Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables several functions, including cholesterol transfer activity; heparan sulfate proteoglycan binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Involved in several processes, including negative regulation of macromolecule metabolic process; plasma lipoprotein particle remodeling; and regulation of defense response. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within several processes, including cholesterol catabolic process; cholesterol efflux; and lipoprotein metabolic process. Located in extracellular space. Part of low-density lipoprotein particle. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and sensory organ. Used to study Alzheimer's disease; age related macular degeneration 1; and homocystinuria. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); biliary tract cancer (multiple); eye disease (multiple); and familial hyperlipidemia (multiple). Orthologous to human APOE (apolipoprotein E).

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Gene Ontology Evidence Code Abbreviations:

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