ICR

No details. Maint. by Cri.

ICR/Bc(NB.Duplicatename)

Inbr 29. Albino. Origin: BLU:Ha(ICR) outbred stock from the Institute of Cancer Research in 1958, to Arbor Scientific Co. Ltd., to UBC, Vancouver in 1977, followed by sib mating. Maint. by Bc.

ICR/Ha(NB.Duplicatename)

Inbr: F43 +. Albino. Genet: A, B, c, P, rd⁺. Origin: Hauschka from `Swiss Webster' stock purchased from J. C. Landis in 1947.

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Characteristics

Litter size 8.3 _ 0.13 with 30% preweaning mortality. High intrastrain aggression. Has been typed at several polymorphic loci (Hauschka and Mirand, 1973). Susceptible to colon carcinogenesis by 1,2-dimethylhydrazine (cf. 3/7) (Evans et al., 1977., 1977). High histamine release from peritoneal mast cells induced by compound 48/80, a calcium dependent histamine releaser (3/8) (Toda et al 1989). High histamine release from peritoneal mast cells induced by Ca2+ ionophore A23187 ( c.f. 7/8, contrast C57BL/6) (Toda et al 1989). Susceptible to the anaphylactic death following an intravenous injection of bovine serum albumin into primed mice (Lei et al, 1996).

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Evans J. T., Shows T. B., Sproul E. E., Paolini N. S., Mittelman A., and Hauschka T. S. (1977) Genetics of colon carcinogenesis in mice treated with 1, 2-dimethylhydrazine. Cancer Res. 37, 134-136.

Hauschka T. S. and Mirand E. A. (1973) The `Breeder: HA (ICR)' Swiss mouse, a multipurpose stock selected for fecundity. Liss, In Perspectives in Cancer Research and Treatment (ed. Murphy, G.P.), Alan R.

Lei H. Y., Lee S. H., and Leir S. H. (1996) Antigen-induced anaphylactic death in mice. International Archives of Allergy and Immunology 109, 407-412.

Toda S., Kimura M., and Tohya K. (1989) Strain differences in histamine release from mouse peritoneal mast cells induced by compound 48/80 or A23187. Jikken Dobutsu - Experimental Animals 38, 135-137.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK