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Gene Ontology Classifications
Symbol
Name
ID
Ppara
peroxisome proliferator activated receptor alpha
MGI:104740

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Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; lipid binding activity; and nuclear receptor activity. Involved in several processes, including negative regulation of appetite; peroxisome proliferator activated receptor signaling pathway; and regulation of gene expression. Acts upstream of or within several processes, including enamel mineralization; positive regulation of biosynthetic process; and wound healing. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; early conceptus; gut; hemolymphoid system gland; and skeletal muscle. Used to study diabetes mellitus and schizophrenia. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).



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Filter annotations by: Aspect  Category  Evidence 

 
Context
Inferred From
Data error.
 


Gene Ontology Evidence Code Abbreviations:

Experimental:
EXP
Inferred from experiment
HMP
Inferred from high throughput mutant phenotype
HGI
Inferred from high throughput genetic interaction
HDA
Inferred from high throughput direct assay
HEP
Inferred from high throughput expression pattern
IDA
Inferred from direct assay
IEP
Inferred from expression pattern
IGI
Inferred from genetic interaction
IMP
Inferred from mutant phenotype
IPI
Inferred from physical interaction
Homology:
IAS
Inferred from ancestral sequence
IBA
Inferred from biological aspect of ancestor
IBD
Inferred from biological aspect of descendant
IKR
Inferred from key residues
IMR
Inferred from missing residues
IRD
Inferred from rapid divergence
ISA
Inferred from sequence alignment
ISM
Inferred from sequence model
ISO
Inferred from sequence orthology
ISS
Inferred from sequence or structural similarity
Automated:
IEA
Inferred from electronic annotation
RCA
Reviewed computational analysis
Other:
IC
Inferred by curator
NAS
Non-traceable author statement
ND
No biological data available
TAS
Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory