Gene Ontology Classifications

Symbol
Name
ID

Casp8
caspase 8
MGI:1261423

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Automated description from the Alliance of Genome Resources (Release 7.5.0)

Enables cysteine-type endopeptidase activator activity involved in apoptotic process and cysteine-type endopeptidase activity. Involved in several processes, including circulatory system development; negative regulation of necroptotic process; and proteolysis. Acts upstream of or within several processes, including hepatocyte apoptotic process; positive regulation of cysteine-type endopeptidase activity; and regulation of apoptotic process. Located in cytoplasm; nucleus; and plasma membrane. Part of Noc1p-Noc2p complex. Is expressed in several structures, including brain; early conceptus; gonad; hemolymphoid system; and limb bud. Used to study atopic dermatitis and autoimmune lymphoproliferative syndrome type 2B. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and lung cancer. Orthologous to human CASP8 (caspase 8).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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