DC

Inbr (Le) 100. Agouti, +. Origin: mutation to dancer Dc arose in an obese stock outcrossed to a BALB/c x C3H/He hybrid in 1956. One cross to C3H/HeJ, then inbred. Heterozygotes exhibit circling and head tossing behaviour but are not deaf. Homozygotes die at birth with cleft lip and cleft palate. A neurological mutation "scrambler" appeared in 1991. Homozygotes have unstable gait, with phenotype and pathology resembling reeler (Sweet et al, 1996). Maint. by Le.

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Sweet H. O., Bronson R. T., Johnson K. R., Cook S. A., and Davisson M. T. (1996) Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration. Mamm. Genome 7, 798-802.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK