Automated description from the Alliance of Genome Resources (Release 7.4.0)
Predicted to enable RNA polymerase I core promoter sequence-specific DNA binding activity. Predicted to be involved in RNA polymerase I preinitiation complex assembly and nucleolar large rRNA transcription by RNA polymerase I. Predicted to act upstream of or within transcription by RNA polymerase I. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of RNA polymerase I core factor complex and RNA polymerase transcription factor SL1 complex. Is expressed in heart and limb. Human ortholog(s) of this gene implicated in Lynch syndrome and mismatch repair cancer syndrome. Orthologous to human TAF1B (TATA-box binding protein associated factor, RNA polymerase I subunit B).
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