Summative Diagnosis:
Mutant Type 1:
Cardiovascular phenotypes: Congenital heart disease associated with with heterotaxy, including dextrocardia, double outlet right ventricle (DORV), Taussig-Bing type DORV, muscular VSD (mVSD), atrioventricular septal defects (AVSD), and coronary fistula

Noncardiovascular phenotype: Dextrogastria, right lung isomerism, omphalocele, gastroschisis


Mutant Type 2:
Cardiovascular phenotypes: Heterotaxy with complex congenital heart disease such as transposition of the great arteries (TGA;{SDD}) and dextrocardia with double outlet right ventricle (DORV;{ILL}).

Noncardiovascular phenotype: anophthalmia, short snout, micrognathia, cleft palate

Phenotypic Similarity to Human Syndrome:
Mutant Type 1:
Heterotaxy


Mutant Type 2:
Carpenter's syndrome



Fyler Codes
The Fyler code developed by The Boston Children's Heart Foundation in Boston Children's Hospital provides a hierarchical clinical diagnosis of congenital cardiovascular defects and other disorders. These codes are used to delineate pathology in the mutant mouse models that parallel human disease and can be cross referenced to the International Pediatric and Congenital Cardiac Code (IPCCC) (http://www.ipccc.net/).

Fyler Codes	Code Description
602	DORV, ventricular defect committed to aorta
110	Dextrocardia
1100	Atrioventricular canal (endocardial cushion defect)
1320	Ventricular septal defect, muscular
190	Heterotaxy Syndrome
2230	Coronary fistula (arterio-venous or arterio-cameral)
3804	Congenital heart disease
4404	Omphalocele
600	Double outlet right ventricle
610	DORV, Taussig bing