Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including double-strand break repair via homologous recombination; negative regulation of macromolecule biosynthetic process; and terminal button organization. Predicted to act upstream of or within chromatin organization. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; hemolymphoid system; and nervous system. Used to study left ventricular noncompaction. Human ortholog(s) of this gene implicated in Sifrim-Hitz-Weiss syndrome; colorectal cancer (multiple); lung cancer (multiple); and lymphoma. Orthologous to human CHD4 (chromodomain helicase DNA binding protein 4).
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