Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and chromatin binding activity. Involved in several processes, including endoplasmic reticulum unfolded protein response; mitotic G2 DNA damage checkpoint signaling; and negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway. Acts upstream of or within regulation of ossification. Located in endoplasmic reticulum and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; lung; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1).
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