Gene Ontology Classifications

Symbol
Name
ID

Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
MGI:1100842

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable glial cell-derived neurotrophic factor receptor activity; integrin binding activity; and neurotrophin receptor activity. Acts upstream of or within nervous system development. Predicted to be located in axon; extracellular space; and neuronal cell body. Predicted to be part of plasma membrane protein complex and receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; lung; musculoskeletal system; and nervous system. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human GFRA1 (GDNF family receptor alpha 1).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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