Gene Ontology Classifications

Symbol
Name
ID

Calr
calreticulin
MGI:88252

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables calcium ion binding activity; carbohydrate binding activity; and mRNA binding activity. Involved in several processes, including peptide antigen assembly with MHC class I protein complex; positive regulation of phagocytosis; and protein stabilization. Acts upstream of or within cortical actin cytoskeleton organization; positive regulation of non-canonical NF-kappaB signal transduction; and regulation of meiotic nuclear division. Located in endoplasmic reticulum; external side of plasma membrane; and extracellular space. Part of MHC class I peptide loading complex. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and white fat. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to human CALR (calreticulin).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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