Gene Expression Literature Summary

• Symbol: Brca1
• Name: breast cancer 1, early onset
• ID: MGI:104537

64 matching records from 64 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E2.5	E3	E4	E6.5	E7	E7.5	E8.5	E9.5	E10	E10.5	E11	E11.5	E12	E12.5	E13	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	E19.5	E20	E	P
Immunohistochemistry (section)														1	1	1	1									1					4
In situ RNA (section)				1		1		1		2		2		2	1	5	2	4	1	2	1			1		1	1		1		3
Immunohistochemistry (whole mount)																	1					1				1				2	6
In situ RNA (whole mount)								2		3										2
Northern blot	1		1		1	1	2	1		2	1			1				3	1			1	1			1					7
Western blot								2						1												1					2
RT-PCR		1				3	3	3	1	2			1	2		1	1	1	1		2			2	1	1		1		1	13
cDNA clones							1			1								1						1
RNase protection				1												1										1					3

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Brca1  breast cancer 1, early onset
Results	Reference
3*	J:30135 Abel KJ, Xy J, Yin GY, Lyons RH, Meisler MH, Weber BL, Mouse Brca1: localization sequence analysis and identification of evolutionary conserved domains. Hum Mol Genet. 1995 Dec;4(12):2265-73
3*	J:314268 Akagawa R, Nabeshima YI, Kawauchi T, Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
1*	J:50839 Ayi TC, Tsan JT, Hwang LY, Bowcock AM, Baer R, Conservation of function and primary structure in the BRCA1-associated RING domain (BARD1) protein. Oncogene. 1998 Oct 22;17(16):2143-8
2	J:321831 Bai F, Wang C, Liu X, Hollern D, Liu S, Fan C, Liu C, Ren S, Herschkowitz JI, Zhu WG, Pei XH, Loss of function of BRCA1 promotes EMT in mammary tumors through activation of TGFbetaR2 signaling pathway. Cell Death Dis. 2022 Mar 2;13(3):195
1*	J:74077 Bennett LM, McAllister KA, Blackshear PE, Malphurs J, Goulding G, Collins NK, Ward T, Bunch DO, Eddy EM, Davis BJ, Wiseman RW, BRCA2-null embryonic survival is prolonged on the BALB/c genetic background. Mol Carcinog. 2000 Jul;28(3):174-83
5	J:74101 Bernard-Gallon DJ, De Latour MP, Sylvain V, Vissac C, Aunoble B, Chassagne J, Bignon YJ, Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Int J Oncol. 2001 Feb;18(2):271-80
5	J:45456 Blackshear PE, Goldsworthy SM, Foley JF, McAllister KA, Bennett LM, Collins NK, Bunch DO, Brown P, Wiseman RW, Davis BJ, Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Oncogene. 1998 Jan 8;16(1):61-8
1	J:291201 Cao Y, Li M, Liu F, Ni X, Wang S, Zhang H, Sui X, Huo R, Deletion of maternal UHRF1 severely reduces mouse oocyte quality and causes developmental defects in preimplantation embryos. FASEB J. 2019 Jul;33(7):8294-8305
1*	J:67880 Chandler J, Hohenstein P, Swing D, Tessarollo L, Sharan S, Human BRCA1 gene rescues the embryonic lethality of Brca1 mutant mice. Genesis. 2001 Feb;29(2):72-7
2	J:241332 Chen HR, Juan HC, Wong YH, Tsai JW, Fann MJ, Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cereb Cortex. 2017 Mar 01;27(3):2289-2302
1	J:325357 Chomiak AA, Guo Y, Kopsidas CA, McDaniel DP, Lowe CC, Pan H, Zhou X, Zhou Q, Doughty ML, Feng Y, Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022 Jun 17;25(6):104354
5	J:38616 Connor F, Smith A, Wooster R, Stratton M, Dixon A, Campbell E , Tait TM , Freeman T , Ashworth A, Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene. Hum Mol Genet. 1997 Feb;6(2):291-300
1	J:173089 Daniel K, Lange J, Hached K, Fu J, Anastassiadis K, Roig I, Cooke HJ, Stewart AF, Wassmann K, Jasin M, Keeney S, Toth A, Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1. Nat Cell Biol. 2011 May;13(5):599-610
2	J:336101 Dickinson K, Hammond L, Akpa M, Chu LL, Lalonde CT, Goumba A, Goodyer P, WT1 regulates expression of DNA repair gene Neil3 during nephrogenesis. Am J Physiol Renal Physiol. 2023 Mar 1;324(3):F245-F255
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
2*	J:31571 Gowen LC, Johnson BL, Latour AM, Sulik KK, Koller BH, Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities. Nat Genet. 1996 Feb;12(2):191-4
2*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
8*	J:33880 Hakem R, de la Pompa JL, Sirard C, Mo R, Woo M, Hakem A, Wakeham A, Potter J, Reitmair A, Billia F, Firpo E, Hui CC, Roberts J, Rossant J, Mak TW, The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell. 1996 Jun 28;85(7):1009-23
1	J:225041 Hasegawa K, Sin HS, Maezawa S, Broering TJ, Kartashov AV, Alavattam KG, Ichijima Y, Zhang F, Bacon WC, Greis KD, Andreassen PR, Barski A, Namekawa SH, SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. Dev Cell. 2015 Mar 9;32(5):574-88
1	J:69602 Hohenstein P, Kielman MF, Breukel C, Bennett LM, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen GJ, Devilee P, Fodde R, A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Oncogene. 2001 May 3;20(20):2544-50
1*	J:227197 Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodriguez-Acebes S, Lecona E, Murga M, Mendez J, Blasco MA, Fernandez-Capetillo O, NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity. EMBO J. 2015 Nov 3;34(21):2604-19
1*	J:242195 Juan HC, Lin Y, Chen HR, Fann MJ, Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death Differ. 2016 Jun;23(6):1038-48
1	J:193691 Keimpema E, Tortoriello G, Alpar A, Capsoni S, Arisi I, Calvigioni D, Hu SS, Cattaneo A, Doherty P, Mackie K, Harkany T, Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1935-40
1	J:263685 Kitami K, Kitami M, Kaku M, Wang B, Komatsu Y, BRCA1 and BRCA2 tumor suppressors in neural crest cells are essential for craniofacial bone development. PLoS Genet. 2018 May;14(5):e1007340
1	J:184521 Koss M, Bolze A, Brendolan A, Saggese M, Capellini TD, Bojilova E, Boisson B, Prall OW, Elliott DA, Solloway M, Lenti E, Hidaka C, Chang CP, Mahlaoui N, Harvey RP, Casanova JL, Selleri L, Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
3	J:153169 Kouznetsova A, Wang H, Bellani M, Camerini-Otero RD, Jessberger R, Hoog C, BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes. J Cell Sci. 2009 Jul 15;122(Pt 14):2446-52
1	J:161203 Kumar R, Bourbon HM, de Massy B, Functional conservation of Mei4 for meiotic DNA double-strand break formation from yeasts to mice. Genes Dev. 2010 Jun 15;24(12):1266-80
2*	J:215685 Lamparter C, Winn LM, Tissue-specific effects of valproic acid on DNA repair genes and apoptosis in postimplantation mouse embryos. Toxicol Sci. 2014 Sep;141(1):59-67
1	J:147414 Landry J, Sharov AA, Piao Y, Sharova LV, Xiao H, Southon E, Matta J, Tessarollo L, Zhang YE, Ko MS, Kuehn MR, Yamaguchi TP, Wu C, Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. PLoS Genet. 2008 Oct;4(10):e1000241
15	J:29684 Lane TF, Deng C, Elson A, Lyu MS, Kozak CA, Leder P, Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice. Genes Dev. 1995 Nov 1;9(21):2712-22
1*	J:278517 Li M, Huang T, Li MJ, Zhang CX, Yu XC, Yin YY, Liu C, Wang X, Feng HW, Zhang T, Liu MF, Han CS, Lu G, Li W, Ma JL, Chen ZJ, Liu HB, Liu K, The histone modification reader ZCWPW1 is required for meiosis prophase I in male but not in female mice. Sci Adv. 2019;5(8):eaax1101
1	J:243570 Liu KH, Sun XF, Feng YZ, Cheng SF, Li B, Li YP, Shen W, Li L, The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis. Toxicol Appl Pharmacol. 2017 Aug 15;329:9-17
1	J:288654 Lun MP, Shannon ML, Keles S, Reisli I, Luche N, Ryan D, Capuder K, Notarangelo LD, Lehtinen MK, Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome. Am J Pathol. 2019 Dec;189(12):2440-2449
13	J:28391 Marquis ST, Rajan JV, Wynshaw-Boris A, Xu J, Yin GY, Abel KJ, Weber BL, Chodosh LA, The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues. Nat Genet. 1995 Sep;11(1):17-26
1*	J:84329 McCarthy EE, Celebi JT, Baer R, Ludwig T, Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. Mol Cell Biol. 2003 Jul;23(14):5056-63
1	J:301847 Ni L, Xie H, Tan L, Multiple roles of FOXJ3 in spermatogenesis: A lesson from Foxj3 conditional knockout mouse models. Mol Reprod Dev. 2016 Dec;83(12):1060-1069
1	J:325726 Oura S, Hino T, Satoh T, Noda T, Koyano T, Isotani A, Matsuyama M, Akira S, Ishiguro KI, Ikawa M, Trim41 is required to regulate chromosome axis protein dynamics and meiosis in male mice. PLoS Genet. 2022 Jun;18(6):e1010241
1	J:207293 Pao GM, Zhu Q, Perez-Garcia CG, Chou SJ, Suh H, Gage FH, O'Leary DD, Verma IM, Role of BRCA1 in brain development. Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1240-8
5	J:176173 Passemard S, El Ghouzzi V, Nasser H, Verney C, Vodjdani G, Lacaud A, Lebon S, Laburthe M, Robberecht P, Nardelli J, Mani S, Verloes A, Gressens P, Lelievre V, VIP blockade leads to microcephaly in mice via disruption of Mcph1-Chk1 signaling. J Clin Invest. 2011 Aug 1;121(8):3071-87
1	J:149563 Pulvers JN, Huttner WB, Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors. Development. 2009 Jun;136(11):1859-68
8	J:40064 Rajan JV, Marquis ST, Gardner HP, Chodosh LA, Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues. Dev Biol. 1997 Apr 15;184(2):385-401
1*	J:161528 Rantakari P, Nikkila J, Jokela H, Ola R, Pylkas K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R, Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice. Hum Mol Genet. 2010 Aug 1;19(15):3021-9
1*	J:310000 Shapiro AM, Miller-Pinsler L, Wells PG, Breast cancer 1 (BRCA1)-deficient embryos develop normally but are more susceptible to ethanol-initiated DNA damage and embryopathies. Redox Biol. 2016 Apr;7:30-38
2	J:30136 Sharan SK, Wims M, Bradley A, Murine Brca1: sequence and significance for human missense mutations. Hum Mol Genet. 1995 Dec;4(12):2275-8
1	J:297664 Simonson L, Vold S, Mowers C, Massey RJ, Ong IM, Longley BJ, Chang H, Keratin 13 deficiency causes white sponge nevus in mice. Dev Biol. 2020 Dec 1;468(1-2):146-153
1	J:192592 Sotiropoulou PA, Karambelas AE, Debaugnies M, Candi A, Bouwman P, Moers V, Revenco T, Rocha AS, Sekiguchi K, Jonkers J, Blanpain C, BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev. 2013 Jan 1;27(1):39-51
1	J:40595 Suzuki A, de la Pompa JL, Hakem R, Elia A, Yoshida R, Mo R, Nishina H, Chuang T, Wakeham A, Itie A, Koo W, Billia P, Ho A, Fukumoto M, Hui CC, Mak TW, Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev. 1997 May 15;11(10):1242-52
2*	J:272586 Suzuki T, Kikuguchi C, Nishijima S, Nagashima T, Takahashi A, Okada M, Yamamoto T, Postnatal liver functional maturation requires Cnot complex-mediated decay of mRNAs encoding cell cycle and immature liver genes. Development. 2019 Feb 15;146(4):dev168146
1	J:322322 Tanno N, Takemoto K, Takada-Horisawa Y, Shimada R, Fujimura S, Tani N, Takeda N, Araki K, Ishiguro KI, FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis. iScience. 2022 Apr 15;25(4):104008
1*	J:314103 Ulmke PA, Sakib MS, Ditte P, Sokpor G, Kerimoglu C, Pham L, Xie Y, Mao X, Rosenbusch J, Teichmann U, Nguyen HP, Fischer A, Eichele G, Staiger JF, Tuoc T, Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Stem Cell Reports. 2021 Apr 13;16(4):968-984
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1	J:91673 Wang X, Wang RH, Li W, Xu X, Hollander MC, Fornace AJ Jr, Deng CX, Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure. J Biol Chem. 2004 Jul 9;279(28):29606-14
1*	J:190636 Wiese CB, Ireland S, Fleming NL, Yu J, Valerius MT, Georgas K, Chiu HS, Brennan J, Armstrong J, Little MH, McMahon AP, Southard-Smith EM, A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
1*	J:85108 Wong JC, Alon N, Mckerlie C, Huang JR, Meyn MS, Buchwald M, Targeted disruption of exons 1 to 6 of the Fanconi Anemia group A gene leads to growth retardation, strain-specific microphthalmia, meiotic defects and primordial germ cell hypoplasia. Hum Mol Genet. 2003 Aug 15;12(16):2063-76
1*	J:70271 Xu X, Qiao W, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX, Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Nat Genet. 2001 Jul;28(3):266-71
4*	J:54105 Xu X, Weaver Z, Linke SP, Li C, Gotay J, Wang XW, Harris CC, Ried T, Deng CX, Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells. Mol Cell. 1999 Mar;3(3):389-95
2*	J:299665 Xu Z, Li X, Li H, Nie C, Liu W, Li S, Liu Z, Wang W, Wang J, Suppression of DDX39B sensitizes ovarian cancer cells to DNA-damaging chemotherapeutic agents via destabilizing BRCA1 mRNA. Oncogene. 2020 Nov;39(47):7051-7062
1	J:306240 Yamaguchi H, Kitami K, Wu X, He L, Wang J, Wang B, Komatsu Y, Alteration of DNA Damage Response Causes Cleft Palate. Front Physiol. 2021;12:649492
1	J:347775 Yoshimura S, Shimada R, Kikuchi K, Kawagoe S, Abe H, Iisaka S, Fujimura S, Yasunaga KI, Usuki S, Tani N, Ohba T, Kondoh E, Saio T, Araki K, Ishiguro KI, Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions. Nat Commun. 2024 Apr 29;15(1):3330
1	J:211548 Zhao Y, Ransom JF, Li A, Vedantham V, von Drehle M, Muth AN, Tsuchihashi T, McManus MT, Schwartz RJ, Srivastava D, Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2. Cell. 2007 Apr 20;129(2):303-17
2	J:268403 Zhou L, Dai H, Wu J, Zhou M, Yuan H, Du J, Yang L, Wu X, Xu H, Hua Y, Xu J, Zheng L, Shen B, Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development. FASEB J. 2017 Jan;31(1):132-147
1	J:261328 Zou J, Ma W, Li J, Littlejohn R, Zhou H, Kim IM, Fulton DJR, Chen W, Weintraub NL, Zhou J, Su H, Neddylation mediates ventricular chamber maturation through repression of Hippo signaling. Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):E4101-E4110