Automated description from the Alliance of Genome Resources (Release 7.3.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding activity; and protein phosphatase 2A binding activity. Involved in several processes, including cellular response to nitric oxide; negative regulation of fat cell differentiation; and negative regulation of insulin secretion. Acts upstream of or within several processes, including insulin receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; and positive regulation of biosynthetic process. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to human FOXO1 (forkhead box O1).
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