Automated description from the Alliance of Genome Resources (Release 7.3.0)
Enables microtubule binding activity and small GTPase binding activity. Involved in flagellated sperm motility; positive regulation of protein localization to cilium; and positive regulation of smoothened signaling pathway. Acts upstream of or within several processes, including axoneme assembly; determination of left/right symmetry; and epithelial cilium movement involved in extracellular fluid movement. Located in Golgi apparatus; ciliary basal body; and sperm flagellum. Is expressed in bronchus; nasal cavity epithelium; and nervous system. Used to study primary ciliary dyskinesia 33. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 33. Orthologous to human GAS8 (growth arrest specific 8).
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