Gene Ontology Classifications

Symbol
Name
ID

P2rx2
purinergic receptor P2X, ligand-gated ion channel, 2
MGI:2665170

Go Annotations as Summary Text (Tabular View) (GO Graph)

Automated description from the Alliance of Genome Resources (Release 7.5.0)

Enables extracellularly ATP-gated monoatomic cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including neuromuscular synaptic transmission; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is active in neuronal dense core vesicle. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Used to study autosomal dominant nonsyndromic deafness 41. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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