Inbred Strains
of Mice: PBA
Inbr: F20 +. Albino. Genet: c. Origin: P. C. Bailey from a pair of pet
shop mice purchased in Birmingham, Alabama, in 1958.
Characteristics
Litter size 6.1; 6 week weight 21 g (both sexes); mean life-span 317 days
in males, 268 days in females. Spontaneous lymphomas 100%, mammary tumours
74%, pulmonary adenomas 77% in animals over 1 year (
Bailey et al., 1970., 1970). Development of spontaneous adenomas
associated with increased serum concentration of IgG
1 and IgG
2
immunoglobulins (
Schrohenloher and
Bailey, 1972).
Bailey
P. C., Leach W. B., and Hartley M. W. (1970) Characteristics of a new
inbred strain of mice (PBA) with a high tumor incidence: preliminary report.
J. Natl. Cancer Inst. 45, 59-73.
Schrohenloher R. E. and Bailey P. C. (1972) Atypical immunoglobulins
associated with spontaneous lymphomas in an inbred strain of mice. J.
Natl. Cancer Inst. 49, 1027-1037.
INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW
Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester,
UK
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