SB

Inbr (Le) 101. Pale grey. sa,bg,A^w. Origin: mutations to sa and bg, possibly rediation-induced, occurred independently in stocks used for mutation rate studies at Oak Ridge. Rl to Le 1961, then sib-mated.

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Characteristics

Develops progressive infectious pneumonitis associated with the beige gene. Also has a high incidence of lymphadenopathy, including reticulum cell neoplasms and atypical lympho-proliferative lesions. Beige mice have giant lysosomal granules in the leukocytes and pigment dilution closely analogous to the Chediak-Higashi syndrome in man and similar disorders in mink and cattle. These mice appear to be a suitable model for the study of the increased susceptibility to infection seen with this syndrome (Lane and Murphy, 1972).

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Lane P. W. and Murphy E. D. (1972) Susceptibility to spontaneous pneumonitis in an inbred strain of beige and satin mice. Genetics 72, 451-460.

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INBRED STRAINS OF MICE
Updated 9 Apr. 1998
Michael FW Festing
MRC Toxicology Unit, Hodgkin Building,
University of Leicester, UK