SAMP2

Inbr. ?+62. Origin: as SAMP1. Albino (c)

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Characteristics

Shows accelerated aging (Takeda et al 1991). All mice over 7 months have amyloidosis in which AApoAII often co-exists with AA amyloid protein (Higuchi et al 1983). The incidence of contracted kidney is about 73% at over 10 months of age. Median survival is 304 days in conventional conditions.

Appears to be a suitable model for studies of senile lung (Teramoto et al, 1994).

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Higuchi K., Matsumura A., Honma A., Takeshita S., Hashimoto K., Hosokawa M., Yasuhira K., and Takeda T. (1983) Systemic senile amyloid in senescence-accelerated mice: A unique fibril protein demonstrated in tissue from various organs by the unlabelled immunoperoxidase method. Lab. Invest. 48, 231-240.

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919.

Teramoto S., Fukuchi Y., Uejima Y., Teramoto K., Oka T., and Orimo H. (1994) A novel model of senile lung: Senescence-accelerated mouse (SAM). American Journal of Respiratory and Critical Care Medicine 150, 238-244.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK