Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of insulin secretion; positive regulation of transcription by RNA polymerase II; and response to glucose. Acts upstream of or within several processes, including embryonic morphogenesis; negative regulation of cellular response to growth factor stimulus; and nervous system development. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in breast cancer; colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2).

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Gene Ontology Evidence Code Abbreviations:

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