Gene Ontology Classifications

Symbol
Name
ID

Gabrg2
gamma-aminobutyric acid type A receptor, subunit gamma 2
MGI:95623

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables GABA-A receptor activity; chloride channel activity; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Contributes to GABA-gated chloride ion channel activity. Involved in cellular response to histamine; chloride transmembrane transport; and inhibitory synapse assembly. Acts upstream of or within several processes, including adult behavior; chemical synaptic transmission; and gamma-aminobutyric acid signaling pathway. Located in axon and plasma membrane. Part of GABA-A receptor complex. Is active in GABA-ergic synapse. Is expressed in central nervous system; eye; palatal shelf; and peripheral nervous system ganglion. Used to study generalized epilepsy with febrile seizures plus. Human ortholog(s) of this gene implicated in alcohol dependence; alcoholic liver cirrhosis; amphetamine abuse; brain disease (multiple); and heroin dependence. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2).

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Aspect

Category

Evidence

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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