OXYS

Inbr.F>75.

Colour: Albino.

Genet. c.

Origin: Developed in 1972 at the Institute of Cytology and Genetics, Russian Academy of Sciences (Novosibirsk) by Salganik and Solovyova from Wistar stock by selection for susceptibility to cataractogenic effect of galactose-rich diet and brother-sister mating of highly susceptible rats (Solovyova et al 1975). In 1992, due to new findings, the S symbol was assigned to this strain. However, since this S symbol has previously been used to designate the Dahl Salt Sensitive strain the symbol assigned to the strain is now: OXYS. To the Division of Laboratory Animal Medicine, the University of North Carolina at Chapel Hill 1994 at F72.

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Characteristics

Inherited overproduction of free radicals, high levels of lipid peroxidation, protein oxidation, DNA rearrangements, morbid conditions mimicking human degenerative diseases: cataract, emphysema, cardiomyopathy, carcinogenesis; short life-span and low fecundity. Intensive transport of monosaccharides into the cells (Salganik et al 1994).

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Salganik R. I., Solovyova N. A., Dikalov S. I., Grishaeva O. N., Semenova L. A., and Popovsky A. V. (1994) Inherited enhancement of hydroxyl radical generation and lipid peroxidation in the S strain rats results in DNA rearrangments, degenerative diseases, and premature aging. Biochemical and Biophysical Research Communications 199, 726-733.

Solovyova N. A., Morozkova T. S., and Salganik R. I. (1975) Development of the inherited galactosemia symptoms in rats. Genetika 5, 63-72.

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INBRED STRAINS OF RATS
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK