Inverted Screen for Project: NIH-0752 Test Description: A motor strength deficit is apparent when there is a 50% point difference between (-/-) or (+/-) mice and (+/+) mice for the fell down response. 0/8 or 1/8 (-/-) or (+/-) mice not climbing indicates impaired motor coordination. 7/8 or 8/8(-/-) or (+/-) mice climbing up indicates enhanced motor coordination.

Results Genotype Ratio Fell Down % Ratio Climbed Up % +/+ (n=4) 1/4 25 1/4 25 +/- (n=8) 0/8 0 6/8 75 WT Population Fell Down 3.62 Climbed Up 60.04 *Red color coding indicates a notable difference.

Inverted Screen data for Project: NIH-0752 - Results        Mouse Label Genotype Age (days) Test Result Weight at Testing Comments F-57 het 90 Climbed Up 20.4 climbed up in 13 seconds F-58 het 90 Climbed Up 23.2 climbed up in 2 seconds M-59 het 90 Did Not Climb 31.7 M-61 het 90 Climbed Up 33.8 climbed up in 9 seconds F-74 het 89 Climbed Up 28.7 climbed up in 40 seconds F-75 het 89 Climbed Up 26.1 climbed up in 16 seconds M-81 het 89 Did Not Climb 32.4 M-82 het 89 Climbed Up 31.3 climbed up in 20 seconds F-56 wt 90 Did Not Climb 20.2 M-60 wt 90 Did Not Climb 31.1 F-73 wt 89 Fell Down 22.0 fell down in 35 seconds M-83 wt 89 Climbed Up 32.2 climbed up in 29 seconds

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Lexicon Phenotypic Analysis software version 05.05.00.05