Automated description from the Alliance of Genome Resources (Release 7.3.0)
Predicted to enable guanylate cyclase activity. Predicted to contribute to adenylate cyclase activity and cytidylate cyclase activity. Involved in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Acts upstream of or within several processes, including cGMP biosynthetic process; positive regulation of nitric oxide mediated signal transduction; and relaxation of vascular associated smooth muscle. Located in synapse. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study primary open angle glaucoma. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1).
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