Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; nervous system development; and regulation of protein metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is active in cell surface; intracellular vesicle; and presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; metanephros; peripheral nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease (multiple); cognitive disorder; traumatic brain injury; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein).

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Gene Ontology Evidence Code Abbreviations:

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