CAST

Inbr ?+34 (1989). Origin: same as CASA. Resistant to flavivirus, unlike most laboratory mice except C3H.RV (Sangster et al 1993). Low retinal ganglion cell number (2/24) (Williams et al, 1996). Used as a tester strain in a novel strategy for mapping new mutations in laboratory mice using simple sequence repeats (SSR) with DNA pools from mutant and wild-type F2 progeny. A set of 39 SSRs is expected to screen 94% of the autosomal genome in crosses with laboratory strains (Taylor et al, 1994).

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Sangster M. Y., Heliams D. B., MacKenzie J. S., and Shellam G. R. (1993) Genetic studies of flavivirus resistance in inbred strains derived from wild mice: evidence for a new resistance allele at the flavivirus resistance locus (Flv). J. Virol. 67, 340-347.

Taylor B. A., Navin A., and Phillips S. J. (1994) PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse. Genomics 21, 626-632.

Williams R. W., Strom R. C., Rice D. S., and Goldowitz D. (1996) Genetic and environmental-control of variation in retinal ganglion-cell number in mice. Journal of Neuroscience 16, 7193-7205.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK