Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; and protein kinase binding activity. Involved in several processes, including cellular response to cytokine stimulus; glial cell differentiation; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including mRNA transcription by RNA polymerase II; negative regulation of glycolytic process; and retinal rod cell differentiation. Located in cytoplasm and plasma membrane. Part of transcription regulator complex. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hindlimb long bone. Used to study colorectal cancer; hyper IgE recurrent infection syndrome 1; inflammatory bowel disease; peripartum cardiomyopathy; and psoriasis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3).

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Gene Ontology Evidence Code Abbreviations:

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