NZY

Inbr: F120 (Wehi). Cinnamon piebald (?). Genet: b, s. Origin: see NZB; a piebald male appeared at F2 which was mated with a tan sister; at F4 a piebald brother-sister appeared; b x s mating with selection for piebald gene, s led to fixation of the coat pattern at F7.

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Characteristics

High incidence of mammary tumours and pituitary adenomas. Megacolon 10%, associated with the s gene (Bielschowsky and Schofield, 1962). Highly susceptible to induction of connective tissue tumours by 4-nitroquinone N-oxide (1/5) (Searle and Spencer, 1966). A subline has been developed: NZYf/Bu Inbr: 65 since fostering. Origin: NZY at F26 were fostered on NZC. A marked reduction in mammary cancer but pituitary tumour incidence unchanged.

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Bielschowsky M. and Schofield G. C. (1962) Studies on megacolon in piebald mice. Aust. J. Exp. Biol. Med. Sci. 40, 395-404.

Searle C. E. and Spencer A. T. (1966) Induction of tumours of connective tissue by repeated applications of 4-nitroquinoline N-oxide to mouse skin. Brit. J. Cancer 20, 877-885.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK