LP

Inbr (J) 125. Colour: white-bellied agouti with white patches A^w,s. Origin: Dunn 1928 from a chinchilla stock from Castle and some coat colour stocks from English fanciers. To Scott, to Dickie 1947, to J 1949. Maint. by J.

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Characteristics

High emotionality (4/15) (Thompson, 1953). Susceptible to audiogenic seizures (1/11) (Fuller and Sjursen, 1967). Long life-span in conventional conditions (22/22 = 748 days in males, 22/22 = 799 days in females) (Storer, 1966). Overall tumour incidence 26% in males and 30% in females, with a wide range of tumour types, including mammary tumours (14% in females, 3% in males), lymphoma (1% in males, 8% in females), lung tumours (5% in males, 4% in females) and soft-tissue sarcomas (7% in males, 6% in females) (Smith et al. 1973). High plasma cholesterol at 12 and 24 weeks (1/8) (Weibust, 1973). High serum ceruloplasmin levels in females (5/27) and males (8/26) (Meier and MacPike, 1968). Low plasma cholinesterase activity in males (19/22) (Angel et al., 1967., 1967). Low hypoxanthene-guanine phosphoribosyl transferase in thalamus (7/7) (Suran, 1973). Low brain monoamine oxidase (6/7) and catechol-O-methyltransferase activity (7/7) (Tunnicliff et al., 1973., 1973). High mean heart rate adaptation (1/7) (Blizard and Welty, 1971). Large spinal cord (4/25) (Roderick et al., 1973., 1973). Small kidney/body weight ratio (17/21) (Schlager, 1968). Susceptible to skin ulceration by DMBA (cf. 13/22) (Thomas et al., 1973., 1973). Highly resistant to the induction of catalepsy by haloperidol (8/8) associated with midbrain dopamine D2 receptor density levels (Kanes et al, 1993)

Low retinal ganglion cell number (5/24) (Williams et al, 1996).

High lymphocyte phytohaemagglutinin response (9/43) (Heiniger et al., 1975., 1975). Poor immune response to ovomucoid, but good response to ovalbumin (cf. 6/12) (Vaz et al., 1971., 1971). Discriminator between `H' and `L' sheep erythrocytes (cf. 12/18) (McCarthy and Dutton, 1975).

Resistant to induction of diabetes mellitus by encephalomyocarditis virus (cf. 7/14) (Boucher et al., 1975., 1975).

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Angel C. R., Mahin D. T., Farris R. D., and Woodward K. T. (1967) Heritability of plasma cholinesterase activity in inbred mouse strains. Science 156, 529-530.

Blizard D. A. and Welty R. (1971) Cardiac activity in the mouse: strain differences. J. Comp. Physiol. Psychol. 77, 337-344.

Boucher D. W., Hayashi K., Rosenthal J., and Notkins A. L. (1975) Virus-induced diabetes mellitus. III. Influence of sex and strain of host. J. Infect. Dis. 131, 462-466.

Fuller J. L. and Sjursen F. H. (1967) Audiogenic seizures in eleven mouse strains. J. Hered. 58, 135-140.

Heiniger H. J., Taylor B. A., Hards E. J., and Meier H. (1975) Heritability of the phytohaemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis. Cancer Res. 35, 825-831.

Kanes S. J., Hitzemann B. A., and Hitzemann R. J. (1993) On the relationship between D2 receptor density and neuroleptic-induced catalepsy among eight inbred strains of mice. J. Pharmacol. Exp. Therapeut. 267, 538-547.

McCarthy M. M. and Dutton R. W. (1975) The humoral response of mouse spleen cells to two types of sheep erythrocytes. J. Immunol. 115, 1316-1321.

Meier H. and MacPike A. D. (1968) Levels and heritability of serum ceruloplasmin activity in inbred strains of mice. Proc. Soc. Exp. Biol. Med. 128, 1185-1190.

Roderick T. H., Wimer R. E., Wimer C. C., and Schwartzkroin P. A. (1973) Genetic and phenotypic variation in weight of brain and spinal cord between inbred strains of mice. Brain Res. 64, 345-353.

Schlager G. (1968) Kidney weight in mice: strain differences and genetic determination. J. Hered. 59, 171-174.

Smith G. S., Walford R. L., and Mickey R. M. (1973) Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids. J. Natl. Cancer Inst. 50, 1195-1213.

Storer J. B. (1966) Longevity and gross pathology at death in 22 inbred strains of mice. J. Gerontol. 21, 404-409.

Suran A. A. (1973) Hypoxanthine-guanine phorphoribosyl transferase in brains of mice. Regional distribution in seven inbred mouse strains. Life Sci. 13, 1779-1788.

Thomas P. E., Hutton J. J., and Taylor B. A. (1973) Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice. Genetics 74, 655-659.

Thompson W. R. (1953) The inheritance of behaviour: behavioural differences in fifteen mouse strains. Can. J. Psychol. 7, 145-155.

Tunnicliff G., Wimer C. C., and Wimer R. E. (1973) Relationships between neurotransmitter metabolism and behaviour in seven inbred strains of mice. Brain Res. 61, 428-434.

Vaz N. M., Phillips-Quagliata J. M., Levine B. B., and Vaz E. M. (1971) H-2 linked genetic control of immune responsiveness to ovalbumin and ovomucoid. J. Exp. Med. 134, 1335-1348.

Weibust R. S. (1973) Inheritance of plasma cholesterol levels in mice. Genetics 73, 303-312.

Williams R. W., Strom R. C., Rice D. S., and Goldowitz D. (1996) Genetic and environmental-control of variation in retinal ganglion-cell number in mice. Journal of Neuroscience 16, 7193-7205.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK