Automated description from the Alliance of Genome Resources (Release 7.2.0)
Enables extracellular matrix binding activity. Acts upstream of or within cell-matrix adhesion. Located in external side of plasma membrane and focal adhesion. Is expressed in several structures, including hematopoietic system; liver; mesenchyme derived from splanchnopleure; umbilical blood vessel; and yolk sac. Used to study platelet-type bleeding disorder 16. Human ortholog(s) of this gene implicated in Glanzmann's thrombasthenia; platelet-type bleeding disorder 16; thrombocytopenia; and von Willebrand's disease 1. Orthologous to human ITGA2B (integrin subunit alpha 2b).
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