Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in several processes, including nervous system development; positive regulation of cold-induced thermogenesis; and regulation of respiratory gaseous exchange by nervous system process. Acts upstream of or within several processes, including negative regulation of type B pancreatic cell proliferation; nervous system development; and regulation of neuron differentiation. Located in nucleus. Is expressed in several structures, including adrenal gland; epibranchial placode; genitourinary system; gut; and nervous system. Used to study congenital central hypoventilation syndrome. Human ortholog(s) of this gene implicated in colorectal cancer; congenital central hypoventilation syndrome; and neuroblastoma. Orthologous to human PHOX2B (paired like homeobox 2B).

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Gene Ontology Evidence Code Abbreviations:

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