetic process P 14 10 GO:0006029 proteoglycan metabolic process P 17 12 GO:0006508 proteolysis P 634 72 GO:0051603 proteolysis involved in cellular protein catabolic process P 125 31 GO:0015992 proton transport P 59 6 GO:0019047 provirus integration P 1 0 GO:0009954 proximal/distal pattern formation P 10 10 GO:0001522 pseudouridine synthesis P 9 2 GO:0042559 pteridine and derivative biosynthetic process P 11 0 GO:0042558 pteridine and derivative metabolic process P 12 1 GO:0009113 purine base biosynthetic process P 1 0 GO:0006144 purine base metabolic process P 7 2 GO:0043096 purine base salvage P 2 2 GO:0009217 purine deoxyribonucleoside triphosphate catabolic process P 2 2 GO:0009215 purine deoxyribonucleoside triphosphate metabolic process P 2 2 GO:0009155 purine deoxyribonucleotide catabolic process P 2 2 GO:0009151 purine deoxyribonucleotide metabolic process P 2 2 GO:0042451 purine nucleoside biosynthetic process P 1 0 GO:0009136 purine nucleoside diphosphate biosynthetic process P 1 1 GO:0009137 purine nucleoside diphosphate catabolic process P 3 3 GO:0009135 purine nucleoside diphosphate metabolic process P 4 4 GO:0042278 purine nucleoside metabolic process P 5 3 GO:0009127 purine nucleoside monophosphate biosynthetic process P 10 0 GO:0009128 purine nucleoside monophosphate catabolic process P 1 0 GO:0009126 purine nucleoside monophosphate metabolic process P 11 0 GO:0015860 purine nucleoside transport P 2 1 GO:0009145 purine nucleoside triphosphate biosynthetic process P 48 0 GO:0009146 purine nucleoside triphosphate catabolic process P 4 4 GO:0009144 purine nucleoside triphosphate metabolic process P 54 4 GO:0006164 purine nucleotide biosynthetic process P 66 7 GO:0006195 purine nucleotide catabolic process P 7 6 GO:0006163 purine nucleotide metabolic process P 75 14 GO:0046129 purine ribonucleoside biosynthetic process P 1 0 GO:0009180 purine ribonucleoside diphosphate biosynthetic process P 1 1 GO:0009181 purine ribonucleoside diphosphate catabolic process P 3 3 GO:0009179 purine ribonucleoside diphosphate metabolic process P 4 4 GO:0046128 purine ribonucleoside metabolic process P 4 3 GO:0009168 purine ribonucleoside monophosphate biosynthetic process P 10 0 GO:0009169 purine ribonucleoside monophosphate catabolic process P 1 0 GO:0009167 purine ribonucleoside monophosphate metabolic process P 11 0 GO:0006166 purine ribonucleoside salvage P 3 3 GO:0009206 purine ribonucleoside triphosphate biosynthetic process P 48 0 GO:0009207 purine ribonucleoside triphosphate catabolic process P 2 2 GO:0009205 purine ribonucleoside triphosphate metabolic process P 52 2 GO:0009152 purine ribonucleotide biosynthetic process P 60 1 GO:0009154 purine ribonucleotide catabolic process P 5 4 GO:0009150 purine ribonucleotide metabolic process P 67 5 GO:0043101 purine salvage P 3 3 GO:0021937 Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation P 4 4 GO:0021860 pyramidal neuron development P 3 3 GO:0021859 pyramidal neuron differentiation P 3 3 GO:0019363 pyridine nucleotide biosynthetic process P 11 3 GO:0019364 pyridine nucleotide catabolic process P 3 0 GO:0019362 pyridine nucleotide metabolic process P 23 6 GO:0008615 pyridoxine biosynthetic process P 2 0 GO:0008614 pyridoxine metabolic process P 2 0 GO:0019856 pyrimidine base biosynthetic process P 4 0 GO:0006208 pyrimidine base catabolic process P 1 1 GO:0006206 pyrimidine base metabolic process P 8 3 GO:0009197 pyrimidine deoxyribonucleoside diphosphate biosynthetic process P 2 0 GO:0009196 pyrimidine deoxyribonucleoside diphosphate metabolic process P 2 0 GO:0046125 pyrimidine deoxyribonucleoside metabolic process P 3 1 GO:0009177 pyrimidine deoxyribonucleoside monophosphate biosynthetic process P 1 0 GO:0009176 pyrimidine deoxyribonucleoside monophosphate metabolic process P 1 0 GO:0009212 pyrimidine deoxyribonucleoside triphosphate biosynthetic process P 3 1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process P 3 1 GO:0009221 pyrimidine deoxyribonucleotide biosynthetic process P 4 1 GO:0009219 pyrimidine deoxyribonucleotide metabolic process P 4 1 GO:0006290 pyrimidine dimer repair P 4 4 GO:0000720 pyrimidine dimer repair via nucleotide-excision repair P 1 1 GO:0046135 pyrimidine nucleoside catabolic process P 1 0 GO:0009139 pyrimidine nucleoside diphosphate biosynthetic process P 2 0 GO:0009138 pyrimidine nucleoside diphosphate metabolic process P 2 0 GO:0006213 pyrimidine nucleoside metabolic process P 6 2 GO:0009130 pyrimidine nucleoside monophosphate biosynthetic process P 2 0 GO:0009129 pyrimidine nucleoside monophosphate metabolic process P 2 0 GO:0015864 pyrimidine nucleoside transport P 1 1 GO:0009148 pyrimidine nucleoside triphosphate biosynthetic process P 3 1 GO:0009147 pyrimidine nucleoside triphosphate metabolic process P 12 1 GO:0006221 pyrimidine nucleotide biosynthetic process P 18 1 GO:0006220 pyrimidine nucleotide metabolic process P 19 2 GO:0046133 pyrimidine ribonucleoside catabolic process P 1 0 GO:0046131 pyrimidine ribonucleoside metabolic process P 3 1 GO:0009174 pyrimidine ribonucleoside monophosphate biosynthetic process P 1 0 GO:0009173 pyrimidine ribonucleoside monophosphate metabolic process P 1 0 GO:0009209 pyrimidine ribonucleoside triphosphate biosynthetic process P 9 0 GO:0009208 pyrimidine ribonucleoside triphosphate metabolic process P 9 0 GO:0009220 pyrimidine ribonucleotide biosynthetic process P 11 0 GO:0009218 pyrimidine ribonucleotide metabolic process P 11 0 GO:0015855 pyrimidine transport P 1 0 GO:0006090 pyruvate metabolic process P 21 7 GO:0008616 queuosine biosynthetic process P 1 0 GO:0046116 queuosine metabolic process P 1 0 GO:0046874 quinolinate metabolic process P 1 0 GO:0045426 quinone cofactor biosynthetic process P 9 2 GO:0042375 quinone cofactor metabolic process P 10 3 GO:0032482 Rab protein signal transduction P 27 1 GO:0016601 Rac protein signal transduction P 13 7 GO:0021942 radial glia guided migration of Purkinje cell P 1 1 GO:0060019 radial glial cell differentiation P 1 1 GO:0009956 radial pattern formation P 1 1 GO:0007265 Ras protein signal transduction P 144 41 GO:0019046 reactivation of latent virus P 1 1 GO:0032800 receptor biosynthetic process P 2 1 GO:0032801 receptor catabolic process P 1 1 GO:0043113 receptor clustering P 11 11 GO:0007168 receptor guanylyl cyclase signaling pathway P 2 1 GO:0031623 receptor internalization P 3 3 GO:0043112 receptor metabolic process P 24 22 GO:0001881 receptor recycling P 5 4 GO:0006898 receptor-mediated endocytosis P 15 11 GO:0000725 recombinational repair P 8 8 GO:0051481 reduction of cytosolic calcium ion concentration P 1 1 GO:0000320 re-entry into mitotic cell cycle P 3 3 GO:0060004 reflex P 8 8 GO:0031099 regeneration P 11 7 GO:0003002 regionalization P 146 145 GO:0045055 regulated secretory pathway P 63 50 GO:0065009 regulation of a molecular function P 303 175 GO:0014056 regulation of acetylcholine secretion P 2 2 GO:0060046 regulation of acrosome reaction P 1 1 GO:0032956 regulation of actin cytoskeleton organization and biogenesis P 32 7 GO:0030834 regulation of actin filament depolymerization P 21 2 GO:0030832 regulation of actin filament length P 32 7 GO:0030833 regulation of actin filament polymerization P 10 5 GO:0051125 regulation of actin nucleation P 1 1 GO:0008064 regulation of actin polymerization and/or depolymerization P 31 7 GO:0001508 regulation of action potential P 35 32 GO:0046006 regulation of activated T cell proliferation P 9 6 GO:0001969 regulation of activation of membrane attack complex P 1 1 GO:0002673 regulation of acute inflammatory response P 12 12 GO:0002864 regulation of acute inflammatory response to antigenic stimulus P 12 12 GO:0002819 regulation of adaptive immune response P 19 19 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. P 19 19 GO:0045761 regulation of adenylate cyclase activity P 16 5 GO:0032344 regulation of aldosterone metabolic process P 1 1 GO:0046634 regulation of alpha-beta T cell activation P 11 11 GO:0046637 regulation of alpha-beta T cell differentiation P 4 4 GO:0046640 regulation of alpha-beta T cell proliferation P 9 9 GO:0033238 regulation of amine metabolic process P 50 44 GO:0006521 regulation of amino acid metabolic process P 50 44 GO:0042984 regulation of amyloid precursor protein biosynthetic process P 2 2 GO:0022603 regulation of anatomical structure morphogenesis P 46 15 GO:0045765 regulation of angiogenesis P 30 18 GO:0002002 regulation of angiotensin levels in blood P 1 1 GO:0045767 regulation of anti-apoptosis P 3 2 GO:0050854 regulation of antigen receptor-mediated signaling pathway P 11 10 GO:0042981 regulation of apoptosis P 367 261 GO:0032098 regulation of appetite P 4 4 GO:0032012 regulation of ARF protein signal transduction P 10 0 GO:0048710 regulation of astrocyte differentiation P 4 4 GO:0009786 regulation of asymmetric cell division P 1 1 GO:0043462 regulation of ATPase activity P 1 1 GO:0045607 regulation of auditory receptor cell differentiation P 3 3 GO:0031133 regulation of axon diameter P 3 3 GO:0030516 regulation of axon extension P 14 12 GO:0048841 regulation of axon extension involved in axon guidance P 3 3 GO:0048690 regulation of axon extension involved in regeneration P 1 1 GO:0050770 regulation of axonogenesis P 29 25 GO:0050864 regulation of B cell activation P 36 34 GO:0045577 regulation of B cell differentiation P 8 8 GO:0002712 regulation of B cell mediated immunity P 11 11 GO:0030888 regulation of B cell proliferation P 20 19 GO:0050855 regulation of B cell receptor signaling pathway P 1 1 GO:0002661 regulation of B cell tolerance induction P 1 1 GO:0050795 regulation of behavior P 2 2 GO:0051098 regulation of binding P 20 15 GO:0050789 regulation of biological process P 3479 1570 GO:0065008 regulation of biological quality P 504 278 GO:0009889 regulation of biosynthetic process P 154 97 GO:0030193 regulation of blood coagulation P 4 2 GO:0001991 regulation of blood pressure by circulatory renin-angiotensin P 7 7 GO:0001990 regulation of blood pressure by hormones P 16 16 GO:0001992 regulation of blood pressure by vasopressin P 3 3 GO:0050880 regulation of blood vessel size P 33 24 GO:0030510 regulation of BMP signaling pathway P 15 14 GO:0050878 regulation of body fluids P 78 37 GO:0040014 regulation of body size P 50 48 GO:0030500 regulation of bone mineralization P 15 8 GO:0046850 regulation of bone remodeling P 29 22 GO:0045124 regulation of bone resorption P 6 6 GO:0051924 regulation of calcium ion transport P 7 7 GO:0051925 regulation of calcium ion transport via voltage-gated calcium channel P 2 2 GO:0017158 regulation of calcium ion-dependent exocytosis P 4 3 GO:0046586 regulation of calcium-dependent cell-cell adhesion P 1 1 GO:0050848 regulation of calcium-mediated signaling P 11 10 GO:0030817 regulation of cAMP biosynthetic process P 5 4 GO:0030814 regulation of cAMP metabolic process P 6 5 GO:0043255 regulation of carbohydrate biosynthetic process P 4 4 GO:0006109 regulation of carbohydrate metabolic process P 6 5 GO:0060043 regulation of cardiac muscle cell proliferation P 3 3 GO:0043281 regulation of caspase activity P 31 22 GO:0009894 regulation of catabolic process P 12 9 GO:0050790 regulation of catalytic activity P 262 150 GO:0042069 regulation of catecholamine metabolic process P 6 6 GO:0050433 regulation of catecholamine secretion P 6 6 GO:0051940 regulation of catecholamine uptake during transmission of nerve impulse P 1 1 GO:0043088 regulation of Cdc42 GTPase activity P 1 1 GO:0032489 regulation of Cdc42 protein signal transduction P 1 1 GO:0050865 regulation of cell activation P 86 79 GO:0030155 regulation of cell adhesion P 45 29 GO:0051726 regulation of cell cycle P 344 102 GO:0045595 regulation of cell differentiation P 146 131 GO:0051302 regulation of cell division P 3 1 GO:0042659 regulation of cell fate specification P 2 1 GO:0001558 regulation of cell growth P 79 7 GO:0001560 regulation of cell growth by extracellular stimulus P 2 1 GO:0031341 regulation of cell killing P 15 15 GO:0030334 regulation of cell migration P 52 41 GO:0022604 regulation of cell morphogenesis P 46 15 GO:0051270 regulation of cell motility P 59 48 GO:0031344 regulation of cell projection organization and biogenesis P 1 1 GO:0042127 regulation of cell proliferation P 310 280 GO:0030503 regulation of cell redox homeostasis P 2 1 GO:0008360 regulation of cell shape P 46 15 GO:0008361 regulation of cell size P 108 24 GO:0006884 regulation of cell volume P 3 2 GO:0022407 regulation of cell-cell adhesion P 9 8 GO:0033632 regulation of cell-cell adhesion mediated by integrin P 1 1 GO:0001952 regulation of cell-matrix adhesion P 7 7 GO:0031326 regulation of cellular biosynthetic process P 138 84 GO:0031329 regulation of cellular catabolic process P 1 1 GO:0051128 regulation of cellular component organization and biogenesis P 53 24 GO:0032535 regulation of cellular component size P 32 7 GO:0031323 regulation of cellular metabolic process P 2094 687 GO:0051453 regulation of cellular pH P 2 0 GO:0050794 regulation of cellular process P 3117 1311 GO:0032268 regulation of cellular protein metabolic process P 1 1 GO:0043457 regulation of cellular respiration P 1 1 GO:0046605 regulation of centrosome cycle P 1 1 GO:0030826 regulation of cGMP biosynthetic process P 2 2 GO:0030823 regulation of cGMP metabolic process P 3 3 GO:0045073 regulation of chemokine biosynthetic process P 7 7 GO:0032642 regulation of chemokine production P 1 1 GO:0050920 regulation of chemotaxis P 7 6 GO:0030300 regulation of cholesterol absorption P 4 4 GO:0032330 regulation of chondrocyte differentiation P 3 3 GO:0002676 regulation of chronic inflammatory response P 1 1 GO:0042752 regulation of circadian rhythm P 3 3 GO:0042749 regulation of circadian sleep/wake cycle P 2 2 GO:0045188 regulation of circadian sleep/wake cycle, non-REM sleep P 1 1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep P 1 1 GO:0045187 regulation of circadian sleep/wake cycle, sleep P 2 2 GO:0050818 regulation of coagulation P 8 3 GO:0030449 regulation of complement activation P 2 2 GO:0031279 regulation of cyclase activity P 18 7 GO:0030802 regulation of cyclic nucleotide biosynthetic process P 7 6 GO:0030799 regulation of cyclic nucleotide metabolic process P 9 8 GO:0000079 regulation of cyclin-dependent protein kinase activity P 11 7 GO:0001959 regulation of cytokine and chemokine mediated signaling pathway P 3 3 GO:0042035 regulation of cytokine biosynthetic process P 50 45 GO:0001817 regulation of cytokine production P 29 27 GO:0002718 regulation of cytokine production during immune response P 2 2 GO:0050707 regulation of cytokine secretion P 5 4 GO:0042268 regulation of cytolysis P 2 1 GO:0051493 regulation of cytoskeleton organization and biogenesis P 33 8 GO:0045583 regulation of cytotoxic T cell differentiation P 1 0 GO:0031347 regulation of defense response P 27 27 GO:0050688 regulation of defense response to virus P 2 2 GO:0050691 regulation of defense response to virus by host P 1 1 GO:0050773 regulation of dendrite development P 5 5 GO:0048814 regulation of dendrite morphogenesis P 5 5 GO:0040034 regulation of development, heterochronic P 5 5 GO:0048638 regulation of developmental growth P 1 0 GO:0048070 regulation of developmental pigmentation P 1 1 GO:0050793 regulation of developmental process P 245 187 GO:0051101 regulation of DNA binding P 10 7 GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator P 2 2 GO:0051052 regulation of DNA metabolic process P 21 15 GO:0000018 regulation of DNA recombination P 5 4 GO:0006282 regulation of DNA repair P 1 0 GO:0006275 regulation of DNA replication P 11 8 GO:0030174 regulation of DNA replication initiation P 3 2 GO:0042053 regulation of dopamine metabolic process P 6 6 GO:0060159 regulation of dopamine receptor signaling pathway P 3 3 GO:0014059 regulation of dopamine secretion P 5 5 GO:0051584 regulation of dopamine uptake P 1 1 GO:0045995 regulation of embryonic development P 7 2 GO:0030100 regulation of endocytosis P 34 30 GO:0042663 regulation of endodermal cell fate specification P 1 0 GO:0045601 regulation of endothelial cell differentiation P 4 1 GO:0001936 regulation of endothelial cell proliferation P 6 6 GO:0045604 regulation of epidermal cell differentiation P 6 6 GO:0007176 regulation of epidermal growth factor receptor activity P 3 1 GO:0042058 regulation of epidermal growth factor receptor signaling pathway P 6 4 GO:0045682 regulation of epidermis development P 8 8 GO:0030856 regulation of epithelial cell differentiation P 7 7 GO:0050678 regulation of epithelial cell proliferation P 24 24 GO:0045646 regulation of erythrocyte differentiation P 9 8 GO:0060079 regulation of excitatory postsynaptic membrane potential P 6 6 GO:0007096 regulation of exit from mitosis P 2 1 GO:0017157 regulation of exocytosis P 18 16 GO:0045598 regulation of fat cell differentiation P 8 7 GO:0042304 regulation of fatty acid biosynthetic process P 1 1 GO:0019217 regulation of fatty acid metabolic process P 7 6 GO:0046320 regulation of fatty acid oxidation P 1 1 GO:0045924 regulation of female receptivity P 2 2 GO:0040036 regulation of fibroblast growth factor receptor signaling pathway P 4 4 GO:0048145 regulation of fibroblast proliferation P 8 7 GO:0030092 regulation of flagellum biogenesis P 1 1 GO:0008590 regulation of frizzled signaling pathway P 1 1 GO:0046643 regulation of gamma-delta T cell activation P 1 1 GO:0045586 regulation of gamma-delta T cell differentiation P 1 1 GO:0040029 regulation of gene expression, epigenetic P 49 21 GO:0043467 regulation of generation of precursor metabolites and energy P 1 1 GO:0032583 regulation of gene-specific transcription P 4 3 GO:0002634 regulation of germinal center formation P 3 3 GO:0045685 regulation of glial cell differentiation P 8 8 GO:0014013 regulation of gliogenesis P 8 8 GO:0031946 regulation of glucocorticoid biosynthetic process P 2 2 GO:0031943 regulation of glucocorticoid metabolic process P 3 2 GO:0006111 regulation of gluconeogenesis P 2 2 GO:0046324 regulation of glucose import P 6 5 GO:0035227 regulation of glutamate-cysteine ligase activity P 1 1 GO:0005979 regulation of glycogen biosynthetic process P 1 1 GO:0005981 regulation of glycogen catabolic process P 1 1 GO:0006110 regulation of glycolysis P 1 0 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway P 18 14 GO:0021936 regulation of granule cell precursor proliferation P 7 7 GO:0030852 regulation of granulocyte differentiation P 1 1 GO:0045423 regulation of granulocyte macrophage colony-stimulating factor biosynthetic process P 3 3 GO:0040008 regulation of growth P 144 72 GO:0060123 regulation of growth hormone secretion P 3 2 GO:0040009 regulation of growth rate P 2 2 GO:0043087 regulation of GTPase activity P 61 10 GO:0031282 regulation of guanylate cyclase activity P 2 2 GO:0051797 regulation of hair follicle development P 2 0 GO:0008016 regulation of heart contraction P 35 32 GO:0045610 regulation of hemocyte differentiation P 1 1 GO:0046984 regulation of hemoglobin biosynthetic process P 1 1 GO:0035065 regulation of histone acetylation P 2 1 GO:0051569 regulation of histone H3-K4 methylation P 1 1 GO:0051570 regulation of histone H3-K9 methylation P 1 1 GO:0031060 regulation of histone methylation P 2 2 GO:0031056 regulation of histone modification P 4 3 GO:0046885 regulation of hormone biosynthetic process P 2 2 GO:0032350 regulation of hormone metabolic process P 3 3 GO:0046883 regulation of hormone secretion P 20 12 GO:0051336 regulation of hydrolase activity P 106 42 GO:0002883 regulation of hypersensitivity P 12 12 GO:0043122 regulation of I-kappaB kinase/NF-kappaB cascade P 14 9 GO:0033083 regulation of immature T cell proliferation P 4 4 GO:0033084 regulation of immature T cell proliferation in the thymus P 4 4 GO:0002697 regulation of immune effector process P 16 16 GO:0050776 regulation of immune response P 109 74 GO:0002837 regulation of immune response to tumor cell P 4 4 GO:0002682 regulation of immune system process P 111 76 GO:0002889 regulation of immunoglobulin mediated immune response P 11 11 GO:0002637 regulation of immunoglobulin production P 2 2 GO:0051023 regulation of immunoglobulin secretion P 6 6 GO:0050727 regulation of inflammatory response P 27 27 GO:0002861 regulation of inflammatory response to antigenic stimulus P 12 12 GO:0060080 regulation of inhibitory postsynaptic membrane potential P 3 3 GO:0045088 regulation of innate immune response P 10 10 GO:0032960 regulation of inositol trisphosphate biosynthetic process P 1 1 GO:0031585 regulation of inositol-1,4,5-triphosphate receptor activity P 1 1 GO:0046626 regulation of insulin receptor signaling pathway P 5 5 GO:0050796 regulation of insulin secretion P 10 6 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway P 3 3 GO:0033623 regulation of integrin activation P 1 1 GO:0045113 regulation of integrin biosynthetic process P 1 1 GO:0032479 regulation of interferon type I production P 1 1 GO:0045357 regulation of interferon-beta biosynthetic process P 2 1 GO:0045072 regulation of interferon-gamma biosynthetic process P 6 5 GO:0032649 regulation of interferon-gamma production P 8 8 GO:0032651 regulation of interleukin-1 beta production P 1 1 GO:0050706 regulation of interleukin-1 beta secretion P 1 1 GO:0045360 regulation of interleukin-1 biosynthetic process P 1 0 GO:0032652 regulation of interleukin-1 production P 1 1 GO:0050704 regulation of interleukin-1 secretion P 1 1 GO:0045074 regulation of interleukin-10 biosynthetic process P 1 1 GO:0032653 regulation of interleukin-10 production P 2 2 GO:0045075 regulation of interleukin-12 biosynthetic process P 7 7 GO:0032655 regulation of interleukin-12 production P 2 2 GO:0045366 regulation of interleukin-13 biosynthetic process P 1 0 GO:0045076 regulation of interleukin-2 biosynthetic process P 13 12 GO:0032663 regulation of interleukin-2 production P 2 2 GO:0045399 regulation of interleukin-3 biosynthetic process P 3 3 GO:0045402 regulation of interleukin-4 biosynthetic process P 3 3 GO:0032673 regulation of interleukin-4 production P 1 1 GO:0045405 regulation of interleukin-5 biosynthetic process P 1 1 GO:0032674 regulation of interleukin-5 production P 1 1 GO:0045408 regulation of interleukin-6 biosynthetic process P 9 8 GO:0032675 regulation of interleukin-6 production P 7 7 GO:0033157 regulation of intracellular protein transport P 9 9 GO:0032386 regulation of intracellular transport P 9 9 GO:0043269 regulation of ion transport P 11 11 GO:0045191 regulation of isotype switching P 12 11 GO:0048296 regulation of isotype switching to IgA isotypes P 2 1 GO:0048293 regulation of isotype switching to IgE isotypes P 4 4 GO:0048302 regulation of isotype switching to IgG isotypes P 8 8 GO:0046425 regulation of JAK-STAT cascade P 13 11 GO:0043506 regulation of JNK activity P 14 10 GO:0046328 regulation of JNK cascade P 18 16 GO:0045616 regulation of keratinocyte differentiation P 1 0 GO:0051547 regulation of keratinocyte migration P 1 1 GO:0043549 regulation of kinase activity P 131 99 GO:0043300 regulation of leukocyte degranulation P 5 5 GO:0001910 regulation of leukocyte mediated cytotoxicity P 15 15 GO:0002703 regulation of leukocyte mediated immunity P 14 14 GO:0051340 regulation of ligase activity P 2 1 GO:0046890 regulation of lipid biosynthetic process P 2 2 GO:0043550 regulation of lipid kinase activity P 5 5 GO:0019216 regulation of lipid metabolic process P 19 15 GO:0051004 regulation of lipoprotein lipase activity P 2 2 GO:0050828 regulation of liquid surface tension P 4 0 GO:0032879 regulation of localization P 1 1 GO:0040012 regulation of locomotion P 63 52 GO:0048169 regulation of long-term neuronal synaptic plasticity P 11 9 GO:0032803 regulation of low-density lipoprotein receptor catabolic process P 1 1 GO:0051339 regulation of lyase activity P 18 7 GO:0051249 regulation of lymphocyte activation P 83 76 GO:0002911 regulation of lymphocyte anergy P 1 1 GO:0045619 regulation of lymphocyte differentiation P 22 20 GO:0002706 regulation of lymphocyte mediated immunity P 14 14 GO:0050670 regulation of lymphocyte proliferation P 53 49 GO:0016241 regulation of macroautophagy P 2 2 GO:0043030 regulation of macrophage activation P 4 4 GO:0045649 regulation of macrophage differentiation P 3 3 GO:0043405 regulation of MAP kinase activity P 59 50 GO:0043408 regulation of MAPKKK cascade P 18 13 GO:0033025 regulation of mast cell apoptosis P 1 1 GO:0032763 regulation of mast cell cytokine production P 2 2 GO:0043304 regulation of mast cell degranulation P 4 4 GO:0045631 regulation of mechanoreceptor differentiation P 3 3 GO:0045652 regulation of megakaryocyte differentiation P 1 0 GO:0040020 regulation of meiosis P 4 4 GO:0045634 regulation of melanocyte differentiation P 2 2 GO:0042391 regulation of membrane potential P 39 35 GO:0043380 regulation of memory T cell differentiation P 1 1 GO:0019222 regulation of metabolic process P 2171 731 GO:0048552 regulation of metalloenzyme activity P 2 2 GO:0045343 regulation of MHC class I biosynthetic process P 2 1 GO:0045346 regulation of MHC class II biosynthetic process P 4 4 GO:0031114 regulation of microtubule depolymerization P 10 7 GO:0031113 regulation of microtubule polymerization P 2 2 GO:0031110 regulation of microtubule polymerization or depolymerization P 13 10 GO:0051900 regulation of mitochondrial depolarization P 2 2 GO:0046902 regulation of mitochondrial membrane permeability P 2 1 GO:0051881 regulation of mitochondrial membrane potential P 3 3 GO:0007088 regulation of mitosis P 27 13 GO:0046602 regulation of mitotic centrosome separation P 1 1 GO:0030071 regulation of mitotic metaphase/anaphase transition P 6 0 GO:0000019 regulation of mitotic recombination P 2 2 GO:0045655 regulation of monocyte differentiation P 1 1 GO:0032944 regulation of mononuclear cell proliferation P 53 49 GO:0050684 regulation of mRNA processing P 2 2 GO:0043488 regulation of mRNA stability P 13 10 GO:0045974 regulation of mRNA translation, snRNA-mediated P 1 0 GO:0044246 regulation of multicellular organismal metabolic process P 3 3 GO:0051239 regulation of multicellular organismal process P 292 222 GO:0051147 regulation of muscle cell differentiation P 4 3 GO:0006937 regulation of muscle contraction P 32 17 GO:0031641 regulation of myelination P 2 2 GO:0033032 regulation of myeloid cell apoptosis P 1 1 GO:0045637 regulation of myeloid cell differentiation P 34 29 GO:0030885 regulation of myeloid dendritic cell activation P 1 1 GO:0002761 regulation of myeloid leukocyte differentiation P 17 16 GO:0002886 regulation of myeloid leukocyte mediated immunity P 8 8 GO:0045661 regulation of myoblast differentiation P 8 4 GO:0032814 regulation of natural killer cell activation P 3 3 GO:0042269 regulation of natural killer cell mediated cytotoxicity P 12 12 GO:0002858 regulation of natural killer cell mediated cytotoxicity directed against tumor cell target P 1 1 GO:0002855 regulation of natural killer cell mediated immune response to tumor cell P 1 1 GO:0002715 regulation of natural killer cell mediated immunity P 1 1 GO:0051960 regulation of nervous system development P 2 2 GO:0050767 regulation of neurogenesis P 43 39 GO:0031644 regulation of neurological process P 40 35 GO:0043523 regulation of neuron apoptosis P 34 31 GO:0045664 regulation of neuron differentiation P 26 25 GO:0048168 regulation of neuronal synaptic plasticity P 14 12 GO:0001505 regulation of neurotransmitter levels P 86 67 GO:0046928 regulation of neurotransmitter secretion P 18 15 GO:0051588 regulation of neurotransmitter transport P 1 1 GO:0051580 regulation of neurotransmitter uptake P 1 1 GO:0043313 regulation of neutrophil degranulation P 1 1 GO:0045658 regulation of neutrophil differentiation P 1 1 GO:0042345 regulation of NF-kappaB import into nucleus P 4 4 GO:0045428 regulation of nitric oxide biosynthetic process P 9 8 GO:0050999 regulation of nitric-oxide synthase activity P 2 2 GO:0051171 regulation of nitrogen compound metabolic process P 1 0 GO:0006808 regulation of nitrogen utilization P 1 0 GO:0051133 regulation of NK T cell activation P 2 2 GO:0051136 regulation of NK T cell differentiation P 4 4 GO:0043070 regulation of non-apoptotic programmed cell death P 1 1 GO:0014061 regulation of norepinephrine secretion P 1 1 GO:0008593 regulation of Notch signaling pathway P 4 4 GO:0048024 regulation of nuclear mRNA splicing, via spliceosome P 1 1 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process P 1923 575 GO:0046822 regulation of nucleocytoplasmic transport P 12 11 GO:0030808 regulation of nucleotide biosynthetic process P 7 6 GO:0006140 regulation of nucleotide metabolic process P 10 8 GO:0042481 regulation of odontogenesis P 3 3 GO:0042487 regulation of odontogenesis of dentine-containing teeth P 5 5 GO:0048713 regulation of oligodendrocyte differentiation P 3 3 GO:0046620 regulation of organ growth P 7 7 GO:0033043 regulation of organelle organization and biogenesis P 33 8 GO:0030278 regulation of ossification P 24 17 GO:0045667 regulation of osteoblast differentiation P 11 10 GO:0045670 regulation of osteoclast differentiation P 14 13 GO:0002082 regulation of oxidative phosphorylation P 1 1 GO:0051341 regulation of oxidoreductase activity P 3 3 GO:0052547 regulation of peptidase activity P 1 1 GO:0050730 regulation of peptidyl-tyrosine phosphorylation P 32 31 GO:0002849 regulation of peripheral T cell tolerance induction P 1 1 GO:0002658 regulation of peripheral tolerance induction P 1 1 GO:0006885 regulation of pH P 18 8 GO:0050764 regulation of phagocytosis P 16 16 GO:0019220 regulation of phosphate metabolic process P 55 46 GO:0043551 regulation of phosphoinositide 3-kinase activity P 5 5 GO:0014066 regulation of phosphoinositide 3-kinase cascade P 2 2 GO:0032429 regulation of phospholipase A2 activity P 1 1 GO:0043666 regulation of phosphoprotein phosphatase activity P 5 1 GO:0051174 regulation of phosphorus metabolic process P 55 46 GO:0042325 regulation of phosphorylation P 55 46 GO:0046532 regulation of photoreceptor cell differentiation P 2 2 GO:0050932 regulation of pigment cell differentiation P 2 2 GO:0048548 regulation of pinocytosis P 1 1 GO:0050926 regulation of positive chemotaxis P 7 6 GO:0060078 regulation of postsynaptic membrane potential P 10 10 GO:0050884 regulation of posture P 6 6 GO:0043266 regulation of potassium ion transport P 4 4 GO:0002700 regulation of production of molecular mediator of immune response P 4 4 GO:0043067 regulation of programmed cell death P 371 264 GO:0000074 regulation of progression through cell cycle P 341 99 GO:0009794 regulation of progression through embryonic mitotic cell cycle P 1 1 GO:0007346 regulation of progression through mitotic cell cycle P 20 17 GO:0033261 regulation of progression through S phase P 5 3 GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process P 3 2 GO:0031952 regulation of protein amino acid autophosphorylation P 1 1 GO:0001932 regulation of protein amino acid phosphorylation P 50 44 GO:0043393 regulation of protein binding P 6 4 GO:0042176 regulation of protein catabolic process P 10 8 GO:0043244 regulation of protein complex disassembly P 1 1 GO:0046825 regulation of protein export from nucleus P 2 1 GO:0043496 regulation of protein homodimerization activity P 2 1 GO:0042306 regulation of protein import into nucleus P 9 9 GO:0045859 regulation of protein kinase activity P 126 94 GO:0051896 regulation of protein kinase B signaling cascade P 5 5 GO:0032880 regulation of protein localization P 1 1 GO:0051246 regulation of protein metabolic process P 226 136 GO:0031399 regulation of protein modification process P 6 5 GO:0050708 regulation of protein secretion P 14 12 GO:0031647 regulation of protein stability P 8 3 GO:0051223 regulation of protein transport P 11 10 GO:0031396 regulation of protein ubiquitination P 5 4 GO:0030162 regulation of proteolysis P 13 8 GO:0032313 regulation of Rab GTPase activity P 27 1 GO:0032483 regulation of Rab protein signal transduction P 27 1 GO:0035020 regulation of Rac protein signal transduction P 4 3 GO:0032318 regulation of Ras GTPase activity P 30 4 GO:0046578 regulation of Ras protein signal transduction P 93 14 GO:0001919 regulation of receptor recycling P 3 2 GO:0048259 regulation of receptor-mediated endocytosis P 1 0 GO:0045589 regulation of regulatory T cell differentiation P 2 2 GO:0043576 regulation of respiratory gaseous exchange P 2 2 GO:0002831 regulation of response to biotic stimulus P 4 4 GO:0032101 regulation of response to external stimulus P 9 9 GO:0032104 regulation of response to extracellular stimulus P 4 4 GO:0032095 regulation of response to food P 4 4 GO:0032107 regulation of response to nutrient levels P 4 4 GO:0047484 regulation of response to osmotic stress P 2 2 GO:0048583 regulation of response to stimulus P 42 42 GO:0002834 regulation of response to tumor cell P 4 4 GO:0046668 regulation of retinal cell programmed cell death P 4 4 GO:0032319 regulation of Rho GTPase activity P 2 2 GO:0035023 regulation of Rho protein signal transduction P 51 7 GO:0007468 regulation of rhodopsin gene activity P 3 3 GO:0046831 regulation of RNA export from nucleus P 1 1 GO:0051252 regulation of RNA metabolic process P 17 13 GO:0043487 regulation of RNA stability P 15 11 GO:0007090 regulation of S phase of mitotic cell cycle P 5 3 GO:0046877 regulation of saliva secretion P 1 1 GO:0051046 regulation of secretion P 52 39 GO:0051931 regulation of sensory perception P 4 3 GO:0051930 regulation of sensory perception of pain P 4 3 GO:0051282 regulation of sequestering of calcium ion P 3 2 GO:0048172 regulation of short-term neuronal synaptic plasticity P 1 0 GO:0009966 regulation of signal transduction P 316 151 GO:0007063 regulation of sister chromatid cohesion P 1 1 GO:0043416 regulation of skeletal muscle regeneration P 1 1 GO:0051056 regulation of small GTPase mediated signal transduction P 115 15 GO:0051150 regulation of smooth muscle cell differentiation P 1 1 GO:0048660 regulation of smooth muscle cell proliferation P 3 2 GO:0006940 regulation of smooth muscle contraction P 16 13 GO:0043109 regulation of smoothened activity P 1 1 GO:0008589 regulation of smoothened signaling pathway P 12 12 GO:0002028 regulation of sodium ion transport P 4 4 GO:0050810 regulation of steroid biosynthetic process P 1 1 GO:0033143 regulation of steroid hormone receptor signaling pathway P 3 1 GO:0019218 regulation of steroid metabolic process P 7 6 GO:0032872 regulation of stress-activated MAPK cascade P 2 1 GO:0051153 regulation of striated muscle cell differentiation P 3 2 GO:0006942 regulation of striated muscle contraction P 2 2 GO:0016202 regulation of striated muscle development P 13 8 GO:0045884 regulation of survival gene product activity P 11 9 GO:0050803 regulation of synapse structure and activity P 3 2 GO:0008582 regulation of synaptic growth at neuromuscular junction P 2 2 GO:0048167 regulation of synaptic plasticity P 21 19 GO:0050804 regulation of synaptic transmission P 34 30 GO:0032222 regulation of synaptic transmission, cholinergic P 1 1 GO:0032225 regulation of synaptic transmission, dopaminergic P 2 2 GO:0032228 regulation of synaptic transmission, GABAergic P 4 4 GO:0051966 regulation of synaptic transmission, glutamatergic P 2 1 GO:0051963 regulation of synaptogenesis P 4 4 GO:0050863 regulation of T cell activation P 63 57 GO:0002667 regulation of T cell anergy P 1 1 GO:0045580 regulation of T cell differentiation P 17 15 GO:0046013 regulation of T cell homeostatic proliferation P 2 2 GO:0001914 regulation of T cell mediated cytotoxicity P 3 3 GO:0002709 regulation of T cell mediated immunity P 2 2 GO:0042129 regulation of T cell proliferation P 42 39 GO:0050856 regulation of T cell receptor signaling pathway P 9 8 GO:0002664 regulation of T cell tolerance induction P 2 2 GO:0045625 regulation of T-helper 1 cell differentiation P 1 1 GO:0002825 regulation of T-helper 1 type immune response P 1 1 GO:0045628 regulation of T-helper 2 cell differentiation P 3 3 GO:0002828 regulation of T-helper 2 type immune response P 3 3 GO:0045622 regulation of T-helper cell differentiation P 4 4 GO:0050758 regulation of thymidylate synthase biosynthetic process P 1 1 GO:0048505 regulation of timing of cell differentiation P 5 5 GO:0060164 regulation of timing of neuron differentiation P 1 1 GO:0060165 regulation of timing of subpallium neuron differentiation P 1 1 GO:0002643 regulation of tolerance induction P 2 2 GO:0002652 regulation of tolerance induction dependent upon immune response P 1 1 GO:0002649 regulation of tolerance induction to self antigen P 1 1 GO:0045449 regulation of transcription P 1886 543 GO:0051090 regulation of transcription factor activity P 23 12 GO:0042990 regulation of transcription factor import into nucleus P 8 8 GO:0006356 regulation of transcription from RNA polymerase I promoter P 2 1 GO:0006357 regulation of transcription from RNA polymerase II promoter P 377 308 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress P 2 2 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress P 2 2 GO:0046021 regulation of transcription from RNA polymerase II promoter, mitotic P 2 1 GO:0006359 regulation of transcription from RNA polymerase III promoter P 1 0 GO:0043620 regulation of transcription in response to stress P 3 2 GO:0006355 regulation of transcription, DNA-dependent P 1811 447 GO:0045896 regulation of transcription, mitotic P 2 1 GO:0045898 regulation of transcriptional preinitiation complex assembly P 1 1 GO:0051338 regulation of transferase activity P 134 102 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway P 10 8 GO:0032908 regulation of transforming growth factor-beta1 production P 1 1 GO:0032910 regulation of transforming growth factor-beta3 production P 1 0 GO:0006417 regulation of translation P 130 76 GO:0043555 regulation of translation in response to stress P 2 2 GO:0043558 regulation of translation initiation in response to stress P 2 2 GO:0006448 regulation of translational elongation P 2 0 GO:0006450 regulation of translational fidelity P 1 0 GO:0006446 regulation of translational initiation P 22 7 GO:0006447 regulation of translational initiation by iron P 1 1 GO:0051969 regulation of transmission of nerve impulse P 34 30 GO:0051049 regulation of transport P 83 72 GO:0042534 regulation of tumor necrosis factor biosynthetic process P 6 6 GO:0032680 regulation of tumor necrosis factor production P 10 9 GO:0001810 regulation of type I hypersensitivity P 8 8 GO:0002892 regulation of type II hypersensitivity P 8 8 GO:0001796 regulation of type IIa hypersensitivity P 8 8 GO:0001803 regulation of type III hypersensitivity P 3 3 GO:0001807 regulation of type IV hypersensitivity P 1 1 GO:0042509 regulation of tyrosine phosphorylation of STAT protein P 9 8 GO:0042516 regulation of tyrosine phosphorylation of Stat3 protein P 4 4 GO:0042522 regulation of tyrosine phosphorylation of Stat5 protein P 2 2 GO:0042525 regulation of tyrosine phosphorylation of Stat6 protein P 1 0 GO:0051438 regulation of ubiquitin-protein ligase activity P 1 0 GO:0051440 regulation of ubiquitin-protein ligase activity during meiotic cell cycle P 1 0 GO:0050675 regulation of urothelial cell proliferation P 1 1 GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway P 5 5 GO:0019229 regulation of vasoconstriction P 8 5 GO:0042312 regulation of vasodilation P 1 1 GO:0045069 regulation of viral genome replication P 1 1 GO:0050792 regulation of viral reproduction P 2 2 GO:0030111 regulation of Wnt receptor signaling pathway P 23 19 GO:0045066 regulatory T cell differentiation P 3 3 GO:0060087 relaxation of vascular smooth muscle P 3 3 GO:0001836 release of cytochrome c from mitochondria P 11 9 GO:0051209 release of sequestered calcium ion into cytosol P 3 2 GO:0019430 removal of superoxide radicals P 3 3 GO:0001977 renal blood volume regulation of blood pressure P 5 5 GO:0001999 renal response to blood flow during renin-angiotensin regulation of blood pressure P 2 2 GO:0002001 renin secretion into blood stream P 1 1 GO:0002018 renin-angiotensin regulation of aldosterone production P 2 2 GO:0002034 renin-angiotensin regulation of blood vessel size P 3 3 GO:0002016 renin-angiotensin regulation of body fluid levels P 4 4 GO:0048478 replication fork protection P 1 1 GO:0001302 replicative cell aging P 2 2 GO:0002085 repression of premature neural plate formation P 1 1 GO:0000003 reproduction P 410 262 GO:0019098 reproductive behavior P 14 14 GO:0033057 reproductive behavior in a multicellular organism P 5 5 GO:0003006 reproductive developmental process P 86 77 GO:0022414 reproductive process P 202 146 GO:0048609 reproductive process in a multicellular organism P 67 55 GO:0048608 reproductive structure development P 53 52 GO:0000712 resolution of meiotic joint molecules as recombinants P 1 1 GO:0045730 respiratory burst P 2 1 GO:0007585 respiratory gaseous exchange P 21 17 GO:0030323 respiratory tube development P 61 60 GO:0009628 response to abiotic stimulus P 163 119 GO:0001101 response to acid P 3 3 GO:0043279 response to alkaloid P 10 9 GO:0001975 response to amphetamine P 8 8 GO:0046677 response to antibiotic P 7 0 GO:0046685 response to arsenic P 3 1 GO:0048678 response to axon injury P 6 4 GO:0032493 response to bacterial lipoprotein P 1 0 GO:0009617 response to bacterium P 106 48 GO:0009607 response to biotic stimulus P 201 91 GO:0046686 response to cadmium ion P 2 2 GO:0031000 response to caffeine P 1 1 GO:0009743 response to carbohydrate stimulus P 3 3 GO:0042221 response to chemical stimulus P 412 154 GO:0032025 response to cobalt ion P 1 0 GO:0042220 response to cocaine P 9 8 GO:0009409 response to cold P 7 7 GO:0046688 response to copper ion P 3 3 GO:0031960 response to corticosteroid stimulus P 1 1 GO:0052565 response to defense-related host nitric oxide production P 1 1 GO:0052551 response to defense-related nitric oxide production by other organism during symbiotic interaction P 1 1 GO:0052173 response to defenses of other organism during symbiotic interaction P 1 1 GO:0002021 response to dietary excess P 3 3 GO:0006974 response to DNA damage stimulus P 227 89 GO:0042493 response to drug P 42 30 GO:0043331 response to dsRNA P 11 10 GO:0009719 response to endogenous stimulus P 245 100 GO:0043627 response to estrogen stimulus P 1 0 GO:0045471 response to ethanol P 7 6 GO:0043330 response to exogenous dsRNA P 8 8 GO:0009605 response to external stimulus P 430 210 GO:0009991 response to extracellular stimulus P 14 11 GO:0032094 response to food P 5 5 GO:0009620 response to fungus P 13 12 GO:0010332 response to gamma radiation P 8 8 GO:0051384 response to glucocorticoid stimulus P 1 1 GO:0009749 response to glucose stimulus P 3 3 GO:0009629 response to gravity P 2 2 GO:0009408 response to heat P 30 7 GO:0009746 response to hexose stimulus P 3 3 GO:0009725 response to hormone stimulus P 15 8 GO:0052200 response to host defenses P 1 1 GO:0052572 response to host immune response P 1 1 GO:0042542 response to hydrogen peroxide P 10 7 GO:0001666 response to hypoxia P 19 17 GO:0052564 response to immune response of other organism during symbiotic interaction P 1 1 GO:0010035 response to inorganic substance P 11 7 GO:0032868 response to insulin stimulus P 2 2 GO:0010212 response to ionizing radiation P 21 18 GO:0014072 response to isoquinoline alkaloid P 3 3 GO:0009416 response to light stimulus P 70 55 GO:0032496 response to lipopolysaccharide P 10 10 GO:0010042 response to manganese ion P 1 0 GO:0009612 response to mechanical stimulus P 16 16 GO:0046689 response to mercury ion P 1 0 GO:0010038 response to metal ion P 8 6 GO:0002237 response to molecule of bacterial origin P 15 14 GO:0002238 response to molecule of fungal origin P 3 3 GO:0043278 response to morphine P 3 3 GO:0032495 response to muramyl dipeptide P 1 1 GO:0010046 response to mycotoxin P 1 1 GO:0009624 response to nematode P 2 2 GO:0035094 response to nicotine P 7 7 GO:0031667 response to nutrient levels P 12 10 GO:0014070 response to organic cyclic substance P 10 9 GO:0010033 response to organic substance P 17 15 GO:0006970 response to osmotic stress P 10 9 GO:0051707 response to other organism P 156 72 GO:0006979 response to oxidative stress P 47 31 GO:0000305 response to oxygen radical P 5 4 GO:0048265 response to pain P 10 10 GO:0043434 response to peptide hormone stimulus P 2 2 GO:0032494 response to peptidoglycan P 1 1 GO:0009268 response to pH P 2 2 GO:0019236 response to pheromone P 104 0 GO:0051789 response to protein stimulus P 31 12 GO:0001562 response to protozoan P 3 3 GO:0014074 response to purine P 1 1 GO:0009314 response to radiation P 91 72 GO:0000302 response to reactive oxygen species P 16 11 GO:0009651 response to salt stress P 1 1 GO:0042594 response to starvation P 8 6 GO:0048545 response to steroid hormone stimulus P 2 1 GO:0006991 response to sterol depletion P 2 2 GO:0050896 response to stimulus P 2092 748 GO:0006950 response to stress P 723 310 GO:0000303 response to superoxide P 4 4 GO:0009266 response to temperature stimulus P 45 21 GO:0009636 response to toxin P 19 12 GO:0014073 response to tropane P 9 8 GO:0002347 response to tumor cell P 6 4 GO:0006986 response to unfolded protein P 31 12 GO:0009411 response to UV P 24 21 GO:0010224 response to UV-B P 4 4 GO:0010225 response to UV-C P 2 2 GO:0009615 response to virus P 46 16 GO:0009611 response to wounding P 281 110 GO:0009410 response to xenobiotic stimulus P 14 3 GO:0010165 response to X-ray P 11 9 GO:0001878 response to yeast P 3 3 GO:0010043 response to zinc ion P 2 1 GO:0060041 retina development in camera-type eye P 8 8 GO:0060042 retina morphogenesis in camera-type eye P 2 2 GO:0060040 retinal bipolar neuron differentiation P 1 1 GO:0046666 retinal cell programmed cell death P 6 6 GO:0046549 retinal cone cell development P 1 1 GO:0042670 retinal cone cell differentiation P 1 1 GO:0031290 retinal ganglion cell axon guidance P 7 6 GO:0001895 retinal homeostasis P 4 4 GO:0042574 retinal metabolic process P 5 4 GO:0046548 retinal rod cell development P 5 5 GO:0042573 retinoic acid metabolic process P 8 5 GO:0048384 retinoic acid receptor signaling pathway P 5 5 GO:0001523 retinoid metabolic process P 12 10 GO:0042572 retinol metabolic process P 3 3 GO:0008090 retrograde axon cargo transport P 3 3 GO:0042147 retrograde transport, endosome to Golgi P 3 2 GO:0000301 retrograde transport, vesicle recycling within Golgi P 1 1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER P 3 1 GO:0045090 retroviral genome replication P 1 0 GO:0043691 reverse cholesterol transport P 2 2 GO:0007266 Rho protein signal transduction P 75 19 GO:0021568 rhombomere 2 development P 1 1 GO:0021546 rhombomere development P 1 1 GO:0007622 rhythmic behavior P 7 6 GO:0043179 rhythmic excitation P 2 2 GO:0048511 rhythmic process P 80 54 GO:0060024 rhythmic synaptic transmission P 4 4 GO:0042727 riboflavin and derivative biosynthetic process P 1 0 GO:0042726 riboflavin and derivative metabolic process P 1 0 GO:0009231 riboflavin biosynthetic process P 1 0 GO:0006771 riboflavin metabolic process P 1 0 GO:0022613 ribonucleoprotein complex biogenesis and assembly P 185 19 GO:0042455 ribonucleoside biosynthetic process P 1 0 GO:0042454 ribonucleoside catabolic process P 1 0 GO:0009188 ribonucleoside diphosphate biosynthetic process P 1 1 GO:0009191 ribonucleoside diphosphate catabolic process P 5 3 GO:0009185 ribonucleoside diphosphate metabolic process P 6 4 GO:0009119 ribonucleoside metabolic process P 7 4 GO:0009156 ribonucleoside monophosphate biosynthetic process P 14 0 GO:0009158 ribonucleoside monophosphate catabolic process P 1 0 GO:0009161 ribonucleoside monophosphate metabolic process P 15 0 GO:0009201 ribonucleoside triphosphate biosynthetic process P 48 0 GO:0009203 ribonucleoside triphosphate catabolic process P 3 2 GO:0009199 ribonucleoside triphosphate metabolic process P 53 2 GO:0009260 ribonucleotide biosynthetic process P 65 1 GO:0009261 ribonucleotide catabolic process P 7 4 GO:0009259 ribonucleotide metabolic process P 74 5 GO:0000027 ribosomal large subunit assembly and maintenance P 1 0 GO:0042273 ribosomal large subunit biogenesis and assembly P 2 1 GO:0000055 ribosomal large subunit export from nucleus P 1 0 GO:0006610 ribosomal protein import into nucleus P 5 2 GO:0000028 ribosomal small subunit assembly and maintenance P 1 0 GO:0042274 ribosomal small subunit biogenesis and assembly P 2 0 GO:0042257 ribosomal subunit assembly P 2 0 GO:0042255 ribosome assembly P 4 0 GO:0042254 ribosome biogenesis and assembly P 119 6 GO:0032790 ribosome disassembly P 1 0 GO:0000054 ribosome export from nucleus P 1 0 GO:0060013 righting reflex P 5 5 GO:0031123 RNA 3'-end processing P 17 6 GO:0032774 RNA biosynthetic process P 1838 463 GO:0009452 RNA capping P 2 0 GO:0006401 RNA catabolic process P 32 7 GO:0050779 RNA destabilization P 3 2 GO:0006354 RNA elongation P 6 0 GO:0006368 RNA elongation from RNA polymerase II promoter P 2 0 GO:0006405 RNA export from nucleus P 15 9 GO:0016246 RNA interference P 1 1 GO:0030422 RNA interference, production of siRNA P 1 1 GO:0006403 RNA localization P 51 11 GO:0016070 RNA metabolic process P 2220 505 GO:0001510 RNA methylation P 1 0 GO:0009451 RNA modification P 20 5 GO:0043631 RNA polyadenylation P 11 2 GO:0006396 RNA processing P 334 29 GO:0008380 RNA splicing P 170 13 GO:0000394 RNA splicing, via endonucleolytic cleavage and ligation P 3 1 GO:0000375 RNA splicing, via transesterification reactions P 41 9 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile P 41 9 GO:0043489 RNA stabilization P 2 2 GO:0050658 RNA transport P 50 9 GO:0006278 RNA-dependent DNA replication P 6 2 GO:0031047 RNA-mediated gene silencing P 11 2 GO:0035194 RNA-mediated posttranscriptional gene silencing P 3 2 GO:0018144 RNA-protein covalent cross-linking P 1 0 GO:0021903 rostrocaudal neural tube patterning P 3 3 GO:0016072 rRNA metabolic process P 51 3 GO:0000154 rRNA modification P 4 0 GO:0006364 rRNA processing P 51 3 GO:0009303 rRNA transcription P 5 4 GO:0031529 ruffle organization and biogenesis P 1 1 GO:0051320 S phase P 7 4 GO:0000084 S phase of mitotic cell cycle P 7 4 GO:0019510 S-adenosylhomocysteine catabolic process P 1 1 GO:0046498 S-adenosylhomocysteine metabolic process P 1 1 GO:0006556 S-adenosylmethionine biosynthetic process P 1 1 GO:0046500 S-adenosylmethionine metabolic process P 1 1 GO:0046541 saliva secretion P 3 3 GO:0007431 salivary gland development P 12 12 GO:0007435 salivary gland morphogenesis P 6 6 GO:0045214 sarcomere organization P 10 8 GO:0032788 saturated monocarboxylic acid metabolic process P 2 2 GO:0014044 Schwann cell development P 3 3 GO:0014037 Schwann cell differentiation P 7 7 GO:0001949 sebaceous gland cell differentiation P 1 1 GO:0048733 sebaceous gland development P 1 1 GO:0019748 secondary metabolic process P 43 25 GO:0019932 second-messenger-mediated signaling P 120 69 GO:0046903 secretion P 244 134 GO:0032940 secretion by cell P 203 102 GO:0032252 secretory granule localization P 1 1 GO:0033363 secretory granule organization and biogenesis P 1 1 GO:0045045 secretory pathway P 172 80 GO:0007379 segment specification P 8 8 GO:0035282 segmentation P 41 41 GO:0001887 selenium metabolic process P 1 1 GO:0001514 selenocysteine incorporation P 5 5 GO:0035058 sensory cilium biogenesis P 5 5 GO:0008052 sensory organ boundary specification P 1 1 GO:0007423 sensory organ development P 182 170 GO:0007600 sensory perception P 1465 156 GO:0050913 sensory perception of bitter taste P 19 2 GO:0007606 sensory perception of chemical stimulus P 1248 18 GO:0050953 sensory perception of light stimulus P 110 48 GO:0050954 sensory perception of mechanical stimulus P 95 77 GO:0019233 sensory perception of pain P 25 24 GO:0007608 sensory perception of smell P 1179 12 GO:0007605 sensory perception of sound P 91 73 GO:0050909 sensory perception of taste P 44 5 GO:0050951 sensory perception of temperature stimulus P 7 7 GO:0042989 sequestering of actin monomers P 1 0 GO:0051208 sequestering of calcium ion P 3 2 GO:0019915 sequestering of lipid P 10 10 GO:0051238 sequestering of metal ion P 3 2 GO:0042137 sequestering of neurotransmitter P 1 1 GO:0009070 serine family amino acid biosynthetic process P 6 0 GO:0009071 serine family amino acid catabolic process P 8 0 GO:0009069 serine family amino acid metabolic process P 17 2 GO:0032329 serine transport P 1 1 GO:0042427 serotonin biosynthetic process P 2 0 GO:0006587 serotonin biosynthetic process from tryptophan P 2 0 GO:0042428 serotonin metabolic process P 4 2 GO:0007210 serotonin receptor signaling pathway P 2 2 GO:0007198 serotonin receptor, adenylate cyclase inhibiting pathway P 1 1 GO:0007208 serotonin receptor, phospholipase C activating pathway P 1 0 GO:0001820 serotonin secretion P 4 4 GO:0060009 Sertoli cell development P 1 1 GO:0060008 Sertoli cell differentiation P 2 2 GO:0060011 Sertoli cell proliferation P 4 4 GO:0006434 seryl-tRNA aminoacylation P 2 0 GO:0007530 sex determination P 17 15 GO:0007548 sex differentiation P 74 66 GO:0019953 sexual reproduction P 283 176 GO:0019626 short-chain fatty acid catabolic process P 1 1 GO:0046459 short-chain fatty acid metabolic process P 3 2 GO:0015739 sialic acid transport P 1 0 GO:0007172 signal complex assembly P 13 11 GO:0006465 signal peptide processing P 4 0 GO:0007165 signal transduction P 3508 686 GO:0007227 signal transduction downstream of smoothened P 1 1 GO:0007338 single fertilization P 38 25 GO:0000012 single strand break repair P 3 0 GO:0007062 sister chromatid cohesion P 5 4 GO:0000819 sister chromatid segregation P 17 5 GO:0001501 skeletal development P 172 136 GO:0048705 skeletal morphogenesis P 21 20 GO:0048637 skeletal muscle development P 71 64 GO:0048741 skeletal muscle fiber development P 63 56 GO:0043501 skeletal muscle plasticity P 1 1 GO:0043403 skeletal muscle regeneration P 3 3 GO:0043588 skin development P 11 10 GO:0043589 skin morphogenesis P 1 1 GO:0030431 sleep P 4 3 GO:0007183 SMAD protein complex assembly P 4 0 GO:0007184 SMAD protein nuclear translocation P 4 3 GO:0007264 small GTPase mediated signal transduction P 327 58 GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis P 2 2 GO:0051145 smooth muscle cell differentiation P 9 9 GO:0048659 smooth muscle cell proliferation P 4 3 GO:0006939 smooth muscle contraction P 23 17 GO:0060083 smooth muscle contraction involved in micturition P 2 2 GO:0048745 smooth muscle development P 4 4 GO:0007224 smoothened signaling pathway P 28 28 GO:0021938 smoothened signaling pathway in regulation of granule cell precursor cell proliferation P 4 4 GO:0021910 smoothened signaling pathway in ventral spinal cord patterning P 2 2 GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification P 2 2 GO:0021775 smoothened signaling pathway involved in ventral spinal cord interneuron specification P 2 2 GO:0016074 snoRNA metabolic process P 1 1 GO:0006408 snRNA export from nucleus P 1 1 GO:0051030 snRNA transport P 1 1 GO:0035176 social behavior P 8 8 GO:0055078 sodium ion homeostasis P 3 1 GO:0006814 sodium ion transport P 109 16 GO:0060023 soft palate development P 1 0 GO:0016444 somatic cell DNA recombination P 28 26 GO:0002200 somatic diversification of immune receptors P 31 29 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus P 28 26 GO:0002566 somatic diversification of immune receptors via somatic mutation P 8 8 GO:0016445 somatic diversification of immunoglobulins P 29 27 GO:0002208 somatic diversification of immunoglobulins during immune response P 20 18 GO:0002568 somatic diversification of T cell receptor genes P 2 2 GO:0016446 somatic hypermutation of immunoglobulin genes P 8 8 GO:0021523 somatic motor neuron differentiation P 3 3 GO:0007525 somatic muscle development P 3 2 GO:0016447 somatic recombination of immunoglobulin gene segments P 26 24 GO:0002204 somatic recombination of immunoglobulin genes during immune response P 20 18 GO:0002681 somatic recombination of T cell receptor gene segments P 2 2 GO:0018993 somatic sex determination P 2 2 GO:0048103 somatic stem cell division P 6 6 GO:0035019 somatic stem cell maintenance P 2 2 GO:0060133 somatotropin secreting cell development P 2 2 GO:0060126 somatotropin secreting cell differentiation P 3 3 GO:0032525 somite rostral/caudal axis specification P 1 1 GO:0001757 somite specification P 3 3 GO:0001756 somitogenesis P 32 32 GO:0010092 specification of organ identity P 13 13 GO:0010159 specification of organ position P 1 1 GO:0007380 specification of segmental identity, head P 1 1 GO:0042305 specification of segmental identity, mandibular segment P 1 1 GO:0007382 specification of segmental identity, maxillary segment P 1 1 GO:0007288 sperm axoneme assembly P 4 4 GO:0048240 sperm capacitation P 4 2 GO:0035092 sperm chromatin condensation P 2 2 GO:0046692 sperm competition P 1 0 GO:0007321 sperm displacement P 1 0 GO:0042713 sperm ejaculation P 1 1 GO:0030382 sperm mitochondrion organization and biogenesis P 3 3 GO:0030317 sperm motility P 21 20 GO:0007286 spermatid development P 40 34 GO:0048515 spermatid differentiation P 42 36 GO:0007289 spermatid nuclear differentiation P 5 5 GO:0007290 spermatid nuclear elongation P 1 1 GO:0048137 spermatocyte division P 1 1 GO:0007283 spermatogenesis P 189 104 GO:0035036 sperm-egg recognition P 18 13 GO:0008295 spermidine biosynthetic process P 3 1 GO:0046203 spermidine catabolic process P 1 0 GO:0050983 spermidine catabolic process to deoxyhypusine, using deoxyhypusine synthase P 1 0 GO:0008216 spermidine metabolic process P 5 1 GO:0006597 spermine biosynthetic process P 2 1 GO:0046208 spermine catabolic process P 2 1 GO:0008215 spermine metabolic process P 6 3 GO:0046511 sphinganine biosynthetic process P 1 0 GO:0006667 sphinganine metabolic process P 2 1 GO:0006669 sphinganine-1-phosphate biosynthetic process P 1 0 GO:0006668 sphinganine-1-phosphate metabolic process P 2 1 GO:0046520 sphingoid biosynthetic process P 6 4 GO:0046521 sphingoid catabolic process P 4 3 GO:0046519 sphingoid metabolic process P 25 17 GO:0030148 sphingolipid biosynthetic process P 15 6 GO:0030149 sphingolipid catabolic process P 10 6 GO:0006665 sphingolipid metabolic process P 42 18 GO:0006686 sphingomyelin biosynthetic process P 3 0 GO:0006685 sphingomyelin catabolic process P 3 0 GO:0006684 sphingomyelin metabolic process P 7 1 GO:0006670 sphingosine metabolic process P 3 2 GO:0021510 spinal cord development P 12 12 GO:0021513 spinal cord dorsal/ventral patterning P 5 5 GO:0021520 spinal cord motor neuron cell fate specification P 2 2 GO:0021522 spinal cord motor neuron differentiation P 6 6 GO:0021529 spinal cord oligodendrocyte cell differentiation P 1 1 GO:0021511 spinal cord patterning P 6 6 GO:0021965 spinal cord ventral commissure morphogenesis P 1 1 GO:0051225 spindle assembly P 6 5 GO:0007056 spindle assembly involved in female meiosis P 1 1 GO:0007057 spindle assembly involved in female meiosis I P 1 1 GO:0031577 spindle checkpoint P 4 2 GO:0051653 spindle localization P 2 1 GO:0051255 spindle midzone assembly P 1 1 GO:0051257 spindle midzone assembly involved in meiosis P 1 1 GO:0007051 spindle organization and biogenesis P 14 10 GO:0051300 spindle pole body organization and biogenesis P 1 0 GO:0048536 spleen development P 8 8 GO:0000387 spliceosomal snRNP biogenesis P 3 0 GO:0000245 spliceosome assembly P 21 6 GO:0002040 sprouting angiogenesis P 1 1 GO:0048682 sprouting of injured axon P 2 2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane P 16 0 GO:0030322 stabilization of membrane potential P 1 0 GO:0001964 startle response P 12 11 GO:0007262 STAT protein nuclear translocation P 3 2 GO:0048864 stem cell development P 6 6 GO:0048863 stem cell differentiation P 8 8 GO:0017145 stem cell division P 9 9 GO:0019827 stem cell maintenance P 6 6 GO:0006694 steroid biosynthetic process P 69 19 GO:0006706 steroid catabolic process P 6 5 GO:0006463 steroid hormone receptor complex assembly P 1 1 GO:0030518 steroid hormone receptor signaling pathway P 13 11 GO:0008202 steroid metabolic process P 140 55 GO:0016126 sterol biosynthetic process P 29 6 GO:0016127 sterol catabolic process P 4 4 GO:0016125 sterol metabolic process P 71 28 GO:0015918 sterol transport P 13 11 GO:0002223 stimulatory C-type lectin receptor signaling pathway P 2 2 GO:0043149 stress fiber formation P 3 3 GO:0051403 stress-activated MAPK cascade P 3 2 GO:0031098 stress-activated protein kinase signaling pathway P 46 37 GO:0055002 striated muscle cell development P 14 12 GO:0051146 striated muscle cell differentiation P 28 25 GO:0006941 striated muscle contraction P 31 14 GO:0007519 striated muscle development P 115 95 GO:0021756 striatum development P 2 2 GO:0021544 subpallium development P 5 5 GO:0060163 subpallium neuron fate commitment P 2 2 GO:0006929 substrate-bound cell migration P 5 5 GO:0006931 substrate-bound cell migration, cell attachment to substrate P 1 1 GO:0006930 substrate-bound cell migration, cell extension P 1 1 GO:0021843 substrate-independent telencephalic tangential interneuron migration P 3 3 GO:0021826 substrate-independent telencephalic tangential migration P 3 3 GO:0015744 succinate transport P 1 1 GO:0006104 succinyl-CoA metabolic process P 3 1 GO:0001967 suckling behavior P 7 7 GO:0000103 sulfate assimilation P 4 3 GO:0008272 sulfate transport P 12 2 GO:0051923 sulfation P 2 2 GO:0000097 sulfur amino acid biosynthetic process P 10 4 GO:0000098 sulfur amino acid catabolic process P 3 1 GO:0000096 sulfur amino acid metabolic process P 15 7 GO:0000101 sulfur amino acid transport P 1 1 GO:0044272 sulfur compound biosynthetic process P 26 14 GO:0044273 sulfur compound catabolic process P 3 1 GO:0006790 sulfur metabolic process P 57 34 GO:0006791 sulfur utilization P 4 3 GO:0006801 superoxide metabolic process P 17 9 GO:0042554 superoxide release P 3 3 GO:0043129 surfactant homeostasis P 4 4 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity P 4 4 GO:0044403 symbiosis, encompassing mutualism through parasitism P 4 1 GO:0048485 sympathetic nervous system development P 3 3 GO:0050808 synapse organization and biogenesis P 43 40 GO:0007129 synapsis P 12 10 GO:0051124 synaptic growth at neuromuscular junction P 4 4 GO:0007268 synaptic transmission P 185 130 GO:0060084 synaptic transmission involved in micturition P 3 3 GO:0007271 synaptic transmission, cholinergic P 13 5 GO:0001963 synaptic transmission, dopaminergic P 8 8 GO:0051932 synaptic transmission, GABAergic P 4 4 GO:0035249 synaptic transmission, glutamatergic P 9 7 GO:0060012 synaptic transmission, glycinergic P 2 2 GO:0016081 synaptic vesicle docking during exocytosis P 1 0 GO:0048488 synaptic vesicle endocytosis P 8 7 GO:0016079 synaptic vesicle exocytosis P 10 5 GO:0016188 synaptic vesicle maturation P 4 4 GO:0016082 synaptic vesicle priming P 1 1 GO:0016080 synaptic vesicle targeting P 2 1 GO:0048489 synaptic vesicle transport P 23 16 GO:0007416 synaptogenesis P 17 17 GO:0007130 synaptonemal complex assembly P 7 5 GO:0048731 system development P 1600 1325 GO:0042110 T cell activation P 116 105 GO:0002286 T cell activation during immune response P 8 7 GO:0002870 T cell anergy P 1 1 GO:0031295 T cell costimulation P 8 8 GO:0030217 T cell differentiation P 59 51 GO:0002292 T cell differentiation during immune response P 8 7 GO:0033077 T cell differentiation in the thymus P 23 22 GO:0043029 T cell homeostasis P 9 8 GO:0001777 T cell homeostatic proliferation P 3 3 GO:0001913 T cell mediated cytotoxicity P 4 4 GO:0002456 T cell mediated immunity P 7 7 GO:0042098 T cell proliferation P 55 52 GO:0050852 T cell receptor signaling pathway P 18 16 GO:0033153 T cell receptor V(D)J recombination P 2 2 GO:0033371 T cell secretory granule organization and biogenesis P 1 1 GO:0045058 T cell selection P 17 15 GO:0002517 T cell tolerance induction P 2 2 GO:0007217 tachykinin signaling pathway P 3 1 GO:0035121 tail morphogenesis P 2 2 GO:0019530 taurine metabolic process P 2 0 GO:0015734 taurine transport P 1 1 GO:0042330 taxis P 101 40 GO:0022029 telencephalon cell migration P 6 6 GO:0021537 telencephalon development P 23 23 GO:0021978 telencephalon regionalization P 2 2 GO:0000723 telomere maintenance P 17 12 GO:0007004 telomere maintenance via telomerase P 4 2 GO:0032200 telomere organization and biogenesis P 17 12 GO:0016114 terpenoid biosynthetic process P 3 0 GO:0006721 terpenoid metabolic process P 14 11 GO:0015904 tetracycline transport P 7 0 GO:0006729 tetrahydrobiopterin biosynthetic process P 6 0 GO:0046146 tetrahydrobiopterin metabolic process P 6 0 GO:0046653 tetrahydrofolate metabolic process P 1 0 GO:0033014 tetrapyrrole biosynthetic process P 13 5 GO:0033015 tetrapyrrole catabolic process P 3 0 GO:0033013 tetrapyrrole metabolic process P 18 6 GO:0016109 tetraterpenoid biosynthetic process P 3 0 GO:0016108 tetraterpenoid metabolic process P 4 1 GO:0021794 thalamus development P 1 1 GO:0045063 T-helper 1 cell differentiation P 3 2 GO:0042088 T-helper 1 type immune response P 8 5 GO:0045064 T-helper 2 cell differentiation P 4 4 GO:0042092 T-helper 2 type immune response P 6 6 GO:0042093 T-helper cell differentiation P 8 7 GO:0050955 thermoception P 3 3 GO:0001659 thermoregulation P 12 10 GO:0042724 thiamin and derivative biosynthetic process P 1 0 GO:0042723 thiamin and derivative metabolic process P 2 1 GO:0009229 thiamin diphosphate biosynthetic process P 1 0 GO:0042357 thiamin diphosphate metabolic process P 1 0 GO:0006772 thiamin metabolic process P 2 1 GO:0015888 thiamin transport P 2 1 GO:0006125 thioredoxin pathway P 2 2 GO:0021678 third ventricle development P 1 1 GO:0009088 threonine biosynthetic process P 1 0 GO:0006566 threonine metabolic process P 1 0 GO:0006435 threonyl-tRNA aminoacylation P 3 0 GO:0045061 thymic T cell selection P 14 13 GO:0050757 thymidylate synthase biosynthetic process P 1 1 GO:0048538 thymus development P 11 10 GO:0030878 thyroid gland development P 10 10 GO:0042404 thyroid hormone catabolic process P 2 2 GO:0006590 thyroid hormone generation P 5 2 GO:0042403 thyroid hormone metabolic process P 10 7 GO:0009888 tissue development P 274 203 GO:0001894 tissue homeostasis P 25 24 GO:0048729 tissue morphogenesis P 74 50 GO:0042246 tissue regeneration P 11 7 GO:0048771 tissue remodeling P 119 86 GO:0002507 tolerance induction P 4 4 GO:0002461 tolerance induction dependent upon immune response P 1 1 GO:0002513 tolerance induction to self antigen P 3 3 GO:0002224 toll-like receptor signaling pathway P 5 5 GO:0009404 toxin metabolic process P 1 1 GO:0006350 transcription P 1946 562 GO:0042991 transcription factor import into nucleus P 8 8 GO:0006360 transcription from RNA polymerase I promoter P 10 5 GO:0006366 transcription from RNA polymerase II promoter P 419 318 GO:0006383 transcription from RNA polymerase III promoter P 3 0 GO:0006352 transcription initiation P 27 4 GO:0006361 transcription initiation from RNA polymerase I promoter P 4 3 GO:0006367 transcription initiation from RNA polymerase II promoter P 11 1 GO:0042790 transcription of nuclear rRNA large RNA polymerase I transcript P 1 1 GO:0006353 transcription termination P 6 0 GO:0006351 transcription, DNA-dependent P 1834 463 GO:0051123 transcriptional preinitiation complex assembly P 1 1 GO:0006283 transcription-coupled nucleotide-excision repair P 4 2 GO:0030321 transepithelial chloride transport P 2 2 GO:0006927 transformed cell apoptosis P 4 2 GO:0007179 transforming growth factor beta receptor signaling pathway P 46 28 GO:0032905 transforming growth factor-beta1 production P 1 1 GO:0032907 transforming growth factor-beta3 production P 1 0 GO:0000041 transition metal ion transport P 54 16 GO:0006412 translation P 436 87 GO:0006414 translational elongation P 50 6 GO:0006413 translational initiation P 45 7 GO:0006451 translational readthrough P 5 5 GO:0006415 translational termination P 4 0 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway P 77 55 GO:0007171 transmembrane receptor protein tyrosine kinase activation (dimerization) P 2 2 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway P 162 100 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway P 20 1 GO:0019226 transmission of nerve impulse P 218 161 GO:0006810 transport P 2280 488 GO:0007089 traversing start control point of mitotic cell cycle P 3 2 GO:0005991 trehalose metabolic process P 1 0 GO:0019432 triacylglycerol biosynthetic process P 4 4 GO:0019433 triacylglycerol catabolic process P 2 2 GO:0006641 triacylglycerol metabolic process P 17 16 GO:0006642 triacylglycerol mobilization P 2 2 GO:0006099 tricarboxylic acid cycle P 23 0 GO:0006100 tricarboxylic acid cycle intermediate metabolic process P 15 1 GO:0006842 tricarboxylic acid transport P 2 1 GO:0007351 tripartite regional subdivision P 5 5 GO:0001682 tRNA 5'-leader removal P 1 0 GO:0043039 tRNA aminoacylation P 52 0 GO:0006418 tRNA aminoacylation for protein translation P 52 0 GO:0006399 tRNA metabolic process P 102 4 GO:0006400 tRNA modification P 7 2 GO:0008033 tRNA processing P 50 4 GO:0031119 tRNA pseudouridine synthesis P 5 2 GO:0006388 tRNA splicing P 3 1 GO:0001829 trophectodermal cell differentiation P 1 1 GO:0001834 trophectodermal cell proliferation P 1 0 GO:0032023 trypsinogen activation P 1 1 GO:0006569 tryptophan catabolic process P 3 2 GO:0019441 tryptophan catabolic process to kynurenine P 2 2 GO:0006568 tryptophan metabolic process P 8 3 GO:0006436 tryptophanyl-tRNA aminoacylation P 2 0 GO:0035295 tube development P 167 166 GO:0035239 tube morphogenesis P 117 116 GO:0007021 tubulin folding P 3 0 GO:0042533 tumor necrosis factor biosynthetic process P 6 6 GO:0032640 tumor necrosis factor production P 15 14 GO:0033209 tumor necrosis factor-mediated signaling pathway P 1 0 GO:0000160 two-component signal transduction system (phosphorelay) P 15 0 GO:0016068 type I hypersensitivity P 8 8 GO:0002445 type II hypersensitivity P 8 8 GO:0001794 type IIa hypersensitivity P 8 8 GO:0001802 type III hypersensitivity P 3 3 GO:0001806 type IV hypersensitivity P 1 1 GO:0006572 tyrosine catabolic process P 5 0 GO:0006570 tyrosine metabolic process P 13 3 GO:0007260 tyrosine phosphorylation of STAT protein P 12 11 GO:0042508 tyrosine phosphorylation of Stat1 protein P 1 1 GO:0042503 tyrosine phosphorylation of Stat3 protein P 6 6 GO:0042506 tyrosine phosphorylation of Stat5 protein P 3 3 GO:0042505 tyrosine phosphorylation of Stat6 protein P 1 0 GO:0006437 tyrosyl-tRNA aminoacylation P 2 0 GO:0006744 ubiquinone biosynthetic process P 8 2 GO:0006743 ubiquinone metabolic process P 8 2 GO:0006512 ubiquitin cycle P 384 29 GO:0006511 ubiquitin-dependent protein catabolic process P 119 26 GO:0019276 UDP-N-acetylgalactosamine metabolic process P 2 0 GO:0006048 UDP-N-acetylglucosamine biosynthetic process P 1 0 GO:0006047 UDP-N-acetylglucosamine metabolic process P 3 1 GO:0006222 UMP biosynthetic process P 1 0 GO:0046049 UMP metabolic process P 1 0 GO:0030968 unfolded protein response P 12 11 GO:0009826 unidimensional cell growth P 1 0 GO:0006636 unsaturated fatty acid biosynthetic process P 1 0 GO:0033559 unsaturated fatty acid metabolic process P 1 0 GO:0032789 unsaturated monocarboxylic acid metabolic process P 2 2 GO:0019860 uracil metabolic process P 1 1 GO:0046415 urate metabolic process P 1 1 GO:0015747 urate transport P 1 1 GO:0000050 urea cycle P 7 0 GO:0000051 urea cycle intermediate metabolic process P 10 2 GO:0019627 urea metabolic process P 7 0 GO:0015840 urea transport P 2 1 GO:0001658 ureteric bud branching P 18 18 GO:0001657 ureteric bud development P 32 32 GO:0046108 uridine metabolic process P 1 1 GO:0060157 urinary bladder development P 1 1 GO:0001655 urogenital system development P 75 72 GO:0006063 uronic acid metabolic process P 2 2 GO:0032796 uropod organization and biogenesis P 1 1 GO:0050674 urothelial cell proliferation P 1 1 GO:0006228 UTP biosynthetic process P 9 0 GO:0046051 UTP metabolic process P 9 0 GO:0009650 UV protection P 4 4 GO:0033151 V(D)J recombination P 6 6 GO:0007035 vacuolar acidification P 1 0 GO:0006624 vacuolar protein processing P 1 0 GO:0007034 vacuolar transport P 16 5 GO:0007033 vacuole organization and biogenesis P 18 12 GO:0006573 valine metabolic process P 1 0 GO:0006438 valyl-tRNA aminoacylation P 2 0 GO:0048010 vascular endothelial growth factor receptor signaling pathway P 14 13 GO:0001944 vasculature development P 204 164 GO:0001570 vasculogenesis P 29 29 GO:0042310 vasoconstriction P 16 12 GO:0001987 vasoconstriction of artery during baroreceptor response to lowering of blood pressure P 1 1 GO:0042311 vasodilation P 13 12 GO:0001984 vasodilation of artery during baroreceptor response to increased blood pressure P 1 1 GO:0030103 vasopressin secretion P 1 1 GO:0007418 ventral midline development P 2 2 GO:0021517 ventral spinal cord development P 6 6 GO:0021514 ventral spinal cord interneuron differentiation P 2 2 GO:0021521 ventral spinal cord interneuron specification P 2 2 GO:0055015 ventricular cardiac muscle cell development P 2 2 GO:0055012 ventricular cardiac muscle cell differentiation P 6 6 GO:0055010 ventricular cardiac muscle morphogenesis P 5 5 GO:0021591 ventricular system development P 2 2 GO:0000038 very-long-chain fatty acid metabolic process P 6 5 GO:0006901 vesicle coating P 3 0 GO:0048278 vesicle docking P 16 0 GO:0006904 vesicle docking during exocytosis P 15 0 GO:0006906 vesicle fusion P 3 1 GO:0051648 vesicle localization P 12 8 GO:0016050 vesicle organization and biogenesis P 11 8 GO:0006903 vesicle targeting P 6 3 GO:0048199 vesicle targeting, to, from or within Golgi P 1 1 GO:0030050 vesicle transport along actin filament P 2 0 GO:0047496 vesicle transport along microtubule P 5 5 GO:0016192 vesicle-mediated transport P 388 134 GO:0021750 vestibular nucleus development P 1 1 GO:0021562 vestibulocochlear nerve development P 1 1 GO:0019079 viral genome replication P 2 1 GO:0019058 viral infectious cycle P 3 1 GO:0016032 viral reproduction P 6 3 GO:0022415 viral reproductive process P 5 2 GO:0006926 virus-infected cell apoptosis P 3 3 GO:0007495 visceral mesoderm-endoderm interaction involved in midgut development P 1 1 GO:0007522 visceral muscle development P 1 1 GO:0007632 visual behavior P 20 19 GO:0008542 visual learning P 20 19 GO:0007601 visual perception P 109 47 GO:0006776 vitamin A metabolic process P 16 13 GO:0042819 vitamin B6 biosynthetic process P 2 0 GO:0042816 vitamin B6 metabolic process P 2 0 GO:0009110 vitamin biosynthetic process P 18 5 GO:0009111 vitamin catabolic process P 3 0 GO:0042359 vitamin D metabolic process P 3 3 GO:0042360 vitamin E metabolic process P 1 1 GO:0042371 vitamin K biosynthetic process P 1 0 GO:0042373 vitamin K metabolic process P 2 1 GO:0006766 vitamin metabolic process P 60 32 GO:0051180 vitamin transport P 4 1 GO:0030704 vitelline membrane formation P 1 0 GO:0042297 vocal learning P 1 1 GO:0030104 water homeostasis P 3 2 GO:0006833 water transport P 11 2 GO:0042364 water-soluble vitamin biosynthetic process P 17 5 GO:0042365 water-soluble vitamin catabolic process P 3 0 GO:0006767 water-soluble vitamin metabolic process P 37 13 GO:0010025 wax biosynthetic process P 3 1 GO:0010166 wax metabolic process P 3 1 GO:0050872 white fat cell differentiation P 2 2 GO:0016055 Wnt receptor signaling pathway P 118 39 GO:0060070 Wnt receptor signaling pathway through beta-catenin P 3 3 GO:0007223 Wnt receptor signaling pathway, calcium modulating pathway P 20 1 GO:0042060 wound healing P 79 38 GO:0035313 wound healing, spreading of epidermal cells P 2 2 GO:0042178 xenobiotic catabolic process P 1 1 GO:0006805 xenobiotic metabolic process P 12 2 GO:0005997 xylulose metabolic process P 1 1 GO:0055069 zinc ion homeostasis P 6 5 GO:0006829 zinc ion transport P 18 7 GO:0007354 zygotic determination of anterior/posterior axis, embryo P 2 2 GO:0031638 zymogen activation P 3 3