MSM

Inbr. 20. White-bellied agouti A^w,b,c. Origin: Wild mice trapped in Mishima City, Shizuoka Prefecture, Japan and inbred in 1979 by Moriwaki. Has not been crossed with laboratory mice. Previously called M.MOL-MSM. Resistant to the development of lymphoma, due to at least two loci in crosses involving strain SL/Kh (Pataer et al, 1996). Fibroblast-like cells from the brains of these mice immortalise in tissue culture in a similar way to those of other strains (Yuasa et al, 1996). C3HxMSM F1 hybrids treated with N-methyl-N-nitrosourea (MNU) develop squamous cell carcinomas of the forestomach with about 20% and 15% having mutations in H-ras and p53, respectively (Masui et al, 1997).

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Masui T., Tezuka N., Nakanishi H., Inada K. I., Miyashita N., and Tatematsu M. (1997) Induction of invasive squamous cell carcinomas in the forestomach of (C3H x MSM)F1, MSM, and C3H mice by N-methyl-N-nitrosourea and mutational analysis of the H-ras and p53 genes. Cancer Lett. 111, 97-104.

Pataer A., Kamoto T., Lu L. M., Yamada Y., and Hiai H. (1996) Two dominant host-resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 56, 3716-3720.

Yuasa T., Abe E., Oshimura M., and Namba M. (1996) Immortalization of cells from brains derived from a strain (MSM/MSfB6C3F1) of wild mouse. Acta Medica Okayama 50, 319-324.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK