PN

Inbr 52. Albino c. Origin: Albino mice from pet shop in New Zealand in 1948. From Palmerston North Hosp. to Massey Univ. as 'NOS outbred'. To Glaxo Labs of New Zealand as 'GW outbred'. Back to Palmerston North as 'PN'. Maintained by Wigley in Med. Res Dept. and inbred starting in 1964, with selection for positive ANA (anti nuclear antibody) in first three generations.

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Characteristics

Antinuclear antibodies appear at about 5 months, and 80% are positive by 10 months. Develops lupus erythematosus with glomerular depositis of IgG, IgM and IgA (Wigley et al., 1975., 1975). Maint. by Hm, Mac.

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Wigley R. D., Craig A. S., Williamson K. I., and Couchman K. G. (1975) Spontaneous arteritis and glomerulitis in mice: a comparison of light and electron microscope renal changes in PN/n, NZB/Bl, 101/Mac and CBA/Mac mice. Lab. Invest. 33, 8-15.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK