FVB

Inbr. F38. Albino,A,B,c,D,P. Origin: Outbred N:GP (NIH General Purpose) Swiss mice established at the National Institutes of Health in 1935. In 1966 two strains (HSFS/N and HSFR/N) were selected for sensitivity and resistance, respectively, to challenge with histamine following pertussis vaccination. In the early 1970s a group of mice at the eighth inbred generation of HSFS/N were found to carry the Fv1^b allele for sensitivity to the B strain of Friend leukaemia virus. Homozygous mice were then inbred as strain FVB, without further selection for histamine sensitivity (Taketo et al 1991). Rowe (NIH) to Amsterdam, 1978.

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Characteristics

Strain is useful for the production of transgenic mice on a fully inbred genetic background. They have a vigorous reproductive performance with large litters. Fertilized eggs contain large and prominant pronuclei which facilitate the microinjection of DNA, and following injection survive as well as C57BL/6 x SJL F1 hybrids, and much better than pure-line C57BL/6 (Taketo et al 1991). The strain has been typed at at least 44 marker loci on 15 chromosomes. Relatively insensitive to the initiation of papillomas following initiation by 7,12-dimethylbenz(a)anthracene and promotion with 12-o-tetradecanoylphorbol-13-acetate (TPA), but a high proportion progress to carcinomas (Hennings et al, 1993). A new strain 129-derived embryonic stem cell line, H3. gives good levels of germ-line transmission in chimeras involving FVB (Kim et al, 1996).

60% survival to 24 months of age in both sexes with 55% and 66% gross tumour incidence in males and females, respectively at that time. Most common tumour types were lung alveolar-bronchiolar, hepatocellular, subcutis neural crest and Harderian gland adenomas in males and lung, pituitary, ovarian, lymphomas, histiocytic sarcomas, Harderian gland adenomas and pheochromocytomas in females (Mahler et al, 1996). Maint. by N, A, J.

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Hennings H., Glick A. B., Lowry D. T., Krsmanovic L. S., Sly L. M., and Yuspa S. H. (1993) FVB/N mice: An inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis 14, 2353-2358.

Kim D., Park D. H., Kang N. G., Namkoong Y., and Shin H. S. (1996) A new embryonic stem-cell line with germ-line competence in the FVB/N background. Molecules and Cells 6, 577-581.

Mahler J. F., Stokes W., Mann P. C., Takaoka M., and Maronpot R. R. (1996) Spontaneous lesions in aging FVB/N mice. Toxicologic Pathology 24, 710-716.

Taketo M., Schroeder A. C., Mobraaten L. E., Gunning K. B., Hanten G., Fox R. R., Roderick T. H., Stewart C. L., Lilly F., Hansen C. T., and Overbeek P. A. (1991) FVB/N: An inbred mouse strain preferable for transgenic analyses. Proc. Natl. Acad. Sci. USA 88, 2065-2069.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK