Automated description from the Alliance of Genome Resources (Release 7.3.0)
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within several processes, including cellular response to interleukin-6; negative regulation of transcription by RNA polymerase II; and positive regulation of protein sumoylation. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is expressed in genitourinary system and pancreas epithelium. Human ortholog(s) of this gene implicated in adenomatoid tumor; hepatocellular carcinoma; and peritoneal mesothelioma. Orthologous to human TRAF7 (TNF receptor associated factor 7).
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