Gene Ontology Classifications

Symbol
Name
ID

Gucy1a1
guanylate cyclase 1, soluble, alpha 1
MGI:1926562

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Automated description from the Alliance of Genome Resources (Release 7.5.0)

Predicted to enable guanylate cyclase activity and nitric oxide binding activity. Predicted to contribute to adenylate cyclase activity and cytidylate cyclase activity. Involved in retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission. Acts upstream of or within several processes, including cGMP biosynthetic process; positive regulation of nitric oxide mediated signal transduction; and relaxation of vascular associated smooth muscle. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Used to study primary open angle glaucoma. Human ortholog(s) of this gene implicated in Moyamoya disease. Orthologous to human GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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