Inbred Strains
of Mice: NOR1
Inbr F16. Albino. Origin: Accidental genetic outcross-backcross of NOD
with C57BL/KsJ, followed by b x s mating (
Prochazka
et al (1992)
Characteristics
The strain is an insulin-resistant and diabetes-free strain which carries
the diabetogenic
H2g7 complex
on chromosome 17. Although completely resistant to cyclophosphamide-induced
diabetes, the mice have peripheral T-lymphocyte accumulation characteristic
of NOD/Lt. Similarly, the peritoneal macrophages show the depressed interleukin-1
secretion seen in NOD, but the T-suppressor lymphocyte function is more
robust. The strain may be regarded as an MHC-matched diabetes-resistant
control strain for NOD/Lt (
Prochazka et
al 1992).
Prochazka
M., Serreze D. V., Frankel W. N., and Leiter E. H. (1992) NOR/Lt mice:
MHC-matched diabetes-resistant control strain for NOD mice. Diabetes
41, 98-106.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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