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Inbred Strains of Mice: SAMP3

SAMP3

Inbr ?+56. Origin: as SAMP1. Albino (c).

Characteristics:

Shows accelerated aging (Takeda et al 1991). The first of the SAMP series to show degenerative changes in the condyle of the temporomandibula joint, reaching approx 50% at 7-9 months and 100% at over 12 months (Chen et al 1989). Median survival time is 507 days in conventional conditions.

Chen W. H., Hosokawa M., Tsuboyama T., Ono T., Iizuka T., and Takeda T. (1989) Age-related changes in the temporomandibular joint of the senescence accelerated mouse (SAM): SAM-P/3 as a new murine model of degenerative joint disease. Am. J. Pathol. 135, 379-385.

Takeda T., Hosokawa M., and Higuchi K. (1991) Senescence-accelerated mouse (SAM): A novel murine model of accelerated senescence. J. Amer. Geriatr. Soc. 39, 911-919.

INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK
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