Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 7.4.0)

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in mononuclear cell differentiation and regulation of gene expression. Acts upstream of or within several processes, including defense response to protozoan; positive regulation of macromolecule biosynthetic process; and response to bacterium. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system; intestine; and lens. Used to study familial chronic myelocytic leukemia-like syndrome. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8).

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Gene Ontology Evidence Code Abbreviations:

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