APN

Inbr. (1998) F26. Albino, c. Origin: Outbred Swiss Webster mice from Connaught Laboratories, Toronto, Canada, selected by Casley and Whitehouse, Banting Research Centre, Ottawa, Canada, for nonresponsive serum alanine aminotransferase (ALT) following administration of 150mg/kg acetaminophen per os, with brother x sister mating started in 1993 (see also APS).

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Characteristics

Low caffeine 3-demethylation activity (8/8). Hepatic CYP1A2 mRNA, protein and enzyme activity (MROD, acetanilide 4-hydroxylation) was significantly lower than for strain C3H (Casley et al 1997a, b).

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Casley W. L., Menzies J. A., Girard M., Larocque L., Mousseau N., Whitehouse L. W., and Moon T. W. (1997a) Differences in caffein 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains. Fundam. Appl. Toxicol. 40, 228-237.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK