APS

Inbr. (1998) F26. Albino, c. Origin: Outbred Swiss Webster mice from Connaught Laboratories, Toronto, Canada, selected by Casley and Whitehouse, Banting Research Centre, Ottawa, Canada, for elevated serum alanine aminotransferase (ALT) following administration of 150mg/kg acetaminophen per os, with brother x sister mating started in 1993 (see also APS).

---

Characteristics

Males and females show approx. 2-fold increase in caffein 3-demethylation relative to strain APN. CYP1A2 mRNA and enzyme activity are also elevated approx 2-fold relative to the APN strain (Casley et al, 1997a,b)

---

Casley W. L., Menzies J. A., Girard M., Larocque L., Mousseau N., Whitehouse L. W., and Moon T. W. (1997a) Differences in caffein 3-demethylation activity among inbred mouse strains: a comparison of hepatic Cyp1a2 gene expression between two inbred strains. Fundam. Appl. Toxicol. 40, 228-237.

---

INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK