Inbred Strains
of Mice: GT
Inbr (Le) 28. Breeders are agouti:
A,gt/+;gt/gt are light grey
with white belly spot and have tremors like myelin deficient mice. Origin:
Developed by Lane.
gt mutation arose in strain HYIII/Le in 1977
at F55. One outcross to C3HeB/FeJ x C57BL/6-
AwJ
F1, then bxs. Has a spontaneous spongiform encephalopathy whose expression
is determined by the interaction of genetic factors and an unconventional
unrecognised transmissible agent (
Sidman et
al 1985). The strain is maintained only as frozen embryos by Dr. T
Cunliffe-Beamer.
Sidman
R. L., Kinney H. C., and Sweet H. O. (1985) Transmissable spongiform encephalopathy
in the gray tremor mutant mouse. Proc. Natl. Acad. Sci. USA 82,
253-257.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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