Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.5.0)

Enables serine-type endopeptidase activity. Involved in G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion. Acts upstream of or within several processes, including platelet activation; positive regulation of cell growth; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in collagen-containing extracellular matrix. Is expressed in several structures, including adrenal gland; gonad; liver; musculoskeletal system; and yolk sac endoderm. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); appendicitis; artery disease (multiple); autoimmune disease (multiple); and thrombophilia (multiple). Orthologous to human F2 (coagulation factor II, thrombin).

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Gene Ontology Evidence Code Abbreviations:

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