Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables protein kinase binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; negative regulation of apoptotic process; and regulation of gene expression. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including cellular response to cytokine stimulus; embryonic placenta development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including cell-cell junction; microtubule cytoskeleton; and mitochondrion. Is active in glutamatergic synapse and mitochondrial intermembrane space. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Used to study Proteus syndrome and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including Cowden syndrome 6; breast cancer (multiple); colorectal cancer (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1).

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Gene Ontology Evidence Code Abbreviations:

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