Automated description from the Alliance of Genome Resources (Release 7.4.0)
Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including endocytosis; heart development; and negative regulation of Wnt signaling pathway. Located in external side of plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).
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