Inbred Strains
of Mice: BRVR
Inbr: F83+. Albino. Genet: c. Origin: Webster (1933a,b) developed two lines
resistant and susceptible to infection by
Bacillus enteritidis (
Salmonella
sp.) by selection on the basis of a progeny test, followed by full-sib
mating. Mortality under specified test conditions was 15% and 85%, respectively,
and was about 39% in the unselected controls. Later tests (
Webster,
1937) with louping ill and St Louis encephalitis viruses led to the
development of three lines designated BSVS (bacteria-susceptible, virus-susceptible),
BSVR (bacteria-susceptible, virus-resistant) and BRVS (bacteria-resistant,
virus-susceptible). Later BRVR (bacteria-resistant, virus-resistant) mice
were developed from a cross between BSVR and BRVS, with subsequent selection
for resistance to the two agents, and full-sib mating. There may have
been some confusion between the lines in the past, and authenticity should
not always be assumed.
Characteristics
Hydronephrosis in 11% of females and 18% of males (1/13) (
Taylor and Fraser, 1973), 34-42% in males and 30-34% in
females (
Collins et al., 1971., 1971).
Resistant to
Salmonella, some encephalitic viruses and experimental
allergic encephalomyelitis (
Staats, 1976). Resistant
to experimental allergic encephalomyelitis (cf. 6/14) (
Levine and Sowinski, 1973). Resistant to induction of experimental
autoimmune thyroiditis (cf. 2/5) (Vladutiu and Rose, 1971a). Carries gene
for resistance to group B arbovirus infection (cf. strain PRI) (
Darnell et al., 1974., 1974). Differences between the responses
of BRVR and BSVS to infections and various antigens are listed by Boehme(
1970).
Boehme D. H. (1970)
Resistance to Salmonella infections in inbred mouse strains. Bull.
N.Y. Acad. Med. 46, 499-508.
Collins
G. R., Goodheart C. R., and Henson D. (1971) Spontaneous heritable hydronephrosis
in inbred mice. I. Description, incidence and distribution of lesions.
Lab. Animal Sci. 22, 333-338.
Darnell
M. B., Koprowski H., and Lagerspatz K. (1974) Genetically determined resistance
to infection with group B arboviruses. I. Distribution of the resistance
gene among various mouse populations and characteristics of gene expression
in vivo. J. Infect. Dis. 129, 240-247.
Levine
S. and Sowinski R. (1973) Experimental allergic encephelomyelitis in inbred
and outbred mice. J. Immunol. 110, 139-143.
Staats J. (1976) Standardized
nomenclature for inbred strains of mice: Sixth listing. Cancer Res.
36, 4333-4377.
Taylor
D. M. and Fraser H. (1973) Hydronephrosis in inbred strains of mice with
particular reference to the BRVR strain. Lab. Anim. 7,
229-236.
Webster L. T. (1937)
Inheritance of resistance of mice to enteric bacterial and neurotropic
virus infections. J. Exp. Med. 65, 261-286.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
Analysis Tools